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Sulfamethoxazole / trimethoprim for Acne User Reviews (Page 3)

Brand names: Bactrim, Bactrim DS, Septra, Co-trimoxazole, SMZ-TMP DS, Septra DS, Bactrim Pediatric, Bactrim IV, Bethaprim Sulfatrim Pediatric Bethaprim Pediatric …show all brand names

Sulfamethoxazole / trimethoprim has an average rating of 7.7 out of 10 from a total of 183 reviews for the off-label treatment of Acne. 72% of reviewers reported a positive experience, while 17% reported a negative experience.

Reviews for Sulfamethoxazole / trimethoprim

  • missj...
  • September 30, 2014

Bactrim DS (sulfamethoxazole / trimethoprim) "I am 24 years old and have struggled with hormonal acne for the past year. I turned into a hermit. I tried a few things with my GP- changed my pill to Estelle- waited 3 months but nothing changed, it only worsened, tried many many many face washes, was prescribed Eryacne and doxycycline, which helped for a short period of time until it came back. I had had enough and decided to get a referral to a dermatologist- I wish I had done this sooner! He gave me Bactrim, which I was to take twice a day for 2 months as well as Epiduo gel. This combination was my saviour! I am now down to 1 tablet a day for another 2 months using Epiduo every second night. This is amazing and cleared up my acne but it does make you VERY sensitive to the sun."

10 / 10
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  • Anonymous
  • May 3, 2013

Bactrim (sulfamethoxazole / trimethoprim) "I took Bactrim for a month and I quickly saw the cystic acne disappear. So I started to reduce the dosage to 1 pill a day, then I stopped. In all, I was on the medication for a period of 2 months because I didn't like the idea of taking antibiotics for a large period of time. Recently, I've been having minor breakouts, but I'm paranoid. I am afraid to get filled with cystic acne again. So I decided to start retaking the antibiotics since I still have a couple of refills. Unfortunately I don't have health insurance anymore and I can't follow up with any Dr. "

8 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • January 7, 2020

Bactrim DS (sulfamethoxazole / trimethoprim) "I've been taking Bactrim for about 2 months now, and my acne is no better or worse than before I started. I haven't experienced any negative side effects, but that doesn't really matter when I haven't experienced any effects at all."

2 / 10
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Frequently asked questions

  • Cathe...
  • Taken for less than 1 month
  • January 25, 2020

Bactrim (sulfamethoxazole / trimethoprim) "I took Bactrim for my cystic acne for the first time a few days ago. Took my first dose a few hour before bed, and started to notice my tongue and mouth going numb. I took 2 Benadryl to sooth the symptoms. The next morning I called both my pharmacist and doctor, and told me that it was definitely an allergic reaction. Fast forward a few days later, my mouth has the same symptoms as if I burned my mouth on something scolding hot! My tongue has an entire layer “burned” off, as well as my inner left cheek, with blisters inside of my mouth. Needless to say I’m definitely allergic to this medication. They then prescribed my minocycline, but I’m very afraid to even attempt to try it after this experience!"

1 / 10
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  • Omair...
  • December 15, 2015

Bactrim (sulfamethoxazole / trimethoprim) "Didn't do anything for me. I still have severe acne like always. It's been 2 years but no fix. Tried doxycycline, minocycline and this. None of them ever worked. I also have super oily skin and this medicine doesn't fix that. It only kills the bacteria, which in my case is not a big problem. Oily skin is giving me acne. Plus I was applying erythromycin 2% on face. Nothing happened. Took it for a month. Finally going on Accutane soon. It was the last resort for me."

1 / 10
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Are you taking this medicine?

  • Dylan...
  • Taken for 1 to 6 months
  • July 21, 2016

Bactrim (sulfamethoxazole / trimethoprim) "I have tried nearly every antibiotic (doxy, mino, ampicillin, etc) for acne prescribed by 3 dermatologists over 5 years. The only one that worked was doxycycline, which stopped working after 4 months. Then I tried bactrim which cleared my moderate-severe teenage acne gradually (and noticeably) over 1.5 months. Deffinetly the most effective one out there besides accutane."

10 / 10
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  • gingslo
  • October 7, 2015

Bactrim DS (sulfamethoxazole / trimethoprim) "Ok so I have delt with acne my entire life even in my 30s. I was given this med for another issue and I noticed my skin is clearing up. I have been reading some of the reviews and not to be judgmental but I am shocked at how many people are using this med for 6 plus months. Transplant patients it's a must(my mother is one) but to use this long term is not my cup of tea. With bacteria becoming more and more immune to everyday meds what will they do when they have a severe infection like staph and it no longer works. Hospital bound on vanco, I know from experience. Trust me my acne is horrible and I truly understand the heartbreak but risking immunity from an antibiotic is not worth to me. Think long term. Just my opinion, God bless!"

8 / 10
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  • LoRrdd
  • April 8, 2015

Bactrim (sulfamethoxazole / trimethoprim) "Late September of 2014 I began to get hormonal cystic acne around my mouth, cheeks and chin. I tried a lot of different methods before finally reaching the end of my desperation. I went to the dermatologist and he prescribed me bactrim. I have seen nothing but great results--better than I could have hoped for. I had read plenty of reviews about bactrim and read that many people started to see results within 3 months of use. I too saw major results within that time frame. Patience is the key when taking bactrim but from my experiences with it, I promise it will be what you're acne prone skin has been dreaming of!"

10 / 10
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  • Anna...
  • June 12, 2014

Bactrim (sulfamethoxazole / trimethoprim) "I'm 16 now and started using Bactrim when I was 15, I tried many other acne treatments like Proactiv and other topical gels but none of those worked as well as the Bactrim antibiotic! If you just started using this medication give it time it took me about two months to see results but after 6 I had no acne only breaking out occasionally! Wish I had a before and after picture because it was crazy how well my skin cleared. I used to take it twice a day and once my skin was totally clear I only started taking it a few times a week and I started breaking out again and acne came back I'm back taking it twice a day so hopefully it can do the trick again! But I'll post again in a few months if/when I see results in my skin again!"

8 / 10
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  • BAano
  • June 8, 2016

Bactrim DS (sulfamethoxazole / trimethoprim) "Dermatologist put me on Bactrim DS, to be taken twice a day with food. No side effects in the first few days and did a good job at clearing up my face. Currently I am on the 9th day and experiencing severe side effects. Fever, chills, extreme joint pain, muscle weakness and overall sluggishness. Also experiencing difficulty breathing, a tight chest, headache, and dizziness to the point of almost falling over, for no reason. The most severe of the side effects is the joint paint. Can hardly take a step on my right leg and cannot lift anything with my right arm. Bactrim does it's job however at the expense of your health. Please do your research before starting this drug!"

5 / 10
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  • Leona...
  • February 8, 2016

Bactrim (sulfamethoxazole / trimethoprim) "I tried almost every topical an acne sufferer can get from drug stores, from natural to other kinds of drugs for acne, but none ever worked. My acne is moderate to severe type of acne. I am not saying that this medicine will work for you same way it does for me, but you should consider it when you talk to your Doctor. I've been taking this medicine for over a year now and I can't be any more clearer. I used to get tiny whiteheads all over my face, like when I try to pinch my skin, you can squeeze them out like small pieces of oil that became oxidized and yellow. Before I got this medicine, almost every day of my life I'd have to deal with new bumps just after one healed. My face is scarred, but this is the best one I have tried ever."

10 / 10
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  • DaveB...
  • February 20, 2010

Bactrim (sulfamethoxazole / trimethoprim) "I have used solydyne in the past, two different dosages. They worked at first then stopped working. Again they the increased dosage, even that stopped working. Then i was put on bactrim. The nice thing about bactrim for me was that it worked every time you use. I was give a strong prescription 100mg twice daily. And then 50mg twice daily for an year. The nice thing about bactrim is you see it working. The acne where it used to be becomes dried out and you feel that the meds are working. With others i have seen it disappear and then appear again. With bactrim it was just really clean. I have recently started doxycyline and it has not worked so far. Not a bit. It does seemed working the first week but not any more."

10 / 10
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  • Vin
  • June 21, 2015

Bactrim DS (sulfamethoxazole / trimethoprim) "Having acne for most of your teenage years into your early 20s is not fun. Being a 21 year old who went through Doxycycline and Minocycline, I thought I exhausted all of my options. I saw a few dermatologists who pushed Accutane down my throat. I said no. I went to my family doctor and I've been on Bactrim DS for over 6 months now and it is the best thing that has cleared up my acne. So powerful. I would highly recommend this medication."

9 / 10
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  • Anonymous
  • January 25, 2010

Bactrim (sulfamethoxazole / trimethoprim) "I have horrible hormonal acne and Bactrim has been the only systemic drug that has helped. Problem is I took it for years, randomly when needed. After years of usage, oddly I became allergic to it. I broke out in large red spots that were extremely sensitive. It's a serious allergy. I have permanent dark bruises all over my body and it has been years since I've used it. If you haven't tried Bactrim. Try it. It will work for you."

10 / 10
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  • MissA...
  • January 8, 2021

Sulfatrim (sulfamethoxazole / trimethoprim) "I've always had a problem with acne off and on since high school. In the past few years it mutated into giant bug bite-like swelling mostly around my mouth, chin, and forehead. Sometimes actually causing a fat lip that had to be injected with cortisone. It was beyond painful and embarrassing. It just kept getting worse. I was put on Sulfatrim 800/160 mg. I took 1 pill an hour before bed with 2 glasses of water. I've been on it for 38 days. My skin has not had a breakout since I started this antibiotic. I have not had any side effects either. Today my dermatologist said that I made his day when he looked at my skin and said it is beautiful. I can't explain to anyone how it feels to be free of cystic acne after what I've gone through. My skin is glowing and looks so healthy now. I am being put on a lower dose of 400/80 mg. I will continue this med for another 2 months then see where I'm at. I am so happy and grateful that this has worked for me. Pretty much changed my life."

10 / 10
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  • Anonymous
  • August 5, 2011

Septra (sulfamethoxazole / trimethoprim) "This medicine has done only good things for me. I have taken it for about 3 weeks now. It cleared up my moderately severe acne very quickly no negative side effects. The only side effect I had was decreased appetite which I was not opposed to as I usually eat too much anyway!"

10 / 10
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  • Neelab
  • Taken for less than 1 month
  • August 10, 2018

Bactrim (sulfamethoxazole / trimethoprim) "Never had acne especially in high school I had the clearest skin. I started college and work, and TBH I was very depressed. I got acne on my chin, then slowly on my jawline, and all over my face, I tried everything, nothing seems to work. I really wanted to go on Accutane because my self-esteem and confidence were gone. I was ready to do anything to get rid of my acne. I went and visited a dermatologist, he prescribed me Bactrim with spironolactone. The first two weeks I would say I kinda got a breakout but then after like four weeks my skin was clear, acne free. I still got some scaring, but no active acne which is good. One side effect I would say is that I felt very tired and sleepy. I would defiantly say try this before going on accutane."

9 / 10
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  • Angelic
  • Taken for 1 to 6 months
  • March 21, 2015

Bactrim (sulfamethoxazole / trimethoprim) "My 15yr old son had terrible acne due to being inherited. We tried every facial wash and lotion out there. The dermatologist tried a couple antibiotics and nothing seemed to work. Accutane was our next option which I didn't want to do. A month ago his primary doctor prescribed Bactrim for an infection and we were shocked when it TOTALLY cleared his face and back up! We called the docs office and he now takes it daily with no side effects! Such a blessing!"

10 / 10
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  • L 1995
  • September 13, 2016

SMZ-TMP DS (sulfamethoxazole / trimethoprim) "I took this medication SMZ/TMP for acne/scars on my face. I had a very severe allergic reaction. My face was swollen and lips. My hands swelled up. I had terrible pains in my wrists up to my arms and pain in my stomach/abdomen. This happened after taking it for around a week. My dad had to drive me to the Emergency Room because I couldn't swallow and was almost choking. I was so scared. I warn anyone going on this medication to think twice. I had no idea I would have an Anaphylaxis reaction to it. Very serious. It was Hell going through this and I really thought I would die. I didn't know what was happening to me as I was choking in my sleep. My mom looked up the side effects and that's when we found out it was a terrible reaction."

1 / 10
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  • Tulloch
  • Taken for 1 to 2 years
  • June 23, 2017

Bactrim (sulfamethoxazole / trimethoprim) "It's the silver bullet! Well, for me at least. I can only add my highest recommendation for Bactrim to treat my cystic acne, the kind that produces cysts around 2-3 cm in diameter all over my body and face. I've been on Accutane and every other antibiotic there is, but the Bactrim has saved me. It is hard on your digestive system, and I still haven't come up with a good solution for that yet, but I can certainly live with it if it means no more painful cysts which need to be cut out and operated on medically (no fun at all). I've always had cystic acne, but the Bactrim seems to kill the bacteria that produce the cysts, so as long as it keeps working I'm happy."

10 / 10
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  • Natalie...
  • September 26, 2015

Bactrim (sulfamethoxazole / trimethoprim) "While using Bactrim my acne cleared up very well and I was very happy. Unfortunately after a month I found out I was allergic to sulfa so I can't take it anymore. Sucks because it was the first thing I took that actually worked! Just my luck."

9 / 10
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  • Gwen
  • February 20, 2015

Bactrim (sulfamethoxazole / trimethoprim) "The medicine worked SO well on my acne. Not even 10 days after beginning the prescription and my acne was already clearing up. Unfortunately I had an allergic reaction to the Sulfa in the medicine and was rushed to the hospital because the reaction caused the platelet levels in my blood to drop to extremely dangerous levels. I'm still searching for a medicine that works like this one did without the sulfa in it."

8 / 10
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  • AcneS...
  • Taken for 5 to 10 years
  • June 8, 2017

Bactrim (sulfamethoxazole / trimethoprim) "Bactrim has been very effective for me, and I've taken it on and off for seven years. I have had no serious side effects (at least none which manifested as of now), and the Bactrim does a good job of controlling my acne. Side effects are a big deal in acne medication (Accutane dried my skin and tetracycline caused ear ringing). While I occasionally get a breakout while on Bactrim, the severity and frequency of the acne has decreased. On a side note, I've found my acne is most well behaved with a low or no dairy diet."

9 / 10
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  • Idkwh...
  • February 22, 2017

Bactrim (sulfamethoxazole / trimethoprim) "Okay, so I had suffered with Acne ever since I hit puberty.. I was a 'pizza' face, so to say.. I had tried multiple things and thousands of dollars to try and get rid of my acne... Eventually though, I found out I had PCOS, so yay! Hormonal Acne. ._. Anywaaays, My dermatologist prescribed me Bactrim along with Spironolactone. Within a week, I had a completely clear face. No acne at all... But unfortunately, after 3-4 week I found out I I was apart of the unlucky few who ended up being allergic to it. So sad. If I could ever take it again, I would in a heart beat. But It has been about 6 months since I've been on Bactrim and I am still pretty much clear with very few breakouts."

10 / 10
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  • Sandy
  • Taken for 1 to 6 months
  • March 28, 2018

Bactrim (sulfamethoxazole / trimethoprim) "I had been a long time acne sufferer, than I had my daughter. I seemed to have had less aggressive breakouts, but than suddenly I began to get cystic acne around my chin and lower face. It got to the point where I didn’t want to leave my house. I finally went to a well respected Dermatologist who put me on Bactrim temporarily before I can start the process for accutane; suddenly my face began to clear up drastically within a week! I was extremely happy with the results. And opted out of accutane all together. I really couldn’t believe that my cystic acne was disappearing right before my eyes. I also purchased a retinol and hydroquinone cream that my derm sold in his office that helped lighten up my scars significantly. Hope this helps. Good luck!"

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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