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SMZ-TMP DS and Nausea: What Users Say

Nausea: mentioned by 11 users (20.4%)

Based on user experiences from 54 SMZ-TMP DS reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 20.4%
headaches 14.8%
vomiting 11.1%
insomnia 9.3%
shortness of breath 9.3%
anxiety 7.4%
burning 7.4%
chills 7.4%
confusion 7.4%
itching 7.4%

Reviews for SMZ-TMP DS

Showing 11 reviews tagged with "nausea". Clear filters to view all 54 reviews.
Commonly mentioned side effects
  • Ano...
  • Taken for less than 1 month
  • April 10, 2019

For Urinary Tract Infection "I was prescribed sulfamethoxazole and trimethoprim (SMZ/TMP) twice a day for 7 days for a UTI. I have one pill left, almost all the symptoms are gone. The first day I took the pill, I was extremely sleepy. Every day after that, I had a horrible headache in the back of my head and a stiff neck that came and went every few hours, also brought on by light sensitivity. Nausea, out of breath at times, cold sweat on exertion, and jittery."

2 / 10
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36 Report
  • tdu...
  • July 3, 2017

For Kidney Infections "I will not ever take this medication again (generic form of Bactrim DS). I landed in the ER with a severe kidney infection... was given antibiotics, nausea medication, and pain medication through an IV. Went home six hours later and started the Bactrim that night. I woke up at 2 AM absolutely drenched head to toe in sweat, with chills... couldn't fall back asleep. The next day I had the worst headache... terrible, terrible pain in the base of my skull, and a horribly stiff and sore neck. Any time I stood up I could feel my blood pressure in my head sore, just throbbing. I had zero appetite. I stopped the Rx after 2.5 days. I felt worse after I started the Rx than before it. Never, ever again."

1 / 10
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29 Report
  • Sic...
  • March 25, 2020

For Kidney Infections "Wow, I should have looked at reviews prior to taking this SMZ-TMP DS medication. I had this prescribed for a UTI/possible kidney infection. I only had a 3-day course. On day 2, I woke up extremely sick, horrid headache that turned into nausea and vomiting. That caused the headache to be even worse. I felt so weak and dehydrated, like the worst hangover of my life, except there was no alcohol involved!! :( I had to drink water all day, or else I felt I was gonna pass out and did nothing but lay on the couch under the blankets. Moving in any way made me out of breath. I finished the dose as I was scared to not finish since the internet says it’s bad to not complete antibiotics. On the night of day 2, I was finally recuperating, but surely after taking the morning dose of day 3, I went back to feeling super crappy!!! I’m hoping my infection is gone, but my back is still hurting, so I guess we’ll have to wait and see. Anyone taking this, beware!! Make sure to eat a lot and drink a lot, a lot of fluids."

1 / 10
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17 Report

Frequently asked questions

  • Pry...
  • Taken for less than 1 month
  • November 8, 2016

For Prostatitis "Dr. prescribed this med for my prostatitis symptoms, on day 5 of a 28-day plan. Noticeable reduction in symptoms so far. Pain seems to be fading as the days pass. Was told to take the whole prescription, as just because the symptoms fade doesn't mean it's gone. Some light side effects are lightheadedness, occasional nausea, and some interrupted sleep, some body tingling also during the day. But if it makes these symptoms go away, it's worth the tradeoff. Better than feeling like your bladder area is on fire. If you can handle the slight side effects for a couple of weeks, I would recommend giving this a try. Although everyone is different and side effects may differ."

7 / 10
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23 Report
  • Lil...
  • Taken for less than 1 month
  • May 20, 2019

For Bacterial Infection "I have dysuria, furuncle of the groin, cellulitis at the same time. I was given sulfamethoxazole plus TMP/DS 800 every 12 hours. I also have Hashimoto's disease and took my levothyroxine a while after taking Bactrim (sulfamethoxazole plus TMP). The first day I started having cramps on the left side of my stomach, thinking it was normal. I took the second pill after 12 hours, and I was worse than before: light headache, nausea, full and heavy stomach feeling. Then I took the third pill in the morning, and soon I was having chest pain, nausea, tired irregular heartbeat, fatigue, tight chest, pain in my teeth, lips, and muscle pain. The symptoms are not improving. I called the pharmacy, and they wanted me to call my doctor, but I will stop this medication, as per my primary doctor. I will have a long talk with them tomorrow, as according to my medical records, I shouldn’t have been on this medication."

10 / 10
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16 Report

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  • Mrs...
  • Taken for less than 1 month
  • October 26, 2019

For Urinary Tract Infection "First time ever taking this medicine. I have had stomach pains and nausea. I did everything the Dr told me to, and I still have the horrible side effects! I thought it was from the UTI. After reading all the other comments, I see it’s from the medication. The Dr only gave me a 3-day supply. I have had a headache from day one of the pills, and I have been constipated, too. Calling the Dr tomorrow to see what we can do to get rid of the side effects. Will not take this ever again!"

1 / 10
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10 Report
  • Gee...
  • Taken for less than 1 month
  • November 23, 2021

For Urinary Tract Infection "This worked quickly for my UTI caused by Klebsiella pneumoniae. I was prescribed this for 1 pill every 12 hours for 3 days. I took this along with a variety of probiotics, and I didn’t have too many issues. My only problem was that it didn’t tell me anywhere that I should probably avoid alcohol, so after day one I had two beers and woke up in the middle of the night with nausea and vomiting. After that episode, I was totally fine, just rested throughout the day. This was surprisingly mild for me, and it worked really well. I am hoping it will help stop my reoccurring UTIs."

9 / 10
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2 Report
  • Not...
  • Taken for less than 1 month
  • March 17, 2022

For Urinary Tract Infection "Prescribed this for a UTI. Took it at 6 PM, and by 11 PM, I was so nauseous I had to take a chewable pill for it. Finally got to sleep only to awaken after 4 AM with tingling in most of my upper body, throat is dry. Noticed that the urge to go isn't there, and I'm going just to go because I'm drinking plenty of water to help flush out the bacteria. I'm calling for a different medication later. Forgot to mention that I'm feeling very jittery as if I had a pot of coffee."

1 / 10
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1 Report
  • Mim...
  • Taken for less than 1 month
  • June 19, 2019

For Urinary Tract Infection "Took one pill at 7 AM. At 7 PM, had the worst burning nausea and vomiting. Never experienced anything like this before. Never taking it again."

1 / 10
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13 Report
  • Anonymous
  • Taken for less than 1 month
  • May 28, 2017

For Urinary Tract Infection "Spent first day sleeping and second too, even though I ate something first. The nausea was awful. Third day and I'm still not sure it's working."

4 / 10
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7 Report
  • Sus...
  • April 10, 2016

For Sinusitis "Severe diarrhea, severe nausea, and vomiting after 2 doses."

1 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.