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Quetiapine for Obsessive Compulsive Disorder User Reviews (Page 2)

Brand names: Seroquel, Seroquel XR

Quetiapine has an average rating of 8.6 out of 10 from a total of 46 reviews for the off-label treatment of Obsessive Compulsive Disorder. 76% of reviewers reported a positive experience, while 4% reported a negative experience.

Reviews for Quetiapine

  • eli...
  • December 28, 2011

Seroquel (quetiapine) "Have been on and off Seroquel for a few years for severe obsessive compulsive disorder, generalized anxiety disorder and post traumatic stress disorder. Self harm has been a big compulsion for me. With this medicine it really helps reduce that and many other compulsions. Only big side effect is weight gain. But after being it for half a year I realize I'd rather be over weight then have the symptoms i typically have."

10 / 10
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41 Report
  • Matt
  • August 18, 2016

"Drug is absolutely amazing and SAVED my life. Literally (clinical depression). I sleep like a rock every night, and this drug improved my life in everyway. The only side effect I've found is it's actually given me OCD issues that I never had before."

10 / 10
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29 Report
  • Anonymous
  • April 20, 2021

"For 3 years I was suffering from severe anxiety and OCD. Previously I'd had "classic" germ OCD, but this time it was primarily obsessive thoughts. It was the worst period of my life, leading to severe depression etc. Two SSRIs and SSRI+Risperidone+exercise+therapy did not work. Finally a doc added 100 mg Seroquel to SSRI instead of risperidone, and this changed everything. It empowered me to take control of my thoughts. Adding exercise, my life changed from extreme misery to a normal and happy life. Med. literature does not show Seroquel as a useful addition to SSRI for OCD and it does for risperidone. This may be true for germ OCD. For me, it was the complete opposite. The doc. who gave me Seroq. said that for me with elaborate, obsessive, in retrospect absurd, thoughts about how things go wrong in the future, risp. belongs to the trash bin, and Seroq. is likely helpful, which it was. If this is your case, talk to your doctor."

10 / 10
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14 Report

Frequently asked questions

  • Anonymous
  • January 23, 2012

Seroquel (quetiapine) "Puts me to sleep like turning off a light switch. Which has greatly helped me work and be on a normal schedule. Before I would stay up for 24-36 hours straight, then sleep 15 hours and then repeat. Been taking it 7 years. Now when I decide it is bedtime, I take it and 9 out of 10 times I am sleeping in 20-60 minutes. It works just as well for me at 25 mg or 200 mg....same effect. Personally, 15 minutes after I take it though I absolutely will not give my OCD the time of day, not because it goes away but because if I do the medicine makes it harder to focus and deal with whatever is bothering me and it can go on and on worse than normal. And the more drowsy I get the worse it is to focus."

9 / 10
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33 Report
  • uuerh
  • Taken for 1 to 2 years
  • May 18, 2024

"I've been using Quetiapine for my OCD symptoms for the past 1 year, and the results have been quite positive. Initially, I was skeptical about its effectiveness, but I've noticed a significant reduction in my obsessive thoughts and compulsive behaviors since starting the medication. Quetiapine has helped me better manage my anxiety levels, allowing me to engage more effectively in therapy and daily activities. Overall, it has been a valuable addition to my treatment regimen for OCD."

10 / 10
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1 Report

Are you taking this medicine?

  • Obses...
  • October 22, 2009

Seroquel XR (quetiapine) "Diagnosed with GAD and OCD, more so the mental aspect (the obsessions). On clonazepam, Zoloft 200mg and Seroquel XR 50mg a few hours before bed. I have to say that it feels great and helps me fall asleep, but I still have some anxiety driven dreams. The hours before sleep are wonderful, it really takes you down a level or two. I just wish it lasted 24 hours."

7 / 10
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34 Report
  • Rob...
  • January 23, 2016

"After many years of sleep problems due to my ADHD I was prescribes seroquel 12.5 mg instead of melatonin. This medicine knocked me out in an hour. I finally can sleep again. Seems like during daytime my mood is a bit more stable."

8 / 10
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21 Report
  • JoyBl...
  • February 15, 2021

"This drug is the reason, after severe symptoms for my entire life including OCD induced anorexia nervosa at 15. I was finally correctly diagnosed as my pathological thoughts only calmed down after its administration by my (at the time new) psychiatrist and increase to maximum dose for my size"

7 / 10
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10 Report
  • Lulu
  • Taken for 1 to 2 years
  • October 5, 2021

"I was diagnosed with OCD last January and then with an affective mood disorder in June. I tried 5 different drugs including lithium (which for me was the absolute worst) last year and this was last drug my psychiatrist prescribed and I have been on it since Sept 2020 it is by far the best. I am me again. I still have Pure O but the intrusive thoughts are so much easier to manage with Quetiapine. It does make me a little drowsy at night but I appreciate the help it provides me in getting a decent nights sleep. Highly recommend."

9 / 10
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8 Report
  • npocko
  • December 17, 2018

"I use quetiapine in conjunction with Luvox with adequate results. Thoughts are less overwhelming, but still present. I usually have a fairly high tolerance for medications, and experience few side-effects, however this drug was an exception. I started on 25mg (the lowest dose available) and they made me mentally and physically exhausted for almost 24 hours. I was unable to function normally for at least 12 hours after the initial dose. I went off them because of this, but started again at the suggestion of my psychiatrist. She suggested halving the tablets. I just went with the 25mg, but took them very early in the evening (no later than 5 pm). I found I could wake up okay in the morning, and was myself by about 11am. I've been on them for about 3 months now and have increased the dosage steadily. I have just moved up to 100mg and feel fine. No side-effects, except for memories in the couple of hours after taking the drug feeling vague and seeming somehow dreamlike."

8 / 10
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13 Report
  • Amy
  • Taken for 1 to 6 months
  • November 6, 2021

"SSRI meds were not working for my depression/OCD/severe panic, after a horrendous breakdown earlier this year, ending in me moving back in with my parents for 6 months, I spoke to my GP about adding a different medication "off-label" to help ease my symptoms (at this point I'd been living in a constant state of panic for a number of months). I am pregnant so Quetiapine was recommended by my antenatal mental health team. There's no magic pill for anything, however this has been a game changer. I've gone from being a vegetable, who couldn't eat or leave the house, to feeling a bit more like myself again, I am back living in my own home with my husband and starting to socialise too. I still have OCD, and annoying intrusive thoughts, but the anxiety and panic is now way reduced, more like an irritating discomfort. This med has helped me get back on track with my recovery and I am starting to enjoy each day bit by bit (I'm also getting brilliant sleep and no daytime drowsiness!)"

8 / 10
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6 Report
  • Steve...
  • Taken for 5 to 10 years
  • April 3, 2022

"I've been on and off it for ten years, mostly for sleep and as an antipsychotic. It does not alleviate my looping thoughts at all. It has minimal effect on my anxiety levels. Sure, it puts me to sleep, but it also makes me feel lethargic. I take it because it is all my doctor suggests for me. All I can say is that it's better than nothing, I'm not a fan of this medication, never have been. To reiterate, it has zero impact on my off symptoms."

2 / 10
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4 Report
  • SEDU
  • Taken for 1 to 2 years
  • August 26, 2022

"This really helps. I have OCD and cyclothymia. Cyclothymia is almost fully cured. OCD is much better - but on higher doses it gets worse. Therapy is very important and understanding yourself too. I take Kwetaplex XR by Adamed (I'm from Poland - it's just Quetiapine which is long-acting ? I have no idea how to name it) - 150 mgs. Sleep is improved. It has some side effects you can relieve. I saw changes in thinking on higher doses and I felt lazy and anxious. Now I started to lose weight and everything is alright"

7 / 10
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2 Report
  • Parie
  • Taken for less than 1 month
  • December 23, 2022

"50 mg of Quetiapine helped immensely (and quickly) with OCD that no longer (after 20 years) responded to 350 mg of Luvox with Klonopin. I now take all three, and the OCD has really been tamed. I do get an upset stomach, but it sure beats the suffering of OCD! I feel very relaxed now."

10 / 10
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1 Report
  • Anonymous
  • Taken for 1 to 6 months
  • November 14, 2022

"I have been on Seroquel for 5 months so far for intrusive thoughts and anxiety. My experience is not the best nor the worst. Started off with lexapro 10mg and seroquel 25mg. I went up to 150mg to help with the side effects of lexapro and then I quit lexapro. Seroquel helped my anxiety and intrusive thoughts tremendously, until I got up 150mg. After a week of being on 150mg my depression increased by a million folds. Me and my psych went up to 300mg hoping it works, but it just made my depression worse. Now I am tappering down and got to 75mg/day and depression is lifting but still not great. The tapering process was very slow but the side effects were still awful. My biggest issue is that it gave me depression. I only had intrusive thoughts and anxiety which it does treat, but honestly the depression side effect is not worth it."

4 / 10
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1 Report
  • GoldS...
  • Taken for 2 to 5 years
  • October 20, 2013

"This is the only medication that seems to stop my the repetitive thoughts. It also improves improve mood and anxiety . Need to exercise alot though to fight the dreaded weight gain."

10 / 10
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60 Report
  • Downu...
  • Taken for 5 to 10 years
  • November 22, 2016

"This drug has changed my life, Almost eliminated the obsessive thoughts, still have the occasional bad episode but they have reduced 95%"

10 / 10
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46 Report
  • Diamo...
  • Taken for 10 years or more
  • August 29, 2019

"I’ve been on Seroquel since 2007 and it has helped me greatly. I no longer suffer from intrusive thoughts. I have gained a a lot of weight, though. I take 500 mg a day."

9 / 10
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21 Report
  • user
  • Taken for 1 to 6 months
  • November 23, 2023

"It's the ONE that works for me! It works very, very well! I'm anxiety-free!"

10 / 10
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4 Report
  • Joom
  • January 4, 2021

"My daughter has been on this medicine, 25 mg. Since 2 weeks and intrusive thoughts are decreasing."

7 / 10
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14 Report
  • drew_...
  • January 19, 2011

Seroquel (quetiapine) "If OCD thoughts are keeping you up at night this works well. Turns the brain off with literally 25 mg a night one hour before I want to sleep. Daytime Paxil has worked best for me."

10 / 10
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34 Report
  • Stryc...
  • Taken for 1 to 6 months
  • March 26, 2016

"Great after 3 months......but will make you gain 1,444,765 pounds. No bs!"

7 / 10
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22 Report
  • Anonymous
  • December 4, 2011

Seroquel (quetiapine) "It helped with my OCD intrusive thoughts, but made me VERY agitated and a feeling of skin crawling. Even at 1/4 of a tablet and I was really anxious."

5 / 10
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22 Report
  • Zombie
  • December 17, 2016

"This is a zombie drug."

1 / 10
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15 Report
  • Rylee
  • Taken for 1 to 6 months
  • September 12, 2020

"Improves mood greatly, hunger increase, although very sedating but when staying awake you get a high like effect."

6 / 10
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7 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.