Deplin for Depression User Reviews (Page 4)
Deplin has an average rating of 7.4 out of 10 from a total of 88 reviews for the treatment of Depression. 67% of reviewers reported a positive experience, while 18% reported a negative experience.
Reviews for Deplin
- Fred...
- Taken for 1 to 6 months
- August 27, 2022
"I had been struggling with depression for many years. Had many bad experiences with the usual anti-depressants, SSRIs and such. After doing the gene psych test and finding out I was homozygous for the MTHFR gene, I asked my doctor if I could try Deplin and he said yes. After just three days it felt like my depression had mostly gone away. After three months I continue to feel better still. This drug has really been a miracle for me. And I have experienced zero side effects from it. I take the 15 mg. I take it in combination with 7.5 mg of mirtazapine. I hope this helps somebody who is on the fence about taking Deplin. It is a little bit pricey but for me it has been worth every penny."
- Severe...
- Taken for less than 1 month
- December 14, 2021
"I was so hopeful hearing about the possibilities of Deplin and depression. I've tried twice once at 15mg for about a week and had bad headaches. My doctor suggested taking half (7.5mg) the dose to see if my body would adjust at a lower dose and unfortunately it hasn't. In early start though my mood was better and I was sleeping restfully while the short time on it. The headaches are like migraine severity. Starts in the neck up the back of my head and towards my ears. Lasts for a few days in which I have to Aleve just to be able manage the pain. It would have been great to see if this would continue to improve my depression but it's definitely not worth the painful side effect I experience."
- Jinx
- Taken for 1 to 6 months
- May 18, 2023
"Deplin may have saved my life from menopausal depression. I am heterozygous for the C677T polymorphism in the MTHFR gene, but never had mood issues until late peri menopause (2023). In late March, throughout April and half of May, I experienced serious mood changes related to lower endogenous estrogen. Despite having an estrogen + Dr and good HRT, my mood deteriorated to the point where I went from highly productive and functional to extremely lethargic, unmotivated, exhausted and deeply emotionally vacant. I felt like a shell of myself. I told my new psychiatrist about the genetic test from 2018 and he recommended Deplin 15mg in addition to the Lexapro I had started a year before. I was skeptical, but about 3 weeks after starting it, I noticed a significant improvement in my mood, sleep, energy and motivation and it remains. If you’re in menopause and having difficulty with your mood, you may want to ask your Dr about Deplin and/or the genetic test."
- Amybee
- Taken for 1 to 6 months
- June 11, 2022
"I started taking Deplin along with my other meds for depressive disorder and CPTSD. It may have boosted my energy but it caused extreme anxiety. I haven’t felt as panicky while out in public in years as I did while taking Deplin. The anxiety stopped once I stopped taking it."
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- kva
- Taken for less than 1 month
- December 16, 2020
"I'm tapering off Prozac and am only taking 2.5mg. I prefer not to go on SNRI 's or SSRI's. I asked my psychiatrist what could I try instead. He suggested Deplin 15 and gave me 12 capsules. I have taken 6 so far and the only thing I noticed that it slows my lower GI tract. Hoping for better feelings in the future."
- Baillie
- Taken for 6 months to 1 year
- July 23, 2022
"I take lexapro 20mg which works well for my anxiety but not quite so well for my depression and I was always tired . I started taking 15mg Deplin and quickly started to feel more energy. I have more motivation now and just feel better in general. I do have the homogenous C667T MTHFR variant and also had a slight folate deficiency before starting."
- Mwieie
- Taken for 1 to 6 months
- August 17, 2018
"Holy moly Deplin has changed my life. I took SSRIs that kind of worked but not totally. Started taking Deplin and it has just given me the rest of my life back."
- Scotty
- Taken for 2 to 5 years
- June 13, 2019
"I have been taking Deplin 15 mg daily as a supplement to other drugs for my Bipolar illness. It works well and I have no noticeable side effects from it"
- Anonymous
- September 17, 2009
"No side effects, many more plus/up days than before. Seems the longer I am on the Deplin in conjunction with my antidepressant, the better my moods and overall feeling gets."
- Stone...
- Taken for 1 to 6 months
- July 29, 2016
"It has helped me quite a bit, although it doesn't seem to have antidepressant effects. It's definitely helping me "think" better - I'm not confused anymore."
- Anonymous
- July 28, 2009
"This has helped better than anything else I have tried."
- Lori
- Taken for 1 to 2 years
- October 29, 2019
"Taken Deplin for MDD for nearly 2 yrs and no change in my depression. I recently stopped taking it to save money."
- JSano
- Taken for 1 to 6 months
- July 2, 2019
"The medicine after two weeks I felt dis-oriented confused and flat definitely not any helper more of a deterrent."
- Treat...
- Taken for 1 to 6 months
- March 4, 2019
"We observed no positive contributions to my treatment of depression. No effect at all. Deeply disappointed."
- Rich...
- Taken for 6 months to 1 year
- July 21, 2016
"Long history of medication resistant recurrent major depression. Tried Deplin 15 mg daily for 6 months. No improvement at all seen with Deplin. Total waste of money for me."
- Court...
- Taken for 2 to 5 years
- June 27, 2017
"Started taking Deplin to curb the side effects I was feeling on Lexapro. I'm not really sure if was working or if I just thought it was working. It also cost a lot of money."
- mikoy
- Taken for 1 to 6 months
- May 25, 2016
"Not worked for my depression. Zero effect."
- joy
- Taken for less than 1 month
- April 19, 2016
"I'm just starting deplin I need energy I been taking Wellburtion for two yrs now 100 mg 3 times daily I pray it work for my energy level."
Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.
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"I was having major anxiety and insomnia stemming from shoulder surgery. I wasn’t sure what was wrong with me. I eventually found a psychiatrist and he prescribed klonopin. That made me more depressed. I decided I needed a better psychiatrist. After meeting with this doctor, he decided to do the genetic testing. Three days later I find I have MTHFR. Compound heterozygous. Been on Deplin 15mg for over a year. I also take 10 mg Lexapro per day. Anxiety is better and I’m not nearly as angry. Changed my life for the better. Better late than never. I’m 54"