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Cytomel and Fatigue: What Users Say

Fatigue: mentioned by 5 users (9.6%)

Based on user experiences from 52 Cytomel reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

heart palpitations 17.3%
anxiety 15.4%
depression 11.5%
hair loss 11.5%
fatigue 9.6%
weight gain 9.6%
brain fog 7.7%
insomnia 7.7%
muscle pain 7.7%
sweating 7.7%

Reviews for Cytomel

Commonly mentioned side effects
  • Ash...
  • October 3, 2013

For Underactive Thyroid "I was on Synthroid only for 8 years after being diagnosed with Hypothyroidism. My dose was changed many times over that time frame by 4 different Endocrinologists, but I still felt bad: weight gain, fogginess, depression, chronic fatigue, you name it. 6 weeks ago, I was put on 10 mcg of Cytomel by a new doc that I am seeing 100 miles from my hometown, and I am happy to say that for the first time in 8 years, I have relief from my symptoms. I have lost 10 pounds in 6 weeks. I am happy, not in a fog anymore, and I have the energy to enjoy life once again. The Cytomel made all the difference."

10 / 10
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510 Report
  • Lau...
  • August 31, 2019

For Hypothyroidism, After Thyroid Removal "I have had Hashimoto's hypothyroidism for 40 years. I was on generic levothyroxine for most of that time. As I reached 50, my new endocrinologist decided I should add 5mcg (of very potent) T3, also known as Cytomel, to my 150mcg of levothyroxine. Initially, like many patients, I felt great, then it got real bad. I am sorry, I know some people do very well on it, but many do not. Here is what I experienced in order of severity: Super dark Thoughts, Severe Depression, Rage, Rapidly Cycling Moods, Facial Swelling, Extreme Itching, Nighttime Coughing, Intense Migraines, Insomnia, Heat Intolerance, Dilated Neck Veins, Extreme Fatigue, Hot Flashes with the Inability to Sweat. If you experience any or all of these, you are not alone and you are not crazy!"

1 / 10
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110 Report
  • Luc...
  • Taken for less than 1 month
  • July 22, 2022

For Underactive Thyroid "I have Hashimoto's disease and hypothyroidism with it. I was on Tirosint for a while and all the other T4 medications: Levothyroxine, Synthroid, Tirosint. This Cytomel makes me feel amazing and turns my brain back on immediately after taking it. Cytomel also seems to get rid of almost all the horrible joint pain and muscle aches from the other thyroid medications. It also helps to reduce my muscle stiffness and gets rid of those pesky muscle spasms. I think that all the T4 drugs actually cause more pain all over the body, but they are usually effective at getting rid of hypothyroid symptoms. I noticed this after I forgot to take my Synthroid for one day, less pain but more fatigue."

10 / 10
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13 Report

Frequently asked questions

  • Clc...
  • Taken for less than 1 month
  • December 27, 2020

For Underactive Thyroid "I gained 25 lbs on an antidepressant over 9 months. I have tapered off, but no weight loss. Have some fatigue, low temp. Doc said, although the rest of the blood panel of tests was okay, he would like to see my Free T3 around 3. It was 2.56. I took my second dose this a.m., 5 mcg. Same both days. Anxious, dizzy, feel like I'm weak in my legs. Tearful - almost foggy. Doc said it was a low dose and I might feel better, or notice zero change. No more for me... I don't like the way it makes me feel."

1 / 10
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  • Jou...
  • Taken for 5 to 10 years
  • April 23, 2022

For Underactive Thyroid "Taking Synthroid for Hashimoto’s and continued to have fatigue, muscle aches, and cramps. Adding Doctor generic Liothyronine was like taking nothing. Switching to brand name Cytomel 5 mcg 2x daily, I felt normal for the first time in 10 years. Muscle aches/cramping gone, good energy and mental focus returned. I have my heart under control, and I’m still on Cytomel. Hair loss I've also had, and you need to have your selenium levels tested. I had some doctor-prescribed supplements I had to stop because they contained selenium and it built up. Right now the biggest problem is that I can’t get my Cytomel Rx filled because Pfizer has some backorder that’s gone on for two months with no explanation. I have to take generic liothyronine for now; fatigue and muscle cramps are back."

10 / 10
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11 Report

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