L-methylfolate User Reviews & Ratings (Page 5)

• jonny...
• November 12, 2016

Deplin (l-methylfolate) for Depression "I am taking 225 mg of Lamictal for depression. The Dr. wanted me to try this along with the Lamictal. I took it once, at bedtime and woke up with the worst headache I've had in my entire life, and it lasted all day. Also had very loud ringing in my ears which lasted all day. Not good. Needless to say, I did not take it again, so I cannot comment on its effectiveness."

• Aging...
• Taken for less than 1 month
• May 20, 2014

Deplin (l-methylfolate) "I finished the 6 day trial, and I must say I felt so good on the last 2-3 days on Deplin. I didn't experience the crazy lows I had in the last few months. I don't truly have depression, more like bipolar 2, and on no medications. I love my emotions, and want to work with them, so my naturopath suggested we try Deplin. I will be seeing her again next week, and I will ask her to continue it."

• Jinx
• Taken for 1 to 6 months
• August 23, 2023

Deplin (l-methylfolate) for Depression "I have a genetic mutation which lowers my body's ability to convert folic acid into its active form, but had never been prescribed Deplin for my bouts with depression and lifelong insomnia. This spring, my mood started to decline and my sleep was worse. At one point, I was taking three medications for sleep. I told my new psychiatrist about my old genetic test results regarding folic acid, and he thought I should try 15 mg of Deplin. Within two weeks, my sleep improved dramatically - I was able to discontinue a sleeping medication, and within 3-4 weeks, my mood also became much more stable and consistent. I've now been taking Deplin for almost six months and have been able to discontinue another sleep medication (I still take one for sleep). Although I still get short bouts of lower moods, they are nothing compared to what they were prior to Deplin. I tried at least five add-on antidepressants prior to Deplin with no results. I had no side effects, and it's very easy to take - a real lifesaver!"

• TZT
• Taken for 1 to 2 years
• April 9, 2018

Deplin (l-methylfolate) for Depression "If you are taking Deplin because of the MFTHR genetic abnormality, you were misled by your doctor(s). This genetic test is being pushed by the pysch field even though it has not been proven. Look up the studies on MFTHR and you will soon learn that most of what you read about are myths. That being said Deplin does have its benefits. "

• ktexas
• October 27, 2014

Deplin (l-methylfolate) for Depression "For the past several years I have been trying to find the right balance to deal with the anxiety and depression of Post Traumatic Stress Disorder. I have been on Citalopram for the depression and that seems to work well. It has been hard to find an antipsychotic that works and currently I'm on Latuda. I'm also on a mood stabilizer Lamictal. My Dr added Deplin. Long story I wound up without my Latuda and Deplin for about 6 weeks. In 6 weeks I was off the charts on the ups and my old patterns were popping up. Not good. I went back on the Latuda and began evening out but still had too much up. Now I've been back on the Deplin for a week and I feel completely numb. Trouble sleeping at the right times, trouble being awake or at least alert at the right times."

• Ablack
• Taken for less than 1 month
• April 27, 2018

For Depression "I've had depression for most of my life and have been suffering from premenstrual dysphoric disorder (PMDD) the last five. I was prescribed l-methylfolate by my psychiatrist to go along with my anti-depressants a year ago but for some reason I didn't take them. If only I knew!!!! I took those and noticed a difference right away but when I ran out, my insurance wouldn't cover it (different insurance company at the time) so I had to go OTC. I have felt so much better since taking the MethylPro at 10mg. I am actually happy, content and I laugh. My PMDD is calming down. I've only been on it about two weeks consistently. Yesterday I woke up and exercised!!!!!!! I've been doing some type of exercise the past week almost every day. Yoga, dance, kickboxing (not actual kickboxing but as exercise). It's amazing how much energy I have, but it isn't that caffeine-driven energy feeling, if that makes sense. I haven't been tested for the gene mutation and am going to inquire about it when I speak with my doctor next."

• seanbam
• December 7, 2010

Deplin (l-methylfolate) "I never responded to any medication for anxiety and depression, which was made worse by most medications. Deplin was a miracle for me. I started to use it this summer and my response was immediate. My response seemed to pop out this summer but I learned that some people can have this response and need to lower the dose and start and stop the medication. Also my response could have been do to the Klonopin that I reduced after 20 years of usage. Overall this medicine was a miracle for me.."

• KTgreen
• Taken for 6 months to 1 year
• November 15, 2017

For Depression "I started taking MethylPro after I was prescribed Deplin and could not afford the monthly cost once my insurance discontinued it. MethylPro has actually made me feel better than ever, I believe I was having a reaction to one of the additives in Deplin and it was making my skin itch. I no longer have that issue and I feel the effects more quickly on the MethylPro. It has allowed me to no longer be on antidepressants and two months ago I started taking one with cofactors, I'm now training for a half marathon in March. Life is now fulfilling and I'm full of energy, L-methylfolate has been a game changer for me!"

• Snowpea
• Taken for less than 1 month
• May 7, 2019

For Depression "Tried Neurofolin today As was considering giving it to my late teen with low mood and energy I though I would be the guinea pig first. Had a positive experience. Felt focused and alert all day with sustained results and improved mood and outlook. A little jittery but personally managed ok with that.."

• Amybee
• Taken for 1 to 6 months
• October 2, 2022

For Depression "I thought Deplin was helping my depression at first, but soon realized that the severe anxiety and insomnia I was experiencing coincided with when I started taking it. Granted, I take other meds, but I had zero anxiety and practically no trouble sleeping before I added Deplin. It’s a shame because at first I thought it was helping me, but the side effects were intolerable."

• maxm
• August 20, 2010

For Depression "I am a 63 year old man (a psychologist) who has had treatment-resistant depression for many years. In the past ten years I also have had frequent (10-15/month) migraines--migraine and mood disorders often appear together. I started on Deplin 7.5 mg/day along with Zoloft 50 mg./day last month. I had been on Zoloft alone previously with no improvement. After 3-4 weeks of no change in mood or functioning, my psychiatrist increased the Deplin to 15 mg./day and the Zoloft to 75 mg./day (not a high dose). Within a few days, I experienced an increase in energy and sharp decrease in depressed mood--to the point where I'm feeling back to what "normal" was decades ago. I have been through numerous antidepressants and never experienced this."

• Finally
• Taken for 1 to 6 months
• February 1, 2020

For Depression "Hi I've suffered from depression since my early thirties . At that was when it was diagnosed. I've tried most of the antidepressants and for short periods of time they certainly have assisted me come out of some pretty dark places. Now in to my 50s I'm tired of taking the medication and do not feel that it has been assisting me. Recently I have tried Nurofolin and I can't believe the difference. I weaned myself off the antidepressants and then began taking your folin within two weeks my mood was lighter and my anxiety reduced considerably. I have now been taking it for well over 3 months. I would definitely recommend this for anyone who has work done the work and now just wants something to keep their mood balanced. Of course this is not for everyone but in my experience I am so grateful to finally find something that truly helps without the chemical side affects."

• Frust...
• December 6, 2019

For Depression "tl;dr: 5-MTHF, methyl folate calcium salt, whatever it's called by the manufacturer, some forms work better for some people than others. My depression responded poorly to nearly every antidepressant on the market for 10+ yrs. Turns out I'm homozygous for the MTHFR mutation. Started taking 1mg L-methyfolate pills by Superior Source, increasing every few days to hit the recommended 15mg/day for depression. Had an immediate improvement in energy, and my other meds, like Allegra, started working better. I also tried OptiFolate 7.5mg, MD Life 5mg, and NOW 5mg. My depression symptoms and skin-picking came back on each of those. My psych finally wrote me a prescription and now I'm on 15mg pills made by Breckenridge. They work as well for me as Opti Folate: not very well at all. YMMV (your mileage may vary), I've seen reviews on Amazon where people responded much better to Opti Folate than Superior Source. Do your research, & try different makers if one doesn't work for you. I'm waiting for a new prescription."

• John_...
• October 16, 2014

For Depression "I'm 47 and heterozygous for both MTHFR mutations. I just came out of a deep, dark depression with the help of Effexor. I started taking 0.5 milligrams of methyl folate (yes, a very low dose) about a month ago. Even this small amount of methyl folate (in combo with methyl B12) affects me deeply and immediately. I take it before 8 in the morning, and it still influences my sleep that night. I have never been an active dreamer, but on methyl folate, I dream A LOT. I seem to feel more awake and active in the afternoons, as well. I agree with the commenter about being on methyl folate for a period of time before deciding if it works for you. You may feel the effects immediately, or later on. There may be ups and downs."

• Murph
• Taken for 1 to 6 months
• January 20, 2021

Deplin (l-methylfolate) for Folate Deficiency "Hey gang, I took a gene test after nearly having no luck with any SSRIs and all the negative side effects. Once I started taking this, I was able to take 5mg Lexapro and .5mg of rexulti w/ no side effects, especially zero sexual side effects. I had Depressions, Anxiety, DP/DR and it nearly broke me last year. But this stuff I believe changed my life and allowed my body to react positively to the medications."

• NotDy...
• Taken for 1 to 6 months
• January 24, 2022

For Depression "I have a double mutation with the MTHFR situation. It took a long time to get my insurance to cover this. I take 15 mg twice a day and just like all these other reviews - I am no longer dying. I see that a lot of people are taking 15 mg once a day so I don't know why I'm on it twice a day but I went from feeling like somebody who was literally being swallowed up by quicksand to somebody who is alive. I've been on it for 5 months. I have no side effects. It feels crazy to feel normal."

• Brian
• September 2, 2021

Deplin (l-methylfolate) for Depression "I was having major anxiety and insomnia stemming from shoulder surgery. I wasn’t sure what was wrong with me. I eventually found a psychiatrist and he prescribed klonopin. That made me more depressed. I decided I needed a better psychiatrist. After meeting with this doctor, he decided to do the genetic testing. Three days later I find I have MTHFR. Compound heterozygous. Been on Deplin 15mg for over a year. I also take 10 mg Lexapro per day. Anxiety is better and I’m not nearly as angry. Changed my life for the better. Better late than never. I’m 54"

• Anony...
• Taken for 1 to 6 months
• April 7, 2021

For Folate Deficiency "Life changing. After 3 years of trying different SSRI’s that didn’t work for my Depression or Severe Anxiety, I finally did a gene test and not only found 5 medications that were suitable for me, but they saw that I had the homozygous C667T MTHFR mutation, meaning my folic acid conversion was pretty much non existent. This made so, so much sense for a lot of things that happened to me, and I began taking 75mg of Pristiq (SNRI), and 15 mg of L-methylfolate supplements. After several months of these meds, therapy sessions, and even starting exercise again, I am a changed person. The hamster wheels in my head have finally slowed down, I’m not seeing darkness (figuratively) all the time anymore, and I haven’t had a panic attack in months. These results and these capsules have saved me."

• Lennie
• April 8, 2011

For Depression "I have battled depression and anxiety for 15 years and was prescribed Klonopin. Over the years I have remained on Klonopin, in addition to Paxil which was added 6 years ago. I didn't see any significant changes in my depression, but my anxiety was under control. After trying several antidepressants with no significant change in my depressive mood, I was frustrated. My doctor, prescribed Methylfolate and today is my 2nd day taking the medicine. I woke up this morning with hope, energy, and excitement. It has been years since I have felt excited about what a day in my life would unfold, and it happened today. I feel like I am participating in life today as opposed to being a spectator."

• Fred...
• Taken for 1 to 6 months
• August 27, 2022

Deplin (l-methylfolate) for Depression "I had been struggling with depression for many years. Had many bad experiences with the usual anti-depressants, SSRIs and such. After doing the gene psych test and finding out I was homozygous for the MTHFR gene, I asked my doctor if I could try Deplin and he said yes. After just three days it felt like my depression had mostly gone away. After three months I continue to feel better still. This drug has really been a miracle for me. And I have experienced zero side effects from it. I take the 15 mg. I take it in combination with 7.5 mg of mirtazapine. I hope this helps somebody who is on the fence about taking Deplin. It is a little bit pricey but for me it has been worth every penny."

• Fox_C...
• May 1, 2017

For Depression "Wow, this stuff is amazing! It did not work at first, but my sister, who is a nurse, told me, that because I had gastric bypass, that I probably need to take more than the 15 mg because gastric bypass patients do not absorb nutrients very well at all and need supplements. I am now taking 45 mg per day without any side effects. And the negative thinking has all but disappeared. I had a DNA test done as my new psychiatric nurse practitioner, after having listened to my woes of having no success with meds or ECT immediately insisted that I take the DNA test. As she suspected, I have not one but two mutations on my MTHFR gene, which decreases my ability to process folic acid in a big way. She suggested that I try Inositol/Choline too."

• Blewee
• Taken for 1 to 2 years
• February 10, 2021

For Depression "Very good supplement for the treatment of depression. It's definitely good as an add-on to prescription antidepressants. Most people with mental health issues are lacking in folic acid and l-methylfolate is the most potent kind of folate."

• just...
• Taken for 2 to 5 years
• January 8, 2018

For Depression "So, here goes, I started taking Duplin about five years ago, after I found out I was missing sets of both genes. It really explained a lot of what I went through as a teen. I noticed a life changing difference. I have to explain that I am a young 60 years old. This may or may not hit a nerve with you but I serious think that this drug has put my libido in overdrive. Can anyone relate? I am going to cut them in half from now on and see if this helps."

• LURee
• August 9, 2016

Deplin (l-methylfolate) "Prescribed for my young daughter with Autism and epilepsy, anxiety- hair pulling , but the dose was too high and caused even more anxiety, so found reducing it from every day, to once a week, and sometimes just twice a month, makes a huge difference for her to receive the benefit without the heightened anxiety. I muscle test for the amount and timing, and notice when she is pulling her eyelashes, hair or eyebrows."

• dd220
• Taken for less than 1 month
• December 17, 2023

For Folate Deficiency "I took L-Methylfolate after watching a YouTube video. I was experiencing terrible stomach problems and losing weight that I didn't need to lose. I had had all of the gastro tests, which all indicated there were no problems. When my doctor asked me why I wasn't eating, I told her, 'I just feel so much better if I don't eat or drink (water!)'. After watching the YouTube video that described how people with 'food allergies' or 'food intolerances' could become much improved, I started to take it. The first dose was on Tuesday. By Wednesday, I felt energized and had reduced symptoms. On Thursday (which was Thanksgiving), I had the entire dinner from appetizers, soup, salad, turkey and all the sides, plus pumpkin pie (Note: I did it over 4 hours). It was an absolute miracle. Talk about being grateful. Life has remained good. No pain, lots of energy, happy, and eating. I haven't put back any weight, but I can live with that."