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Guaifenesin / pseudoephedrine and Tremors: What Users Say

Brand names: Mucinex D, Mucinex D Maximum Strength, Congestac, Decongest II, Ambifed-G, Guaifenex PSE 85, Deco-D, Mucus D, Coldmist Jr, ExeFen, Mucus Relief D, Entex PSE, Nalex CR, Mardrops-EX, Poly-Vent IR, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Fenex-PSE, G-Phed, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Guaivent PD, Guaibid D Pediatric, Eudal SR, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Desal II, GP 500, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Ami-Tex PSE, Ru-Tuss DE, Guaifenex RX Guaitab Guiatuss PE Degen II Guaivent (Ethex) Tusnel Pediatric Drops Altarussin PE Sinutab Non Drying Robitussin Severe Congestion Humibid GC Guaifenex GP Dynex ExeFen-IR Durasal II Guiadrine PSE Guiatex II SR Coldmist Drituss GP Coldmist LA Guaifenex PSE 80 Aldex GS Despec-SR Maxifed Ambi 60/1000 Ambi 60/580 Ambi 80/780 Aquatab D Dose Pack …show all brand names

Tremors: mentioned by 15 users (5.8%)

Based on user experiences from 257 Guaifenesin / pseudoephedrine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

insomnia 28.0%
anxiety 21.4%
increased heart rate 9.3%
tremors 5.8%
dizziness 5.4%
nausea 5.4%
drowsiness 5.1%
cough 3.9%
dry mouth 3.5%
tiredness 3.5%

Reviews for Guaifenesin / pseudoephedrine

Showing 15 reviews tagged with "tremors". Clear filters to view all 257 reviews.
Commonly mentioned side effects
  • Bre...
  • Taken for less than 1 month
  • February 2, 2020

For Cough and Nasal Congestion "I have been laying here all night after taking Mucinex D. My brain won’t shut down. I am wide awake. Mucinex D does help with nasal congestion. I do not have the jitters or the racing heart. After reading the other reviews, I know now why I can’t sleep. UGH!"

7 / 10
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32 Report
  • Jmi...
  • Taken for less than 1 month
  • February 9, 2014

For Cough and Nasal Congestion "I've been plugged up literally for years and had found no relief until now. I had tried everything from frequently rinsing my sinuses with a neti pot system to prescriptions such as Nasonex, warm/moist heating pads, other over-the-counter medicines, etc. At this moment, I feel pretty great. I took my first Mucinex D tab yesterday late afternoon and my second one this morning. My nose feels completely clear, the pressure behind my eyes is gone, my head feels normal for once... even my ears feel less plugged and are not clicking and popping nearly as much as usual. I'm surprised I have not had the insomnia and jitters that it seems most others have experienced. No unpleasant side effects so far. I highly recommend this! The relief is worth the $$."

9 / 10
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41 Report
  • k8f...
  • Taken for less than 1 month
  • October 10, 2015

For Cough and Nasal Congestion "Started taking this a week ago because of terrible congestion in my head and chest along with RX Tessalon Perles. I'd taken something years before with the same ingredients as Mucinex that helped immensely and thought that the money was worth it. I've been on it a week, every twelve hours, and haven't been able to sleep more than five hours a night (about 4 a.m. after taking it at midnight until 9 a.m.). I still have terrible congestion with heavy thick mucus. Just finally realized about thirty minutes ago that the Mucinex is the only change. I can't rest, and with the added jitters and insomnia, I feel worse than before. I wish I hadn't taken it to begin with."

1 / 10
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26 Report
  • Man...
  • Taken for less than 1 month
  • April 6, 2019

For Cough and Nasal Congestion "Calmed that annoying every 30-second cough, but I barely slept a wink! I'm really happy to have relief from the cough, so I can't complain too much. No jitters or anxiety - but I'm up at 5 a.m. googling 'does Mucinex DM keep you awake' lol it does absolutely keep you up, it is the pseudoephedrine ingredient. I wouldn’t recommend the nightly dosage if you want to sleep at all, just in the morning. Had quite a few hot flashes as well. Kept wanting to turn the air conditioner down lower than ever?"

8 / 10
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18 Report
  • yaw...
  • January 16, 2014

For Cough and Nasal Congestion "Bad case of bronchitis and sinus pressure. I took Mucinex DM, 1 pill every 12 hours, for a week. I would fall asleep fine but wake up 3-4 hours later and could not get back to sleep. I ran out of DM, and for the last few days took the Mucinex D instead. Not much sleep the first night, NO sleep at all last night combined with a lot of post-nasal drip and the jitters. So glad I finally figured it out, as I'm a walking zombie right now. I will never take Mucinex D past the morning hours again."

8 / 10
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22 Report

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  • mad...
  • Taken for less than 1 month
  • February 8, 2020

For Cough and Nasal Congestion "Thankful I found this site to calm my nerves. I took Mucinex D around 11 PM and fell asleep for about an hour, woke up to my whole body shaking. Of course, started to think of the worst, so made the shakes worse. Then realized it was a part of the side effects of Mucinex D. I will no longer be taking."

1 / 10
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10 Report
  • mol...
  • August 1, 2017

For Cough and Nasal Congestion "For those experiencing nervousness and jitters, just keep in mind pseudoephedrine is a stimulant drug similar to amphetamine and methamphetamine. All cold drug names with a 'D' after them have pseudoephedrine, so get the same drug without the 'D' in its name."

5 / 10
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13 Report
  • The...
  • Taken for less than 1 month
  • December 15, 2015

For Cough and Nasal Congestion "My mom caught the cold I have just beaten, and it affected her much worse. After consulting a doctor/friend, she recommended trying Mucinex 12 hour. At around 7 PM, she took two 600 mg tablets. She reported being awake all night with heart palpitations, jitters, and a pounding headache. She also threw up in the middle of the night and feels nauseous again this morning. The cough is coming back as the Mucinex wears off. The drug worked to stop the coughing, but the side effects can be hard on some."

1 / 10
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12 Report
  • Yen...
  • Taken for less than 1 month
  • August 8, 2022

For Cough and Nasal Congestion "I took this around 9 PM, it is now 4:26 AM, and I have not been able to sleep at all! I have extreme dry mouth and jitters. I really wish this was specified on the box or mentioned by my doctor. I just want this out of my body! I will NOT be taking this again. This is just a reminder of why I typically DO NOT take medicine."

1 / 10
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2 Report
  • So...
  • Taken for less than 1 month
  • December 30, 2017

For Cough and Nasal Congestion "I took one around 7:30 at night, and I’ve probably slept a few hours. I already have bad anxiety and a panic disorder, so this just pushed my anxiety through the roof. My nose feels so much better, but having this feeling is not worth it at all. I have the jitters, heart racing, and almost full panic attack. For others with this problem, I don’t recommend taking it at night and just be super cautious during the day. I’ll be staring at the wall for the next couple of hours, waiting for this to pass."

4 / 10
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3 Report
  • Sni...
  • Taken for less than 1 month
  • January 6, 2016

For Cough and Nasal Congestion "I've had pretty bad sinus congestion start and bronchitis is going around my family, so I immediately got on Mucinex. The regular Mucinex wasn't doing anything for me (blue box). I bought the maximum strength D, and it's been a game changer. I can breathe through my nose, and I don't feel plugged up at all. I had no trouble sleeping last night, BUT I also have to take melatonin to sleep every night, so maybe it offset the jitters some people report. I'm very happy with it. I will keep taking it until this is gone."

9 / 10
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2 Report
  • Jul...
  • January 22, 2018

For Cough and Nasal Congestion "I took it at about 5 PM today when my cough was getting worse. It is now 5:30 AM, and I haven't slept one bit. I am so jittery, nauseous, and dizzy. My heart is racing, and my whole body is shaking. My cough is significantly better, but the fact that I will not be getting sleep tonight for even a minute is quite the turn-off. I will never take this drug again."

1 / 10
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1 Report
  • Moi...
  • January 10, 2015

For Cough and Nasal Congestion "Helped somewhat with congestion, but I could not continue to take it due to insomnia (even after taking it during the day), jitters, dizziness, and anxiety."

4 / 10
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27 Report
  • Anonymous
  • February 10, 2012

For Cough and Nasal Congestion "Great stuff. I didn't get the jitters, though I can feel a little extra buzz in there. Finally, after weeks of stuffiness and coughing, I am quiet this afternoon. 10 stars!"

10 / 10
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11 Report
  • Mit...
  • December 16, 2017

For Cough and Nasal Congestion "This medicine cleared my nose but also made me feel dizzy, gave me tremors, nausea, and made my heart pound. I felt awful after taking this and wouldn't recommend it to anyone."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.