L-methylfolate User Reviews & Ratings (Page 4)

• Maybe...
• Taken for less than 1 month
• April 15, 2018

Deplin (l-methylfolate) for Folate Deficiency "I just started deplin today! I’ve been reading people’s comments and half say it’s helped them and half have not. I’ve also researched it and have read so many different articles. From my understanding you should start off at a low dose and if that doesn’t help then take more. If the dosage is to high or low and your not feeling better adjust it. I personally wouldn’t give up after trying it one time at one dose. This medicine has changed peoples lives into feeling like a normal happy person with energy. I personally hope it works for me and I feel better! I’m not giving up! Try to research it before giving up. I wish everyone good luck with deplin."

• Zarat...
• Taken for less than 1 month
• March 1, 2018

Deplin (l-methylfolate) for Depression "I had the swab genetic test done. I lack the MFTHR gene that creates the enzyme that breaks down folic acid to folate. Without folate depression is very likely. My DR prescribed Deplin as it would take 60 bottles of over the counter folate to equate to the convenient orange capsule. The first three weeks my depression and anxiety got worse. My doctor wasn't helpful but I kept taking it. I’m around week 5 and I am able to see my compulsive eating as not good for me as I am morbidly obese. I don't feel overly happy but more in control in a chaotic World and able to focus more. I'll chat to my doctor about getting off Lamictal once I've had a couple months on Deplin. I am far less paranoid and explosive but I have routine scary dreams being out of control. I can't put my finger on it but I think I am better off with Deplin and apprehensive to go off it. This is not the placebo effect talking. I think I can lose weight and get off the bipolar meds. I pay $160 for three months supply."

• Male...
• Taken for 1 to 2 years
• February 15, 2015

For Depression "Depression sufferer my whole life. On Deplin for last year and my lows vanished within first week on 15mg/day. It's all I'm taking and the benefit is absolutely profound. Zero side effects. Most psychiatrists downplay the lack of studies but it definitely works for me better than anything else I've tried. Good luck."

• Anxio...
• Taken for 1 to 6 months
• October 12, 2018

For Depression "L-methylfolate is a great. I spent the last 3 years with increasingly crippling anxiety and it was starting to limit my ability to work and live. At the point of attempting anti-depressants. Luckily I came across an article for an l-methylfolate product. Given it's just processed folate and B12, I gave it a try, because the side effects are so limited. WOW. AMAZING. Within a week (15mg per day) I had my life back. I still get anxious but it's like all of a sudden it's not so bad. I can laugh, smile and be happy. I'm a better husband and father. Anyone who is struggling with thoughts of low self worth, anxiety or depression, it is worth considering trialling this drug. I wouldn't say that if the side effects weren't so limited: it's just folate after all!"

• Goodue
• November 11, 2016

Deplin (l-methylfolate) for Depression "I've gone through deepshit, to the wall depression - had ECT et al while on meds. Went off and have NOOOO regrets b/c I finally started having feelings again (after 25 years on meds).... But I went through deep retaliation at work for speaking out against a bully, and the PTSD from that became deeply real only after two lawsuits were settled and every state/federal complaint was successfully settled. I won... but the PTSD won even more. And ya think you can find a shrink who looks at alternatives to antidepressants? HA! My only salvation came in the form of my doctor, an internist, who suggested I go to ER b/c of thyroid stuff. While 5 days on a med/surg unit was not free from shit... I got connected with a shrink who prescribed THIS."

• Elsie...
• February 24, 2012

For Depression "I have suffered from depression for about 30 years.. crippling depression with anxiety since 1992. I am 62. I have taken nearly every antidepressant and none really worked. I read this forum about four months ago and decided to order 5-MTHF,10 mg. After about three weeks, I realized I was coming up from the deep depression. I was taking 20 mg of Lexapro and cut that down to 10 mg a day. I am excited that this might be what I need but will wait a while before foregoing with the Lexapro because I'm not ready to enter that deep depression if this doesn't work by itself. I am so excited even if I do have to continue the Lexapro. To feel like getting out of bed, doing normal things and feeling good is great. I will post updates."

• CK1210
• May 26, 2016

Deplin (l-methylfolate) for Depression "I have been on Deplin 15mg for about 3.5 months. I have the mutation and was hopeful that this would help. I noticed no change whatsoever in my anxiety or depression. I also started having severe joint pain and nothing had changed but adding Deplin. My doctor recommended that I stop the Deplin. I have been off for 3 days and continue to have joint pain. Would love to hear from others with a similar experience."

• Mered...
• Taken for 1 to 6 months
• October 17, 2018

Deplin (l-methylfolate) for Folate Deficiency "I also have Anxiety Disorder. 20 mg Prozac, .05 Klonopin. My Dr. kept telling me to take it, take it but I've always resist. Anyway I'm taking it. I can't tell you how good I feel although I didn't really know why. I didn't understand how laking something in my body could effect the drugs I take or just my overall health. I feel great for the first time in a long time. Don't hesitate."

• Jon...
• Taken for less than 1 month
• May 14, 2019

For Depression "I have been struggling with depression and anxiety for 4 years. I used trintellix helped me a lot with memory and anxiety but I was extremely flat for emotions, I then started modafinil and got a huge improvement. Then I was changed to methylphenidate 20 mg ER and the trintellix was reduced to 10 mg. I was using B Vit combo includes methyl folate and methylcobalamine, I suspected it make me anxious but one of my friend told me that it gives extreme energy on high dose so I started 10 mg Methylfolate on first day I was so happy in the morning in the afternoon I was extremely angry yet felt powerful. A friend recommended that I should use niacin with it, so I added 500 mg niacin. Now I cry when listen music or reading what I like. It gives huge boost to methylphenidate, also anger went away when I added niacin I feel emotions so deep and cry with happiness. I am not hyperactive anymore but I have high energy levels, I can go work, then the gym after meet with friends and slept like a baby. I hope this will not change in time."

• JDmom...
• Taken for 1 to 6 months
• January 12, 2015

For Depression "After YEARS of depression & anxiety I'd been on countless combinations of medicines. The past few years severe health problems (open heart surgery @ 37 and a bowel resection @ 39 over 200 days in hospital) have contributed to the lowest lows of my life. I've spent the vast majority of the past two years in pajamas. EVERYTHING felt overwhelming. Living a normal life again seemed impossible. I had absolutely NO energy & believed I'd feel tired forever which made me sad all the time. After adding Deplin to the Celexa I've been taking for years, I am amazed by the results. It's been like flipping a switch in my brain. The darkness has been flooded with light. I have the motivation to live life again. Deplin is nothing short of a miracle!"

• stgecko
• Taken for less than 1 month
• February 4, 2015

Deplin (l-methylfolate) for Depression "I've been using antidepressants for quite a few years now. I seem to have gone through the entire list of antidepressants. My latest script is Escitalopram Tabs, 10mg. We recently added Abilify and this Deplin Caps, 15mg. I've been feeling a bit better. One of these two give me an awful case of Heartburn! Painful it is. I'll mention it during my next appointment. Now, as before, I can't watch anything with intense emotions as I'll breakdown and start crying. At age 52 I find it a bit annoying. Before I added these last two medicines I found myself crying more frequent than not. The movie "UP" really freaked me out. Anyway I'm disabled with intractable pain. That's what started all the depression stuff."

• RAOBA...
• Taken for 6 months to 1 year
• February 27, 2017

Deplin (l-methylfolate) for Folate Deficiency "After a suprise DNA test done by my Primary Care Doctor I recieved a call from the distribitor of this so called Vitamin and the caller tried to pressure me into auto shipments of prescription before I ever received my DNA results my Doctor. My Doctor had shared my DNA results with the makers of Deplin before sharing them with me. Deplin 15 caused extreme bloating and pain twice resulting in cracked ribs, sternum etc. I now suffer from shallow breathing and have a lump in my chest where my sternum bone broke with damage to my rib cage and struggle to breath deeply though my lungs are clear. My Ox levels have dropped my 5 % over the past year and I was fired by my Doctor that caused this when I refused to keep taking it. Kick backs?"

• Pay...
• April 21, 2017

For Depression "As mentioned in other reviews Deplin is designed to augment other medications to increase their efficacy. All Deplin is is L-methylfolate packaged as a Prescription medication by Drug manufacturers to make money on a supplement that is readily available for much less cost. If you are paying more than $30/month check out other brands It sells L-Methylfolate 15 mg 30 capsules for $30. They also have 7.5 mg capsules. Methylpro is not a generic Deplin. Methylpro is L-methylfolate. Deplin is L-Methylfolate. No difference. Naturopaths and savvy Doctors (not the medication only white coats) have been using L-methylfolate years and years before it was packaged as an expensive prescription "drug". Do your homework, save money and stick it to the man"

• sting...
• September 29, 2009

Deplin (l-methylfolate) for Depression "I have had partial response to my antidepressant. I have had a hard time finding one as my chemistry responds unfavorably to many drugs. Deplin was advised by my Doctor who has actually participated in clinical trials. She had seen no adverse effects and thought it would work great for me. On 3rd day I felt like my old self for first time in 1 year. Unfortunately, that night I had auditory hallucinations... first time in my life... and a very restless night. Went off and slept okay. Tried just doing folic acid and Vitamin B6 and had the same response, only worse. Didn't sleep the whole night. Both my Psychiatrist and Psychologist say I am the only person who they have ever seen have a negative reaction. Like I said, I felt great. Good luck."

• Laura...
• Taken for 1 to 6 months
• May 31, 2017

Deplin (l-methylfolate) for Depression "I started this supplement with high hopes. I was given it to boost the effectiveness of the Pristiq I'm taking. After using it for over a month I'm disappointed. Really have experienced no change. I'll keep searching for the right combination of meds."

• Steve
• Taken for 1 to 2 years
• November 6, 2023

For Borderline Personality Disorder "It was recommended to me when a genetic test indicated I had mutations in both sides for the MTHFR gene. I started taking 15 mg/day and within the first two weeks there was a profound improvement. In fact, I'd only filled one two-week pill caddy and forgot to fill the second, so I accidentally stopped taking it after 14 days. On day 16, I had the worst day I'd had in weeks, and on day 17, after realizing what happened and resuming, I felt good again. I have been taking it since January 2022, almost two years, and these have been the most BD symptom-free of my adult life. I think I should stock up enough to last the rest of my life. If the world goes to hell and I can't get meds anymore, LMF is the one I don't ever want to run out of. The only side effects are related to intestinal processes that could just as easily be caused by the Metformin and aren't anywhere near as bad as the positive effects are good."

• Seeking
• Taken for less than 1 month
• December 16, 2017

Deplin (l-methylfolate) for Depression "MUST take Deplin and not a generic and definitely not over the counter folic acid or folate! These can make things worse! My C spinal fluid showed that I have a less prominent type of folate abnormality. Wasn't detected in a gene swab test. Anyway, just started taking 15mg as an Anti-depressant add-on. Made my depression & anxiety worse!!! I would stop taking it, but my doc has me taking a lower dose as she recognizes that Deplin can cause a worsening of symptoms in certain folks. It just needs to be started low and gradually increased. So, please start with a low dose if it makes you MORE anxious/depressed at 15mg. Too early to say it helps, but the lower dose is needed, to start, for some. And it may take many months to work--for some!"

• Jonat...
• Taken for 2 to 5 years
• February 26, 2020

Deplin (l-methylfolate) for Depression "I took this for a while at the recommendation of my psychiatrist. I have the double mthfr mutation. It did nothing for me and is prohibitively expensive. I’m not sure if I buy into their mthfr serotonin theory, but it seems to work for some. For me, I would get these weird sensations in my hands and feet, almost like they were heavier or more sensitive, and I felt like my sleep was less restful (even I got 8 hours consistently) because I was always tired. It made me feel off as well, but I assume that is just depression medication in general."

• Cindy...
• July 14, 2009

Deplin (l-methylfolate) for Depression "I've been on Deplin for 20 days now, along with Zoloft. I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100) so I had to go off it. I was put on Zoloft as a stop gap, but have tried it in the past without much success, as with all the others. They say it can take 4-6 weeks before Deplin has its full effect. I'm still hopeful, but I do so wish I'd seen the overnight change like others. "

• pjano
• Taken for 1 to 6 months
• September 19, 2018

Deplin (l-methylfolate) for Folate Deficiency "I started taking klonopin after several years of depression, 2 bouts of major depression, and Tension myositis syndrome (TMS). It helped the TMS a great deal but after about a year symptoms of major depression and anxiety returned. The Psychiatrist wanted to prescribe more klonopin and when I declined that, she recommended Deplin. Deplin has helped. I now am able to wake up in the morning and speed of thought is almost normal. I still have mood instability but symptoms have decreased. I also have been able to significantly reduce use of klonopin and hope to be off it completely as Deplin therapy continues."

• Julz
• October 24, 2019

For Depression "So, I've been on a litany of meds for 40 years. I have BPD1, major depressive disorder with psychotic features. I sometimes have delusions and hallucinations. Both suicidal and homicidal ideations. This has been utterly unbearable because no antidepressants or antipsychotics have ever helped me. The antidepressants cause me to feel suicidal. About a year ago, doctor gave me Deplin. I take it when I need to and it works. Just 3 days ago, I felt suicidal and was hearing the voices inside my head. Day 3 of Deplin and I feel better again. I only use Deplin and nothing else. Yes it's tough managing the other symptoms by myself but they're nothing next to my depressive episodes. All I can say is that L-methylfolate is helping me. It is the only thing that has ever helped. There are some side effects like palpitations, insomnia and some restlessness but I don't care."

• Lynne...
• Taken for 1 to 6 months
• September 18, 2022

Deplin (l-methylfolate) for Depression "I took Deplin during a former depressive episode but in a much smaller dose. I cannot say if it helped with the effects of depression. During this episode my doctor recommended tailgating 15 mg. I was taking Deplin for 3 months. I was having unbearable anxiety and began looking carefully at the side effects of my meds. Deplin can cause severe anxiety along with other negative side effects. There is an article online called ‘ Anxiety Nutrition Solutions’ by Trudy Scott with Dr. Benjamin Lynch. He is a major supporter of methyl folate. He talks in the article about the different side effects patients can experience on Deplin, severe anxiety among them. If you’re taking Deplin and are feeling anxiety, please read."

• Anonymous
• October 10, 2009

Deplin (l-methylfolate) for Depression "I am hearted by the 6 reviews. I have just started on Deplin. I have been on Remeron for two years. I cannot tolerate serotonin type medicines such as Prozac, Lexapro. Remeron worked beautifully at first but effects have slowly worn off and my anxiety and mild depression returned. I pray Deplin will work for me and I can regain my enthusiasm and joy in life. I am happy for those of you who have been helped. Wish me luck."

• Lucy
• October 24, 2019

Deplin (l-methylfolate) for Folate Deficiency "I am 66 years old and have suffered from ADD, depression, brain fog, fatigue, extreme anxiety all my life. 30 years ago I was put on Dextroamphetamine 3-4 times a day, and it was a miracle. I came to life, both physically and especially mentally and I slept wonderful. Now that drug has little to no effect on me. My doctor, after doing a gen test on me, says I have a gene mutation and prescribed Deplin for me. At first I felt nothing, now 2 months later, I feel a difference. Not a huge difference."

• Rose
• Taken for 1 to 6 months
• August 14, 2018

For Depression "I’ve been on so many antidepressants. None made me feel great. Improved the depression for a while then poop out. Or the dose was raised and had no emotions at all. I started Enlyte. I’m in month 3. It’s subtle and gradual for me. But I’m napping less. Back to reading and doing art work again. I feel much less of the “ugh this is too hard” I’m putting one foot in front of the other on automatic instead of such a forced effort. Well worth the $30 a month. I don’t miss any work as work is less of a drag so it pays for itself. I’m living my life for the first time since I was a teenager. At age 60!"