Mavyret and Upset Stomach: What Users Say

• Deb...
• Taken for less than 1 month
• January 29, 2020

For Hepatitis C "I just finished one month of treatment on Mavyret, and the side effects are definitely easing up. The effects at first were harsh: flu-like symptoms, fatigue, tummy ache, fogginess, and probably the nausea was the worst of all for me. (I suffer from migraines, so I’m more sensitive to nausea), but it’s lessening as I enter into the second month. I go for a first-month checkup on Monday, so I’m hoping things are looking good. Do the treatment, your health is the first priority. You will get through this, and once you're hep C free, this will be a distant memory. Good luck, fellow patients!!!"

• Jun...
• Taken for 1 to 6 months
• February 6, 2018

For Hepatitis C "Just finished 8 weeks on Mavyret, few headaches, but I had nausea all the way through and really bad stomach problems. It didn’t seem to matter if I’d eaten little and often. I struggled eating properly at all in the whole 8 weeks. But now I’m done, I’m feeling better in myself, more energy, just generally well for the first time in 15 years. I have type 2 diabetes and it didn’t interfere at all. So grateful."

• Dan...
• Taken for 1 to 6 months
• March 18, 2018

For Hepatitis C "During the 8-week course, I had some nausea, stomach issues, fatigue, and tiredness. I took the 3 pills regularly at 7 PM with my dinner meal. My blood work showed the virus was undetectable after 2 weeks. At completion, I did not regain my energy and needed to rest in the morning and again tired in late afternoon, gradually, within 2 months, the fatigue got worse, and I have an achy neck and shoulder. The virus is still undetectable, so why am I still feeling tired?"

• SM8...
• February 15, 2018

For Hepatitis C "Took 8 weeks. I am on hemodialysis. No other meds except for a phosphorus binder with meals. BW shows no virus in my system at the end of treatment!! Worst side effects for me: fatigue (horrible, almost impossible not to take naps during the day); slight headaches (I normally never have them); stomach cramps, which became worse as treatment progressed, a constant gnawing pain in the belly accompanied by some nausea (best to take dose on a FULL stomach - yogurt and cereal in the a.m. is NOT enough); cloudy mind, no motivation, moderate depression, living in a 'dreamworld' (this was the worst for me and kind of slips in and takes you over, a feeling of never waking up from a dream, left of center, distanced from everyone, irritable, somewhat hopeless). Lastly, I had looser stools than normal and a lot of flatulence along with night sweats and tingling skin at times, which included numbness in both arms often when sleeping. BUT all that said, I am SUPER HAPPY I did this. It was worth the eight weeks of 'hell.'"

• Cur...
• Taken for 1 to 6 months
• February 28, 2020

For Hepatitis C "Started my week 8 today. Very little side effects. First couple of days had an upset stomach, but I found if I grazed a little all day, I got rid of all stomach upset. A little tired and achy, but so worth it. I am now Hep C free. Bloodwork on week 4 was clear."

• Pen...
• January 31, 2018

For Hepatitis C "Currently on week 3. The first few days, I was very tired and had the worst headache, but once your body adjusts to the med, the side effects diminish. I learned that I took Mavyret best with my biggest meal of the day. Every person is different, but for me, taking it with just a slice of toast or a bowl of cereal wasn't working out in a good way. It gave me horrible stomach issues. This week, I noticed that I have much more energy. I feel great overall. Forgot to mention that I also take several other meds for PTSD and depression: Prozac, Wellbutrin, Effexor, Topamax, Minipress, and Vistaril. No drug interactions and no weird side effects. Mavyret is definitely worth the try. Every person is different, but so far in my journey, I say it's a true blessing."

• Ban...
• Taken for 1 to 6 months
• November 18, 2018

For Hepatitis C "Have 2 genotypes as it has mutated. My hep C I have had for 30 years. I am a 45-year-old male and have started Mavyret 4 days ago. I have noticed side effects: thinning of hair, pale skin, no energy, irritability, depression, sore stomach, vomiting, itchiness, hot and cold flushes, but hopefully I will beat this disease."

• Mea...
• Taken for less than 1 month
• December 9, 2020

For Hepatitis C "I have had hepatitis C since 2013, and it is now 2020. I started Mavyret 4 weeks ago, and my blood work from the third week mark showed my chronically high AST and ALT levels have normalized drastically. On top of that, my viral load went from 650,000 to 15, this is an amazing medication. The first two weeks, I had diarrhea, a pounding headache, stomach discomfort, and major fatigue. Fatigue is still an issue. I wish I had gotten this medication sooner, as I have mild liver fibrosis. Don’t wait to get treated for hep C, this medication is expensive, however, there are ways to get treatment without coming out of pocket. Thank you, Optimum Health."

• Emi...
• Taken for 1 to 6 months
• September 15, 2018

For Hepatitis C "So I commented before. After 2 weeks, viral load was 0. 4 weeks, AST and ALT and all blood work normal! BUT, not to be ungrateful, my stomach is jacked up. I have 2 weeks left. I have no energy, nonstop diarrhea and gas, constant headaches (mild). I've found Tylenol helps better than Advil/naproxen. I start a new job in 2 days. I thought about going to the ER today to get a stomach workup. But after reading other comments, it makes me feel better that the kidney/liver gas pain isn't that abnormal. I've also reported symptoms. Say a prayer for energy and diarrhea at the new job, hahaha! Even though I'm clear, I'll definitely keep taking meds to make sure I'm cured!"

• Ell...
• Taken for 1 to 6 months
• December 21, 2018

For Hepatitis C "I'm just into week 4. I'm experiencing severe fatigue, joint and muscle aches, some stomach issues. However, seeing what a family member went through years ago to be treated, I feel lucky. I'm just wondering when this fatigue will improve. I've been worn out and tired for years now and can't wait to feel better."

• Mav...
• Taken for less than 1 month
• August 3, 2018

For Hepatitis C "I just began my 8-week treatment, and the first 2 days I had slight headaches, nothing major. Today is day four, but I have not yet had time to take my fourth dose, and I woke up with chest pains, headache, and stomach cramps. Not sure if all of this is related. The headache is still very light, but I'm more concerned about the chest pain. Has anyone experienced side effects besides the two listed on their website? And I'm so tired all the time!"

• Ash...
• Taken for 1 to 6 months
• June 21, 2022

For Hepatitis C "I am a 36-year-old female, had hep C 10 years, no liver problems, very healthy. While taking Mavyret, I felt fine, maybe a headache here and there. But I had every bad side effect weeks following the meds. I have severe panic, severe stomach issues. My advice would be to continue eating healthy and chugging water even after the meds are done because they aren't really done. And if you suffer from bad anxiety, ask the doctor for a sedative because you will need it. I have never felt this bad in my life. I have been to the ER multiple times since quitting and can't seem to calm myself, had to take leave from work. My brain cannot handle any stress whatsoever. My first blood panel was clear of hep C, though."

• Lau...
• Taken for less than 1 month
• June 16, 2018

For Hepatitis C "So I am 3 weeks in. I take mine right before bed and woke up throughout the night with diarrhea and would have a weird intense headache in the first week. After that, I felt fine, but today is kind of rough. I missed a dose because I was too nauseous to eat. So I took it this morning, and it’s not going very well. Major stomach issues and vomiting. I may have a stomach bug because it’s very intense to the point I can’t go to work. I just wanted to see if these symptoms are common, and I see they are just not so intense. I have to remind myself how lucky I am to have the chance to take such an expensive medication to change my life, so this is a small price to pay."

• Roc...
• Taken for less than 1 month
• June 20, 2018

For Hepatitis C "Today is my first day with Mavyret, and I'm so very grateful to have this medication, but also nervous after reading about stomach aches so bad that people couldn't sleep and had vomiting. However, then you read much more positive reviews, and that weighs much more, plus possible cure. I'm a tan Italian Jersey boy, used to the beach and nightlife, but getting rid of this hep C means more than anything, just not sure what's the best time to take the three pills once a day. Fingers crossed. Let's get this cure started."

• tbo...
• Taken for 1 to 6 months
• May 28, 2018

For Hepatitis C "I'm on day five of treatment. For the first two days, I had a headache, but not anymore. I am very fatigued, though. Looking forward to my end results!!! Was told not to take my Nexium while on Mavyret, so I'm having bad stomach issues."

• Bth...
• Taken for 1 to 6 months
• June 10, 2021

"I'm a 22-year-old ex-IV drug user. I found out I had Hep C about 2 years ago when I got clean. I was undetectable at my 4-week blood draw, and I just finished my last dose of my 8-week cycle on June 7th. I had a little foggy brain and fatigue my first couple of days taking it, and that was it, nothing to miss work over. My worst side effect was just having to go to the bathroom more often. Since stopping Mavyret, I've had an upset stomach a couple of times, and I'm breaking out all of a sudden (I never really get pimples). I'm just going to assume it's the drug working its way out of my body. Overall, seems to be a great drug, well worth the little side effects I endured! (P.S. Take at night with a snack right before bed.)"

• Mya...
• Taken for less than 1 month
• February 18, 2022

For Hepatitis C "So I started Mavyret 2 days ago, and so far my symptoms have been headache, fatigue, slight confusion, and dizziness. But other than that, it's going okay so far. I'm the type of person that my stomach gets upset very easily if I don't eat or if I work too hard. I need to eat more often, so I'm really hoping that this stuff doesn't mess with my stomach. So far, I haven't been nauseous, and I really hope that I don't get nauseous. But I will come back in 8 weeks when I complete and give an update. Anything is possible, you just got to keep trying."

• Yli...
• Taken for 1 to 6 months
• February 14, 2021

For Hepatitis C "I have hepatitis C, gen. 3. I am a 31-year-old female. I found out I had Hep C when I was pregnant. I had my baby 10 weeks ago, the baby is healthy. I am on day 6 of Mavyret. I have experienced some pretty uncomfortable symptoms so far. Right after I take the Mavyret at night with a meal, I experience dry mouth, extreme fatigue, nausea. The next day I am very tired and have some stomach issues and am very tired. I know it’s worth it to keep going, so I will finish the medicine for the 8 weeks. I just hope there are no lasting ailments afterward."

• Ash...
• Taken for less than 1 month
• May 26, 2022

For Hepatitis C "I am a 36-year-old female and have been diagnosed with hep C for 6 years. I am about 2 days away from finishing my 4th week, so right about the halfway mark. I read someone on here write they have some good days and some weird days, and I couldn't have written that better myself. I can't say I have experienced fatigue, but a general weirdness, and kind of out of it sometimes. I am a single mother of a 4-year-old boy. I work full time in a busy grocery store, and my job is physical and draining. So far, I haven't missed any work. My first week, I didn't feel much of anything, my second week, my anxiety spiked, but so did my energy level. In the third week, my stomach started feeling like it's burning, and constant acid reflux and burning tongue (I have GERD). I do get a weird headache. I eat a large meal and drink tons of water around the clock, take meds at 6 PM."

• Rew...
• Taken for less than 1 month
• June 27, 2019

For Hepatitis C "Had hep C for 15 years. I'm starting week two. Despite stomach cramping, headaches, and fatigue, I am so excited to do this treatment. It's a Godsend."

• Cja...
• Taken for less than 1 month
• May 6, 2018

For Hepatitis C "Day 3, very hopeful. Side effects not so bad. Stomach cramps a little. Minimal nausea. If this is all the side effects, it'll be a piece of cake."

• Don...
• Taken for less than 1 month
• February 23, 2018

For Hepatitis C "Just finished week 4. A headache at times, but the stomach issues are an issue - I have acid reflux - but I get to look forward to a longer life..."