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Estradiol Patch and Night Sweats: What Users Say

Night sweats: mentioned by 7 users (4.2%)

Based on user experiences from 168 Estradiol Patch reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

itching 18.5%
hot flashes 16.1%
rash 7.1%
redness 6.5%
headaches 6.0%
night sweats 4.2%
insomnia 3.6%
sweating 3.0%
burning 2.4%
sore breasts 2.4%

Reviews for Estradiol Patch

Commonly mentioned side effects
  • NJ ...
  • Taken for 1 to 6 months
  • June 12, 2015

For Postmenopausal Symptoms "This refers to the Mylan estradiol twice weekly patches. After 16 comfortable years using Vivelle Dot estradiol patches, I was supplied by Express Scripts with the new, supposedly 'generic' Mylan estradiol transdermal dot patches in the same strength, 0.025 mg. During the 4 1/2 weeks I used the Mylan product, I developed hot flashes, night sweats, brain fog, and urinary tract infections. I could not understand what was wrong until I recalled that my symptoms began when I started the Mylan product. I found out that Vivelle Dots are still under patent. Mylan patented its own competing transdermal patch in order not to infringe the Novertis patent. It is NOT the same product. A return to Vivelle Dots solved my problem."

1 / 10
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  • Hot...
  • Taken for 1 to 6 months
  • August 8, 2019

For Postmenopausal Symptoms "I was using Vivelle Dot and then Minivelle for 10+ years. Due to the cost and no insurance, I switched to the generic patch. It does NOT work. The change in my estrogen levels was drastic... as if I wasn’t getting any at all. The hot flashes and night sweats returned. These patches are trash. I will be paying the outrageous price for Minivelle to get my hormones balanced again."

1 / 10
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41 Report
  • AZN...
  • Taken for 1 to 6 months
  • September 24, 2022

For Postmenopausal Symptoms "I was prescribed the mylar estradiol patches 0.5 mg twice weekly. I've had no issues with adherence, except 1 patch, and that was user error. It definitely improved my symptoms of night sweats and vaginal dryness. I'm also taking 200 mg of progesterone to combat insomnia. I had an ovary-sparing total hysterectomy in January this year and noticed an increase in symptoms. Labs show ovaries still working, but levels up and down, consistent with perimenopause at 45 years old. Don't suffer needlessly, there's help!"

9 / 10
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13 Report
  • BRa...
  • Taken for 1 to 6 months
  • December 2, 2020

For Postmenopausal Symptoms "I was switched from the Sandoz Estradiol Patch to Mylan Estradiol Patch by my insurance company. Sandoz was working fine, Mylan doesn't work well at all. I'm awake half the night with hot flashes and night sweats. This is crazy. Also, sticking problems as others have said. I will be begging my GYN for something different!"

1 / 10
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16 Report
  • Joa...
  • Taken for 1 to 2 years
  • May 3, 2019

For Hypoestrogenism "I’m 9 years post-hysterectomy. I started out with Vivelle Dot, then changed to Minivelle Dot when it came out. Never had any trouble. Insurance change last year (2018). Since there’s now a generic for Minivelle, I can pay $15 for Mylan or pay a penalty for the brand name and pay $188 for Minivelle. With a coupon, $135. I’ve tried to deal with all the problems with the Mylan patches for a YEAR! They do NOT deliver the same amount of estradiol as Minivelle. I’ve gained 20 lbs and have gotten horrible wrinkles. I firmly believe it’s the patch and lack of estrogen. Patches fall off, which is irritating. I still have hot flashes and night sweats. My endocrinologist even did an estrogen level test, and it was lower than in 2017 when on Minivelle. If my gyno will request Minivelle, my insurance will allow it and not charge a penalty. With a coupon, it should be about $40. I’m hoping!!!"

1 / 10
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20 Report

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  • Son...
  • Taken for 1 to 2 years
  • June 12, 2022

For Postmenopausal Symptoms "I have been using the Mylan Estradiol patch for over a year now. I don't quite understand the thing with the adhesive and it coming off. I've never had that problem. I started putting it on after my showers on my abdomen below my belly button but found that it works best for me to put it on my upper butt area. One thing I can say is it has never come off. It has worked well for my night sweats, which were unbearable."

10 / 10
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8 Report
  • Buf...
  • Taken for 10 years or more
  • July 24, 2022

For Postmenopausal Symptoms "Vivelle Dot worked great, but insurance stopped covering. Generic was okay until the last few months when Mylan was the brand I was given. It doesn’t stick well at all, and I’m having open blisters and redness that are painful and itchy. I’m not using them because I’m afraid of getting an infection. I’m also getting hot flashes and night sweats after 10 years without them. I called Mylan but still need to fill out the extensive paperwork for the customer complaint. Tried to get Vivelle again, but it would be $500 a month. I don’t know what to do. I really need the bone benefits from estrogen and don’t absorb oral meds well."

1 / 10
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6 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.