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Zoloft for Depression User Reviews (Page 3)

Zoloft has an average rating of 6.8 out of 10 from a total of 585 reviews for the treatment of Depression. 57% of reviewers reported a positive experience, while 22% reported a negative experience.

Reviews for Zoloft

  • Nurse...
  • Taken for 6 months to 1 year
  • November 16, 2014

"I am 39 years old, was a new nurse and struggling with major depression. I had not been to a doctor in years and broke down crying at the first visit. Started 50 mg a day. Felt a little funny the first couple of days but now feel much better! Everyone noticed a change for the better and I even got a promotion at work! I feel so much better and have not had any side effects!"

9 / 10
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  • NewUser
  • January 29, 2009

"I just started Zoloft 3 days ago, and the side effects so far have been very clear. For me, I haven't been able to eat. I've never been a good eater, but I don't need to lose weight, and I am eating maybe half of what I used to just a few days ago. Nothing seems to taste very good, and I feel full after very little food. I get nausea for about 10-15 minutes about 4-5 times a day, that I didn't have before. My head feels really weird, like I can feel the chemicals running through my brain. It's really weird. I had problems sleeping before taking Zoloft, so not sure if that is a side effect. A lot of good reviews - going to stick it out."

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  • Rosie
  • Taken for 10 years or more
  • September 10, 2019

"I have been on Zoloft and the generic sertraline on and off for many, many years, on 50 mg. Recently, I developed symptoms of depression, panic, etc., due to health issues. I have a great GP who encourages me to manage my depression, so with his agreement I increased my dose to 100 mg and suffered every symptom for weeks. Anxiety, nausea, shaking, insomnia. After 10 weeks, these symptoms have all but disappeared. After reading all the reviews, I vowed to share my experience too. Remember, the symptoms WILL go away. It may take longer for some people than others to feel better. You may feel good one day but not the next. Hang in there. It takes time. I now feel almost ready to go back to 50 mg."

8 / 10
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134 Report

Frequently asked questions

  • AnneJay
  • Taken for 6 months to 1 year
  • April 5, 2017

"My original post was 10/2/16 - had great results immediately on 50mg daily. I am able to hold down a full-time job that I love, which was impossible prior to Zoloft. Rarely have anxiety anymore, my relationship with my husband has improved, and the constant 'internal storm' is gone. At 51, I finally feel HAPPY!!! Keep trying everyone!"

10 / 10
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176 Report
  • Sal
  • Taken for 6 months to 1 year
  • June 3, 2019

"I'm so thankful for Zoloft. I laid in bed all day, sleeping as much as possible, never eating, never bathing, and honestly being way too angry at other people. I used to have panic attacks all the time, and nothing could cheer me up. When I started taking Zoloft, I immediately started feeling a certain euphoria and gigglyness through the first week or so (which I know is rather uncommon) and I was slightly dizzy for about the first two weeks. But that wore off, and I have zero side effects, now months into taking it. I'm not 'euphoric'... I just feel normal. I don't feel neurotic anymore. It's such a relief."

10 / 10
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Are you taking this medicine?

  • Princ...
  • April 30, 2017

"I want to take the time out to thank whoever invented Zoloft. I used to be so depressed. I didn't want to be around my kids or my husband. I would tell my husband I was tired of existing. My life was turning inside out. So I knew I needed help. I talked to my doctor, explained to her what I was going through, and she said Zoloft would be perfect. I didn't want to believe I needed meds, but it wasn't bad at all. I'm happy now, my kids love to play with me and think I'm so cool! My husband, who was so patient, just loves all over me and he's proud I didn't give up. I'm only 28 years old and I feel like I'm a teen all over! Thanks Zoloft."

10 / 10
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  • Babyl...
  • March 2, 2017

"If you are scrolling through 1000's of reviews like I was, this one is for you. I started Zoloft three weeks ago for Major Depression and overwhelming anxiety and panic attacks. I started at 25mg for a week, then up to 50mg. Initially, I felt a million times worse, constant panic attacks, increase in suicidal intrusive thoughts, deep depression. But, after just 1 week at 50mg, I noticed a difference in mood, and it's been better and better since. Fight through the initial worsening of symptoms if you can! I asked for Xanax to help me get through it. It definitely gets worse before it gets better for some people, but it was 100% worth it for me! I also had slight nausea, a sore neck, and some dizziness that all seem to be subsiding."

10 / 10
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More FAQ

  • LRano
  • Taken for 1 to 2 years
  • September 1, 2015

"I've suffered with anxiety for years but finally came to a head a few years ago. Had some personal family issues that became overwhelming. I was always mad, sad, frustrated, you name it, and that was me. My brain could not stop thinking about my problems. It was very tiring. I finally went to the doctor and he prescribed Zoloft 25 mg. For the first few days, I felt like brain waves going on in my head but no big deal. Within 2 weeks, I started feeling happy! A few months later, the doctor put me up to 50 mg. I felt the brain waves again for about 48 hours and then stopped. I've been on Zoloft for about one year. It was the best thing I could have done for myself. Oh, I can still get mad or sad but not as severe or for as long."

10 / 10
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  • Sierra
  • January 15, 2013

"I have been on Zoloft 50mg for about 6 months now. I got on it because I could not control my anger. I would go from okay to completely angry in just a matter of moments. Everything and anything would set me off, and I couldn't control it. So, I went to the doctor and he put me on Zoloft. I have lost close to 40 lbs since being on the medicine because I have no appetite anymore. I do not feel like a zombie; instead, I am able to control my anger better. I still get upset and angry, but I don't lash out like I used to. I feel like I have control of my life now."

9 / 10
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  • Nikki
  • Taken for 1 to 6 months
  • October 6, 2019

"This drug changed my life. I feel better than I ever could have imagined after starting Zoloft. I had suffered with depression, unmedicated, since childhood. Finally, I got a doctor who would give me the antidepressants I needed. I was started on 25 mg for the first week, then 50 mg. I've been on 50 for 5 months now and so far so good. I've noticed drastic changes in my mood and my stress levels. Things that would've sent me into a panic attack before now only get me mildly stressed. I don't have random crying fits anymore. I'm not angry. The main side effect I had upon starting was no appetite. I felt nauseated every time I ate and had no desire to eat either, other than just to stop feeling hungry. That lasted about a month. Other than that, I haven't experienced any negative side effects."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • March 10, 2020

"I started taking sertraline around 5 weeks ago today (25mg). The first few days were fine. I only had a bad stomach for a day or so. However, at around week 2, I felt awful, was having extreme suicidal thoughts. I carried on taking the medication, as I know it gets a lot worse before it gets better. At 5 weeks now, I have increased my dose to 35.7mg, and I feel pretty good. Haven’t had any side effects from increasing the dose slightly just yet. It’s worth sticking it out through the hard times; there is definitely a light at the end of the tunnel!"

8 / 10
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  • Anonymous
  • August 28, 2020

"I refuse to let what happened to me happen to anyone else. I’m 18 year old petite female. I began taking 25mg of zoloft for anxiety and mild depression. On day 3, I experienced serotonin shock syndrome. I woke up suddenly in the middle of the night with my entire body shaking, my heart rate extremely high, and extremely confused. My parents took me to the ER after I told them I felt like my life was ending. The physicians assistant in the ER dismissed me as a panic attack, even tho I’ve had anxiety my entire life and I have never felt close to way I did that night. My experience left me completely traumatized. I struggled to sleep for months afterward, terrified that I would wake up the same way. PLEASE PLEASE consider what you are putting in your body when you take this drug, especially if you’re a smaller person."

2 / 10
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  • Kort
  • Taken for 6 months to 1 year
  • June 23, 2015

"I've always experienced social anxiety growing up. I thought this was normal but it became clear to me during college that I shouldn't be feeling so shy all the time. I was afraid to be myself. I was constantly going back and forth between anxiety and depression for years. I tried meditation, yoga, running, a different diet... But nothing seemed to be working good enough! Enough was enough! I researched Zoloft for a few weeks and finally decided to try it out. WOAH! Other than the initial side effects such as decreased appetite and restlessness, this medication changed my life!!! I feel very comfortable talking to people in social settings.. I could finally be myself! The biggest thing is being patient--- it works!!!!! Good luck everyone!"

10 / 10
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  • Ruhro...
  • July 8, 2017

"20-year-old college student. I've had OCD since I was a kid (depression since junior year of high school) but only within the last year did I make the choice to take an SSRI. There's a lot of ambiguity surrounding antidepressants, and you can't really extract much from reviews without feeling reluctant. Yes, there are side effects that appear within the early stages. It is scary to ingest a drug you know little about. However, I can feel happy again, which I thought I had lost the ability to do. I don't believe everything is hopeless, which I truthfully thought I'd feel the rest of my life. It's been a lifesaver, and at 100mg, nothing feels inherently different about myself. It's just a tablet. Don't let it be more than it ought to be."

9 / 10
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  • Kitten
  • June 21, 2017

"20-year-old female, prescribed 50 mg for major depressive disorder, social anxiety, and just overall generalized anxiety. Been on 50 mg for 3 months now. Side effects were minor, which consisted of insomnia, loss of appetite, and nausea, though they subsided within the first few weeks and I now experience none. I love Zoloft! I can live again! I'm laughing and going out with friends, not laying in bed all day. I can finally breathe, my surroundings seem so much brighter, I don't harbor hate anymore, I'm me again. More ambitious and creative like I was before I fell into this self-destructive path of depression two years ago. I no longer have the desire to self-medicate with drugs and alcohol. I wish I got on Zoloft a long time ago."

10 / 10
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  • Jamid
  • Taken for 1 to 6 months
  • November 22, 2013

"This pill is a miracle for me. I've been taking it for about a month now, and within four days my nagging depression, anxiety, and paranoia were almost completely eliminated, which I had not expected at all. My Obsessive Compulsive Disorder has also calmed down significantly since taking it, and my overall demeanor has changed from angry and suspicious all the time to happy and full of energy."

10 / 10
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  • Dirty...
  • May 26, 2013

"I have been taking Zoloft for 10 years. I take 100 mg daily. I have found that all of my symptoms have diminished. In times of real stress, I take an extra pill. All I can say is that none of the previous drugs I took helped me at all. I have depression and Post-Traumatic Stress Disorder. At age 59, I still react to anything that sounds like gunfire. I spent 33 years working for the government, 2 in the Army, the rest in law enforcement. I have found that I have no issues to deal with. I did once, while out of the country, lose my prescription while backpacking. It was horrible for me and my two friends. I take my pill in the evening before bed. No side effects at all. I found Zoloft to be a godsend for me."

10 / 10
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  • Meano
  • November 7, 2019

"I’m onto my second box of Zoloft. I took the entire first box over a month at 25mg. I had headaches pretty much every day but they weren’t extreme, just a dull ache. There were also a couple of times where I was feeling nauseous; the pharmacist told me to eat before taking the pill, and that actually helped. So after the first month, I reached my prescribed dose of 50mg daily. No headaches at all now, and no negative side effects at all. My mood is so much better; I actually catch myself laughing at things online or on TV. I am so much more calm and patient with my kids. My husband and I were having huge verbal arguments every couple of days, which I now am capable of refusing to do despite his pushing. I can repeatedly say, 'I’m not going to argue with you,' and stay calm for a long time now, which is obviously new to my husband who is so used to getting a big reaction from me. I honestly feel absolutely fantastic with this medication. Going to ask my doctor about upping my dose for better results!"

9 / 10
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  • tini
  • Taken for 2 to 5 years
  • April 14, 2016

"My husband has had depression and at times severe anxiety for years. He would have anxiety attacks so bad he was sure he was having a full-blown heart attack every time, and his anxiety prevented him from sleeping because he was sure he would die in his sleep. His depression was bad as well; he was sure the world would be better off without him. He tried different medications but nothing really worked; some seemed to improve things a little bit, but for the most part, I had given up hope that any of them really do much. Then he tried Zoloft. For him, this was the one. It took the edge off after about a week; after two weeks, I could definitely tell a difference. After about 6 weeks, he was back to his normal self."

10 / 10
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161 Report
  • Gypsy...
  • January 25, 2014

"I saw my doctor after the anxiety I'd been having the last year hit an all-time high in the last six months. I would wake up wondering 'Why? What am I even here for? What am I working for?' I suffered severe muscle tension in my shoulders and lower back, extreme irritability/mood swings & panic attacks. My heart would be POUNDING as if I'd run a 5k when really I was just lying in bed. It is day two of taking Zoloft... I'm singing (still terribly) to songs again. I feel I have gained the sense of 'normal' that my life has always lacked. I am more clear-headed and find rational thinking easier. My depression and anxiety were destroying my relationships. I'm beginning to see this 'light at the end of the tunnel' people speak of. 50mg a day."

7 / 10
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  • Joanna
  • Taken for 6 months to 1 year
  • February 29, 2020

"Been on this med for about a year. 100 mg is the best dosage for me. Really does help depression, but doesn't take away normal grief. When you're happy, I find that on it, you're really happy and calm, when taking your pills daily and not skipping doses. I found that combining with high-quality magnesium also really helps my mood. The combination is great. Magnesium alone did nothing."

8 / 10
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99 Report
  • Vicki
  • Taken for 1 to 6 months
  • December 22, 2019

"This is a very irresponsible website in that you do not instruct the reviewers to state the AMOUNT of Zoloft they take. Without knowing the amount the reviewers are taking, it just amounts to a bunch of worthless babble. It is of no use to anyone."

7 / 10
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102 Report
  • Choco...
  • Taken for less than 1 month
  • December 31, 2015

"On Zoloft 25 mg/day, and my anxiety attacks have stopped. I haven't woken up depressed (used to wake up depressed and stay in bed) or had suicidal thoughts (had suicidal thoughts almost daily). It's like this medicine has filled in the blanks for me. I don't feel high or euphoric or excited or anything other than what I think normal must feel like. It's quite a change from what I was used to - nonstop anxiety, depression, and I was always thinking about suicide - but all that has stopped and is a thing of the past. I can't even believe I was feeling like that. I now know that something was wrong with my brain, and this medicine has fixed it for me. I am so happy to wake up not feeling sad."

10 / 10
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  • Meyla
  • April 8, 2013

"This worked in a way that it got me back on track and made me feel like my old bubbly self. My social skills improved because I love talking to people now. I'm generally happier. Low days are few and far between. Confidence improved and my obsessive thoughts almost ceased completely. Did not experience weight gain. No real side effects reported. This medication helps to get your mind sorted and the rest is up to you to work on yourself."

8 / 10
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  • Lolsh...
  • September 5, 2019

"I put down I have depression, but I also have anxiety and panic attacks and OCD. Everyone is complaining about the nausea. IT GOES AWAY. Moreover, usually after like two days. PLUS this time round, my doctor prescribed me nausea meds for it (I went off it but am going back on because I’m depressed again). Y’all, there is literally medicine that will remove the nausea. And to be honest, for me, it is not that bad as I have IBS as well. Zoloft basically made me chatty, happier, and gave me the inability to cry or feel sad even when I was supposed to be very sad. The inability to feel sad seems pretty good to me. And I was able to feel happy, just not sad. I quit for the sexual side effects. Don’t listen to the people complaining about nausea. I was in bed unable to move for two days from the nausea, and I’m still 10/10 recommending it, so trust me it’s fine."

10 / 10
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102 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.