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Nortriptyline User Reviews & Ratings (Page 3)

Brand names: Pamelor

Nortriptyline has an average rating of 7.3 out of 10 from a total of 567 reviews on Drugs.com. 69% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Nortriptyline

Commonly mentioned side effects
  • Ver...
  • November 18, 2011

For Pain "I had a car accident two years ago and the back, neck, and leg pain crippled me until I tried nortriptyline. I am pain-free and take 50mg which I build up to. After 6 weeks, the only downside is I cannot drink alcohol, but a small price to pay. If I try to reduce them, I go back to the same conditions I had before taking them. I take it at night and actually sleep for 6 hours straight pain-free, which I could not do before. This medicine has given me back my life."

8 / 10
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  • pro...
  • Taken for 1 to 6 months
  • November 23, 2015

For Migraine Prevention "I have been on this since the beginning of October 2015. I never really write any reviews, but I swear this drug saved my life. I am a pro athlete and my migraines had gotten so bad I couldn't train anymore. Almost a year went by with no training. It got to the point that I was going to the hospital at least once a week. CT scans and MRI, the whole nine yards. Finally, the ER doctor told me I should really consider taking this, so I did. Within 2 weeks, I was migraine-free and haven't had one since. It is truly a lifesaver. I am also finding that I am in a better place mentally as well."

10 / 10
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115 Report
  • Lad...
  • November 23, 2020

For Neuralgia "I was diagnosed with trigeminal and occipital neuralgia. I was at my wit's end. Nothing was helping me, and no doctor could tell me what it was. Eventually, I stumbled upon a neurologist who prescribed nortriptyline at 10 mg a day for the first week, increasing to 20 mg thereafter. It knocked out severe neuralgia, 11 on a scale of 1 to 10! I also noticed that my undiagnosed, diffuse but intense joint pain began to lessen as well. I am now able to function like a normal human being again. I am very grateful for this medication."

10 / 10
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66 Report

Frequently asked questions

  • cam...
  • Taken for less than 1 month
  • February 19, 2014

For Migraine Prevention "2 or 3 weeks in with 25mg Nortriptyline at bedtime. Migraines seem reduced, but it has had an unbearable effect on my ACID REFLUX. As long as I eat healthy and avoid trigger foods, I do not take an acid reducer such as omeprazole, but I will need to take it if I continue the Nortriptyline. I tried this medicine about a year ago, but stopped taking it because of heartburn. My doctor said it was not associated with heartburn, but now I have been taking it for the 2nd time and gotten a huge flare-up of heartburn again. I am convinced that for me it is the medicine and not a coincidence now."

6 / 10
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133 Report
  • Anonymous
  • Taken for 10 years or more
  • June 10, 2017

For Depression "Fell into major depression at age 40. Tried 5 different SSRIs and no improvement. Then started Pamelor. Wow, the light went on. On 100mg for 25 years. Life saver. I'll put up with constipation and dry mouth to stay happy."

10 / 10
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98 Report

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  • RLZ...
  • September 13, 2014

Nortriptyline for Depression "My neurologist prescribed Nortriptyline for Neuropathy. It did not help much for that condition. However, at the time, I was suffering from severe depression due to having to place my husband in a nursing home. The medication did wonders for me and I have been a daily user since that time."

8 / 10
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125 Report
  • Jen...
  • Taken for less than 1 month
  • January 21, 2017

For Pain "I am 56 years old with severe chronic nerve pain in my neck from herniation at C6-C7 and C4-C5. I opted for no surgery and I have had zero quality of life, been on bed rest for 4 years. Started PT with pain meds, neurontin 600mg. Slowly able to function in a brain fog but free from strong narcotics. Went to amitriptyline 40mg at night, slept great but next day brain fog with memory lapses and always tired. Now on 10mg nortriptyline I take in the morning because it affects me like a stimulant and hard to sleep at night but been on for a week. I have constipation but taking fiber in water helps. I love being alert with a clear head! So far no pain on 10mg so I won't increase unless I have pain. A very livable dose."

9 / 10
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  • Nic...
  • Taken for 1 to 6 months
  • June 2, 2017

For Depression "I've been taking 10mg nortriptyline now for 5 weeks for severe anxiety and depression. Very happy with results. Still have some depression but it kicked butt on the anxiety. I can function normally again. No side effects at all."

9 / 10
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  • fre...
  • July 12, 2017

For Irritable Bowel Syndrome "One of the first reviews I've written regarding a treatment. My IBS-D got to a point where I was visiting the bathroom about 5-6 times a day. When I wasn't in the bathroom, the uneasiness associated with IBS stopped me from focusing on anything I tried to do. All I wanted to do was stay in bed and distract myself with movies and TV shows. I spent lots of time researching online and trying various treatments including elimination diets, supplements, various exercises, etc. My GP recommended I try Nortriptyline at nights starting at 10mg dosage and said that it'd take around a month to kick in. After about 3 weeks, I switched to taking it in the morning and it's been working wonders ever since. Pretty much IBS free and have my life back."

10 / 10
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92 Report
  • kru...
  • October 19, 2009

For Depression "My doctor switched me to nortriptyline for depression. I started out at 50mg a night for a month, then upped it to 75mg a night. Since taking the 75mg, the depression has gone away. And I feel so much better. I've been on SSRIs for years and was always still depressed. The doctor told me I was allergic to SSRIs and put me on a tricyclic. Worked wonders."

10 / 10
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  • PHa...
  • Taken for 2 to 5 years
  • February 16, 2020

For Depression "I have been on nortriptyline for 2.5 years due to anxiety, and it has significantly improved my quality of life. I do have a dry mouth as a side effect, but it is very worth it in comparison to the benefits that it brings. Prior to starting nortriptyline, I experienced a number of secondary symptoms caused by my anxiety: insomnia, headaches, and loss of appetite. In addition to reducing my anxiety, I now sleep well every night, no longer have frequent headaches, and I have an appetite that allows me to keep my weight at a healthy spot (I was too thin before). These things seem to help my immune system too because I seem to be much better at fighting off/avoiding colds than before I was on this medication. So in summary: This medication helped address my anxiety and a bunch of secondary symptoms that I hadn’t realized were anxiety-related. On this medication, I feel happier and healthier than ever before."

10 / 10
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  • Gra...
  • March 16, 2013

For Migraine Prevention "Been having worsening migraines for 8 or more years. Tried so many different things, I am basically disabled at this point, sick almost daily from either migraine or rebound day. After Topamax, steroids, beta blockers, you name it, I've tried it. Finally I've been put on nortriptyline, after 2 weeks I haven't had a single migraine. I hate to be skeptical but it's almost too good to believe for me since I've been sick so long, so I will be reporting back soon. But I even feel differently just how my brain feels. Right now I'm quite thrilled and the results seem to be what's reported by everyone else here (taking 25mg at night)."

10 / 10
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  • Tre...
  • Taken for 1 to 6 months
  • September 10, 2019

For Migraine Prevention "I have migraine-associated vertigo (1 year +). I forget how many meds I have tried, but 10 mg nortriptyline was fine. I was having good sleep. Dry mouth. My doctor increased it to 20 mg. I started feeling more dizzy and nauseous. In week 2, I experienced blurry vision and slurred speech. I declined further with mobility and strength. I was told to go to the ER and received migraine IV. I was slowly weaned off nortriptyline and thankfully had no more blurry vision or slurred speech. My doctor never talked about these side effects, and this was very frightening."

2 / 10
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  • Hap...
  • Taken for 1 to 2 years
  • October 24, 2019

For Pain "After 7 years of chronic pain in my lower back and stabbing/burning pain in my glute, I was finally prescribed nortriptyline. I waited two weeks to start it as pregabalin had been so horrible. After one dose, I finally was able to sleep for 7 hours. I had been sleeping for about 4 hours a night up until then because of the pain, which didn't respond to ibuprofen, paracetamol, or opioid-based medication. Pain relief lasts for about 17 hours. No side effects other than I do feel a bit sleepy at times. I still take ibuprofen if I have overdone the gardening or housework. Now it works to help me sleep. The dose is 20 mg a night."

10 / 10
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  • Hel...
  • August 31, 2015

For Depression "I was the person who had all kinds of problems and none of them could be linked together. So, I saw many doctors and I tried many drugs. I had major depression, which all the usual antidepressants made worse. Debilitating migraines, moderate to severe muscle and joint pain, severe insomnia, and panic attacks. I was on many medications and in high doses, but they didn't help. It was very frustrating because no one believed what I experienced was real. Until a friend in college said maybe it's just in your head and encouraged me to see a counselor who then sent me to the psychiatrist. He took me off everything I was on and put me on nortriptyline within 3 weeks. I did a 180, except for the panic attacks for which I started taking lorazepam. I'm doing great."

10 / 10
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  • Kat...
  • Taken for 6 months to 1 year
  • September 1, 2016

For Pain "I was given 25 mg Nortriptyline for shingles pain, along with Gabapentin and Tramadol for shingles and back pain. I now have PHN. I have had this pain for 6 months now. I had pretty severe burning pain. Within 3 days, the burning stopped. Most of the pain went away except at night. I went up on the Gabapentin several times. I didn't want to go up on Nortriptyline due to side effects (extreme dry mouth, and it was hard to wake up in the morning). Occasionally, I miss a dose by accident and go to sleep without it. I will hurt so much that I can't do anything but sit and use ice packs all day. Also, my pain will be much worse for 3 whole days following a missed pill. This has happened 5-6 times. Nortriptyline is the most effective medicine I've tried."

8 / 10
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99 Report
  • ber...
  • Taken for 1 to 6 months
  • August 19, 2012

For Pain "After years of disc/nerve pain, I have been on these tablets for around 3 months and the pain has reduced considerably and I sleep much better too. I have been taking 25mg, but have now upped the dose to 50mg and it appears to be working even better. Fingers crossed."

8 / 10
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  • Lom...
  • Taken for less than 1 month
  • August 2, 2013

For Pain "I have been taking this medication for a week and feel so much better. Had a car accident over 20 years ago and I suffer from chronic lower back and hip pain. I take 25mg. However, it has made my hot flashes worse."

8 / 10
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  • Xja...
  • Taken for 1 to 6 months
  • November 12, 2020

For Irritable Bowel Syndrome "Nortriptyline changed my life from the drama of IBS. I went from running to the toilet all the time and canceling days to maybe 4x/month diarrhea, and I actually feel hungry and not scared to eat!! Literally a new person. So glad my NP prescribed it."

9 / 10
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  • mmm...
  • June 13, 2011

For Pain "I've suffered from chronic pain my entire life and often haven't been able to sleep as a result. I found this medication to often be very helpful. Though it took several weeks to really work, it definitely helped me sleep and my pain has decreased. I was started at a very low dose, which gave me a lot of flexibility to move up and down as the situation required. Taking the medication coincided with some slight weight gain, but this could have been due to a variety of other factors. Overall I found it very helpful!"

7 / 10
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  • Anonymous
  • Taken for 10 years or more
  • May 17, 2013

For Migraine Prevention "I've been on nortriptyline for close to 15 years now for migraine treatments after a significant head injury. Before being put on the medicine, I'd get migraines that would put me out for days at a time. After starting out at a low dose, it helped control my migraines and has continued to do so over the past 15 or so years (though with increased dosage). The most common side effects have been drowsiness, dry mouth, quivers in my hands, along with an adverse reaction to prolonged periods of being in the sun. I've also put on a few pounds over the past few years, but that may be the result of moving from an active job to a more sedentary one and not the medication. Overall, nortriptyline has been great at controlling my migraines without too many negatives."

10 / 10
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  • CJC...
  • November 15, 2015

For Migraine Prevention "I never write reviews but for this drug I feel like I have to! I have tried so many drugs, herbal supplements, chiropractor, massage, acupuncture etc. have been hospitalized before for my migraines, and at some periods had them every day. I thought if this is the reality of my life being in pain every day, what is the point? This is the only drug which works and has almost no side effects except for at first a dry, nasty tasting mouth which has gone away for the most part. It took a couple of days to kick in and I'm on a very low dose of 10 mg which I take at night. It's been almost a week pain-free! I feel like a new person and it finally feels like the miracle I've been looking for, so don't give up!"

10 / 10
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  • Xxa...
  • Taken for less than 1 month
  • April 18, 2019

For Migraine Prevention "Tension headaches gone, less stressed/anxious feeling, and better mood. Sleep is perfect. 20 mg in the evening. Do not take during the day, it will make you too tired and 'out of it'. Worked perfectly day one, then seemed to make headaches worse for a while. I stuck with it since I read everywhere it can take up to 4 weeks or even longer to work, and then at 4 weeks, almost exactly everything is much improved. Works great. Went up to 20 mg week 2 (started at 10 mg). 10 mg may have worked just as well...hard to say..."

9 / 10
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70 Report
  • Jan...
  • Taken for 5 to 10 years
  • September 26, 2019

For Panic Disorder "This medicine, nortriptyline, saved my life. Back in 2013, I woke up with panic attacks and anxiety through the roof. I had to end up going on disability twice, and none of the regular depressants/anxiety medications would help. Found an amazing psychiatrist who put me on this life-changing medication. I am on 125 mg a day, and it completely got rid of my anxiety and depression. No more panic attacks. I do take Ativan just in case I feel the anxiety coming on strong, however, the nortriptyline really helps control it. I recommend this medication to anybody with anxiety/panic/depression. You do need to give it time. The first time I was on it, within two months, I was cured. I did get off it for a while to see if I needed it, and I sure did. When I got back on it the second time, it took six months to work. Be patient."

10 / 10
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63 Report
  • Vib...
  • October 30, 2015

For Pain "I started at 10 mg at bedtime for pain in my lower back. The pain would go down both legs and was ruining my life. After a few weeks, I was up to 60 mg, and I am virtually pain-free. I am sleeping great, too. The dry mouth usually comes for me after I up the dose. One thing though, I had a numb spot right above my right knee, which is caused by a pinched nerve in my pelvic region. The numbness has turned to a fullness in my knee now... weird but I can live with it."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.