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Cymbalta for Major Depressive Disorder User Reviews (Page 5)

Cymbalta has an average rating of 6.1 out of 10 from a total of 110 reviews for the treatment of Major Depressive Disorder. 45% of reviewers reported a positive experience, while 30% reported a negative experience.

Reviews for Cymbalta

  • Graham
  • December 29, 2020

"Works great for my chronic muscle pain, and knocks out my sciatica pain...which I LOVE, but it doesn't really seem to work so much as well for my depression...although it seems to keep my anxiety under control, just doesn't seem to lift my mood at all, feel more so ‘numb' I guess is the feeling."

5 / 10
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  • Crod
  • Taken for 1 to 6 months
  • June 1, 2021

"Ok so this (Cymbalta) one worked good, but I had a bad experience with it. This stuff really peps up your mood and works quickly and will make you feel happy and energetic. However I forgot my meds when I flew from CO to TX for my sister's wedding and went into a horrible withdrawal I could not think straight and had unnerving thoughts and felt the lowest I've ever felt in my life, nasty experience. It worked well but the withdrawal I had from forgetting my meds scared me from taking it again. However it will help with depression, but has a few bad side effects."

6 / 10
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  • Lars
  • Taken for 1 to 6 months
  • February 21, 2023

"Cymbalta is a solid drug that I found tolerable. It took away about half of my anxiety and depression. This is more than I can say about most other SSRIs that I have tried. I just tried Nardil and had severe side effects from it so now I am going back to Cymbalta after my washout period. The only side effects of Cymbalta are some headaches and slight insomnia."

8 / 10
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2 Report

Frequently asked questions

  • boobo...
  • May 27, 2015

"Having nauseous feelings, dizziness, clouded distorted head as if hung over, every day at noon time and lasting rest of day! Just started taking 30mg at night along with Wellbutrin and trazadone that I have taken for a couple years now. Not a good feeling. Going to call Dr to see what I should do."

5 / 10
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  • Bengal
  • Taken for 6 months to 1 year
  • January 15, 2021

"I take Cymbalta for my depression, anxiety and fibromyalgia. I was diagnosed MD in 1999 and over the years I have tried several medications. Lexapro was working great and I was on that for a few years until I found out I had fibro and the specialist recommended a change from Lexapro to Cymbalta. I was hesitant because the Lexapro worked GREAT! I was well balanced and able to self-regulate my emotions, but I was also taking Lyrica for the pain and I liked the idea of the Cymbalta helping with nerve pain. I was hopeful that I could stop the Lyrica. My PCP started me at 30mg a day. I knew it took 4-6 weeks to kick in and I was a wreck. At the 2 month mark I called my PCP in a mad panic asking him to bump it up because I was ready to let my inner screams out. He told me to start taking 60mg. I've been on that dosage for 9 months and I have cut my Lyrica down to just one in the morning from 3 times a day. It isn't as good as the Lexapro for me, but it helps with my nerve pain."

7 / 10
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Are you taking this medicine?

  • Metim
  • Taken for less than 1 month
  • January 3, 2021

"I was on the prescription brand name pills Cymbalta 60mg 1x daily for 2 weeks. I was supposed to increase the dosage to 120mg daily per my physician at the 2 week mark. I experienced almost every side effect there is and some other terrible symptoms. I stopped cold turkey since I was having cold turkey symptoms also. My doctor and I believe I had bad reaction to it. It took me about two weeks to recover to my previous baseline issues, I was pretty thankful. It made me terrified to try any other anti depressant in going forward; it was a pretty bad experience."

1 / 10
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  • Nina
  • Taken for 2 to 5 years
  • June 10, 2023

"I first started taking psychiatric medication at 18 to help with depression/anxiety and bulimia. One drug after another, nothing seemed to help, and some even made things worse. I'm now 29. Been on 60mg Cymbalta for approx. 3 years. I personally have not experienced anything groundbreaking, but I also have not had any negative side effects. It's hard to say if Cymbalta has done anything, as I've been on anti-depressants for so long. I will say this is probably the first med that hasn't given me weird side effects. I'm hoping to begin titration soon to see if I'm okay without it. I started taking very low dose Adderall (10mg once a day) - prescribed to me as an off label use for depression - kind of as a last resort after my laundry list of unsuccessful meds. I was very lucky to find a doctor who recommended this route, as the Adderall has alleviated my depression symptoms far more than any anti-depressant."

7 / 10
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More FAQ

  • Skippy
  • August 8, 2021

"I had been on Lexapro for 10 years with good results. Until last fall when the world was going down the drain. I became super super depressed. Doc switched me to Cymbalta 60mg per day. It worked and felt so much better. However these last 3 mo or so I've noticed my happiness has definitely gone down hill. And I've noticed I've become very short tempered, agitated, and angry. I'm contacting my Doc today about switching me back to Lexapro...."

7 / 10
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  • tyhmy...
  • Taken for 2 to 5 years
  • June 26, 2021

"Got prescribed Cymbalta for depression, anxiety and panic attacks. It quickly started working to alleviate all of them and I have not experienced a panic attack since. After being on the med for 3+ years, its effects on depression weren't adequate anymore. I begged my psychiatrist to increase the dose, and by the time they did, it was a bit late and I had an increase in suicidal thoughts & behaviour. Finally after 4 years I was weaned off to try something else. I was having a reaction to another medication so I'm not sure how much of the discomfort was the reaction or if it was the withdrawal. Overall a great med to try if you're anxious *and* depressed, especially since they tend to fuel each other."

7 / 10
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  • Crey
  • Taken for 1 to 6 months
  • December 17, 2021

"Not too shabby, has done me well. I’m far from suicidal and I don’t experience anxiety at all. I’m finally happy, only side effect for me is a decreased ability to experience empathy and I’m on 120mg."

9 / 10
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  • Haley
  • Taken for less than 1 month
  • April 7, 2023

"30 mg does nothing for me. 60 mg made me feel manic, so I tapered down to 30 mg. I’m trying 60 mg again, but this time with Latuda. I’ve been taking it for less than a week, so I haven’t noticed a difference yet."

6 / 10
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  • Anonymous
  • December 7, 2015

"I got switched to this medicine after tapering off Effexor. It was tough at first, but I am now feeling more like myself than I have in years. Thank you cymbalta"

9 / 10
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  • lana
  • Taken for 2 to 5 years
  • May 2, 2014

"It worked well for both my fibromyalgia and my depression for a long time and I had no side effects from it. However it has stopped working for the depression now. I still take it for my fibromyalgia."

8 / 10
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  • Olive...
  • Taken for 1 to 2 years
  • December 16, 2015

"I took 60mg per day for over a year. Worked very well until recently. It kept the depression in check, but the anxiety is back in full swing. Don't skip a dose unless you like the zaps."

7 / 10
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  • Hope...
  • Taken for 1 to 6 months
  • December 25, 2019

"Made my symptoms extremely more worse even at higher does. Effexor or lexapro were better"

1 / 10
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  • Roxie
  • Taken for less than 1 month
  • November 26, 2019

"Been taking it for 7 days for depression and rheumatoid arthritis pain. I’m exhausted and feel like I’m in a fog. I don’t usually have problems with medications but I can’t function on this"

1 / 10
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  • Sill
  • Taken for less than 1 month
  • April 26, 2014

"Caused suicidal ideation"

1 / 10
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  • Stefc...
  • Taken for 1 to 6 months
  • September 23, 2014

"Worked well in terms of mood but had terrible side effects."

6 / 10
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  • Anonymous
  • Taken for 1 to 2 years
  • October 18, 2015

"Mood was boosted for awhile when I first started taking it, but then levelled off to the point of ineffectiveness. Did work very well for my fibromyalgia pain, but not worth the extremely high price."

3 / 10
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  • Ann
  • Taken for less than 1 month
  • June 20, 2022

"Hello I just started Cymbalta five days ago and I feel like really I kind of a little paranoid. Is there anybody who has gone through this by the way it’s 30 mg please let me know"

5 / 10
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2 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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