Deplin for Depression User Reviews (Page 3)

• Hay...
• Taken for 1 to 6 months
• August 1, 2015

"I started taking Deplin 2 months ago in addition to the 300 mg of Wellbutrin I had already been taking for several years. I was experiencing a very low level of chronic depression but generally okay. The doctor recommended I try Deplin to see whether it would increase my level of well-being. I could swear I feel a lot more depressed with the Deplin. Nothing has changed in terms of lifestyle over the past few months, so I can't think of any other explanation. Needless to say, I'm going to stop taking it. I had no idea it might worsen my symptoms."

• Jen...
• Taken for less than 1 month
• August 4, 2014

"I added Deplin 15 mg to a 150 mg dose of Wellbutrin when the Wellbutrin no longer worked as well. It did help for a few days, but then I developed severe muscle weakness, stiffness, and pain, particularly in my neck and shoulders. It was bad enough that I could not turn my head or look up or down without great discomfort. It kind of felt like I had whiplash. I did some research and found that the muscle pain can be a side effect of both medications. I have not ever had this problem on Wellbutrin alone, so I'm inclined to think the Deplin caused this. I quit taking both medications because I couldn't function with the pain and stiffness any longer, and two days later, the pain is still there but is slowly subsiding."

• whi...
• Taken for less than 1 month
• July 8, 2013

"I have been taking Deplin for 18 days, and I do notice a slight change in my depression, brain fog, and energy levels. I think it is being inhibited by my Adderall withdrawal, but I am hoping it is helpful since I've tried many medications and nothing has really helped."

• jer...
• Taken for 1 to 6 months
• July 12, 2019

"Have taken Paxil for years, had a poop out with the Paxil, so the doctor added Deplin 15 mg, that did not work, had lots of confusion, out-of-touch feelings. I cut the Deplin back to 7.5 mg, and in three days, it is doing the same thing as the 15 mg. I would assume if you had a folic deficiency, it would work. However, I must have enough, and this just overloads my system. Not for me, cannot get off of it fast enough."

• chr...
• April 18, 2010

"I hope this helps to all the depressed people out there. I have been seeing a psychiatrist for drug-induced depression. I abused meth, Vicodin, coke, and any other drug you can think of for years, and that has left me a basket case. I have tried many antidepressants, but I suffer too many adverse reactions to the stronger stuff. I am currently on 300mg Wellbutrin and 15 mg Deplin, and I have to say I feel GREAT! However, I had taken the Wellbutrin/Deplin combo in the past, and it stopped working for me after 6 months. The results with the antidepressants were a little funny because I went back to abusing Vicodin. Now I am clean of any drugs and just taking what is prescribed by my doctor, 300mg Wellbutrin and 15 mg Deplin."

• See...
• September 4, 2018

"Update to my previous post: I've now been taking Deplin for close to a year. It serves as an add-on to my antidepressant meds. It hasn't been a magical booster to improve my severe, resistant depression as well as my horrible anxiety. However, over a year's time, Deplin has helped me feel just enough better to justify its cost. A very subtle improvement that is difficult to describe. I'm glad that I stuck with it; not at all noticeable until at least 9 or 10 months. And that time frame (for subtle change) isn't acceptable if you are miserable. But I was improving just enough with my other meds to allow me to continue taking Deplin-just in case it began making a difference ....whenever? Plus, my doctor told me it was good for my overall health, regardless if it touched the depression. This made it easier for me to continue taking it despite feeling no benefit for a long time."

• spr...
• December 15, 2010

"I started taking Deplin yesterday and recently tapered myself off of Cymbalta and Wellbutrin. I still have the Cymbalta withdrawal 'brain zaps,' but have regained my crying reflex that I lose every time I get back on medication. I have been pregnant several times and needed to come off all medications for the duration. Today I had more natural energy than I've had in a long time. I had been taking Hydroxycut just to get myself moving and to the gym as I had reached my maximum weight of 188 last week. Now I don't feel like I need it anymore. My OCD is almost non-existent now. I can complete multiple tasks without spending an eternity detailing every aspect of a small task. This is how I feel after day 2, hopeful this will continue."

• jus...
• March 26, 2014

"I thought I would share my experience, as it may be helpful to others. I have been on this for over 2 years now... and depression-wise (which is what I'm basing my rating off of because that is what this rating is supposed to pertain to), it hasn't done anything for me at all. At least nothing at all that I have ever noticed. I have stayed on the medication because of the fact it does help bring down my homocysteine levels. I have a condition referred to as MTHFR. Basically, it's a liver enzyme condition that makes it so the body doesn't convert proteins/peptides very well. Common condition (1/10 Americans) but rarely tested for. The lab had to look up what to do for drawing blood and testing for it."

• Jin...
• Taken for 1 to 6 months
• August 23, 2023

"I have a genetic mutation which lowers my body's ability to convert folic acid into its active form, but had never been prescribed Deplin for my bouts with depression and lifelong insomnia. This spring, my mood started to decline and my sleep was worse. At one point, I was taking three medications for sleep. I told my new psychiatrist about my old genetic test results regarding folic acid, and he thought I should try 15 mg of Deplin. Within two weeks, my sleep improved dramatically - I was able to discontinue a sleeping medication, and within 3-4 weeks, my mood also became much more stable and consistent. I've now been taking Deplin for almost six months and have been able to discontinue another sleep medication (I still take one for sleep). Although I still get short bouts of lower moods, they are nothing compared to what they were prior to Deplin. I tried at least five add-on antidepressants prior to Deplin with no results. I had no side effects, and it's very easy to take - a real lifesaver!"

• CK1...
• May 26, 2016

"I have been on Deplin 15 mg for about 3.5 months. I have the mutation and was hopeful that this would help. I noticed no change whatsoever in my anxiety or depression. I also started having severe joint pain, and nothing had changed but adding Deplin. My doctor recommended that I stop the Deplin. I have been off for 3 days and continue to have joint pain. Would love to hear from others with a similar experience."

• Zar...
• Taken for less than 1 month
• March 1, 2018

"I had the swab genetic test done. I lack the MTHFR gene that creates the enzyme that breaks down folic acid to folate. Without folate, depression is very likely. My doctor prescribed Deplin, as it would take 60 bottles of over-the-counter folate to equate to the convenient orange capsule. The first three weeks, my depression and anxiety got worse. My doctor wasn't helpful, but I kept taking it. I’m around week 5, and I am able to see my compulsive eating as not good for me, as I am morbidly obese. I don't feel overly happy, but more in control in a chaotic world and able to focus more. I'll chat with my doctor about getting off Lamictal once I've had a couple of months on Deplin. I am far less paranoid and explosive, but I have routine scary dreams being out of control. I can't put my finger on it, but I think I am better off with Deplin and apprehensive to go off it. This is not the placebo effect talking. I think I can lose weight and get off the bipolar meds. I pay $160 for a three-month supply."

• sti...
• September 29, 2009

"I have had a partial response to my antidepressant. I have had a hard time finding one as my chemistry responds unfavorably to many drugs. Deplin was advised by my doctor, who has actually participated in clinical trials. She had seen no adverse effects and thought it would work great for me. On the 3rd day, I felt like my old self for the first time in 1 year. Unfortunately, that night I had auditory hallucinations... first time in my life... and a very restless night. Went off and slept okay. Tried just doing folic acid and Vitamin B6 and had the same response, only worse. Didn't sleep the whole night. Both my psychiatrist and psychologist say I am the only person who they have ever seen have a negative reaction. Like I said, I felt great. Good luck."

• Cin...
• July 14, 2009

"I've been on Deplin for 20 days now, along with Zoloft. I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100), so I had to go off it. I was put on Zoloft as a stopgap, but have tried it in the past without much success, as with all the others. They say it can take 4-6 weeks before Deplin has its full effect. I'm still hopeful, but I do so wish I'd seen the overnight change like others."

• Lau...
• Taken for 1 to 6 months
• May 31, 2017

"I started this supplement with high hopes. I was given it to boost the effectiveness of the Pristiq I'm taking. After using it for over a month, I'm disappointed. Really have experienced no change. I'll keep searching for the right combination of meds."

• See...
• Taken for less than 1 month
• December 16, 2017

"MUST take Deplin and not a generic and definitely not over-the-counter folic acid or folate! These can make things worse! My C spinal fluid showed that I have a less prominent type of folate abnormality. Wasn't detected in a gene swab test. Anyway, just started taking 15 mg as an antidepressant add-on. Made my depression & anxiety worse!!! I would stop taking it, but my doc has me taking a lower dose as she recognizes that Deplin can cause a worsening of symptoms in certain folks. It just needs to be started low and gradually increased. So, please start with a low dose if it makes you MORE anxious/depressed at 15 mg. Too early to say it helps, but the lower dose is needed to start, for some. And it may take many months to work--for some!"

• sky...
• Taken for less than 1 month
• June 5, 2017

"Like many others, I took the Genomind test, which told me that SSRIs were not optimal and that SNRIs were a better choice. After 16 years and 20 different meds, I have had much better success with SSRIs than SNRIs. The test results also said that I was deficient in what Deplin could provide. I have been taking 15 mg of Deplin for almost 3 weeks now and have been experiencing some of the lowest depression that I have ever felt. Today, I woke up feeling just as miserable as I have been for the past 3 weeks, so I decided not to take Deplin. As I slumped through the morning, I started to feel a wave of happiness and excitement for life come over me around 10:30 AM, and I still feel great. I feel like 'my' normal self again. $60 wasted!"

• Jon...
• Taken for 2 to 5 years
• February 26, 2020

"I took this for a while at the recommendation of my psychiatrist. I have the double MTHFR mutation. It did nothing for me and is prohibitively expensive. I’m not sure if I buy into their MTHFR serotonin theory, but it seems to work for some. For me, I would get these weird sensations in my hands and feet, almost like they were heavier or more sensitive, and I felt like my sleep was less restful (even I got 8 hours consistently) because I was always tired. It made me feel off as well, but I assume that is just depression medication in general."

• stg...
• Taken for less than 1 month
• February 4, 2015

"I've been using antidepressants for quite a few years now. I seem to have gone through the entire list of antidepressants. My latest script is Escitalopram Tabs, 10 mg. We recently added Abilify and this Deplin Caps, 15 mg. I've been feeling a bit better. One of these two gives me an awful case of heartburn! Painful it is. I'll mention it during my next appointment. Now, as before, I can't watch anything with intense emotions as I'll break down and start crying. At age 52, I find it a bit annoying. Before I added these last two medicines, I found myself crying more frequently than not. The movie 'UP' really freaked me out. Anyway, I'm disabled with intractable pain. That's what started all the depression stuff."

• Bri...
• September 2, 2021

"I was having major anxiety and insomnia stemming from shoulder surgery. I wasn’t sure what was wrong with me. I eventually found a psychiatrist, and he prescribed Klonopin. That made me more depressed. I decided I needed a better psychiatrist. After meeting with this doctor, he decided to do the genetic testing. Three days later, I found I have MTHFR. Compound heterozygous. I've been on Deplin 15 mg for over a year. I also take 10 mg Lexapro per day. Anxiety is better, and I’m not nearly as angry. Changed my life for the better. Better late than never. I’m 54."

• Lyn...
• Taken for 1 to 6 months
• September 18, 2022

"I took Deplin during a former depressive episode, but in a much smaller dose. I cannot say if it helped with the effects of depression. During this episode, my doctor recommended taking 15 mg. I was taking Deplin for 3 months. I was having unbearable anxiety and began looking carefully at the side effects of my meds. Deplin can cause severe anxiety, along with other negative side effects. There is an article online called ‘Anxiety Nutrition Solutions’ by Trudy Scott with Dr. Benjamin Lynch. He is a major supporter of methyl folate. He talks in the article about the different side effects patients can experience on Deplin, severe anxiety among them. If you’re taking Deplin and are feeling anxiety, please read."

• Fre...
• Taken for 1 to 6 months
• August 27, 2022

"I had been struggling with depression for many years. Had many bad experiences with the usual anti-depressants, SSRIs and such. After doing the gene psych test and finding out I was homozygous for the MTHFR gene, I asked my doctor if I could try Deplin, and he said yes. After just three days, it felt like my depression had mostly gone away. After three months, I continue to feel better still. This drug has really been a miracle for me. And I have experienced zero side effects from it. I take the 15 mg. I take it in combination with 7.5 mg of mirtazapine. I hope this helps somebody who is on the fence about taking Deplin. It is a little bit pricey, but for me, it has been worth every penny."

• kte...
• October 27, 2014

"For the past several years, I have been trying to find the right balance to deal with the anxiety and depression of Post-Traumatic Stress Disorder. I have been on Citalopram for the depression, and that seems to work well. It has been hard to find an antipsychotic that works, and currently, I'm on Latuda. I'm also on a mood stabilizer, Lamictal. My doctor added Deplin. Long story, I wound up without my Latuda and Deplin for about 6 weeks. In 6 weeks, I was off the charts on the ups, and my old patterns were popping up. Not good. I went back on the Latuda and began evening out, but still had too much up. Now I've been back on the Deplin for a week, and I feel completely numb. Trouble sleeping at the right times, trouble being awake or at least alert at the right times."

• jon...
• November 12, 2016

"I am taking 225 mg of Lamictal for depression. The Dr. wanted me to try this along with the Lamictal. I took it once, at bedtime, and woke up with the worst headache I've had in my entire life, and it lasted all day. Also had very loud ringing in my ears, which lasted all day. Not good. Needless to say, I did not take it again, so I cannot comment on its effectiveness."

• Sev...
• Taken for less than 1 month
• December 14, 2021

"I was so hopeful hearing about the possibilities of Deplin and depression. I've tried twice, once at 15 mg for about a week, and had bad headaches. My doctor suggested taking half (7.5 mg) the dose to see if my body would adjust at a lower dose, and unfortunately, it hasn't. In the early start, though, my mood was better, and I was sleeping restfully while on it for a short time. The headaches are like migraine severity. They start in the neck, up the back of my head, and towards my ears. They last for a few days, during which I have to take Aleve just to be able to manage the pain. It would have been great to see if this would continue to improve my depression, but it's definitely not worth the painful side effects I experience."

• Anonymous
• October 10, 2009

"I am heartened by the 6 reviews. I have just started on Deplin. I have been on Remeron for two years. I cannot tolerate serotonin-type medicines such as Prozac and Lexapro. Remeron worked beautifully at first, but the effects have slowly worn off, and my anxiety and mild depression returned. I pray Deplin will work for me and I can regain my enthusiasm and joy in life. I am happy for those of you who have been helped. Wish me luck."