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Misoprostol and Diarrhea: What Users Say

Brand names: Cytotec

Diarrhea: mentioned by 149 users (20.6%)

Based on user experiences from 723 Misoprostol reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

cramps 70.8%
bleeding 35.0%
nausea 28.2%
pain 22.5%
diarrhea 20.6%
vomiting 12.7%
chills 7.5%
blood clots 5.9%
sweating 3.9%
severe pain 3.7%

Reviews for Misoprostol

Commonly mentioned side effects
  • Luc...
  • July 8, 2021

For Abortion "I'm 5 weeks pregnant. Day 1: took 2 misoprostol under the tongue and 2 vaginally. A little cramping and no bleeding at all. Day 2: took 4 misoprostol under the tongue, had cold chills, diarrhea, but still no bleeding. I don't know what to do."

5 / 10
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  • Sis...
  • February 5, 2021

For Abortion "Took the pills at 1 am, put them under my tongue. Experienced mild diarrhea. Went to sleep and woke up at 4 am to push the clots and pregnancy out. It was so painless, I was shocked because I was so scared from the reviews. Heavy bleeding, but that’s just it. Take pain relievers before taking the pills, and you’ll be fine. Trust me ❤️"

10 / 10
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  • Li_...
  • June 7, 2021

For Abortion "I was 8 weeks pregnant. I took the first pill at the doctor's office at 2 pm on a Friday. I didn't feel anything at all for that one. I took the other four in my cheeks the next day at 9 pm and by 9:30, they were mostly dissolved, but I washed it down with water. The only pain medication I took was ibuprofen 30 minutes before. As soon as it dissolved, I noticed a little bit of cramping for like 20 minutes and I also threw up my meal. But that was the only time I threw up, I didn't feel any nausea. My cramping started to get worse for the next three hours. I was sitting on the toilet for like 40 minutes with diarrhea and cramping with only a bit of blood. By 12:00 am, I was bleeding more and passed four clots. After that, my cramping had stopped, and then I was just bleeding like a normal period. Just have some water, relax, and a heating pad, and you'll be fine! Don't let these bad stories scare you away."

10 / 10
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Frequently asked questions

  • Cam...
  • October 13, 2020

For Abortion "Found out I was pregnant soon after finding out I was hit with horrendous morning sickness which was exacerbated by reading the reviews. I was being sick up to 5 times a day, and all I could think about was how sick I would feel when taking these pills! I took the first tablet a day before, this just made me feel sicker. 26 hours later, I took the 4 Misoprostol with two 15mg codeine. As soon as I started feeling cramps, I took another 2 codeine, but they started coming fast and sharp. After about 30 mins, I had to sit on the toilet and had some diarrhoea, and there was bleeding. I was also sick at the same time (not pleasant). I had about 40 mins of sharp pains but bearable, they stopped within the hour, and I passed some clots. I closed my eyes every time I flushed so I never saw anything. A day later, I'm having a regular period and have my appetite back, and have gotten back to my daily life! I will never get into this situation again. For me, it was not as bad as what people make it. Good luck!"

10 / 10
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  • 142...
  • Taken for less than 1 month
  • August 8, 2020

For Abortion "I’m 20 years old with a very strong stomach. I took the first pill at the clinic around 11:30. I was tired and slightly nauseous but I was prescribed promethazine, which helped with the nausea. By 9 am the next morning, I was bleeding a small amount. I decided to eat a meal, take 800 mg of ibuprofen that I was prescribed, and another promethazine for nausea. 45 minutes after taking the pain medicine and nausea medicine, I placed 2 cytotec in each cheek, which dissolved in 15 minutes. I felt the most intense cramping and pain and was honestly screaming in agony. The pain was so severe I threw up everything in my stomach and had diarrhea. This all lasted about 30 minutes and then I began to do breathing exercises that helped calm the pain and made me fall asleep. After that, I had very moderate cramping that was very manageable. Drink lots of water, sleep a lot, and stay calm. You can do it."

7 / 10
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  • Ano...
  • Taken for less than 1 month
  • April 9, 2025

For Abortion "After scouring reviews and worrying myself to death, I wanted to leave a review for those as scared as me. I was 5 weeks and 5 days pregnant. I took the first pill at 5 PM on Monday, no symptoms for 24 hours. The next day at 4:30 PM, I took Tylenol and nausea pills. At 5 PM, I let 4 miso pills start dissolving in my cheeks for 30 minutes. I lightly cramped for the next hour or two, no blood. Hour three, I started to cramp badly, I could feel the dilation in my cervix, and I was curled over the toilet with light spotting. I ran a hot bath, passed one tiny clot, and the cramps were persistent. DO NOT do this alone, I was so dizzy and could not have gotten around without help. (I am anemic and have Hashimoto’s). After two hours in bed with contraction-like cramps, it ramps up, I feel like I am giving birth. After an hour of that, I gush out multiple clots and a lot of blood, and feel better. Now, only light cramps, heavy bleeding, and diarrhea. It’s extremely painful, but doable."

9 / 10
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  • Nic...
  • October 4, 2020

For Abortion "The baby's heart stopped beating around 9 weeks (measured 6 weeks 2 days). I decided to go for medication versus D&C. I woke up at 5:30am and took nausea medicine, 5 mg oxycodone, and 800 mg ibuprofen. I had a light breakfast, and 30 minutes later, I inserted the medication vaginally. I was able to fall back to sleep. Cramps started first, and 30 minutes later, the bleeding began. From 10:30 to 11:30am, I’d say my pain was a 6/10. It wasn’t fun, but it was manageable. I took the next dose of pain relievers and was able to fall back asleep until 1pm. I used the restroom and passed the sac. The cramping reduced down immediately after. I’m in little to no pain now, just bleeding a lot. I’ve been taking it easy all day. So, I definitely recommend taking it in the morning on a day you can spend just laying around. I had no nausea, no diarrhea, no chills, no fever. It honestly wasn’t half as bad as I hyped myself up to believe it would be! You’ve got this, ladies!"

10 / 10
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  • Kel...
  • Taken for less than 1 month
  • January 16, 2020

For Abortion "For a week before my appointment, I kept reading these reviews, and they made me scared out of my mind, but I’m here to tell you, ladies, calm down!! It’s not that bad. I was 6 weeks and 4 days. I took the first pill at the doctor’s office, then the next day at 11:30 a.m., I took 800 mg ibuprofen. At 12:10 p.m., I took the set of 4 pills. I didn’t bleed or anything until 3 hours later. When it started, it actually just felt like the first day of my period. I felt myself passing the clots very easily, kinda had the runs as well, lol. By taking the ibuprofen every 4 hours, the cramps weren’t that bad, and I carried on a normal day, but stayed at home all day to be safe since the bleeding was very heavy that first day."

10 / 10
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  • Mor...
  • Taken for less than 1 month
  • February 4, 2021

For Abortion "DO NOT LET THESE REVIEWS SCARE YOU, EVERYONE'S BODY IS DIFFERENT! I was 6 weeks and 6 days, now I’m about 11 hours into the abortion pill, and it was an extremely smooth process for me. I took 800 mg ibuprofen 30 mins before and took the 4 pills at about 9 PM and started bleeding right away. There was very little to no cramping at all for me. I passed some blood clots the size of a lemon, a golf ball, and smaller. You will bleed a lot and pass a lot of clots! Overall, the experience was very smooth for me. Reading reviews beforehand had me extremely scared, I had anxiety, but everyone’s body is different. I had diarrhea, that’s about it, and now a regular flow today, like a normal period. Don’t let these reviews scare you, remember everyone’s body is different."

10 / 10
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  • tha...
  • July 29, 2019

For Abortion "I’m sharing my experience because I was really nervous after reading reviews. I'm glad I did it though. My experience overall was good. I took the 4 pills orally (inside cheek). The cramps hit an hour after taking the medication. Then I got bad diarrhea for about 4 hours. I had visited the bathroom at least 5 times within those 4 hours. I started bleeding until 2 hours after taking the pills. Honestly, the bleeding was exactly like a heavy period. My cramps just felt like bad period cramps. I didn’t take any pain medication, and I didn’t use a heating pad. I was exactly 5 weeks when I took the pills. My doctor said that’s why my cramps weren’t as bad. The heavy bleeding stopped 24 hours later. I had normal period bleeding for a week and then light bleeding for another week. I bled for exactly 2 weeks and then it stopped. I was relieved. The pregnancy symptoms: nausea, breast tenderness, and bloating took a week to go away."

10 / 10
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  • San...
  • January 24, 2020

For Abortion "I had to leave a review because I can't believe how bad some of these are. Some sound so scary, and I don't want people to read these and get scared off. First, pain medication does NOT interfere with this. I was 5 weeks. I was given the first dose in the office and prescribed nausea meds, 800 mg Ibuprofen, and Tramadol. 24 hours later, I took the nausea meds and Ibuprofen an hour before I put the 4 pills in between my gums and cheek. I had started light spotting. 30 minutes later, I swallowed what was left of the pills. Within 15 minutes, I passed a lemon-sized clot. Cramping was like a bad period. I did take 1 Tramadol, and it made me sleepy. I used a heating pad and had one bout of diarrhea, no nausea. I passed small clots and have been bleeding, but no other large clots. I have a follow-up ultrasound to confirm it worked. This wasn't as bad as some of the other reviewers experienced, and I want people to know that everyone will have a different experience."

10 / 10
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  • Lyn...
  • Taken for less than 1 month
  • September 10, 2024

For Abortion "I'm adding my review because everyone else's helped me. I was nervous like everyone and put it off for quite some time. I took the first pill at 8 PM, laid down, and hoped I didn't get any side effects. I watched TV to keep my mind busy, felt nothing. Twenty-four hours later, I got a bit of cramping and put the four miso pills in my cheeks and let them dissolve. It was around 9:30 PM when I laid down and watched TV. When they kicked in about an hour after, I started getting cold shakes, so I wrapped myself in my blanket and threw on a sweater. I also was cramping and immediately went to the bathroom and had diarrhea. The cramps were more like aching, a bit stronger than a period cramp. It was uncomfortable and hard to fall asleep even though I took a gravel before I took the pills. Nevertheless, I ended up falling asleep shortly after I put a heating pad on my stomach and warmed up. I woke up around 2 hours later, at 12 PM, bled like a period, and felt the pregnancy pass. I had cramps for a few hours and was fine the next day!"

8 / 10
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  • Gio...
  • November 8, 2019

For Abortion "I guess everyone's experience is totally different. I took Misoprostol for abortion 2 days ago, and so far, the experience has been bearable. NO PAIN AT ALL!! On Nov 5th, I placed 2 Misoprostol tablets under my tongue and let them dissolve, and 4 more into my vagina shortly after. (I was a little over 6 weeks pregnant.) Nothing happened immediately besides some severe chills about an hour after, and the tablets did make my tongue tingle a little. The chills continued for about 3 hours off and on with some diarrhea. After I passed the stools, I went to pee, and some clots came out with some blood immediately (NO PAIN). I went back to bed. About 3 hours later, a few more clots and blood but no heavy bleeding. On day 2, the bleeding is very minimal and still NO intense pain... a little cramp... almost unnoticeable, and that's it. Please don't let the reviews scare you! For me, it is not that bad!"

9 / 10
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  • Man...
  • Taken for less than 1 month
  • March 1, 2020

For Abortion "Checking back in after the 2 doses of pills. My ultrasound following the 1 dose was not clear: “clots still remained but I passed pregnancy.” Ibuprofen and nausea meds 45 min before abortion pills. First-time experience was totally fine, except for the runs, and it wasn’t extreme painful runs neither. Relax, girls! Didn’t bleed right away as the first time! I was panicking, accepting I would need the procedure! But 24 hours later, bleeding started, lasted 2 days, normal period type. No pain! No vomiting! No runs this time! Just feeling drained. Clear ultrasound! Doctor approved me, and it’s all over now. Be strong!! I know this is a very traumatic experience, but don’t let them talk you into the procedure without doing a 2 doses first! Medical covered everything. I did mine at Planned Parenthood."

10 / 10
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  • dis...
  • Taken for less than 1 month
  • April 30, 2020

For Abortion "It worked! I didn’t think it would since I am 14 weeks along. (Sadly, I had to lie to get the pills.) The prescription was sent 5 days after my online consultation and 2 days after my payment. I was so nervous, but I followed instructions as stated. I began the process the same day I got the pills at 12:30 p.m., and before 10:30 p.m., I basically gave birth. After the last dose, I began shaking, having shortness of breath, and feeling nauseous. I took my inhaler, drank water and ginger ale, then I was fine again. The cramps were horrible after the first dose to the next day, and I have diarrhea, but it was worth it. I will follow up with a pregnancy test and a doctor to make sure I am okay. My partner assisted me along the way. This has helped tremendously! Site that helped me: aidaccess.org. They are legit!"

10 / 10
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  • Cie...
  • Taken for less than 1 month
  • April 2, 2023

For Abortion "I am writing this review to let you guys know about my experience. I am currently 11 weeks, today, I took my second dose, and honestly, the pain is not bad at all. For me, it’s just the heavy bleeding and diarrhea. Every 30 minutes, I find myself going to the bathroom to change my pads. The pain is a 5 out of 10! I was super scared because I am a big baby when it comes to pain. I took ibuprofen 2 hours later and put a warm bottle on my stomach. Don’t be scared! It’s not painful, just so much blood because I am farther along in the pregnancy. To everybody that’s only a few weeks, it’s going to be a piece of cake."

5 / 10
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  • Can...
  • May 24, 2020

For Abortion "I’m 18. I was 7 weeks pregnant. The first dose of misoprostol did nothing, but maybe an hour after, I threw up, and afterwards felt tired, and my lower stomach began aching slightly. The next day, I took an 800 mg ibuprofen and one tablet of promethazine, and 30 min later, I put the 2 pills on each side of my cheek and just laid back. I felt a quick sharp pain in my stomach when it was dissolving. 15 min passed after swallowing, and my back pains immediately started. They were only slightly worse than when I’m on my period. I laid on a heating pad. The first trip to the bathroom (maybe 20 min after the pills), I saw small droplets of blood, I threw up, and felt as if the side effect of diarrhea was about to kick in. It did in the second trip, and there was also more blood. This time when I went (maybe an hour after), a lot of blood clots came out, and one bigger one did too. This didn’t hurt at all, but I was almost sure it was the pregnancy. The next few bathroom trips were either filled with blood or just #2. I was really tired afterwards."

8 / 10
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  • Sha...
  • December 15, 2020

For Abortion "I can honestly say I have never experienced pain like it in my life. I had never quite heard of just how painful it would be. Like a lot of these reviews, I found people saying, 'It wasn’t that bad,' so I just want to share that it could be awful for you. I had to call an ambulance out, the sweats were that bad I became unresponsive when on the phone to the ambulance. I did not lose lots of blood, and the pregnancy passed within 4 hrs. I could not stop vomiting, and diarrhea did not stop. I wasn’t aware of just how awful this was going to be. I say this not to scare you, but I wish someone had shared this with me beforehand. Please make sure you have someone with you."

2 / 10
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  • Les...
  • January 20, 2021

For Abortion "I was 9 weeks and 2 days. I received the first pill at the clinic Tuesday at 1:30 p.m. I had to wait 24 hours to do the second set of pills, which was Wednesday at 1:30 p.m. I put 4 of the pills under my tongue, let it dissolve for 30 mins, then drank water to swallow what was left over. As 2 mins in, I started to get heavy cramping, but it lasted for 10 mins. Worst 10 mins pain of my life. Now, different people have different pain levels. I had my mom by my side the entire time. I am still in the process, I don’t feel any more cramps, it’s just light cramps right now. I’m bleeding, and I had diarrhea, which lasted about 3 mins, that’s when I saw blood. But it is good to have someone by your side. The only symptoms I had were stomach cramps, and I had chills, which was I was very cold. It’s been 2 hours, it’s 3:20 p.m. right now, but don’t get scared by the reviews, everybody’s body is different. Good luck, guys!!"

4 / 10
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  • Nam...
  • August 28, 2021

For Abortion "I took 4 pills by mouth the day after I went to a clinic, and 30 minutes after taking ibuprofen and nausea medication, and my experience was really smooth. I was only 3-4 weeks, so still early. My cramps weren’t even too bad - I was definitely uncomfortable but I didn’t feel too much pain. Obviously, also bleeding a lot, and some diarrhea, but survivable, I promise. I read all of these reviews beforehand, and they made me cry with the support from everyone. You can do this, I promise. You are strong and you will get through it. Sending love."

10 / 10
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  • Oce...
  • July 11, 2021

For Abortion "Like many others, I was totally frightened by some of your experiences and wasn’t sure if I would want to go through with this. At about 4:20 PM on Friday, I took the first pill. A few hours after that, I had minor cramps and they disappeared. Not too long afterwards, I was nauseated the entire night and into the full next day until I took the next set of pills. An hour after I inserted them into my cheeks, I started feeling the cramps coming, almost four minutes after I sat down with a heating pad, they got intense. I would say 8/10. They felt like really severe period cramps and it lasted for about an hour before I sprawled myself out under the hot shower. For the rest of the night until 1 AM, they hurt, but they were bearable. Now at 9 AM, it feels like a regular period. I threw up once, got diarrhea, and had intense cramping for a short while. It’s not a walk in the park but you can do it, girls. Best of luck. Now on to mental healing for me."

10 / 10
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  • Lua...
  • February 8, 2020

For Abortion "I understand everybody is different, but I feel like most of the reviews here were written to make women afraid. Don’t be, it is your decision to make! I took the first pill at the doctor's office at 5 PM. The next day at 10 PM, I took an ibuprofen 800 mg, and at around 11 PM, I inserted 2 pills of misoprostol in each cheek, kept them there for 40 minutes before swallowing. 30 minutes in, I started having light cramps and could feel the blood coming out of me. I got up to go to the bathroom and could feel a heavy stream of blood coming out of me, but still no pain. Every hour, I replaced my pads, but around 2 AM, the flow was much lighter. I should also mention that I had diarrhea around this time, but no big deal. Around 3 AM, I started having heavier cramps, but I just took another ibuprofen, and it was fine. I was also prescribed Norco for pain and Zofran for nausea, but didn’t have to use it at all. Have someone with you, pain relievers, heating pads, water, etc. You can do this!"

10 / 10
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  • Haz...
  • September 15, 2020

For Abortion "My abortion was very hard but over quickly, to my surprise. At 5 weeks, I took the mifepristone, felt only a little dizzy and weird. 24 hours later, I took misoprostol vaginally and 2 paracetamol, 2 ibuprofen, and within half an hour to an hour, I began getting extreme cramps, then bad diarrhea, which made me feel like I was going to pass out. 1 hour in, the pain was on another level, my whole body was shaking from the shock. I was hot but had chills. I was bleeding, and after 30 minutes of this, I felt relief instantly, which I assumed meant I passed the pregnancy. After that, I was able to eat a little bit and the cramps wore off a lot and just lingered, but nothing compared to those 2 hours of absolute pain. I’m allergic to codeine, which is a stronger painkiller they gave me. If I was able to take something stronger, I would have dealt with the pain better, so keep that in mind. Make sure you don’t do it alone and have someone there for you through it."

10 / 10
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  • Anonymous
  • September 4, 2018

For Cervical Ripening "This is a horrible drug with debilitating side effects. I was prescribed this drug to help dilate my cervix for a procedure. My OBGYN said it would only cause mild cramping. They couldn't have been more wrong! Within 5 minutes after taking it, I was in extreme pain, intense cramps like I've never had before, throwing up, diarrhea, shaking all over, and more. Worse I have ever been...and it lasted more than 15 hours! Wasn't able to have my procedure done the next morning from being so sick. Don't ever take this drug, it's simply not worth it!"

1 / 10
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  • Len...
  • August 27, 2019

For Abortion "I was terrified of what my experience was going to be like after reading so many reviews of people who had bad experiences, but mine went well. I took the mifepristone at the clinic. It made me extremely thirsty, but that was about it. 24 hours later, I took the misoprostol. I had to take the misoprostol twice, 4 pills each time (four hours apart) because I had just reached the 10-week mark. I didn’t have any heating pads or a bottle, so I put Vick’s all over my lower abdomen and lower back to help with the cramping. I ate very light, I only had a smoothie, some crackers, and water. I thought because I had to take the misoprostol twice and due to the fact I was 10 weeks, that the pain would be unbearable. Thankfully, it was more pressure than actual pain. I took the first pill at 9:30 AM, and by 5:00 PM, everything had passed. The only side effect I had from the pills was diarrhea. I would rate the pain a 4/10. It felt like a very heavy period."

9 / 10
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