Lumateperone and Dry Mouth: What Users Say

• Sar...
• Taken for 1 to 6 months
• June 17, 2022

For Bipolar Disorder "Amazing so far. I have been on it for six weeks and after getting past the first three days taking it- which gave me awful headaches, nausea, dry mouth, and fatigue - I started to feel something in me change. After three weeks I can say I noticed that the typical bad, ruminating thoughts of despair and general negativity were decreasing. And now at six weeks I can honestly say I have days where I catch myself and think, “Wow— I haven’t thought anything bad today”. I have never had a med this effective, and have a very sensitive/resistant system that has made med therapy a chore because nothing ever seems to work, or I end up having bad side effects. For the first time in 25+ years I feel hopeful; I am finding real joy in things, laughing genuinely, and I am able to be more compassionate and realistic with the pressures I put on myself. It’s improving my outlook on life and in turn improving my relationships. This is a miracle med for me."

• Cap...
• Taken for less than 1 month
• February 18, 2022

For Schizophrenia "I have had a very positive experience with Caplyta so far. I have been on several antipsychotics that worked but had side effects that were not tolerable. On the first day of taking this, I had dry mouth and a headache. Since then, I have not had a single side effect. After a week on it, I feel great. I haven't gained weight on it which is a good sign. I have more motivation and am sleeping normally after having those problems on Vraylar. My mood is also not flat like it was on the other medications that I had been on previously. I am not normally the person to write reviews but I saw all of the bad reviews and thought that maybe by sharing my experience it would help others. Maybe many people don't write reviews unless they have a bad experience? I am not sure but my experience on it has been very good. Would recommend to anyone who couldn't tolerate the side effects of other antipsychotics."

• Fee...
• Taken for 1 to 6 months
• September 6, 2020

For Schizophrenia "This medicine Caplyta has been a lifesaver for my bipolar! I've experienced sleepiness and dry mouth in the beginning, but those have gone away in the 5 weeks I've been on this medicine. My bipolar is completely under control and the severe depression is gone. I feel motivated, happy and able to participate in life. I'm so happy to have found this medicine. I finally feel 'normal'."

• Bee...
• Taken for 1 to 6 months
• May 23, 2022

For Bipolar Disorder "My God, this medication has changed my life. I am able to separate my emotions from my logic. I'm not depressed or angry anymore. Is this what life is like for 'normal people'? I feel like I have hope in my life which I really haven't had before. I have bipolar 2 as well as C-PTSD. I take this alongside Lamictal, Celexa, and Prazosin (for PTSD nightmares). Whoever made this drug is a lifesaver. I've had side effects of dry mouth and felt an improvement within 2 weeks."

• PAP...
• Taken for 1 to 6 months
• January 23, 2025

For Bipolar Disorder "Really relieved my depression. I was ready to give up and didn’t think I would be able to stay alive much longer. Caplyta changed my life. It is the first antidepressant that worked, and I have tried many. It does make me sedated and sleepy, but the effects only last about two hours. I usually take it before bed, so by morning I am fine. Initially, I had terrible dry mouth, and my nose would plug up, but after about 45 days, those symptoms went away. I hope this medicine is always available. It is very expensive, but fortunately, my insurance covers most of it. I slowly went from 10 to 20 to 40 mgs."

• Fuh...
• Taken for less than 1 month
• March 17, 2022

For Bipolar Disorder "I started this med a couple of days ago. I feel okay. Extreme dry mouth. I literally woke up in the night to chug milk, water, and OJ. That being said, I usually can only sleep 90 minutes each time I fall asleep through the night. I’ve been sleeping 3-5 hours each time the last couple of nights, and for the first time in years, I'm feeling like I’ve had some rest when I awake. For years, crawling out of bed in the morning, I felt like I had the crap beaten out of me. The only side effect I’m worried about is the weight gain. But I will continue to work with my doctor to see if we can make a go of this. I’ve tried many meds over the years. This is the only one I have hope for, as the others made me crazier, made me want to gamble, and one had me so zombified that I was going to Jack in the Box every night for like 200 mini churros."

• PJ6...
• Taken for 6 months to 1 year
• December 23, 2024

For Bipolar Disorder "I was diagnosed with bipolar 1, PTSD, and OCD in 1994. Generally, I have had mostly long, depressed episodes. Normally, I rapid cycle. I went on Caplyta 8 months ago. At first, it made me dizzy, sleepy, with an extremely dry mouth. I was able to finally sleep through the night. After about 2 weeks, I felt a lot less depressed. Since then, my mood has drastically improved. I haven’t felt flat on this med. My emotions are more real. When I laugh, it’s natural. There’s nothing forced about it. I can genuinely FEEL again. I’ve noticed feeling my old personality before I started having bipolar symptoms, more compassionate and smarter. My thinking became clearer. I was able to verbally communicate better. I have motivation I haven’t had in years. I can shower, clean my house, and help others. My appetite has decreased, so I have lost 55 lbs. I’m not sure if that’s a good thing or a bad thing yet. Anyway, Caplyta has been wonderful for me. I am ME again."

• DeA...
• Taken for less than 1 month
• May 5, 2022

For Bipolar Disorder "Took this on day one for bipolar 2, and 2 hours later I felt like I had icy hot all over my body. Then I felt lethargic to the point I had slurred speech, and I could barely move without help. I had a very dry mouth and excessive thirst. The severe headache started, so I took a nap for about an hour. I woke up with neck pain connecting to the back of my head, nausea, and vomiting. A 2-hour shower eased the headache very little, but it continued along with the nausea until the following day. Also, on the following day I had dark urination. I was advised to discontinue the medication."

• use...
• Taken for 1 to 6 months
• October 17, 2023

For Bipolar Disorder "I am ecstatic with Caplyta. I think it is the best medication I've tried over the years. It's effective and has no sexual side effects. - 53-year-old male on antipsychotics, mood stabilizers, and/or antidepressants since 1991. - Effective against depression and psychosis at 42 mg. Tried to reduce the 42 mg dose to reduce too much energy, and the return of psychosis resulted. - Before all medications: lethargic, severely depressed. With Caplyta: energized, alert, clear-thinking, good mood. - Somewhat overly energized, and initial sleep disruption managed with gabapentin (300 mg x3), Buspar (30 mg x3), Ativan, and 200 mg L-Theanine at bedtime. - Minimal side effects: no sexual issues (common with other antipsychotics), no appetite increase or weight gain, no akathisia. - Initial minor side effects: dry mouth, stuffy nose, mild constipation, slight fatigue - all resolved quickly. - Only effective antidepressants since age 17: Lamictal, Abilify, and Caplyta."

• WJL...
• Taken for less than 1 month
• May 5, 2022

For Bipolar Disorder "I was prescribed Caplyta by my psychiatrist. I also have taken Wellbutrin and Lamictal for years. The first day I took it, I thought I was going to die. My neck was burning hot (but on the inside). Then it radiated up to the lower part of my head, then I could feel the heat radiating down my spine. It felt like a hot poker. My feet swelled up, as did my left hand and face. I could barely type a text to my husband for help. I vomited for about 8 hours and couldn’t hold down even a sip of water as my mouth was so dry. My fever was normal, but my insides were on fire. My husband called the late-night nurse, and she said, “Sounds like an allergic reaction, so give her a Benadryl.” I was pretty skeptical, so I took a Xanax too to help relax (which she approved to do). I’m still feeling the horrible “wobbly” effects two days later. I would NEVER have taken this knowing what I would have to endure."

• No ...
• November 17, 2020

For Schizophrenia "I had a stomach ache for 4 weeks after I started Caplyta. I had dry mouth so bad I had open sores in my mouth and on my tongue. I was also extremely tired all the time. I had to spend a lot of time in bed. Worst of all, it didn't work for my schizophrenia. I developed paranoid thoughts. I discontinued it and went back on Olanzapine and felt better in about three days. Caplyta was not a good drug for me. I was hoping it would be. I am disappointed."

• Sti...
• Taken for less than 1 month
• January 28, 2021

For Schizophrenia "I was only on Caplyta for two days, and it’s the worst medication I’ve ever tried. The side effects were absolutely awful. I had insane dry mouth. I was so lightheaded that I felt like I was going to fall every time I stood up. I was nauseous and incredibly anxious, to the point where I had anxiety attacks that lasted up to 4 hours. I couldn’t regulate my body temperature, so I was burning hot and freezing at the same time. Within the 2 days, the voices became a lot worse and it was very overwhelming. It was an absolute nightmare and honestly borderline traumatic for me. If you’re sensitive to medication, I wouldn’t take Caplyta."

• Anonymous
• Taken for 1 to 6 months
• October 8, 2022

For Bipolar Disorder "I take Caplyta with 300 mg Effexor daily for MDD (Major Depressive Disorder). At first, I wasn't sure I wanted to continue the medication, I had terrible dry mouth, nausea, trouble sleeping, and dizziness. I'm glad I stayed on it. My depression has greatly improved. I still have low days, but I generally have more energy. I've lost 12 lbs and no longer have suicidal ideation. My only caveat is I find myself with very high anxiety. I don't know if this is due to the medication or life circumstances. Does anyone else have a lot of anxiety since taking Caplyta?"

• Hrh...
• Taken for less than 1 month
• September 21, 2022

For Bipolar Disorder "This is a very specialized medication. It’s changing everything for me personally. I work in healthcare and have been on the med merry-go-round for a minimum of 15 years. Diagnosis of MDD, PTSD, anxiety/panic attacks, and bipolar II. While, obviously, if you are having any life-threatening side effects, I highly suggest sticking it out for at least a week. Yes, I had the extremely dry mouth, felt drunk in the AM, dizzy, severely tired for the first 5 days. Then things picked up significantly, to the point where I was afraid I may be experiencing hypomania. Immediately spoke with my psychiatrist (knows me well, 6+ years) and after explaining my feelings/actions, she said that it doesn’t sound like hypomania at all and that, most likely, I am actually feeling happiness for the first time. I have just hit the 2-week mark and am still all over the place as far as sleepy or not, hungry/mildly nauseous; overall, I’m not depressed. TBD but feeling better."

• Mau...
• Taken for less than 1 month
• June 9, 2024

For Bipolar Disorder "I began Caplyta 42mg (at night) 8 days ago for Bipolar 2 depression after trying 15 other psych meds — lamictal, abilify, Seroquel, all the antidepressant classes including 2 MAOIs, etc. Antipsychotics turn me into a sexless sad zombie. Antidepressants do nothing (Wellbutrin brand name only 300-400mg works for 3 months then stops). I also have very severe Seasonal Affect Disorder, ADD, and CPTSD. First day on Caplyta, I had the worst throbbing headache of my life, woke up and ran to the bathroom dry heaving from the pain. Any water or food I threw up in under 2 minutes. 1g Tylenol barely touched the pain, maybe reduced 1/5. Also was groggy and couldn’t walk straight. It was like surprise unanesthetized neurosurgery. Day 2, the pain totally vanished. Within 4 days, I noticed myself becoming less withdrawn and more extroverted. It seems to wear off a little by EOD; hoping it stabilizes w/time. Only side effect has been dry mouth, hoping no sexual side effects! Fingers crossed."

• ish...
• Taken for 1 to 6 months
• February 10, 2023

For Bipolar Disorder "I've had an overall pleasant experience with Caplyta 42 mg. I took my first dose on a Friday night and quickly became very drowsy and went to bed early. I woke up the next morning with a horrible headache, but it stopped after a few days. I've been on Caplyta for 5 weeks now, and it still makes me slightly drowsy, which is fine. It helps me sleep, my depression has greatly lifted, and I'm able to get more things done instead of being in a cycle of being too overwhelmed to get anything done. Much to my husband's satisfaction, my libido seems to be coming back a bit after a 2-year dry spell. If you can push through a rough headache for a few days, I think it's worth it. It does give me a dry mouth, but after getting some water and brushing my teeth in the morning, it subsides."

• tep...
• Taken for 6 months to 1 year
• March 14, 2023

For Bipolar Disorder "After having horrible nausea with lithium, my doctor switched me to Caplyta. I felt my highs and lows to be less dramatic. My biggest issue was the extremely dry mouth, but besides that for me, I didn't have huge issues with the other known side effects."

• jus...
• Taken for less than 1 month
• November 30, 2022

For Bipolar Disorder "I'm taking Caplyta for bipolar depression. I am 3 weeks in, and the side effects are kind of rough. Super dry mouth and nausea, constant yawning, and like a shaky feeling. I can tell it's working, but now I'm just noticing the side effects."

• Suz...
• Taken for less than 1 month
• July 29, 2024

For Bipolar Disorder "Very, very tired. Slurred speech, diarrhea, dry mouth, headaches."