Skip to main content

Linaclotide for Chronic Idiopathic Constipation User Reviews (Page 4)

Brand names: Linzess

Linaclotide has an average rating of 6.6 out of 10 from a total of 563 reviews for the treatment of Chronic Idiopathic Constipation. 56% of reviewers reported a positive experience, while 26% reported a negative experience.

Reviews for Linaclotide

  • Hurt
  • Taken for less than 1 month
  • September 20, 2020

Linzess (linaclotide) "Dr gave me samples (290 mcg dosage) for constipation. Took one pill 6 hrs ago and I have been back and forth to the toilet for the last 2 hrs. The first bowel motion was normal, but every other bowel motion after is all water. I feel a rumbling in my belly and I immediately have to run to the bathroom or it will hit the floor. My anus is on fire! I will never take this again and I don't recommend anyone else should."

1 / 10
Was this helpful?YesNo
43 Report
  • Trish
  • Taken for 1 to 2 years
  • September 15, 2020

Linzess (linaclotide) "I've been on this for over a year, it worked at first then stopped up the dose to 290, same works for a while then stops and I have to use milk magnesia. Can't go out and about unless I wear a depend. You never know when it's going to work."

4 / 10
Was this helpful?YesNo
43 Report
  • LIfet...
  • Taken for 1 to 6 months
  • November 22, 2014

Linzess (linaclotide) "From infancy to my 50s, I've used it all - phenothalein laxatives, castor oil, fiber, Miralax, enemas, bisacodyl, exercise, hydration, Zelnorm while it was available, and on and on. Only the phenothalien/old Ex-lax formula laxatives and Zelnorm were of use. Phenothalien also required drinking 8-16 ounces more fluid when you were already congested, adding painfully to existing distension and then needing to wait up to hours. Since that laxative was removed from the US market in the 2000s, availability now is very limited; Zelnorm was recalled by the FDA for strokes and cardiac issues (and did cause punch-in-the-gut cramping.) Linzess is amazing, reliable, no pain, some diarrhea, but complete control and great increased quality of life!"

10 / 10
Was this helpful?YesNo
85 Report
  • Const...
  • Taken for 1 to 2 years
  • August 11, 2019

Linzess (linaclotide) "Linzess is truly a miracle answer to my prayers. I’m not sure how this voodoo medicine works, but it works!! It has been years of cramping and discomfort until I found Linzess. Rectal fissures requiring surgery, hemorrhoids, etc. I would go 3 weeks without pooping WHILE taking stool softeners. Nothing worked. I could down 3 bottles of Miralax and water, senna tablets, along with some of those magnesium drinks in one sitting and still NOTHING. Linzess is MAGIC. I sometimes get diarrhea from using it, but it dulls the pain so it’s nothing like regular diarrhea. Anyway, if you have chronic constipation and have tried everything (or not), Linzess is for you!!"

10 / 10
Was this helpful?YesNo
51 Report
  • Bdani...
  • Taken for less than 1 month
  • July 11, 2014

Linzess (linaclotide) "I was hospitalized for a week because of a bout with diverticulitis. As a result, my intestines, so I was told, stopped pushing waste through. I was constipated for 3 weeks! My doctor gave me samples of Linzess. It was a miracle! I began having bowel movements on the first day! Some mild diarrhea, but I'm going and there is no cramping, no aches, no bloating. Amazing. I have had constipation issues for years, but not anymore! I highly recommend trying it! Thanks Linzess!"

10 / 10
Was this helpful?YesNo
84 Report

Are you taking this medicine?

  • 31...
  • Taken for less than 1 month
  • April 14, 2014

Linzess (linaclotide) "I have had irritable bowel syndrome with severe constipation for 16 years, and this is the first medicine that I can say has truly worked for me. On the medicine, I have diarrhea, bloating, and a lot of gas, but it definitely cleans me out. Hope to get past the gas and bloating once it gets in my system good. Only been taking it for 3 days."

10 / 10
Was this helpful?YesNo
85 Report
  • TBano
  • Taken for less than 1 month
  • June 20, 2017

Linzess (linaclotide) "I am a 21 year old female who suffers with IBS-C. Before this medication I would only go to the bathroom about once a week or sometimes go two weeks. I have been in Linzess 145mg for a week now and it has changed my life forever! My doctor prescribed me to take it in the morning with 2 fiber gummies 30min before breakfast. I now go to the bathroom twice a day! My cramps are not bad and go away once I use the bathroom. I don't get any dizziness. I almost did not take this medication because of the negative reviews but I'm glad I looked passed it! Ask you doctor for coupons as well, I got a coupon for a 90 day supply for $30. Good luck!"

10 / 10
Was this helpful?YesNo
64 Report
  • Jonie...
  • Taken for less than 1 month
  • April 11, 2016

Linzess (linaclotide) "I have had stomach and bowel movement issues since I was 2. I have tried everything. Reflexology, acupuncture, medicines, and drank mineral oil for 10 years. I took one 145 mg pill and in 6 hours, I actually had a bowel movement and several more to follow in the next 6 hours. I weighed myself the next day and I had lost 3 pounds. It does have some not so great side effects, but I am happy that I can go. I don't take it every day because it is too much for me; I can't sit on the toilet all day, but I do take it every other day. It's working for me!"

9 / 10
Was this helpful?YesNo
72 Report
  • KRA
  • Taken for 1 to 6 months
  • December 12, 2013

Linzess (linaclotide) "I have Irritable Bowel Syndrome with constipation. My doctor put me on Linzess 145. I was told to take it 30 minutes before my first meal. However, my schedule doesn't permit me to do so. I take it whenever my bowels are slowing down and I need some help (about once a week). Immediately, I start feeling the effects, starting with gas, then painless bowels that I can literally feel my stomach emptying. On average, it makes me go to the bathroom for 3 hours. It all depends on how much is in there. All in all, love."

10 / 10
Was this helpful?YesNo
86 Report
  • tv200...
  • Taken for 1 to 2 years
  • December 19, 2015

Linzess (linaclotide) "Totally life-changing medicine for people with chronic constipation and straining. I only need one every 4 days to keep me regular now. It is not like other laxatives; this lasts for a couple of days. It's really a great medicine for me. I think it could help many others!"

10 / 10
Was this helpful?YesNo
73 Report
  • Chel...
  • Taken for less than 1 month
  • June 21, 2019

Linzess (linaclotide) "So I’m only on week two, but I have felt better than I have in a really long time!!! The first couple of days I took the 72 mcg and didn’t have a bowel movement yet. The third day I went up to the 145 mcg and I had a bowel movement two hours later! I took that for 4 days and now went back down to 72 just to see if it would work. I’ve been taking 72 since and I have a bowel movement every day. I experienced a little bit of diarrhea but nothing horrible. Nothing that kept me in the bathroom back and forth all day or for hours at a time like others have said on here. I have IBS-C, so I constantly felt bloated. I swear this medication reduced the bloating the very next day!! I felt so much better in general even though I hadn’t a a bm yet!! It works wonders for me! I’d highly recommend it!"

9 / 10
Was this helpful?YesNo
49 Report
  • Nny
  • August 22, 2015

Linzess (linaclotide) "First off, I would like to say that the majority of people not having a good experience with Linzess are not taking it properly. Following my doctor's orders which were also labeled on the packaging from the pharmacy, Linzess 145mg works perfectly for me. I have suffered from chronic constipation since I was a young girl, and now I have a bowel movement every morning! A few things to keep in mind: Linzess takes 2 weeks to cycle through your body before it will work properly. Get through the first two weeks, and it's great. I do have watery stools every morning. Always take it in the a.m., 30 mins prior to breakfast with a full glass of water. I allow 2 hours for Linzess to work through my system. So plan accordingly!"

10 / 10
Was this helpful?YesNo
75 Report
  • Gottago
  • Taken for less than 1 month
  • November 26, 2019

Linzess (linaclotide) "I took Linzess after being constipated for 4 straight days. I took it around 4:30 pm in the afternoon. By 6:30 pm my stomach was gurgling and rolling and by 7 pm I was on the toilet with explosive diarrhea. Everything but the kitchen sink came out of me. And let me tell you it felt great to get cleaned out. My stomach did not hurt. No cramping. Just lots of bathroom trips. Be sure to be at home when you take it. You'll go A LOT. Also drink lots of fluids because diarrhea like that can dehydrate you."

10 / 10
Was this helpful?YesNo
46 Report
  • msboj...
  • Taken for 2 to 5 years
  • March 5, 2019

Linzess (linaclotide) "Linzess is awesome. I've had chronic constipation most of my life. This is the first thing that has worked! I take it and a couple hours later it starts clearing me out. No nausea. No cramping. I feel like a new person. No longer miserable. You will get diarrhea for an hour or so but it's worth not being sick and bloated all the time."

Was this helpful?YesNo
51 Report
  • Anonymous
  • October 26, 2019

Linzess (linaclotide) "I've had IBS C most of my adult life. I've struggled with bouts of several days of constipation followed by a bout of diarrhea as a cycle. My co-pay on Linzess is about $300 per month. My Dr. prescribed 145 mg Linzess and I took it a week before I could get it to work. That was a hard, painful week. After about 5 days of no results I tried taking two at a time as I read in some of the reviews and it finally worked. It worked so well in fact that use it every day. I normally take it as soon as I wake up with a glass of warm water and have a BM within 1 - 2 hours. I have been taking it every day for about 4 months now. I follow it with a teaspoon of Metamucil right after my BM. All in all I would say I'm 80% better off now than I was before. My main encouragement to others is GIVE IT TIME to get started. It could take a week of even more. After it does don't expect perfection. If you have lived with IBS C it could make a major improvement."

8 / 10
Was this helpful?YesNo
46 Report
  • Joshua...
  • Taken for 1 to 6 months
  • March 6, 2016

Linzess (linaclotide) "Linzess has completely changed my life. I am a 28-year-old male who was constantly living with bloatedness and constipation. I would have very irregular bowel movements (once every 2 to 3 days on average) and was not getting enough sleep due to having a constant 'dull' pain in my gut. I tried everything from cleanses, fiber, a cleaner diet, and also another drug (Amitiza) for help. Nothing was working long term, and I still felt drained of my energy. My doctor wrote me a prescription for Linzess (145mcg dose), and after day 1, I no longer felt bloated, and after about a week, my energy level was completely restored. I feel like a completely new person. Some minor diarrhea if taken later in the day. Nothing major though, no other side effects."

10 / 10
Was this helpful?YesNo
70 Report
  • JMcLo...
  • Taken for less than 1 month
  • October 1, 2014

Linzess (linaclotide) "I am a healthy type one diabetic who, in November of 2011, completed my first marathon. That changed in May 2011 when I was diagnosed with gastroparesis. I've been hospitalized 32 times since then and suffer chronic constipation that, like everyone else here, I couldn't fix. It is the most miserable feeling in the world. Clothes don't fit, painful itchy hemorrhoids that cause embarrassing bleeding through my clothes, and hours in the bathroom. I've been on the medicine for two weeks and it's an absolute miracle! I started at 290mcg and realized I could handle 145mcg. The lower dose allows me to have a regular schedule and no accidents. If I feel like I'm backing up at all, I go to 290 for a day or two."

10 / 10
Was this helpful?YesNo
79 Report
  • Sunny
  • March 23, 2017

Linzess (linaclotide) "This medication has been a great for me. I take it every morning (the lowest dose) on an empty stomach when I first wake up. I have had many years of chronic constipation and have tried MANY different things. This is the only thing that has really worked for me. Fortunately, I have not had the diarrhea issues that some people have reported. My doctor did say this can be a side effect for some. For others like me, it has worked great. Like any medication, there is always the chance you may have side effects and have to discontinue it. I think it's worth trying to see if it's right for you if you have had years of constipation that has effected your quality of life."

10 / 10
Was this helpful?YesNo
63 Report
  • DC211
  • January 4, 2015

Linzess (linaclotide) "Was prescribed Linzess for chronic constipation. Within 6 days I gained 7 pounds. When you're only 120 pounds, 7 is great! I'm an extremely active person and healthy eater. Thought it was water weight from the medicine, but been off the medicine for over a week and still weigh the same. Wish I had seen all the posts online about rapid and stubborn weight gain prior to taking the it!"

5 / 10
Was this helpful?YesNo
77 Report
  • Karen...
  • Taken for 1 to 6 months
  • January 28, 2017

Linzess (linaclotide) "Has been a wonder drug for me! Have suffered from extreme constipation for years. Now have a regular bowel movement about 2 hrs after I take it. Took about 2 weeks to work so give it some time! Have never had the diarrhea side effect."

10 / 10
Was this helpful?YesNo
63 Report
  • Borel...
  • January 23, 2013

Linzess (linaclotide) "I have had chronic constipation for twenty years. I have tried everything. Zelnorm was the only thing I ever found that worked. As we all know, they took it off the market in 2007. I have been suffering ever since. Until now! I have only been on Linzess for two days and have had 3 bowel movements with no bad side effects. I'm excited about this new medicine. I'm hoping and praying it continues to work. Give it a try, it's definitely worth it. Good luck."

8 / 10
Was this helpful?YesNo
86 Report
  • Freedom
  • Taken for 1 to 6 months
  • May 17, 2019

Linzess (linaclotide) "I first went to the doctor for constipation at the age of thirteen. I would have a bowel movement only a few times a month. It was a struggle to pass a bowel movement. The laxatives I took would hurt my stomach. Last year I had surgery to repair a hole in my colon. After surgery I stopped having bowel movements and the laxatives wouldn't help anymore. I started taking Linzess this year at forty nine years of age. Where have you been all of my life? Finally after using Linzess it is working I'm regular, no straining and no stomach pain. I feel great."

10 / 10
Was this helpful?YesNo
47 Report
  • Elly...
  • February 13, 2016

Linzess (linaclotide) "This drug has been a lifesaver. After having chronic constipation for years, I feel like a new person. Read the reviews and figured out how it would work best for me. I take the pill in the morning on an empty stomach every 2 to 3 days. I feel so much better now. I used to feel sluggish all the time having had one bowel movement a week. Believe me I tried everything imaginable before this so I was very happy when my gastro dr. suggested this drug."

10 / 10
Was this helpful?YesNo
67 Report
  • compu...
  • Taken for less than 1 month
  • March 11, 2014

Linzess (linaclotide) "I had abdominal surgery and was on opioids for the recovery period. I became constipated and finally gave in and took Linzess. It worked perfectly. I had a normal movement the next morning and had no side effects at all. As long as I take Linzess in the morning, I am regular as clockwork."

Was this helpful?YesNo
78 Report
  • Pros...
  • Taken for 1 to 6 months
  • March 4, 2020

Linzess (linaclotide) "Started with linzess dose of 72mcg; after 8 days doubled the dose to 2 capsules daily, wasn’t getting much relief with one capsule daily. Currently, on 145mcg dose. Have bowel movement daily and weight lost (pro). Experiences nausea, a lot of neuropathy and muscle pains (con)."

5 / 10
Was this helpful?YesNo
40 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Chronic Idiopathic Constipation

Care guides