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Seroquel XR for Bipolar Disorder User Reviews (Page 2)

Seroquel XR has an average rating of 7.3 out of 10 from a total of 106 reviews for the treatment of Bipolar Disorder. 64% of reviewers reported a positive experience, while 17% reported a negative experience.

Reviews for Seroquel XR

  • Jenne...
  • Taken for less than 1 month
  • March 12, 2016

"OK, it's only early days, day 4 to be exact on 50mg morning and night. It's amazing! After reading all the horror stories of the tranquilliser effects, zombie like states+cravings. Its an understatement when I said I was petrified what effect this would have on me. First day within an hour of taking it, I slept for six hours woke up feeling fine, refreshed even. Then dosed up in the evening at 9, again, asleep by 11, slept like a baby. 7am Woke feeling energised, lighter, happier. No drowsiness or brain fuzz! I feel so much more positive about life in general. I feel so blissfully normal! Day 4 still napping within 4 hrs of dose for 2 hrs max but I could push through it. And still sleeping all night!"

10 / 10
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  • Thimb...
  • October 13, 2016

"My diagnosis is Bipolar one. I have been on Serequel XR for 3 years now. I have been stable for one year which is amazing. I am very lucky that this medication works really well for me. For the first few months or so it increased my appetite and I was fairly sedated throughout the day. As I adjusted to the medication this wore off. I now function better than I ever have. Suicidal thoughts are pretty much all gone, and when they do come, they pass. Have not had any depression, and only slightly concerning elevated moods (which happen rarely.) This drug prevents me from psychosis and for that I am extremely thankful. I am on 600mg once at night. UK resident."

10 / 10
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  • happy...
  • Taken for 5 to 10 years
  • November 10, 2013

"I took regular Seroquel which did help somewhat. I would rate that at a 4 out 10. I found about Seroquel XR when people told me to see a pdoc this was in 2007 because I was bipolar 1 and couldn't get it under control on my first visit with pdoc I told her my situation and Seroquel after my visit she gave me 2 samples of Seroquel XR which was only out 4 months at that time it has been a huge help with mania and depression I take 800mgs at bedtime when I wake up I take 400mg Lamictal that helps a great deal for me with the racing thoughts and impulsivity along with 2mg of clonazepam that has been a life saver it took many years in and out the psyc hospitals to finally get it right."

10 / 10
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38 Report

Frequently asked questions

  • Angel...
  • Taken for 6 months to 1 year
  • August 23, 2016

"This med is pretty wonderful for my bipolar mania and my bipolar depression. Only set back is the sedation, but at the same time I've always struggled with anciety, so this side effect is okay with me as it helps the anxiety. Really saved my life."

10 / 10
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  • JoeyBBY
  • July 16, 2016

"First of all, let me start by saying that I hear that this is an expensive drug because of how new it is. Luckily for me (perhaps, lol), my insurance considera me catastrophic due to my checkered past, and pays the entire price because they want me to take this medication and stfu lol. Since taking Seroquel XR, my life has improved so much, and I really have never felt more stable in my life. I've tried anticonvulsants and other antipsychotics and they have not worked for me. This medication really does, to my surprise! The only downfall is that I've gained 10 pounds taking it, but any antipsychotic will do that. Strongly recommend Seroquel XR!"

10 / 10
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Are you taking this medicine?

  • B303
  • May 13, 2017

"SeroquelXR has changed my life for the better. I am currently on 400mg once daily. (I also take klonopin before I go to work). For the last 6 months, I have not had to call out sick from work, which was a monthly occurrence before Seroquel. I have not had to take a leave of absence in the last year. I used to have to take 2 six week leaves a year. I feel much more positive about my job and my life in general. It has been a game changer for me. The only down side is the weight gain. It seems to slow your metabolism down and increase your appetite after taking it, making it difficult to loose weight. I am currently not overweight, so the weight gain is a small price to pay. I do have to exercise regularly and watch more carefully what I eat"

9 / 10
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  • Eeyore
  • Taken for 6 months to 1 year
  • March 21, 2015

"I was recently diagnosed with bipolar and began taking 25-50mgs a night to aid insomnia because at the time I felt relatively well. I appear to be one of the few to embrace the side effect of increased appetite, when I'm manic, depressed or even the slightest bit anxious my appetite disappears. I can go weeks without feeling the need to eat and I love eating! I used to smoke alot of pot to help with my appetite and racing thoughts. I'm now taking 150mg XR at night as I'm currently having a mixed episode. It helps quieten my mind and slows me down a little but I don't feel in any way zombified, at night soon after taking I get sleepy but that's about it!"

7 / 10
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  • Daisy
  • April 6, 2015

"At first I hated this medication, made me really tired, feelings of non reality and weight gain. The doctor who put me on it said to wait and give it a chance. I'm glad I did. I use it to sleep at night, at some point I will reduce it but it's great for now. I have very restful sleeps, but am unable to remember my dreams. I am bipolar and although I am on other medication for it, I believe that Seroquel has been key in my mood stability. I take 100 mg every night, and 25 mg PRN for anxiety if needed. Although I get tired on it, it does slow down my thoughts."

8 / 10
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  • senua...
  • March 23, 2011

"I suffer from bipolar1, OCD, very severe anxiety, and post traumatic stress disorder. I had been in a mental hospital and had taken so many medicines. I could never stop thinking to the point where I stayed awake all night. Mood swings, temper, just raving mad ,waiting to be set off. Some medicines worked for a short time, and others just didn't work. So my psychologist put me on Lamictal, but it works very slowly and you have to start it on a low dose and work your way up. I had taken it before, but my other doctor left and every other doctor wanted to put me on Lithium but I said no because I have Lupus. But when he put me on Seroquel XR, well that's when things began to look a little bit brighter. It does make you sleepy, but its a great medicine, at least for me anyway. Hope this helps."

9 / 10
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  • mom
  • Taken for 1 to 6 months
  • October 19, 2012

"I have had a negative experience on Seroquel. I do not want this to deter anyone from taking it, as everyone's reaction and experience on this medicine is subjective; I just want to put this out there for anyone who might be experiencing similar symptoms and reactions and may be hesitant to say it and to just relate my own experience. I am Bipolar 2 and have untreated ADHD due to the ADHD medicines causing manic episodes. I started Seroquel 2 months ago when I was having a bout of insomnia. I should state that I was on Wellbutrin, Lamictal, and Paxil, and was feeling good. I was productive during the day and upbeat. I was prescribed Seroquel for the insomnia and taken off all the other except Lamictal. I am now a "zombie", depressed, sleepy 24/7."

1 / 10
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34 Report
  • txff
  • March 9, 2010

"Seroquel XR has been a blessing for me. I currently take 600 mg at night. I have suffered from terrible insomnia but with this medicine. I actually get some sleep at night. As far as anxiety goes, it works wonders for me. It totally wiped out my anxiety and I was able to get off of Lithium. In my opinion, it works wonderful for mania, but I wish it helped a little more with my depression. I take 10mg of Prozac to boost that. I did gain some weight but the benefits outweigh this problem. Overall, I think it is a wonderful medicine. I would recommend it highly."

9 / 10
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  • vanil...
  • Taken for 1 to 6 months
  • September 13, 2016

"Have been on Seroquel XR 25mg (once before bed) for about 6 months now and my life has completely changed for the better. Yeah, the weight gain is a pain but its a small price to pay for normality. Social anxiety / severe insomnia has not been an issue for months!! Am finally myself again. Have tried other antipsychotics but nothing works as well as this one. Only downside is an insatiable appetite - but you can minimize weight gain by substituting with fruits etc, which is what Im currently doing."

8 / 10
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25 Report
  • Cyenc...
  • Taken for 2 to 5 years
  • April 8, 2015

"For years I took seroquel in various doses throughout the given day. I was prescribed Seroquel XR about 3 years ago for Anxiety and Bipolar l. Since then it has been very effective. I did not gain weight at all. The only drawback is it does cause dizziness and sleepiness. Therefore, I sometimes opt to take it later than prescribed 7:30pm instead of 6."

10 / 10
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  • Patient...
  • Taken for 1 to 6 months
  • April 29, 2017

"I don't understand all the negative reviews. For me this pill has worked well. It's calmed me right down and has been blissful at moments. It's expensive unfortunately. As for weight gain, I've noticed that it's pretty neutral... Granted I'm weaning off of Zoloft as well so who knows but I find with medications with 'weight gain' as a side effect just trying your hardest to eat a well balanced diet will prevent it. It's too easy to give up and say oh well I'm gonna get fat - - it's very much not the case. Don't give up, if you're bipolar like me there's a chance you can do a lot with your brain so give it a shot and take your life back. I think much more clearly and am more productive. The overwhelming tiredness subsided after one week."

9 / 10
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23 Report
  • tracy
  • January 29, 2021

"Took Seroquel XR for 11 months for depression, bipolar 2. Had rare side effect. This drug causes tooth caries and gum disease. I had to have all 24 of my teeth pulled out. It was devastating. Also difficult to convince the doctor of the problem. Luckily I read the packet inserts."

1 / 10
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  • Anony...
  • June 6, 2016

"I really noticed a negative difference when comparing the XR version to the regular Seroquel. It took longer to kick in and made me so drowsy at work that I felt like I was drunk. I think I was taking 100-200 mg. When I went back to regular Seroquel, 100-200 mg put me to sleep fast and made a difference in stabilizing my mood without me feeling too drowsy to function the next day."

4 / 10
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23 Report
  • Anonymous
  • August 25, 2011

"I used to be so paranoid I couldn't even sleep at night. I would go into manic episodes and be in lala land for days until this wonderful pill came into my life. I have never felt better. I just never felt so good I'm happy."

10 / 10
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33 Report
  • shortie
  • April 9, 2016

"I was prescribed seroquel xr for Bipolar depression My dr started me on 50mg and I am gradually increasing the dosage its been about 4 weeks and I am currently taking 200 mg I will agree that it has helped the hopelesness feelings and suicidal thoughts Which is a plus but the zombie like feeling and dry mouth are tough I have a job that requires constant activity its hard to keep up have to definitely slow down My Dr advised me that these side affects are all normal and eventually I will get used to it can't wait for this to happen"

7 / 10
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23 Report
  • Nessa...
  • March 15, 2017

"I'm 24 yrs old, have severe RA and been talking seroquel XR at 300 milligrams a night for nearly a year.... I was diagnosed bipolar 2 years ago but had so much trouble finding a psychiatrist who was caring enough to listen to me (like a psychologist AND work as a psychiatrist, pill pusher) so my diagnosis went treated and untreated on and off for a while. BUT since I've been seeing my doctor regularly and she seems to genuinely care I've trusted her judgment with her diagnosis and what she thought would help me most.... besides the weight gain, honestly I feel much more stable & I can deal with the world around me as I see it and haven't had any serious depressive episodes or hypomania. This medication has worked wonders for me."

9 / 10
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20 Report
  • Befor...
  • February 7, 2019

"I've taken this med in the past. I required a higher dosage because I was feeling paranoid. A few months ago, I weaned myself off of it, but I took other meds. I started to lose weight, and I was feeling healthy physically, but mentally my mind was active. I don't feel paranoia like I did in the past, but lately I'm taking a low dose of 150mg compared to 600mg several months ago. If I take it too soon before bedtime, I tend to feel groggy in the morning, and it takes me 9 hours of sleep. It can cause weight gain, and diabetes. Make sure you have your blood sugar monitored every 3 months. Eat small snacks, less carbs and exercise. Healthy sleep make you happy."

8 / 10
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  • KoRny...
  • February 3, 2011

"I had a "nervous breakdown" in November of 2009 and ended up in a psych hospital where I was promptly given Seroquel among other medicines. The Seroquel was amazing. I felt like someone switched the on button in my brain and I finally woke up. When I got out of the hospital and sought out a new psychiatrist for treatment, he took me off of the Seroquel because I am diabetic. After a year of unsuccessful treatment with other medicines, I begged to be put back on the Seroquel because the depression was unbearable, and I wasn't responding to other medicines. So he agreed and once again that switch has been flipped on and I feel "normal"! I am only on 300mg. I have to take it early because it knocks me out. In the morning I am very dizzy and have slurred speech."

10 / 10
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  • sloth...
  • Taken for 6 months to 1 year
  • December 2, 2020

"I have been on Seroquel XR for almost a year now. Started on 150mg then went up to 300mg. Today I started 400mg as my moods are getting very impulsive and I’m getting manic. I’ve been on probably over 25+ medications and this is by far the best. Zyprexa made me gain 60 pounds in 6 months and also made my breasts started leaking a milky substance. All I can say is give it a try. It doesn’t hurt at all. You never know if it will be the life changing medicine for you."

8 / 10
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11 Report
  • culle...
  • September 27, 2010

"After much trial an error with other medications I am pleased to find that Seroquel XR really helps. I take 500 mg per day. Started at 200 but worked my way up until I felt better. Wish I had discovered this years ago."

9 / 10
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  • Longh...
  • Taken for 6 months to 1 year
  • November 18, 2017

"I was taking 300 mg of Seroquel XR for 6 months. The best part was being able to get a good night’s sleep. I had only been getting 2-3 hrs rest each night. My mind would race and it was a struggle to stay in bed. I would get up and start cleaning. Additionally, I would spend hours creating plans to organize my life. I had not actually followed any of those plans and I was depressed. I took Latuda for a short period but it made my inability to sleep worse. That’s when I was switched to Seroquel. I loved the way it helped me feel normal. The bad - I gained 30 lbs in 6 months. I asked to be taken off and started taking Geodon. Once again I cannot sleep. I am going to ask to go back to Seroquel XR and focus on following a healthy diet."

9 / 10
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  • Bipol...
  • July 31, 2017

"I have to say I've this medicine a 7 out of 10 because it has brought me out of both some wicked manias and depressive episodes. The sedation is a love-hate relationship with me- It's nice for my anxiety, but is also a nuisance. I MUST take this medicine 12 hours before I need to wake up, or I have trouble waking up. I feel it does interfere with my creative and intellectual abilities a tad bit. Overall, however, it's good med."

7 / 10
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17 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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