Skip to main content

Ondansetron for Nausea/Vomiting User Reviews (Page 2)

Ondansetron has an average rating of 7.7 out of 10 from a total of 382 reviews for the treatment of Nausea/Vomiting. 72% of reviewers reported a positive experience, while 20% reported a negative experience.

Reviews for Ondansetron

  • Essic...
  • Taken for 1 to 6 months
  • January 7, 2015

Zofran (ondansetron) "I am currently 25 weeks pregnant and have had bad nausea/morning sickness since week 5. This medicine has been wonderful. There are times where I still feel sick, but it's bearable and I don't throw up. I've been taking it so long now that the sleepiness it causes doesn't affect me anymore. However, the constipation from it has been a downer."

8 / 10
Was this helpful?YesNo
45 Report
  • harpie
  • January 29, 2015

Zofran (ondansetron) "I take several medications for treatment of Auto-Immune disease. I had hiatle hernia surgery so it is important I do not vomit unless absolutely necessary. Zofran works quickly to eliminate nausea and vomiting and also relaxes me."

10 / 10
Was this helpful?YesNo
43 Report
  • Dani
  • August 19, 2019

Zofran (ondansetron) "This is the best medicine for vomiting I have ever had. I was on IV antibiotics with a lot of side effects, esp nausea and the antibiotics could not be changed and I literally could not hold down water. I had to be on them for 3 months and Zofran (both IV and ODT) helped me immensely. I was able to drink and even eat little with much less nausea. People have to remember no medication may make symptoms resolve completely every time but this comes pretty close. When I took it for regular nausea from a virus or something it worked like 100% nausea gone. For me there was no side effects, and again people have to remember if you're sick some of the symptoms may not be side effects. If your vomiting repeatedly and are dehydrated of course you're going to have a headache. But everyone is different so what works for one may not have the same effects for another. But I'm a health care worker and whoever is given Zofran usually has relief so give it a try if ur doctor says it's ok!good luck"

9 / 10
Was this helpful?YesNo
25 Report

Frequently asked questions

  • Cara
  • Taken for less than 1 month
  • June 14, 2013

Zofran ODT (ondansetron) "I have been very sick and vomiting with my 2nd pregnancy. My doctor prescribed this to me and now I can keep food and liquids down. I can actually get out of bed and play with my 2yr old. It has saved me."

10 / 10
Was this helpful?YesNo
46 Report
  • SickF
  • March 21, 2016

Zofran (ondansetron) "Was very sick from antibiotics and large doses of Prednisone to help with the asthma. Couldn't hold any food down but did take enough water and Gatorade. Kept losing weight and had terrible abdominal cramps with the nausea. Finally saw another Dr after 11 days who prescribed the ZOFRAN and all nausea and cramps totally went away. Finally could start eating again! ZOFRAN was a miracle med for me! !!"

10 / 10
Was this helpful?YesNo
36 Report

Are you taking this medicine?

  • Patient...
  • Taken for 1 to 6 months
  • March 4, 2019

Zofran (ondansetron) "This medication is as close to a miracle for anyone with terrible nausea as it gets. Whether you have a flu or are going through chemo. Zofran is amazing. It works on your seretonin receptors; however it is not like an anti depressant. It target a specific function and suddenly, almost instantly in my case; nausea is gone. I thank my lucky stars that this medication exists. For many it is a huge difference maker."

10 / 10
Was this helpful?YesNo
26 Report
  • icybl...
  • March 13, 2008

Zofran (ondansetron) "I have had nausea and been vomiting for one year and one month, I am 16 and I have spent 90% of my life the past 1.1 year/mo in bed sick. The last month, FINALLY, after so many medications...THIS, WAS IT. I am still being tested as no one knows what is wrong, that is causing me to be so sick...BUT Zofran has made so I can get SOME relief, I am grateful."

9 / 10
Was this helpful?YesNo
59 Report
  • Catst...
  • Taken for less than 1 month
  • February 22, 2021

Zofran ODT (ondansetron) "Horrible drug for me. Actually makes me nauseous and throw up. Nothing tastes right on this medication. One dose had me throwing up and nauseous, not able to eat for a couple days. One dose had me constipated for about 5 days before I was back to normal (with taking stool softeners Rx after surgery). May work for some but for me it’s a NO go."

1 / 10
Was this helpful?YesNo
18 Report
  • Momma...
  • February 1, 2015

Zofran (ondansetron) "I'm 32 weeks 5 days pregnant. Was admitted into maternity yesterday after throwing up every few minutes all yesterday morning. They have me fluids and Gravol but that only made me drowsy, and did nothing for the throwing up so they decided to give me the Zofran. It started working as soon as it was into my body. It's was quick and very effective!"

10 / 10
Was this helpful?YesNo
38 Report
  • Uniqua
  • Taken for less than 1 month
  • February 3, 2016

Zofran ODT (ondansetron) "Today I went to the doctors for some common flu symptoms. They prescribed me Zofran for my nausea and upset stomach. About 10-15 minutes after taking it there was a tremendous relief of everything. It works rapidly and does wonders. I have not experienced any side effects like headaches or nothing yet so everything's good so far."

10 / 10
Was this helpful?YesNo
34 Report
  • Natty_R
  • Taken for 1 to 2 years
  • February 23, 2016

Zofran (ondansetron) "This is such an effective and helpful med. I can't tell you how many times I'd been nauseous and almost immediately got rid of it with the disolvable version. It melts, I wait a few minutes and then it's gone normally."

9 / 10
Was this helpful?YesNo
34 Report
  • Ginger
  • Taken for 6 months to 1 year
  • February 4, 2021

Zofran ODT (ondansetron) "I have extreme anxiety which causes me to have stomach issues to be constantly nauseous. I love this medication but the only side effect I have is constipation but I usually just take a Senakot or just eat the Fiber 1 bars. It works quickly. Doesn't taste the best but absolutely worth it"

10 / 10
Was this helpful?YesNo
17 Report
  • Pat
  • Taken for 2 to 5 years
  • January 7, 2020

Zofran (ondansetron) "I have tried 3 different forms of Zofran on multiple occasions for 2 different reasons, and it has never helped my nausea at all. I have tried it for both my everyday nausea and my migraine nausea, but I would still throw up. I have tried the medication in the forms of: 1. Swallowing the pill 2. Dissolving the tablet in my mouth 3. Getting it pumped into me intravenously (with an IV in the hospital). Zofran just doesn't work on me I guess! It works really well for some people, though."

1 / 10
Was this helpful?YesNo
21 Report
  • Wildf...
  • September 23, 2013

Zofran ODT (ondansetron) "I suffer from chronic lower back pain due to scoliosis and arthritis (42 yrs old). I also suffer from Irritable Bowel Syndrome. I take Zofran almost daily to deal with the miseries of both lower back pain and digestive issues. I still have regular bouts of vomiting, however, Zofran will stop the pain and nausea that would continue for days and land me in the hospital with an IV delivering morphine into my system to stop the cycle of vomiting, nausea, and severe pain. I love my Zofran! It makes life "livable.""

10 / 10
Was this helpful?YesNo
40 Report
  • Goldy
  • Taken for less than 1 month
  • February 25, 2020

"Used 1 dosage for horrible nausea either caused by food poisoning or an intestinal virus. I was writhing around on my bed like Linda Blair in the Exorcist and took 1 x 4 mg Pill. The nausea literally subsided within about 2 minutes. I am one to whine about the profits of big pharma but bless the folks that came up with this. Wish I knew about this 20 years ago after eating a bad oyster and spent 3 days in bed..also a shout out to you pregnant mothers that deal with nausea..it’s the absolute worst.."

10 / 10
Was this helpful?YesNo
20 Report
  • OLou
  • Taken for 1 to 2 years
  • May 3, 2014

Zofran (ondansetron) "This medication works wonders for me whenever I feel sick or nauseous. The flavored tablets that disintegrate under the tongue or in the mouth are very convenient and work really quickly to relieve nausea/vomiting. The only real side effect from it that I have noticed is a slight tired feeling. I'd much rather feel a little sleepy than sick to my stomach. I really recommend this medicine if your doctor also feels that it is right for you."

10 / 10
Was this helpful?YesNo
38 Report
  • Thela...
  • Taken for 1 to 6 months
  • April 19, 2019

Zofran (ondansetron) "I was prescribed ZOFRAN a few months back, I have suffered from nausea since I was 17 (I'm 36 now). This is the only drug that has ever worked for me, all the other over the counter meds just make the nausea worse, this makes my nausea go away with in 30 mins. and keeps it gone for 8 hours, I wish this had been around when I was younger."

10 / 10
Was this helpful?YesNo
23 Report
  • Bella...
  • November 7, 2017

Zofran (ondansetron) "This drug has saved my sanity. I was undiagnosed with a debilitating vomiting sickness. In hospital at least once a week via ambulance. Repetitive vomiting and could not stop. To the point where I would become unresponsive. After about a month into my undiagnosed sickness, at the emergency room, a nurse gave me a wafer of Zofran. It was a huuuuge relief as my uncontrollable vomiting stopped within 10 minutes. I had not heard of the drug but after finally been diagnosed, after 6 months, as having Severe Idiopathic Gastroparesis I found my new best friend. As well as having a kidney transplant and taking a bucket full of anti-rejection meds, I was soooo grateful that some smart cookie out there invented this drug. Saved my life"

10 / 10
Was this helpful?YesNo
27 Report
  • Joy
  • Taken for less than 1 month
  • August 21, 2020

Zofran (ondansetron) "I have gastritis and am going through a flareup now. Very sick...nauseous for 8 hours every day. Zophran doesn't help me at all...even doubling dose, as my dr recommended. He is giving me Reglan. Praying that works. Nausea is the worst!"

1 / 10
Was this helpful?YesNo
18 Report
  • Chris...
  • Taken for less than 1 month
  • April 5, 2016

Zofran (ondansetron) "I was taking Zofran for awful stomach upset with nausea because one of my other medicines I was on I picked up at pharmacy was a generic new form of medication to treat pain. This new medicine made me very sick. Zofran helped out a lot plus I could take it up to four times per-day. However, I'm also on Lexapro for depression and panic attacks. One day after 2 weeks on these meds I had severe shaking happening to me and I never felt this way before.. Come to find out taking both the Zofran and Lexapro on same day each day was high risk of a drug interaction very severe and I was having the symptoms of a bad interaction. I need to change my lexapro to another type of depression med. But, every depression med is bad with zofran."

8 / 10
Was this helpful?YesNo
32 Report
  • asbeen
  • Taken for 6 months to 1 year
  • August 22, 2014

Zofran (ondansetron) "I've had reoccurring nausea for over a year now. The bouts of nausea, dry heaving and vomiting only bile would last for hours. Phenergan did nothing, but Zofran, within 5 min (usually) I'm cured. It does make you sleepy, but well worth a little tiredness. It is expensive without insurance."

10 / 10
Was this helpful?YesNo
36 Report
  • Anonymous
  • October 10, 2012

Zofran (ondansetron) "I can't say enough about Zofran. I was curled in a fetal position in front of the bathroom, on the floor, in a cold sweat after vomiting for the last two hours. The last bout was dry heaving. Still the nausea was crippling me. My wife gave me one pill and within 30 minutes the hell I was going through broke like an ocean tide receding. I keep Zofran in the medicine cabinet now, at all times."

9 / 10
Was this helpful?YesNo
40 Report
  • Kaydubs
  • Taken for 2 to 5 years
  • January 26, 2016

Zofran (ondansetron) "Zofran is a miracle drug! I've had this medication for several years on an as-needed basis. With my IBS and anxiety, I tend to get nauseous easily. Whatever the cause to my nausea may be, Zofran works every single time. Now that its dissolvable it makes it so much easier to take. The relief happens within 20-30 minutes and usually 1 tablet is all I need. I do experience 2 side effects each and every time: a painful headache after the drug wears off (6-8 hours after taken) and constipation (practically nonexistent bowel movements) for 2-3 days. For the headache, OTC migraine meds work best. The constipation isn't bothersome enough to me to treat."

10 / 10
Was this helpful?YesNo
30 Report
  • Sugah
  • Taken for 6 months to 1 year
  • October 6, 2019

Zofran (ondansetron) "I have several chronic conditions and one is called Cyclic Vomiting Syndrome. It's even worse than it sounds. I'm over 40 and have suffered since childhood. Gravol stopped working over a decade ago. Last December was particularly bad with many trips to the ER and I finally got lucky and was given this. It's a miracle drug for me about 95% of the time. I do get some side effects like diarrhea and sweating but they're very bearable. I don't go anywhere without a bottle of these."

10 / 10
Was this helpful?YesNo
19 Report
  • Nicck
  • Taken for 2 to 5 years
  • February 4, 2019

Zofran (ondansetron) "Zofran is THE most reliable medication I have ever taken! It has prevented me from throwing up, or even feeling nauseas 100% of the time! It's sad that when I was growing up in the 1970's, all I could take for nausea was Pepto-Bismal, which NEVER worked to prevent me from getting nauseous or vomiting. Pepto-Bismal is great for diarrhea, but it did NOTHING for my nausea. I can't say enough about Zofran!"

10 / 10
Was this helpful?YesNo
21 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Nausea/Vomiting

Symptoms and treatments

Medicine.com guides (external)