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Methenamine and Difficulty Urinating: What Users Say

Brand names: Hiprex

Difficulty urinating: mentioned by 4 users (3.8%)

Based on user experiences from 105 Methenamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

bad taste 5.7%
burning 3.8%
difficulty urinating 3.8%
bladder issues 2.9%
depression 2.9%
diarrhea 2.9%
headaches 2.9%

Reviews for Methenamine

Commonly mentioned side effects
  • Lon...
  • Taken for less than 1 month
  • November 18, 2019

Methenamine for Bladder Infection "I was prescribed Hiprex for painful bladder syndrome to stop recurring infections. My bladder was already sensitive to certain foods. Within hours of taking this drug, I was in agony. Burning to pee, difficulty peeing, and terrible back pain. I stopped taking the drug after 2 half doses. A week later, my symptoms are still twice as bad as before taking the drug."

1 / 10
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51 Report
  • Pri...
  • Taken for less than 1 month
  • November 5, 2019

Methenamine for Urinary Tract Infection "Hiprex with Vit C 500 mg twice a day for recurrent UTI prevention. I was on Macrodantin 50 mg for 4 months and got a UTI recently. My Dr. at Northwestern Univ. wanted me to try Hiprex. As soon as I took the first pill, I felt the burning through my stomach and bladder. It gave me diarrhea, painful urination, nausea, back pain, vaginal burning, and my bladder started leaking. Tried with Pyridium for 2 days, a little better, but once the Pyridium stops working, this is killing me. I did 6 days, and I'm done. Sucks for me!"

2 / 10
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31 Report
  • Nic...
  • January 27, 2021

Methenamine for Bladder Infection "I have had a urinary tract infection for 18 months. I had all the usual antibiotics, but they didn’t work. I researched Hiprex, and my GP agreed to let me try it. The only side effect I had was painful urination, which has now stopped. If I stop the Hiprex, the infection returns. I don’t know where this will end. I also take 1 g of Trimethoprim at night, but it is now not available because of Brexit. I live in N. Ireland and have no problems getting the prescription, so I don’t understand why it’s not available. I also take Waterfall D-mannose 2 daily on the advice of my urologist."

8 / 10
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21 Report
  • tic...
  • Taken for less than 1 month
  • June 9, 2019

For Prevention of Bladder infection "Just wanted to share my experience for others, as unfortunately, I had bad effects with this drug. I have had UTI infections for many years and had reconstructive surgery on my ureters, so I am prone to infection. When I started methenamine, I began getting painful urination and abdominal pain, which I thought was UTI again. I also seemed to start having a lot of swelling in my nose too. I got tested for infection, but nothing was present, and the pain was awful, I couldn't understand it. Decided to come off the pills, and my symptoms seemed to improve. I think I had an allergic reaction to them. Although I don't know what I am going to use to stop the infections now, I will have to speak to my doctor."

1 / 10
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13 Report

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