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Quetiapine for Depression User Reviews (Page 5)

Brand names: Seroquel, Seroquel XR

Quetiapine has an average rating of 6.4 out of 10 from a total of 177 reviews for the treatment of Depression. 52% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Quetiapine

  • testb...
  • October 28, 2009

Seroquel (quetiapine) "I was prescribed Seroquel 200mg doses along with Lexapro after a bad episode recently. I have been unable to work since and have found my dreams to be vivid and disturbing. This drug should not be taken lightly and I would recommend a second opinion from a medical professional before commencing a course. This drug will make you sleepy, so much so it can be difficult to continue with your employment, driving, development and maintenance of relationships between family and friends, nausea, dizziness, depletion of sex drive and the list continues. It can be helpful in many cases, but please make sure by second or even third opinion."

5 / 10
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31 Report
  • Deanne...
  • October 12, 2016

"I've been on this for a few weeks for insomnia. It is TERRIBLE. It gives me a severe headache every morning and has made my depression increase threefold. I absolutely hate this medication. It has actually made me feel more mentally unstable."

1 / 10
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19 Report
  • maira...
  • Taken for 1 to 6 months
  • October 20, 2020

"I started quetiapine 25 mg at bed time with 150 mg sertraline my mood was not good then I added 25 mg quetiapine at morning with 100 mg sertraline and I am now feeling well with quetiapine but some times I still have depression attacks. I am not sure what to do next."

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11 Report

Frequently asked questions

  • suici...
  • Taken for less than 1 month
  • November 3, 2015

"Got this at ER. Caused my depression to worsen after three weeks. Despite drowsiness, the co-occurrence with restlessness initially caused inability to sleep. Further use led to somnolence, further lack of motivation and suicidal ideation. Discontinuation caused depersonalization and severe aggression. Read the story of Dan Markingson. Not recommended at all for depression."

1 / 10
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20 Report
  • Anonymous
  • January 29, 2011

Seroquel (quetiapine) "I recently started Seroquel 50 MG for depression, panic disorder, anxiety, insomnia. The first couple of days and then up to 150 MG. This medication works great. It creates anxiolytic effects similar to clonazapam and relieves all my anxiety. I Sleep well to. I can actually function thanks to this medication and it works excellently for paranoia and anxiety. I've also found it to work great for sleep. I was previously on Abilify which was very activating and gave me a lot of anxiety and I couldn't sleep more than 1-2 hours. On Seroquel I sleep a full 8 hours and I wake up refreshed and ready for the day. It controls my anxiety and works wonders. Side effects are: No sex drive, and Drowsiness. Great medicine, works great."

10 / 10
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28 Report

Are you taking this medicine?

  • 28yr...
  • January 5, 2010

Seroquel (quetiapine) "I have been taking Seroquel 100mg 3 times daily for several months now and it has not helped me in the least bit. This drug has many negative side effects since being on it I have been feeling extra anxiety, impatient, sore and stiff muscles especially the neck, back, fingers, hand, calves. I have also been having a lot of gas, nightmares are horrible, feel really irritable and often have headaches and jaw pain. The list goes on and if you are feeling this way trust me you are not alone."

1 / 10
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29 Report
  • Vada
  • Taken for 2 to 5 years
  • January 15, 2019

"I have been on the same drug for almost 5 years. Some generics work better than others as far as treating the condition. However, I've had the worst experience with Accord's generic. It instantly gave me headaches ALL the time. I tried to contact the company by phone, email, and the website. I left multiple messages, wanting to speak with them. They never responded and I never was able to actually speak with ANYONE from the company. I've never had this experience with a drug company. It should not be impossible to speak with customer service about my experience with one of their medications."

1 / 10
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14 Report
  • Bipolar...
  • May 17, 2011

Seroquel (quetiapine) "Taking low dose, 25-50mg at bedtime for about two years. I was tired during the day, so we switched to hydroxyzine for the sleep. Bad idea, as I was very irritable and after about 6 months wound up back in the hospital. Low dose Seroquel has positively changed my life. My psych says low dose has remarkable effect on bipolar patients in his practice."

10 / 10
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27 Report
  • Bobby
  • Taken for 1 to 6 months
  • December 22, 2019

"Quetiapine (or Seroquel) isn't helping me at all & I fear it's negating the effect of my anti-depressant Venlafaxine. Every time I try to take it, I quit after about a month because, despite me sleeping better, my mood becomes very low. This time, during a stay in a psychiatric hospital, I've given it a go for 2 months but the depression has got worse and worse, whereas before I would be naturally depressed for a week and then feel better the next week. I'm going to faze it out so I can tell if my AD works or not."

5 / 10
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  • annac...
  • Taken for 6 months to 1 year
  • May 22, 2021

"Me and my husband take quetiapine. I have refractory depression, and he has marijuana addiction + depression. We are both taking desvenlafaxin in the morning and quetiapine 25mg at night. And it has changed my life! At night, we both feel that our dreams re-defines bad memories at the past and turns bad moments as neutral or good memories. I don't know how to explain that. But, at the other side, my speech and memory are worse than before it."

10 / 10
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9 Report
  • JaimeF
  • August 22, 2009

Seroquel (quetiapine) "I've been taking Seroquel for 4 months now. I was in a medical detox for narcotic dependence to pain medication and Xanax. I'm on another medication now which interacts with Xanax, so I can't take it anymore. Since being on Seroquel I sleep amazingly. I used to take 1mg of Xanax and 6 or 7 Tylenol PM's just to fall asleep. Now I take 75mg of Seroquel a night and I fall asleep easily and stay asleep. I do get a weird pain in my hands and fingers, and have started getting muscle pain in my calves. I originally was prescribed to take 25mg in the afternoon and 50 mg at night, but the daytime dose was making me so exhausted I couldn't function and do my daily activities. Taking Seroquel has greatly improved my insomnia, depression, and anxiety."

7 / 10
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28 Report
  • Byrd...
  • Taken for 1 to 2 years
  • July 7, 2014

"I have taken a simple anti-depressant such as Effexor for years. I never felt they fully did the job. When talking to my Dr. one day, I told her my sleep patterns were horrible, with insomnia, or awaking early. She suggested Seroquel as an additive. I have been on it for about a year, and I have never felt so rested. I have a better focus. I even think it has really helped my depression a bit. Yes, it does increase my appetite a bit , but I try to eat healthy foods and walk. You must take it a full 8 hours before you want to awake, or you may be droggy. I am really satisfied."

8 / 10
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21 Report
  • theda...
  • Taken for 6 months to 1 year
  • February 14, 2014

"I have unipolar depression with occasional manic symptoms. For 20 years I was on antidepressants but started Quetiapine about 6 months ago in conjunction with Citalopram. When I reached a daily dose of 300mg I was feeling great mentally. But the side effects of constipation and tiredness made it difficult to stay on this medication long-term so I'll be trying lamotrigine next."

8 / 10
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21 Report
  • Pikey...
  • August 5, 2015

"I have PTSD and bipolar OCD and agrophobia. I'm on 5 mg diazepam, 300 pregablin 225 quetiapine and 408 lymecycline these all daily dosages. I find it spaces me out a fair bit and i do eat more BUT its been an overnight success for me its made life bearable again."

10 / 10
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19 Report
  • EngTe...
  • Taken for less than 1 month
  • August 23, 2012

Seroquel (quetiapine) "I have been taking 150MGx2 along with 10MG of Lexapro to help with chronic depression. Due to divorce this summer, I told my Dr I was feeling more depressed and he raised my dose of Seroquel to 200x2 at bed time. I am a teacher and the last 2 days I have not been able to get up. I start to get dressed and wake up hours later standing at the mirror with a toothbrush in my hand. Lucky for me we don't have students yet but I am terrified I will continue oversleeping and miss my classes. Also, I am having muscle spasms in my right hand, dropping things I am holding, throwing eggs across the room. The only change in my routine is the bump up in dose so the problem has got to be that. "

2 / 10
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23 Report
  • Anonymous
  • March 29, 2011

Seroquel (quetiapine) "I am 49 and have Bipolar II. Been on Seroquel 400 mg for one year. Initially very drowsy, restless legs, dry mouth and blocked nose, most side effects lifted after 3 months. This medicine controlled my racing thoughts, helped me concentrate (I thought I had ADD). Ironically, despite the drowsiness it lifted my extreme exhaustion (I used to have weekly Vitamin B injections because I was so tired). I no longer feel drowsy, managed not to gain weight with the help of a dietitian and an exercise program. I do get very hungry but refuse to give in to the hunger. I also take Wellburtin and Zoloft to help the depression, tearfulness and agitation. I would recommend Seroquel to Bipolar patients."

9 / 10
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25 Report
  • nextneg
  • Taken for less than 1 month
  • June 20, 2018

"I was given seroquel 25mg that I halved for a mood stabilizer. I'm also on mirtazipine 15mg. I have high blood pressure too. This med at even the low dose gave me heart palpitations, ringing in my ears and a panic attack! I'm very sensitive to medication but don't recommend this to anyone else who is using it for a mood stabilizer"

1 / 10
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13 Report
  • Knowl...
  • September 17, 2009

Seroquel (quetiapine) "I love Seroquel! After suffering with insomnia for approximately 30 years, and 2 years of depression, I have finally found a medication that lets me sleep through the night. Plus, I enjoy the groggy and relaxed feeling that I have the following day, although my doctor says that a lot of his patients do not like this feeling."

9 / 10
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25 Report
  • James...
  • January 16, 2021

Seroquel XR (quetiapine) "This medication Seroquel xr caused me to have body chills, and a hung over fatigue. I couldn't do anything after taking 3 pills it hit me like a ton of bricks. I was totally hung over for 2 day bad headaches and I was shaking non stop. I've stopped this medication can't do it again"

1 / 10
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8 Report
  • jayja...
  • September 15, 2011

Seroquel (quetiapine) "I was very reluctant when my doctor suggested Seroquel for my condition. I had been on it before as a sleep aid and while it did improve my sleep greatly, I was miserable the next day. This time he wanted me on it round the clock, and it has made a huge difference. It would seem strange that something which makes you drowsy would help depression too, but for me, this seems to have been the case. I've had very little depression since we got up to the full dose. I'm now on Seroquel XR 200mg."

9 / 10
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21 Report
  • Matt...
  • October 16, 2017

"I have been taking Seroquel at a low dose (50mg) for about 10 years; for insomnia and depression (to augment another mood stabilizer). It generally works very well. I fall asleep almost immediately and have uninterrupted sleep. I do have some grogginess in the morning but it generally wears off within 30-60 minutes. The only other potential side effect I've experienced is elevated cholesterol, but I do not know if the seroquel is causing it; my internist believes it may be hereditary. It's available as a generic and is very inexpensive with my insurance. Overall I find it's a good med."

8 / 10
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13 Report
  • ssr94...
  • August 18, 2010

Seroquel XR (quetiapine) "Was put on this medication for mood stabilization as well as for sleep. At the lowest dose it made me excessively drowsy the next day. As for the mood stabilization all it did there was make me have violent outbursts while on the medication."

1 / 10
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22 Report
  • SuzyQ
  • April 24, 2016

"I suffered from postpartum depression with insomnia. I was on this medication for less than 3 years. It took 4 attempts to discontinue this medication. I felt helpless when trying to stop. I was on 600 mg at one point and I was down to 6.25 mg. I ended up taking it every other night then every 3rd night then finally stopping. I got the approval of my doctor to do this. I still have problems sleeping but I know in time it will get better. I already feel better mentally and all the swelling in my face, hands and feet are gone. Seroquel served a purpose in my life when I needed it but I'm very thankful to be off this poison!"

8 / 10
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15 Report
  • Grego...
  • Taken for 1 to 6 months
  • June 17, 2021

"Listen to what your Psychiatrist says, ask tons of questions but remember, it's YOU taking this medication and not your Psychiatrist. A lot of experimenting is needed before getting a cocktail which works. I'm on 5mg fluoxetine morning, 30mg paroxetine morning, and 150mg of quetiapine at night. (Prozac, Paxil, Seroquel) I was on Mirtazapine also but have let go of that. Results are promising. Very little sleepiness from the quetiapine... serum levels peak 90 minutes after taking... but there is a choice to sleep or not. It's no knock out pill. The method of chemistry with quetiapine is to slow the transmission of neuro-transmitters, so keeps the good stuff in the brain for a while longer, just titrering along. At least this is the construct from the medicos and chemists. It's all black magic. Quetiapine like many other drugs started life as an antihistamine. That's a side benefit of taking it... you can vacuum without a mask. :)"

10 / 10
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7 Report
  • Holly...
  • Taken for less than 1 month
  • October 18, 2015

"I was perscribed this medication by my psyciatrist about a month or so ago. Me and my mother were in no way notified about the effects this medication may have. I am only 15 years of age and I have been on fluoxetine for two years. This particular medication has not agreed with me at all... The same as aripripizol but worse. My symptoms worsened. I even developed more weird behaviours. I was worse than when I had started. I became increasingly paranoid, ten times more anxious and my mood fluctuated constantly. There has been no positive changes to my behaviour or mood and the side effects have effected me drastically. I have just got off the tablets and my depression has worsened and I now have insomnia. It has been in no way positive."

1 / 10
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15 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.