Mepolizumab and Joint Pain: What Users Say

• Nic...
• August 6, 2019

For Asthma "I have been on Nucala for 2 years. I am 41 years old. I’ve had several sinus infections, coughing like crazy, reflux. When the Dr. discovered I had Eosinophilic allergic asthma, he put me on Nucala. About 10 minutes after my injection, I had severe back pain & fatigue. As time goes by, I’m noticing more side effects. I’ve lost 30% of my hair. Severe dry skin on face. Arthritic pain. Headaches. Nucala has helped me tremendously, but I’m so upset about all my thinning/lost hair. I’ve had every blood test done. Thyroid checked. All good. Has to be a side effect. Everyone, PLEASE REPORT ALL YOUR SIDE EFFECTS!!! They need to know so many people are suffering from hair loss, joint pain, fatigue, headaches, muscle spasms, etc. I have to meet with my Dr. again to go over all this."

• Alw...
• Taken for 1 to 2 years
• January 24, 2020

For Asthma "After two years on Nucala, I have had enough. For the past three months, I have had excruciating joint pain in my knees, ankles, wrists, elbows, and fingers to the point that I cannot run at all or even walk without pain. While on Nucala, my joints have always been hurting, but now it's just so much worse. I've also suffered from headaches, sore throat, muscle spasms, chest and back pain, and some eczema. I lost half of my hair in the last two months and some of my eyebrows as well. The weird thing is, all was well for over a year and a half, except for some minor joint ache, but then suddenly everything went bad really fast. Now I have to wait for a few months for Nucala to leave my system, and hopefully things will return to normal. It did help with my asthma and nasal polyps, but now the side effects are just too much."

• Mar...
• Taken for 1 to 6 months
• February 6, 2022

For Asthma "I wanted to thank everyone for taking the time to write their experiences. In particular, one person wrote about the different asthma medications with the same effects. My asthma has been under control while on Xolair, Dupixent, forget Fasenra, and now Nucala. I’ve had muscle and joint pain with all of them, but this is my third month on Nucala, and the muscle and joint pains are worse. I’m having a real hard time with my thumbs, severe pain even when I’m not using my hands. I’ve developed a bone spur on my left thumb that is extremely painful to the touch. I’m not sure if I now have arthritis. I’m so confused about what to do next. I guess I’ll stay on Nucala until it’s obvious beyond any doubt that it is the cause of it all, and I’m unable to manage the pain. Back, neck, spine, hands, muscle spasm on my calves, etc. I forgot to mention my eosinophils were so high I was hospitalized, another reason why I was switched over to Nucala. I hope some will benefit!"

• Str...
• Taken for 1 to 6 months
• January 10, 2020

For Asthma "I have now had my second injection of Nucala. I was so happy with the results of no runny nose, chest congestion was much better. I also have a back problem and have had one hip replacement surgery and am waiting for the second one. I take maintenance medications for pain management. I started with pain so bad, my joints ached, my skin hurt, I was so tired, and got exhausted just going to town and trying to get groceries. I stay on my heating pad day and night. I am up and down frequently, my pain meds are not working well. I made an appointment to go back to the doctor and see what can be done. I liked the results of the Nucala and what it does for my breathing. Anyone have any ideas?"

• Kel...
• Taken for 1 to 6 months
• May 30, 2023

For Asthma, Maintenance "I have only been using Nucala for 4 months, but the improvement has been incredible. My breathing has been so much better. I no longer need prednisone, and I have reduced my inhaler use immensely. Side effects on occasion are some mild back and joint pain."

• eri...
• Taken for 1 to 2 years
• October 11, 2023

For Hypereosinophilic Syndrome "Nucala has definitely regulated my eosinophils. However, my asthma was still causing me discomfort. I ended up having to take Tezpire as well. My joint pain and back pain have been miserable. My strength and endurance are all but gone. I may have to change careers. Not sure what to do."

• Lou...
• October 19, 2024

For Asthma "Suffering from eosinophilic asthma, Nucala did a great job. A side effect for me was arthritis (joint pain of medium to severe grade)."