Fluorouracil topical for Actinic Keratosis User Reviews

• Tiny
• Taken for 2 to 5 years
• October 12, 2015

Efudex (fluorouracil) "I am a 70-year-old male who suffers from Actinic Keratosis from exposure to the harsh rays of the sun. Efudex is a fantastic product. It does exactly what is claimed. Make sure that you wash your hands completely after each application. Do not get it on your lips, or you will experience great discomfort (cracked and bleeding lips). Once you have completed the process (twice a day for 21 days), use Hydroval Cream 0.2% to assist in the healing process (works great)."

• Jojo
• October 19, 2019

Efudex (fluorouracil) "I am a 60-year-old with very fair skin and blue eyes who grew up at the beach. I was regularly burned to a blister stage every year. I had many keratosis burned off from age 30 to 50. Finally advised to use Efudex. I have completed treatments on my face 5 times now over the course of these 10 years. I have an unusually mild reaction each time. In fact, I have to use it for 40 days to get the full benefit. So, you never know how your own skin will react. The dermatologists have been amazed at the length of time it takes me to get a reaction. But for the chest area, the reaction is incredibly painful, red, and fast. Maybe the constant freezing of those places on my face helped more than I know? In any case, maybe it could be recommended to try a small area before using on the entire face. The end results are very good and I would not let fear keep you from trying this."

• Cedric
• Taken for less than 1 month
• November 9, 2020

Efudex (fluorouracil) "57-year-old male, brought up in South Africa, lived in Australia, and 30+ years in the military with sunny deployments. Previously suffered two SCCs and Bowen's disease. I'm on day 25 of Efudex treatment, stopped applying the cream after 21 days. My face is very red and itchy; it's amazing how the cream identifies areas of damage. It's been tough at times, sleepless nights with burning/itching. Strangely, when I stopped applying the cream I suffered from stomach acid; unsure if it's related. The biggest challenge is to persevere to the end. I use Aquaphor from Amazon to soothe the itching. Good luck to everyone!"

• Anonymous
• Taken for less than 1 month
• July 29, 2020

Efudex (fluorouracil) "I so appreciate all your comments. I am day 21 of Efudex, and my GP wants me to keep going another week. I am applying it to my nose, hands, and forearms. My nose is a beacon, as is the area around it. Thank goodness for COVID isolation as it couldn’t be happening at a better time. I was going to stop today, but after reading everyone’s experience, I will keep going for another week. Thank you."

• Gdsangl
• Taken for less than 1 month
• September 13, 2019

Efudex (fluorouracil) "Growing up at the Jersey Shore and summers spent at FL beaches, I fell in love with the warmth of the sun and a healthy tan. At 55, the sun made my chest bubble up and my legs reverse tan. It is no surprise that I had actinic keratosis multiplying fast. I was prescribed Efudex 5% for my chest, neck, and face. I had no idea it was topical chemo. What? I googled everything Efudex, bought Aveeno, vanicream, Aquaphor, asked for anxiety meds for my mounting fears, and took a personal leave from work. It's Day 13, saw Dr., I'm done. I did look beat up. In the afternoon, insane itching... tap tap. Many more dead lesions surface and crust up. I'm using cortisone and Aquaphor on the corners and for lesions around my lips. I will be doing this for years to come, peeling back the many layers of damage. It has not been as bad as it was for others. It's uncomfortable yet tolerable and much better than the alternative - the knife or cancer. Oddly, I feel healthier and fortunate to be given this chance."

• nwfmike
• January 18, 2019

Efudex (fluorouracil) "After years of sun damage, my whole face lit up like a Christmas tree full of red lights within 1 week of twice daily application. Shaving: No problem. Use a sharp razor and light pressure with a mild gel cream. Washing: Try Simple Water Boost Micellar facial gel wash. Great stuff. Cleans your face and does not leave it dry or oily. Does not irritate the burning skin. Still use it every day to clean my face. Lubrication: Try Neutrogena Hydro Boost water gel. Not cheap, but you don't need much. Worked great, no greasy feeling. Used a chilled aloe mask at night during last week. Timeline: Should be able to finish in 3 weeks of twice daily. Still pretty bad for a week after treatment with first 2 layers of skin dried up and peeled away. Had another 2 weeks of peelings. After that, skin was super smooth but still red in some areas. Took another month for most of that to fade away. Definitely recommend using Efudex. It's obviously not fun, but produces great results."

• Florida...
• January 20, 2020

Efudex (fluorouracil) "I am grateful for Efudex, although the treatment is quite difficult, because it is effective, comprehensive and empowering! Skin cancer surgeries are another kind of difficult I hope to avoid! I’ve used Efudex three times on my face...the first two weeks are the easiest, the second two are more challenging. Plan to stay at home week 4 and the first week of healing. If you are using around your mouth, it will be hard to comfortably eat and drink. Eat soft foods and use a straw. With supervision, my doctor directed me to use Efudex on my lips, which was the most challenging of all applications! Because lips are a more sensitive area, I only needed to apply for 7-10 days....I made it to 8 and could do no more. No doubt Efudex is challenging to use, but it beats multiple surgeries where hunks of your face are removed! I plan to use in the future where issues emerge....because the “bad” cancer causing cells will keep appearing. And, now I can do something when they do!"

• coolo...
• Taken for less than 1 month
• April 15, 2016

Efudex (fluorouracil) "I was prescribed Efudex to treat various Actinic Keratoses on my forehead and balding front pate. Firstly, my overall rating is that the treatment is very effective, and I now have a beautiful forehead of smooth skin after 2 weeks and 2 days of treatment and 2 weeks of recovery post-treatment. It may be that my skin damage was mild. In any event, I found the process quite bearable. I applied the cream sparingly at night and in the morning, and there was little to see for 3 or 4 days; the skin then reddened and peeled/flaked - no ulceration or discharge. Although unsightly (looked like a bright rash), as a male, I was still happy to go out and socialize. I used my wife's hair colorant plastic protective gloves but still washed hands thoroughly after use. Happy."

• Annie
• Taken for 1 to 6 months
• March 3, 2019

Efudex (fluorouracil) "One of the most painful experiences of my entire life. I thought childbirth was the worst pain I ever experienced, but this pain is indescribable. I'm at 5 weeks now. Hope to come off soon. Just opening my mouth to try to eat is excruciating. My doctor never warned me about any of this, nor did he tell me I was going to look like a monster."

• Lee
• Taken for less than 1 month
• May 15, 2020

Efudex (fluorouracil) "I am on day 15 of the Efudex cream. I was terrified to start. I was actually prescribed the cream two other times and chickened out due to the photos that I had seen on YouTube. I am doing very well so far. It is super tight and red around my mouth, very hard to smile. I have spots all over my forehead and a few on my cheeks. It’s always a shock to see my face in the mirror. But without looking at myself it feels like I put on one of those peel off face masks just tight. So far I sleep just fine. I don’t however use Vaseline I use calendula it’s for burns and has worked well. I have also used makeup when I had to go out in public. It is definitely convenient being in lockdown because everyone is wearing a mask so it hides my super red chin. I have 6 more days of cream, I am taking this one day at a time. The only side effect so far that I have had is two different days I felt extremely tired."

• Philip
• Taken for less than 1 month
• June 8, 2020

Efudex (fluorouracil) "Male 52, having had ongoing AK issues on scalp and face, regularly frozen with dry ice over past several years. Started using Efudex 2x daily on scalp for past 3 weeks; some mild irritation but not at all problematic; after 2 weeks crusty areas fell away (I did slightly agitate which I know I shouldn't) and will continue to use for another 1-2 weeks. So far so good, material improvement in scalp and tenderness has subsided substantially. Now starting to try small area on forehead below hairline, before doing entire face...just to see if reaction is very different, but this is just SO much better than having intermittent freezing. Will definitely do a second cycle on scalp after a break. Highly recommend based on 3 weeks' usage. Will update further after using on face. Thanks for all the other posts !"

• flyboy
• Taken for less than 1 month
• September 26, 2019

"My dermatologist prescribed a 14-day treatment of Fluorouracil Topical Cream 5%, applied 2 times daily, to treat actinic keratosis on my face, forehead, and temple areas and the beginning of a lesion on my face. During the first few days, there wasn't much different feeling to the skin, but on day 5, the skin started turning red. On day 6, the burning feeling commenced. On day 8, the flaking and peeling started, and it even burned to wash my face, but what I finally found out worked well. After applying the medication, I washed it off after 2 hours as my dermatologist said that's OK because the medication works during the first 2 hours of application. I then applied to the areas a broad spectrum SPF 50 liquid sunscreen, letting it dry, and then a moisturizer, Vanicream Lite Lotion. After stopping treatment, it took about 7 to 10 days for the redness, burning feeling, flaking, and peeling to stop. Now, there are no indications of any actinic keratosis, and the affected areas are all clear."

• Isobel
• Taken for less than 1 month
• May 29, 2020

Efudex (fluorouracil) "I am 70, with chestnut hair, fair skin and blue eyes. My doctor diagnosed actinic keratosis on a small lesion on my face. He recommended Efudix twice a day for 3 weeks. I used a cotton bud to apply the cream as it seemed easier to apply it thinly that way than with my finger. During the first two weeks the lesion started to become red and enlarged slightly. Towards the end of the second and throughout the third week yellowy crusts started to form and the lesion felt tender and raw. If I went out in the sun I put a small plaster over it for protection. After the treatment a scab formed over the whole area that took two weeks to fall off. Then new skin appeared and I have been applying Calendula to aid the recovery. I am left with a pink streak which hopefully will fade with time. Until then I will use a 'hide the blemish' make-up which I would think a man could also use, if need be. Overall very pleased with the result."

• Granny
• Taken for less than 1 month
• January 15, 2020

Efudex (fluorouracil) "I am using efudex and the spots were getting raised and crusty as expected but then it got damp in the shower and came off with a bit of bleeding. It has settled down now . But I was worried if this has set back the process. I would appreciate your comments."

• Nina
• Taken for less than 1 month
• January 8, 2020

Efudex (fluorouracil) "I had a very tiny split on the side of my nose that wouldn’t heal. It was BCC. It was surgically removed. One of the most horrible experiences, emotionally. I used Efudex a year ago for a spot that appeared on my chest. It worked well, although painful and itchy. I am now using it on my forehead, nose and upper lip area. I was shocked at how many spots appeared! Extremely painful when touched, but otherwise just a little itchy on occasion. I am grateful for all the comments here....it gives me courage to keep going. Week 2....."

• wheeler...
• Taken for less than 1 month
• January 18, 2020

Efudex (fluorouracil) "I was prescribed Efudex for basal carcinoma on my leg. Used twice a day for 3 weeks. Excellent result. Now 6 weeks on and just left with red area which I assume will fade with time. I was also told to treat AK on my face, used cream once a day for 4 weeks (stopped 3 days short). As with other comments made, I was not informed by the dr that I would look absolutely monstrous. Immediate reddening of the entire face, followed by scabbing. Still at the scabbing stage. I could get a part in a horror movie. The cream seemed to migrate towards my eyes where I had not applied it. Would I have used Efudix if I had known what I would look like - probably wouldn’t have had the courage as people stare when I am out and about. Determined to continue with my life as normal. Think it’s better than it turning into cancer at a later stage. I await the results with bated breath, although I think this may be many months away."

• Berma
• Taken for less than 1 month
• January 14, 2023

Tolak (fluorouracil) "My first 3 days there was little evidence of use. I've now applied for 12 straight days and I'm very red and blotchy, with some signs of flakiness. I've been living with a burning sensation on my face but it was so bad last night I couldn't sleep. I'm struggling to make 14 nights but hope my dermatologist says I don't have to keep applying... I don't think I can keep going!"

• Sano
• Taken for less than 1 month
• May 8, 2020

Efudex (fluorouracil) "I chose to apply my treatment over 2 periods separated by 6 months. half of face and right arm this time and in 6 months will do the other half. 53 years old, scottish descent growing up in Queensland, Australia. Too late to chip my parents about that. Skin: Fitzpatrick Type 1. I had a good (severe) reaction within 3 days, applying three times per day against the advice of 2 times per day. Within 1 week, yellowish crusting, weeping etc. kept it up for two weeks in total, then stopped and another 2 weeks to recover. Good result. Pain intense, and I was fortunate enough to have a GP that prescribed some decent pain killers and a mild sedative (5mg Diazepam) to help me get through the night. Tried to persevere without the drugs but they proved to be a god send,. Would recommend to do this treatment in Winter and off work or working from home. (Trivial note: started treatment at the same time as working from home due to Covid-19)"

• Ding...
• Taken for less than 1 month
• May 25, 2020

Efudex (fluorouracil) "I am on my 18th day of using Efudix. I am only using on my tip of nose. This morning a horrible crusty scab of blistering came off and it is now red and raw. I am still using as I was told to stop on day 21. I am seeing my doctor tomorrow to see how things are going and whether I should carry on for longer. No pain, just a sort tingling and look like Rudolph the Reindeer, but coping fine. Sleep well and no real side affects."

• In...
• Taken for less than 1 month
• April 8, 2020

Efudex (fluorouracil) "I spent years in the sun scuba diving and hiking in Mexico and Arizona. For years I've constantly had to use lip balm because my lips were so dry. I tried many products and they never worked. My lips would crack and peel all the time. Just recently I got diagnosed with Actinic Chelitis. I have been prescribed a Effudex 5% once a day for 3 to 4 weeks. I am at Week 2 and experiencing severe, almost unbearable, burning pain because of deep sores with massive amounts of oozing and crusting and now bleeding, tightness and severe dryness. I will try to endure another week but I think I would rather surgery any day than this."

• TR100
• Taken for less than 1 month
• October 3, 2019

Efudex (fluorouracil) "Used for 4 weeks to treat what physician thought might be an AK (Actinic Keratosis) - a very tiny dry scaly spot above my upper lip. Efudex was easy to use, not painful, just a gnarly scab that took weeks to fall off. Once gone, the skin was smooth but red. Red spot was 3X larger than the AK being treated (now the size of a pencil eraser). Hoping the redness will heal in time. Finished treatment two months ago but the smooth red splotch remains. It looks far worse than the tiny dry spot I had before I began treatment. Regret using Efudex"

• Lough
• March 31, 2017

Efudex (fluorouracil) "I used efudix for 20 days. Got all the bearable symptoms of rash, redness and sore skin. It took about 2 months for the redness to go completely. The main long lasting side effect I have is that it's been six months and I still have permanently very greasy, greasy skin on my nose and cheeks where I applied it. TIP, make sure you are not prone to rosacea before using it. I didn't know I was prone but the efudix triggered the adult rosacea I never knew I had. (rosacea is like acne, it comes and goes but only in the place where I used the efudix, it's embarrassing and I don't like going in public during flare ups.) I wouldn't recommend this treatment at all. It might be ok on small 2cm spot treatments on the body, NOT THE FACE. Beware"

• Tmano
• Taken for less than 1 month
• March 24, 2020

"I used fu-5 cream on my face recently for sun damaged skin. I had several bad sunburns 40 years ago in my teens. This product has wiped out most of that old damage! Scaly, red and/or brown spots are about 90 percent gone. Applied twice a day for 2 weeks (28 applications). Here's how it goes: Wash face, dry, and apply a thin layer. Nothing happens the first few days. Days 4 - 7 dark spots and redness should appear only on the damaged areas. Beware, days 8 to 14 can be holy Hell with stinging, soreness, inflamed red raw skin...looked like a horror movie monster. Took Aleve and used pure aloe vera gel for relief. Don't use ANY other lotions and do stay out of the sun that second week. Third week healing starts but expect lots of peeling and crazy itching (Neosporin helps). Week 4 WOW the new improved skin shows...just a bit of redness that will fade over time. End results were well worth the pain. I recommend only doing one side of your face at a time - makes it easier to sleep."

• Tjdh
• Taken for less than 1 month
• August 17, 2017

Efudex (fluorouracil) "I had a small spot on nose. Used this twice a date for 14 days. Spot became very red and got scabby where the precancer is on skin. After 14 days stopped treatment. Now in healing process. Using Vaseline twice day. Scabs are showing coming off on own. DON'T PEEL. AREA very red but becoming less a bit. I hear it takes a few weeks for the redness to subside. So far so good. Not too much discomfort. I did get depressed doing this though as it's my face and I didn't want you go in public."

• WJC
• Taken for less than 1 month
• April 7, 2020

Efudex (fluorouracil) "I used Flouroplex about 15 years ago on my chest and face, they were both a mess for 5-6 weeks, but the treatment is worth is. I started seeing the same damage on my chest and face and my DR prescribed Efudex 5%. It works the same and when I spread it on the chest little red spots started showing, then more and more. I look like my chest has the measles. Some are large spots that swell and ooze. It is very itchy with prickly pain, now in the third week, hard to sleep. I'm going to stop at the weeks end for a full 4 weeks. I also treated some specific spots on the side of my face but it just got very red, turned blackish, I stopped that at 3 weeks and it is healing nicely with the help of vaseline. I have not had any side effects with vomiting or headaches as others have reported. Once my chest starts healing I'm going to try some additional spots on my face. It is not pleasant but what chemo treatment would be? The alternative is surgery."