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Guaifenesin / pseudoephedrine for Cough and Nasal Congestion User Reviews (Page 4)

Brand names: Mucinex D, Guaifenex PSE 85, Entex PSE, Entex T, Guiadrine PSE 120, Sinutab Non Drying, Mucinex D Maximum Strength, Nalex CR, Mardrops-EX, Congestac, Poly-Vent IR, Despec-Tab, Guaimax-D, Anatuss LA, Fenex-PSE, G-Phed, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Guaivent PD, Guaibid D Pediatric, Eudal SR, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Decongest II, Desal II, Deco-D, GP 500, Guaifed-PSE, Guai-Vent/PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Ami-Tex PSE, Mucus D, Ru-Tuss DE, Guaifenex RX, Guaitab, Guiatuss PE Degen II Guaivent (Ethex) Tusnel Pediatric Drops Altarussin PE Robitussin Severe Congestion Humibid GC Guaifenex GP Dynex ExeFen-IR Durasal II Guiadrine PSE Guiatex II SR Coldmist Drituss GP Coldmist LA Coldmist Jr Ambifed-G Guaifenex PSE 80 Aldex GS Despec-SR Maxifed ExeFen Mucus Relief D Ambi 60/1000 Ambi 60/580 Ambi 80/780 Aquatab D Dose Pack …show all brand names

Guaifenesin / pseudoephedrine has an average rating of 6.1 out of 10 from a total of 232 reviews for the treatment of Cough and Nasal Congestion. 48% of reviewers reported a positive experience, while 28% reported a negative experience.

Reviews for Guaifenesin / pseudoephedrine

  • Amber
  • September 20, 2016

Mucinex D (guaifenesin / pseudoephedrine) "Took this with food. Made me feel very lethargic and jittery at the same time. My appetite is gone. My congestion is cleared but I can't wait for this medication to wear off. My heart rate speeds up as well. Dry mouth, yuck."

4 / 10
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  • Joyous
  • December 31, 2012

Mucinex D (guaifenesin / pseudoephedrine) "This worked well for me. I had what felt like a pretty bad cold....headache, nasal and chest congestion and generally run down feeling. Stayed in bed the first day and on the second I took the prescribed dose of Mucinex D - 2 tablets at 7:30 pm. I didn't experience the insomnia others spoke of, but maybe my perspective is different, because I KNOW that if I hadn't taken it I'd be up blowing my nose and coughing all night. Yes, I did wake up a few times more than usual, but I wasn't miserable when I did."

10 / 10
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  • Cano
  • March 16, 2019

Mucinex D (guaifenesin / pseudoephedrine) "I took this for some relief of nasal and chest congestion. Let me warn you do not take it, as within a half hour my heart was racing and I was jittery and anxious. On top of it it made me sick to my stomach and I feel like someone is sitting in my chest. I can’t quench my thirst. No matter how much water I drink. I hope this feeling doesn’t last the entire 12 hours. This is horrible. I will never take this again and this should be removed from the market"

1 / 10
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  • Kurt...
  • November 15, 2016

Mucinex D (guaifenesin / pseudoephedrine) "Took first dose at 8:30 am and went to work. Definitely cleared me up so, as directed, took another dose at 12 hours (8:30 pm) and went to bed feeling tired. As medication took effect, I became restless and tossed and turned and found myself unable to sleep. 1:30 am and I'm learning of my mistake. Packaging should definitely be updated to disclose this fact. Works great to clear sinuses but I won't take again at night due to side effect of insomnia"

7 / 10
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  • Thank...
  • October 10, 2018

Mucinex D (guaifenesin / pseudoephedrine) "I took Mucinex D last night because of slight congestion. It’s currently 4 am and I have the PSAT in 4 hours. I’m wide awake with my heart pounding and ears rushing. Thought it was the the worst case of test taking anxiety I’ve had but alas, it was the Mucinex ( the pseudoephedrine part). I do NOT recommend this for night use."

2 / 10
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Are you taking this medicine?

  • Shiroh
  • August 20, 2009

Mucinex D (guaifenesin / pseudoephedrine) "For years I had earaches and dizziness. Doctors told me that the drainage in my ear is messed up but tubes would not fix it as I'm past the age. One nurse practitioner put me on Mucinex D and it worked like magic. I use it only as needed."

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  • Anonymous
  • Taken for less than 1 month
  • October 26, 2018

Mucinex D (guaifenesin / pseudoephedrine) "I have an insanely bad cold and my sinuses are so stopped up I took this thinking it would bring me some relief. It sure did, along with anxiety and feeling like I was cracked out of my mind !!!! Now I’m sitting here at 12AM reading everyone else’s reviews when I have to go back to work tomorrow after 2 days off ... ugh. No one told me the pseudoephedrine would make me so wired!"

5 / 10
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  • Anonymous
  • February 22, 2012

Mucinex D (guaifenesin / pseudoephedrine) "I took the medicine in the morning. I can finally take a deep breath! I have had sinus congestion issues for years, and I wish I would have known about this product much sooner. Its awesome. I only took one pill and I am 6' 4" 270lbs and that seems to me fine for solid relief."

9 / 10
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  • QT PI
  • December 10, 2013

Mucinex D (guaifenesin / pseudoephedrine) "Yep, I took ONLY 1 Mucinex D almost 24 hours ago for the 1st time and I'm still up. During the 1st 12 hours I didn't sleep a wink because I took this pill right before bed. My nose was dripping the whole night. This thing definitely unclogged my sinuses without the uncomfortable burning sensation of inhaling and the pain behind my face. My sinus relief lasted the whole 12 hours! I kept thinking it would wear off sooner. Throughout the day I haven't stopped sneezing and it's a scary sneeze, as in a loud scream, I've been scaring people all day. This is not my normal/typical sneeze. I usually sneeze like a silent little bunny! This is how I found this website to find out what this sneezing is all about. Doctor prescribed."

9 / 10
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  • all...
  • March 10, 2015

Mucinex D (guaifenesin / pseudoephedrine) "I’ve been coughing for days (unable to sleep because of the cough), can’t breathe through my nose and have a congestion headache. Took 2 pills in the morning and it took a while to kick in but several hours later I realized I could actually take a full breath through my nose, headache improved, still coughing but not quite as bad. I didn’t have any issues with feeling jittery or wide awake."

9 / 10
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  • Helped...
  • March 31, 2016

Mucinex D (guaifenesin / pseudoephedrine) "It dehydrates you like crazy and I could not drink enough liquids. My throat got so dry it caused me to cough uncontrollably. For the past 3 nights I could not sleep... Even took 10mg of Ambien which usually knocks me out cold.... But it didn't work. I just found this site and learned that my insomnia is caused by mucinex d. Not worth the lack of sleep!"

5 / 10
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  • Anonymous
  • September 6, 2010

Mucinex D (guaifenesin / pseudoephedrine) "I am definitely feeling better as far as not being congested goes. However, I am writing this at 4:52am because I have not been able to sleep all night long. I took the medicine at about 8pm so I probably won't be doing that again."

8 / 10
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  • sluggo
  • January 5, 2017

Mucinex D (guaifenesin / pseudoephedrine) "Have taken Mucinex D several times over the past few years with congestion. It is the best thing out there to make me feel better during the day but I only take it in the morning with food. Even then I usually don't sleep great at night but do not experience the insomnia others are talking about"

8 / 10
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  • Zany
  • Taken for less than 1 month
  • August 27, 2013

Mucinex D (guaifenesin / pseudoephedrine) "Absolutely amazing! My partner and I have nasal congestion for weeks but 10 minutes after taking one, we coughed and all of a sudden were clear! I feel like I haven't used the bottom half of my lungs in weeks. A little bit expensive. "

10 / 10
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  • Grate...
  • Taken for less than 1 month
  • February 24, 2020

Mucinex D (guaifenesin / pseudoephedrine) "This is Amazing!!!! I was miserable, sinus pressure, headache, stuffy nose, sneezing , coughing up phlegm, and had no sleep because of the cough, I asked the pharmacist what she recommended and this was it , I took it at 12 pm it felt a little better 1 hour in , then my cough was very minimal, then my cough was obsolete, no more stuffy nose, sounded a little congested still , and became very sleepy I was not able to stay awake , this was closer to 9 pm, then I woke up at midnight to take the second dose , it’s been two days and I’m back to myself , I’m amazed. The weird part is that I didn’t get the insomnia or energy other reviewers or the pharmacist have said lol so this is a different affect on everyone , I’m extremely satisfied with the help it gave me ! I advise to be specific about the issues you are experiencing so that you can get the right medication since there are so many different versions of this. Good luck on your recovery"

10 / 10
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  • Shawa
  • November 24, 2016

Mucinex D (guaifenesin / pseudoephedrine) "I took mucinex the capsule as directions state to help me with severe congestion the night before Thanksgiving. After reading the reviews I must say it had the opposite effect on me, it made me tired. The best way for me to describe it was I get like I took a muscle relaxer but not as strong. Just made me feel slightly weak and needed to sleep. Although, definitely helped relieve my symptoms from being congested such as my headache and cough. So for my sake I would want to take it at night and definitely not have to drive anywhere. I am not one to take medication or any drugs for that matter."

9 / 10
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  • Saint
  • Taken for less than 1 month
  • April 6, 2019

Mucinex D (guaifenesin / pseudoephedrine) "Used Mucinex D. Followed the directions and six days later I was admitted to the hospital. My pulse was at 171. The first doctor wanted to stop and restart my heart! I am a healthy, active female with none of the medical conditions listed on the DO NOT TAKE list on the Mucinex D box. Medical bills are over $5,000 so far. Not including the Stress Test and time off from work. Don’t gamble with your heart, stay away from Mucinex D."

1 / 10
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  • Momok...
  • March 17, 2017

Mucinex D (guaifenesin / pseudoephedrine) "Followed directions & took 2x Mucinex D 1200mg at 930PM. Decided to pick this up after bring sick & out of work for 5 days. I was really tired & dozed off at 1130PM. Its 330AM, I can't sleep... I'm wide awake with an extra dry mouth, swelling of the tongue, slight nausea, tossing & turning (anxiety?), tingling/weakness in my arms. Most of my cold symptoms are gone(amazingly!), but I can't shake these side effects right now & am wondering exactly when I'll be able to sleep! I would NOT recommend taking this at night time, & if you are going to try this stuff to start with just 1 pill."

5 / 10
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  • Tired...
  • February 19, 2017

Mucinex D (guaifenesin / pseudoephedrine) "This stuff is torture! I was coughing a little and had some allergy congestion the pharmacist recommend this stuff. Its 2:00 AM I took two pills at 3 in the afternoon and I have been coughing my lungs out ever since. I'm literally coughing so hard I'm sweating and have a headache I feel edgy and there is no hope of getting sleep tonight."

2 / 10
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  • Anonymous
  • March 23, 2010

Mucinex D (guaifenesin / pseudoephedrine) "This medication cleared my completely congested nose in about an hour. I could breathe perfectly clearly through both nostrils! However, as others have mentioned, it made my heart race, and when I was exercising later that night, I felt lightheaded and had to quit early. I also couldn't sleep that night. My heart was feeling very fluttery and I was wide awake in bed. "

7 / 10
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  • J2019
  • Taken for less than 1 month
  • January 7, 2019

Mucinex D (guaifenesin / pseudoephedrine) "After being diagnosed with Bronchitis I took the prescribed dose of 1200mg at 11:30 it is AM, it’s now 3:07 am the next day and I am still not able to go to sleep! Thank God I did not take it every 12 hours as recommended I would be going crazy like the other reviews! So nervous about if I will be falling asleep at work or still wide awake in a few hours. NO REST in sight. I guess it is the pseudoephedrine in it that is keeping me awake."

1 / 10
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  • googled
  • April 20, 2012

Mucinex D (guaifenesin / pseudoephedrine) "My PCP suggested I take this to help with severe congestion. I took 3 doses of the 12 hours (max strength) at the prescribed intervals. Basically one that afternoon, then one the next morning and one that evening. That night I COULD NOT SLEEP. I have never had problems sleeping, and usually could find some way to read for a bit or do a relaxation exercise in the event it took longer than normal. I'm normally asleep by 10 or 11. It's now 4 am, I am not one bit sleepy and I have to get up for work in 2 hours. Should be an interesting day."

3 / 10
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  • Anonymous
  • October 14, 2011

Mucinex D (guaifenesin / pseudoephedrine) "I have severe sinus problems all year long, but worse in the fall. The pressure pain is almost unbearable. My doctor has prescribed everything under the sun to help relieve the symptoms and nothing works better than Mucinex D. I never have any drainage with my sinuses...just the pain/pressure and I can get almost immediate relief after I take 1 bi-layer tablet (1200mg guaifenesin and 120mg pseudoephedrine). The medicine says it has an immediate release layer that works quickly and it does. Then it has an extended release layer that works over the next few hours. I also have the side effect of insomnia, but it's so worth it to relieve that sinus pressure (those of you who have it know what I'm talking about!)."

9 / 10
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  • Mike...
  • Taken for less than 1 month
  • June 30, 2017

Mucinex D (guaifenesin / pseudoephedrine) "Had congestion for 3 weeks. Doctor gave me anti-biotics and suggested mucinex D twice a day. First two days seemed to help congestion somewhat but was no appetite and somewhat anxious. Third night took at 11pm and slept about 2 hours. Woke up with heart racing and anxiety. I couldn't sleep and was pacing. Effects starting to wear off at 10am. Wish I had seen this site first."

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  • Anonymous
  • December 5, 2011

Mucinex D (guaifenesin / pseudoephedrine) "I have experienced fluid in my ears for almost two years. Consulted with two ear and nose specialists and with an allergist. Tried three types of nose sprays and other natural options, like additional vitamin C , pollen defense and the neti pot. Nothing worked until just recently I developed a severe cold and took Mucinex D. To my amazement and happiness the fluid drained from my ears. Clear ears! Problem - one cannot take Mucinex on a permanent basis."

8 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.