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Zoloft for Major Depressive Disorder User Reviews (Page 5)

Zoloft has an average rating of 6.8 out of 10 from a total of 136 reviews for the treatment of Major Depressive Disorder. 57% of reviewers reported a positive experience, while 24% reported a negative experience.

Reviews for Zoloft

  • trl
  • November 8, 2023

"After a few years of extreme anxiety, I went into 15 years of 'fog'. I didn't really feel sad, I just felt empty/dead and like my mind was constantly blank. I could never interact with people because of that, it was just like nothing was ever coming to my mind. Got a lot of my confidence back. Looking forward to social interactions I'd do anything to avoid. Memory is also drastically improved and so are my grades at school. Looking forward to tests (like I used to long ago) and exams causes little stress. I'm gonna need some time getting to know the new me and getting my life on track, but to finally see the light after an indescribable battle is simply life-changing. Started at 25 mg, 50 mg made me worse, felt fatigued, upped it to 100 mg, instantly better, 150 mg first noticeable improvement, then 200 mg. 200 mg felt better and better for the 4 months I've been taking it. I'll leave one point for the chance it becomes even better."

9 / 10
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2 Report
  • Alyssa...
  • February 9, 2017

"I've suffered from all four (Panic/ anxiety/depression/bad thoughts) for 7 years I've never had panic attacks like I do now, I'm finding myself on the internet searching about panic/anxiety attacks how are they cause what causes them, searching more into the answer I got then searching more in to that answer I got and so on, it's to the point I'm scared to eat because I'm scared of having something to spike an attacks, try to avoid leaving my house let along the living room, my doctor gave me zoloft 25mg and I'm so scared to take it, what if it makes me worse what if it don't work, what if something happens while I have my kids alone, can I od, will I get addicted feel like I'm going crazy"

1 / 10
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11 Report
  • Cocco...
  • Taken for 5 to 10 years
  • April 12, 2023

"I had signs of depression and anxiety with school and home life from an early age but I didn’t get diagnosed with major depression disorder till I was 15 years old. My Gp put on me Zoloft at 25mg for one week then put me on 50 mg. After a few years, she bumped me up to 100mg and then lowered the dosage to 75mg which had me feeling way better. I saw my psychiatrist for the first time in 20 years who recommended I go to the hospital to get off my Zoloft and put me on Pristiq. I was there for 6 weeks. I’m still currently on Pristiq 50mg. Pristiq is working better for me than Zoloft."

3 / 10
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3 Report

Frequently asked questions

  • rose
  • Taken for 1 to 6 months
  • September 10, 2018

"I've been suffering from depression and anxiety for as long as I can remember (I began having anxiety at age 5, panic attacks at 10, agoraphobia at 11, depression/panic at 12, and I still suffer from anxiety and depression to this day). Zoloft definitely helped at first, but I almost feel like my body is becoming tolerant to it. Is that possible? It also definitely kinda sucks the life out of u."

6 / 10
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9 Report
  • syeena
  • Taken for 1 to 2 years
  • September 15, 2023

"I have been taking 200mg of Zoloft for more than a year and still on-going. Even though I couldn’t retrieve the “old-me” that I missed, but I feel much more better than I ever had for last 3 years. With Zoloft, I able to pass a day without crying, I able to control my emotions better and decrease in suicidal thought (With other drug, I couldn’t escaped from the thought for every 1-2 days but with Zoloft, it comes only when it’s triggered. The downside is, my brain ’unscheduled-ly’ fogging and I have a hard time especially during exam but it’s much more better than not taking at all."

8 / 10
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Are you taking this medicine?

  • Vyzz
  • June 20, 2017

"It's hard to know if it's working I feel down majority of the time and the only time I'm happy is when I'm ready for bed. I've been on Zoloft for 6 months now at 100mg I just want this to kick in already. Can I take anything else to help me?"

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9 Report
  • Nicolas
  • April 9, 2019

"One day I felt good and the other very bad,I did not know what to think about this medication. I had good days and very bad days. After 3 months taking it I felt like it stopped working as well as it had before, so I stopped it and switch to another antidepressant. For the good days I had I would rate this med 8/10 and for the bad days 2/10. My bad days were more than my good days as it seems."

5 / 10
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7 Report

More FAQ

  • queen...
  • August 17, 2015

"Okay I know these meds are supposed to help people but I have been on a train to hell with these dang antidepressants! Zoloft....ICK!!!! My god in heaven I was sick for eight weeks on this stuff!! It never went away in fact the longer I was on it the sicker I seemed to get. I lost five pounds and just the sight or thought of food made me want to throw up! It made me feel even more depressed the whole time I was on it...I felt like a zombie, I was tired ALL of the time. Finally I threw I away. My husband decided he wanted to give it a shot so he went to the Dr to get a prescription for it. 8 weeks later he was worse!"

1 / 10
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10 Report
  • Dgirl...
  • Taken for 1 to 6 months
  • September 29, 2018

"I took zoloft for almost 3 months. Whether it worked or not didn't matter as after I ate within 10-30 minutes I had diarrhea, flushing my meal right out of me. No nutrients equals no strength and weakness. Couldn't live like that so weaned off of it."

5 / 10
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7 Report
  • JennyS
  • Taken for 1 to 6 months
  • December 17, 2015

"Took Zoloft for Major Depression and Anxiety. Started at 25mg and went up to 75mg over time. Didn't have any full on panic attacks after starting the drug and noticed a lessening of my depression, however I had AWFUL insomnia even when taking it in the morning, and it didn't help my general/social anxiety as much as I hoped. The sleeplessness ended up making me more anxious overall and was not worth the benefits."

6 / 10
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  • 1995
  • Taken for less than 1 month
  • August 2, 2021

"Psychiatrist prescribed me Zoloft for major depression, obsessive compulsive disorder and borderline personality disorder. Day 1 - 17 = 50mg. Day 18 - present = 75mg. I noticed a difference in about 2 days of being on it. Only felt mild nausea for the first 3 days. The most prevalent side effect whilst taking 50mg was fatigue that would begin 45 mins after ingestion in the morning. I have been on 75mg for 2 days now and I don't have the fatigue feeling. Zoloft keeps me at a baseline of 'okay'. It's early days and a small dose but I can still feel quite depressed and angry etc but there is a higher chance of it not being a poisonous cloud over me at all times compared to when I wasn't medicated. I will say that intense mania/dissociation is a symptom I didn't expect to experience (although it was brought on by a complex post traumatic stress disorder trigger.) Zoloft seems to help with my digestive system regularity. Will continue to stay on it. Would recommend."

7 / 10
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  • Crod
  • Taken for 2 to 5 years
  • June 1, 2021

"For me this was the worst med ever. It made me suicidal, low mood, and low motivation. I do not tolerate SSRI or SNRI well. I feel doctors throw these at you without giving antipsychotics, or benzodiazipens a fair chance. No 2 people react to meds the same, and for me zoloft was one of the worst meds."

1 / 10
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  • TheBu...
  • Taken for less than 1 month
  • February 28, 2017

"I took 75 mg for 3 weeks and it didn't really move the needle for my depression. I thought around day 3 I felt a little better, but after that it was pretty much back to being depressed as I had been before. I did feel like I was less easily angered by things, which was nice. It did not help my social anxiety very much or at all. Side effects were not too bad. A little drowsiness the first few days. Some ringing in the ears. Decreased libido the first couple of weeks. The doctor has changed me over to Cymbalta, so we'll see if that works any better. I had high hopes for Zoloft, but I guess it just didn't work for me."

2 / 10
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  • james
  • Taken for less than 1 month
  • January 17, 2018

"Setraline has done absolutely nothing to help my depression, it brought on anhedonia which made me feel really down and just deeply sad. Waited 3 weeks and made me feel way worse, this is the 2nd SSRI I have used. I luckily respond very well to bupropion XL 300mg and it saved me from the complete hell I was in due to the SSRI. I don’t truly believe serotonin is the key to happiness, especially because I responded a hell of a lot better to Wellbutrin which is a norepinephrine and dopamine reuptake inhibitor. All I can do is hope the new medication of ketamine nasal spray will do something good for most people who are suffering."

1 / 10
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6 Report
  • Dumb
  • Taken for 1 to 6 months
  • May 5, 2023

"Helped: impulse, need to cry, stress, happiness Side affects: nausea, sweating, BAD headaches/migraines, cold chills, loss of attention, pain, blurry-ish vision ⚠️NOTE⚠️ I took this 11- present so it may not be the same for high schoolers or above or elementary students Overall, it helped!"

9 / 10
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  • Alex
  • Taken for less than 1 month
  • July 4, 2022

"I experienced very severe diarrhea with Zoloft, since the first day. It was so severe that I had to stay at home and have a toilet next to me. I stopped the medication after 2 days. I am non tolerant to lactose, maybe that is the problem. I am sorry it did not worked for me because they say it is the more efficient medication for general anxiety disorder and obsessive compulsive disorder. I went back to paroxetine, for the moment, which is good, but makes me too sleepy (12 to 15 hours of sleep a day)."

3 / 10
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  • Anonymous
  • Taken for 2 to 5 years
  • February 14, 2022

"I have been on psychiatric medication for nearly 4 years, my main medication is 300mg of Wellbutrin XL and it is great but it does have a side effect of increased anxiety something I already had, to counteract this my doctor prescribed 25mg of zoloft and that has done well up until a few weeks ago and my dosage was doubled… it still works but the sexual side effects are bad enough for me to consider stopping the med at all"

6 / 10
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  • Sill
  • Taken for 10 years or more
  • April 26, 2014

"It keeps me from being suicidal. I have to have this. Great medicine."

10 / 10
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72 Report
  • Mello
  • Taken for 10 years or more
  • January 18, 2020

"Started at 50 mg Zoloft and now at a dose of 200mg a godsend to my life.."

10 / 10
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36 Report
  • crimson
  • Taken for less than 1 month
  • February 20, 2023

"I feel great. Best sleep I have had without any thoughts of the past."

10 / 10
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15 Report
  • Steph...
  • Taken for 2 to 5 years
  • December 7, 2014

"I took Zoloft for a couple of years...it worked great for depression but it absolutely killed my sex drive."

7 / 10
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54 Report
  • Better
  • April 26, 2016

"I've been on Zoloft for 4 years and it's worked great for my depression. I take 50 mg per day."

9 / 10
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42 Report
  • Cookie
  • Taken for 1 to 6 months
  • October 17, 2019

"Within the first month of taking Zoloft my depression symptoms had decreased by about 70%. It helps with my mood, my sadness and overall feeling of worthlessness. I would definitely recommend."

10 / 10
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27 Report
  • Nitel
  • Taken for 1 to 6 months
  • May 3, 2020

"Dare I say damn zoloft was the worst thing I have ever taken. It made me a nauseous zombie, gave me more suicidal thoughts, etc. Overall the worst experience I've had with depression meds."

1 / 10
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19 Report
  • KMaur...
  • Taken for 6 months to 1 year
  • November 3, 2016

"It took me a while to reach an effective dose, but Zoloft was surprisingly effective. It does have a reputation of being a "starter drug" and ineffective, but it has transformed my life."

9 / 10
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29 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Major Depressive Disorder

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