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Duloxetine for Pain User Reviews (Page 3)

Brand names: Cymbalta, Drizalma Sprinkle, Irenka

Duloxetine has an average rating of 7.1 out of 10 from a total of 78 reviews for the off-label treatment of Pain. 68% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Duloxetine

  • Anonymous
  • December 16, 2011

Cymbalta (duloxetine) "I have been on Cymbalta for 5 years for disc herniation and depression. I did have sexual dysfunction but it passes. I have had LITTLE pain in my back since! It is a WONDERFUL medicine but high blood pressure does come with the medicine and dizzy spells for sometime until your body is adjusted to it. My dose is 60MG and I started at 30mg. I definitely love this medicine!"

9 / 10
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  • SnowA...
  • March 27, 2018

"40 years old, fibro, osteo, DDD (degenerative disc disease), I was on the regime of T3's and cannabis when I could afford it. I'm not depressed though. It helped a lot when I took it at nine o'clock at night for the first time. Woke up two hours later vomiting hot flashes and zingy sounds in my head, disorientation etc. I thought this was just a minor side affect and it will go away. I proceeded through the day feeling that I couldn't do anything. But felt little pain. Didn't need my T3s. So I took it again at 9 pm the second night. Well, lets just say, full on seizure, 3 hours vomiting, now today crazy diarrhea. I FELT I WAS DYING. I woke up called health link, then the pharmacist, then saw my Dr who knows I suffer a ton from allergies and little to none help me. We agreed I would give this a chance, but after seeing what I looked like today I'm going to bring the tabs to the pharm and report. I could have died! It's a good I didn't start at 60mg. If I did I would definitely not have been here to tell the story! "

1 / 10
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15 Report
  • Anonymous
  • February 21, 2012

Cymbalta (duloxetine) "At 29 I have multiple joint pain and 2 ruptured lumbar discs with sciatica and numbness in my arm and foot. Taking narcotics and opioids helped but then my meds were stolen from my purse. Went to my pain doc for something to help with withdrawals and pain until my next refill. He gave me a sample of Cymbalta. I am impressed with the results other than the headaches and increase in appetite. Helps with my morning stiffness and loss of balance and makes my pain bearable. I do seem to get really sleepy when the headaches come on but if I can take a power nap it helps. My mood is much better but I attribute that to having less pain as I have never had depression. I hope the headaches go away."

8 / 10
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25 Report

Frequently asked questions

  • migra...
  • Taken for less than 1 month
  • April 30, 2023

"My doctor prescribed this for migraines that I have had for over a month now since covid. The first three nights I had no migraines then on the fourth night I went to bed and woke up with a racing heart, so checked my blood pressure and it was 85 over 45 with a pulse rate of 112. Went back to bed after my heart rate got better then a migraine hit and my pulse skyrocketed. I felt horrible the next day but took it again and the same thing happened. Felt nauseous in the morning and lightheaded like I could pass out. I have decided not to continue this medicine. All I wanted was for my headaches to stop but if this is what I have to do, I say no thank you to Duloxetine."

1 / 10
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  • Anonymous
  • October 28, 2011

Cymbalta (duloxetine) "My new pain doctor put me on Cymbalta a few weeks ago. I took 30 mg 1x per day for a week, then increased the dosage to 60mg 1x per day. I have post thoracotomy pain syndrome (nerve and muscle pain) and pain from scar tissue from major abdominal surgery. The Cymbalta works beautifully. I am pain free for the first time since 2006! My next step is to gradually stop taking the opiate pain medications. Two "cons" about Cymbalta--side effects (these have gone away finally after about 5 days)--including nausea, waking up in the middle up the night, sweating and unable to go back to sleep, and some cold sweats in the morning. The second not so great thing is that since there is no generic, I pay a lot for it. My insurance covers it, but still."

8 / 10
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Are you taking this medicine?

  • Anonymous
  • March 24, 2012

Cymbalta (duloxetine) "I love taking Cymbalta for my depression but because of the high cost of it even with Insurance I am weaning myself off of it. I've noticed that since I am not taking it as often my pain is going away. I know this medication is supposed to help with pain but it has actually caused me lower back and hip pain since day 1."

10 / 10
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  • Feeling...
  • March 6, 2012

Cymbalta (duloxetine) "Since starting Cymbalta I feel as though I have gotten my life back. The daily pain is gone. I can do whatever I want to do now. When I do to much I might be sore but I rebound fast. Also, I take Celebrex and Ambien."

10 / 10
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21 Report

More FAQ

  • Cheryl...
  • May 28, 2018

"I'm very upset at the moment. I am just about 60 years old. I took cymbalta for pain but I didn't like the side effects and it didn't help with the pain enough so I stopped. I have never previously had hot flashes, but since stopping this medication, I am literally plagued by them. I am hoping it will stop. It's been almost two weeks now of constant, out of the blue, hot flashes. I've never had so many problems with a medication and I am very scared that these hot flashes will not end soon."

1 / 10
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  • Charles
  • June 3, 2011

Cymbalta (duloxetine) "I developed Occipital Neuralgia, left side, some years ago. After several treatments with pain specialists and no results, I tried Cymbalta. In 7 weeks I was pain free. This continued for a couple of years until I broke my leg and had to spend 3 months in a nursing home. At the nursing home, the physician switched me to Wellbutrin [less expensive] which was OK but not as good as Cymbalta. After about two years on Bupropion my left side is still OK but it has now developed on my right side. Since I am still taking Bupropion, it obviously isn't working. I'm going to see my physician for Cymbalta."

9 / 10
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  • Ksks
  • Taken for 1 to 6 months
  • January 21, 2023

"I have been suffering from neuropathic facial and orofacial pain for about 3 years. I also have anxiety at high levels. I started taking duloxetine 60 mg daily and after a few weeks, I had improvement in my pain and anxiety. I have experienced side effects of being fatigued and tired all the time, finding it hard to fall asleep, a loss of appetite and initial loss of weight, bigger pupils, and restlessness but they have faded away over time. I would definitely recommend it with constant monitoring by your practitioner for severe side effects."

10 / 10
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  • Annie...
  • Taken for 1 to 6 months
  • December 12, 2019

"Neurologist took me off Prozac, which was working for depression, and put on Cymbalta as a two fold treatment for depression and multiple sclerosis pain. It didn't help at all with depression and made my m.s. pain worse."

1 / 10
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  • JanLi
  • Taken for 1 to 2 years
  • April 16, 2021

"I have been taking Duloxetine 20mg once a day for over a year now. I have a herniated L5 in the spine and could hardly walk a year ago. I cannot walk up to 7 miles a day and in no pain. My mood hasn't changed at all and thus medication has given me my life back."

10 / 10
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7 Report
  • Anonymous
  • December 14, 2011

Cymbalta (duloxetine) "Please talk to your PHARMACIST and let him know what other medications you are taking if you are ever prescribed this medication. I was prescribed this medication for severe neurological pain but my doctor either ignored or overlooked the fact that I was also taking a medication for migraines and I had a very bad interaction between the two medications which led to what I would call bad rage."

1 / 10
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  • Anonymous
  • March 7, 2012

Cymbalta (duloxetine) "I have been taking Cymbalta for about 6 months. It has definetly helped with my plantars fasciitis pain. I still have some discomfort, but it is manageable with the medication. I experience no side effects, and noticed improvement in only a couple of days."

9 / 10
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  • DULOX...
  • Taken for 6 months to 1 year
  • March 31, 2023

"The dry mouth from this med almost destroyed my teeth! Within 5 months I needed 13 new crowns and many fillings. So upset! No one warned me. My dentist will charge $10,000 so must seek cheap dentistry. I don't recommend it! Will take gabapentin instead."

1 / 10
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  • tj bear
  • January 3, 2012

Cymbalta (duloxetine) "I have been using Cymbalta for two of years for neuropathic pain in my feet. It works very well most of the time at the 90mg dose I am taking daily. There are days when I have done some activity that aggravates my back and I have to take an extra 30 mg. This helps but I experience the hot flashes at the 120 dose. I do not have the night terrors but there are times when I have run out of the prescription and if I have not had it for a day I get very vivid dreams. They are not scary but if I wake up from one I'm up until I settle my brain down. Erectile Dysfunction has been a problem and I address it with Cialis or Viagra which are expensive even with my coverage. Reducing the dose to 60mg the day before sex helps."

9 / 10
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  • Anonymous
  • September 15, 2011

Cymbalta (duloxetine) "I took Cymbalta 30mg for fibromyalgia pain and it was such a bad experience. I took it with food at about 5:30 pm and didn't feel any side effects until later in the evening. Did not sleep all night, was very restless with heart beating rapidly, feeling itchy and abdominal cramps."

1 / 10
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  • Anonymous
  • October 30, 2011

Cymbalta (duloxetine) "I have severe neck pain from herniated discs, bulging disc, foraminal stenosis, osteophytes and arthritic changes in the neck. I was also depressed from chronic pain and anxious about the pain. It has interfered with my life and stopped me from enjoying life. I started on Cymbalta about a month ago. My pain seems to have improved some but has not yet gone away. The side effects have been troublesome including dry mouth, constipation, palpitations, rapid heart rate, some sweating, tremor, and difficulty urinating. I plan to give the mediation three months before I suggest a change to my doctor, based on the comments above. Hope it works."

7 / 10
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  • Embra...
  • Taken for less than 1 month
  • November 28, 2020

"Given this med for a pain in my left hip area(possible colon problem) Started on 60mg once daily. Took the first dose last night at 8pm as the warning said could make sleepy. Not my experience. Was struggling to breathe by midnight, felt very laboured and had trouble swallowing. Tried to distract myself by playing a few games on my phone, didn't work. I am full blown anxiety attack still finding breathing very difficult and felt like my head had been jammed in a door, still very dry and trouble swallowing, cotton mouth was terrible even after having some sips of water. Wouldn't wish the overall feeling I had on my least favourite person."

1 / 10
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  • Pho
  • Taken for less than 1 month
  • September 13, 2020

"I took duloxetine for pain and then stopped after 2 weeks. Took it for chronic pain which helped but the side effects were not great. Felt like puking after stopping it and MAJOR depression the 2nd day I was on it. I had many nightmares and sleep was not that great either.Glad I stopped it."

2 / 10
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  • Dandri
  • November 23, 2011

Cymbalta (duloxetine) "I have back pain due to an injury at work. I also have endometriosis and massive scar tissue from my 2 abdominal surgeries. I was having problems well over a year and when my husband decided to walk out my back started hurting more. My Doctor told me that depression can worsen pain. He gave me the Cymbalta 30mg and after one week I'm supposed to up it to 60 mg a day. I am on my 4th day taking it. The first day I had the jitters and my heart beat was higher than normal. I also had almost no sleep that night. So I checked out reviews and found that you shouldn't have caffeine with this prescription. Least to say 4th day no side effects but no coffee either so I'm feeling pretty tired. Less pain but I'm still sore and have tight muscles."

7 / 10
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  • Helen
  • Taken for 2 to 5 years
  • May 1, 2021

"I suffered from nerve type pain from the bottom of my spine down into the hip to the calf. I have neuropathy in the left foot but not pain. The physician started me on 30mg in a.m. which had no result. When the dose was increased to 60 mg in morning and evening, the pain relief was complete. I know my leg is not perfect, but I can live a normal life. I have had multiple myeloma in remission from 1998 to 2016 after transplant and 2 years of dex. It returned in 2016 and I had 18 mos. Off chemo and steroids. After dealing w/a stroke from chemo I have been healthy. No side effects that I observe. ."

10 / 10
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  • Anonymous
  • July 3, 2022

"Helps with the incontinence due to nerve damage . Pain is still there. Severe pain on the left side, head ,neck ,shoulder sometimes so severe it hurts to blink , speak and move around due to occipital neuralgia. God forbid if I have to sneeze. And I'm a person that went through 3 c .sections. It is easy to take being I only take it at night, although it does help me sleep, I don't feel it helps much the next day for being time release capsules."

6 / 10
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  • jeffrey...
  • Taken for less than 1 month
  • January 23, 2013

Cymbalta (duloxetine) "Hardly could walk for 3 years. Been on it for 10 days walking with a lot less pain. Not sure if this medicine did it or higher power but loving life again. I say give a try."

8 / 10
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69 Report
  • Anonymous
  • October 8, 2008

Cymbalta (duloxetine) "I have been taking Cymbalta for about 2 years. I was prescribed it as a test for migraines. I have not had a migraine in the last 2 years. Thank you so much for giving me my life back."

10 / 10
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82 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.