Depakote User Reviews & Ratings (Page 2)
Depakote has an average rating of 6.3 out of 10 from a total of 314 reviews on Drugs.com. 49% of reviewers reported a positive experience, while 27% reported a negative experience.
Reviews for Depakote
- Anonymous
- September 7, 2009
For Bipolar Disorder "I would give Depakote a lower rating based on my personal experience with it, but I don't want to skew the overall rating. For whatever reason, I did not respond to Depakote as a mood stabilizer. This is surely not the case for everyone. The problem is that while taking this medicine, I gained 30 pounds, as I constantly felt hungry. I was warned ahead of time that this tends to keep the brain from perceiving fullness (or something to that effect). I noticed this within a few days of starting Depakote but continued taking it because I didn't have many other options at the time. The weight gain created an entirely new aspect of depression. Just something to keep in mind if you're just starting it and weight gain is an issue."
- chris...
- April 20, 2010
For Bipolar Disorder "Although reading the possible side effects can be scary, this medicine gave me my life back. I had a little hair loss at doses above 1000mg, but it's been great in stabilizing my mood swings. If I go off of it, I have an episode within a month. I had no weight gain (actually lost weight I had gained from taking Seroquel previously). I take it with Wellbutrin SR and a little Abilify. But the Depakote is by far the most effective. I've been on it for over 3 years."
- 1ks
- October 4, 2016
For Bipolar Disorder "I started depakote 3,000mg straight off when I was 15 years old I have since been taken off from it and still paying the price for it. It made me hungry constantly i gained a total of 50 pounds in 7 months I had no energy at all and no feelings no happy thoughts no sad thoughts I was literally a zombie and now I'm still seeing new doctors and switching meds all the time and I've had enough nothing is working and no one can help me I really need help and can't find it anywhere"
- Tiger...
- Taken for 6 months to 1 year
- December 20, 2014
For Bipolar Disorder "I'm on Depakote 250mg in the morning and 500mg at night. I am also on olanzapine 5mg and fluoxetine 20mg, which works wonders together. I have bipolar, and while on Depakote, suffered a bad spell of depression, so was put on fluoxetine, which has changed my life. I'm such a happier, calmer person now."
Are you taking this medicine?
- Anony...
- Taken for 2 to 5 years
- December 23, 2015
For Bipolar Disorder "I am honestly the happiest person ever since my psychiatrist prescribed Depakote for me. NO MORE RAPID CYCLING! I take two 500mg tablets about 20 minutes before bed, and I sleep throughout, only waking up when my back is aching in pain. I'll save that for my Baclofen and Prednisone post. I do not experience the manic highs as I once did; however, I still have my low days, but everyone does! My low days are nowhere near the days when I was on Trileptal or any SSRIs. I was taking Abilify and Lithium for a week (this is my experience). I started seeing the world in two-dimensions, sort of like the early Nintendo characters. I was freaking out! That was it. Make sure to get blood tests every month to ensure your Depakote levels are in line."
- Depan...
- Taken for 1 to 2 years
- April 22, 2019
For Bipolar Disorder "No way! Been on it twice in my life. I was extremely bloated beyond recognition and in a deep mental haze. I could barely function. My doctor kept saying “you need to take care of yourself before you can care for your family”. And she was right. I got off it, weight loss has been slow but I got my face back I looked like a hamster on it and I went up 5 pant sizes on this medication. I got my energy back. On this stuff I slept all day. Off this medication I am enrolled in school and on the path to a new career and I am able to be awake to live my life off this stuff. And care for my family."
- Necik...
- Taken for 1 to 6 months
- June 27, 2021
For Bipolar Disorder "I love this medication. It has been a life saver. I have anxiety that cripples me emotionally and physically, but when I started this I literally felt a weight lift off my shoulders. At first (didn’t last long) it made me a little drowsy, but I didn’t mind, rather be drowsy than panicky and fidgety with racing thoughts. I will say this medication works better for me in smaller doses. If I take 500 mg all at one it makes me emotional. So I take 250 at night (sleep) and 250 in the morning if I need it."
- Chris...
- Taken for 1 to 2 years
- August 19, 2015
For Bipolar Disorder "I have to say this drug did more harm than good, and my body is very dependent on it. In only a year span, I started having serious weight and back issues. I have never had any issues with my back, but all of a sudden my bones started to get brittle. Then the disc herniations started happening, and like a domino effect, my entire spine was damaged. I see a lot of info on children or babies affected with their spine, but apparently, it can do the same for a grown adult. I was put on this medication for anxiety and what my doctor thought was bipolar disorder. Turns out, as time goes by, the doctor lowers my Depakote and came to the conclusion I do not have bipolar disorder. Great... Damage done... Abnormal EEG, spine damage, and severe chemical dependency... Lost my hair, my looks, weight."
- busybee
- July 6, 2010
For Bipolar Disorder "I am shocked to read the high amount of mg's that people are being started on. Every review I have read about Depakote, it's been mainly 1000mg or 500mg. That just blows my mind! With any medicine, you have to be eased into things and adjust from there! I began with 250mg. My doctor told me that after a few weeks I could adjust it to taking 2 doses (500mg). Just to play around with it to see if I, in fact, needed to go higher. So I did. When I changed to 500mg, it made me crazy, nutty, mean, and intolerable. I backed off and on 250mg again. I have been normal and perfectly stable ever since. I have yet to read a person taking the lowest dosage as a starting point. Start slow and work your way up (if needed). This medicine has been a lifesaver!"
- Anne
- May 15, 2013
For Bipolar Disorder "I've been on Depakote for almost a year now. I also take Paxil and Wellbutrin. I gained around 10 lbs right from the start. My weight has seemed to have stayed steady the last few months. It's extremely hard to lose it. I have been through a lot of different medications to try and treat bipolar disorder. Even with the medicines I'm on, I'm still depressed and feel like I don't matter. I'm very sleepy and can lay down and take a nap at any time. I started taking B Complex because I stay so sleepy. My new concern is memory. I can't think of words and dates or names like movie stars very fast and it concerns me."
- Stephie
- Taken for less than 1 month
- September 13, 2018
For Bipolar Disorder "Today is my second day on depakote. I was freezing yesterday and it was 80 degrees. I have been on gabapentin, lithium, celexa, wellbutrin, lexapro, and so many others. I tried to commit suicide 3 weeks ago and that’s when I decided enough was enough. As soon as my oldest started ninth grade I started sleeping on the couch, having crazy mood swings, and then my daughter graduated. I slept on that couch for 6 years. My husband worked 3rd shift and me day shift. I was self medicating with hydros then when I wanted to stop that I got addicted to Suboxone. I also have a thyroid disease and had no idea that played into it. I’ve weaned myself off all drugs and now they started me out 500 mg twice a day. And my thyroid medicine. This is going to be a long road but I know it will be worth it. Please don’t give up."
- Anonymous
- Taken for less than 1 month
- June 1, 2012
For Bipolar Disorder "I am 29 and just diagnosed with bipolar after a horrible manic depression cycle. It's worked great to stabilize my moods, but I'm scared after reading everyone's weight gain stories! I will have to hitch up my diet and exercise plan more. One thing I noticed that I didn't see anyone else write is that I have these horrible and extremely vivid dreams - they seem to be my fears realized. But they are so vivid and real that they hang over me all day. Has anyone else experienced this?"
- Qbug
- Taken for 1 to 6 months
- January 10, 2014
For Bipolar Disorder "Depakote was given to me for onset postpartum psychosis and underlying bipolar 1 as a mood stabilizer. It did its job. Wonderful results mentally, obsessive thoughts were all but gone and combined with my antipsychotic, it made my life much better. But, the weight gain was hellish. I have gained 11 pounds in two weeks, and am looking at switching at my appointment on Monday. So, not good if you are looking for a weight neutral mood stabilizer."
- SOano
- January 27, 2020
For Mania "I have been on antidepressants and benzodiazepines for over thirty years for depression anxiety and racing thoughts from the anxiety. Started Depakote ten days ago and it has made an amazing difference, slowed my mind down enough to significantly reduce my anxiousness, only side effect mild tiredness no groggy feelings this has been so wonderful."
- Ivan
- Taken for 5 to 10 years
- June 8, 2020
For Bipolar Disorder "I've taken the Depakote medication since 2014 and this is the only drug which eases my symptoms without causing extreme sleepiness. Classified as mild case, most of times I experience hypomania. Upon finding closure in therapy to change mindset and behavior, I've been channeling the disposition for self development and productivity, gradually gaining confidence and control, becoming less dependent on the medication, only taking a tablet each time I'm unable to manage the irritability and distress."
- pres
- Taken for 1 to 6 months
- October 30, 2018
For Bipolar Disorder "I've been on depakote for over a month now, it has really helped me. I was diagnosed with bipolar 2 at the age of 16, I'm 21 now. This was the first medicine that I have tried. I still get down and depressed sometimes, but it is nothing like I used to. All of my suicidal thoughts have stopped, I used to have them multiple times a day. Depakote has also help very well with my anger and aggression issue, I feel as if i can live a normal life now and handle tough situations better. I would definitely recommend this medicine for anyone dealing with bipolar disorder!"
- GlowC...
- Taken for 5 to 10 years
- October 14, 2012
For Bipolar Disorder "I am a female, first diagnosed at age 19 with bipolar disorder. They first tried Zyprexa which I had a horrible reaction to. The Depakote made me feel like a zombie for months, until it brought me back down to 'normal'. I stayed on approx 500 mg/day for almost 6 years, then backing down to 250mg until I stopped. I had started to feel depressed at 31 and was put on Lexapro, this led to a manic episode within a few months. Alas I am back on Depakote 500mg/day. It has saved me. Luckily no significant weight gain besides 10 lbs I lost being manic, but I do work out and try to eat healthy."
- Bolar
- Taken for 6 months to 1 year
- June 30, 2014
For Bipolar Disorder "This medication helped my symptoms tremendously. The main issue I had (and had to stop taking the medication) was low platelet count. Please if you are on this medication have your platelets checked routinely. My therapist never told me this could be a side effect... I finally went to my family physician because I was bruising so badly."
- TLGeer
- September 1, 2016
For Bipolar Disorder "I have major bi-polar disorder as well as severe depression and PTSD. This med (along with Seroquel and Wellbutrin) has been a literal lifesaver. For the first time in my life my moods are stable as well as manageable."
- Boss...
- Taken for 1 to 6 months
- April 27, 2019
For Migraine Prevention "I was on Depakote 500 mg once a day with no effect on my migraines. BUT I have noticed I’m no longer impulsively spending. So I guess it’s possible that I’m bipolar as well...? My doctor has upped my dose to twice a day and so far so good. No headache this month and adding to my savings every week lol."
- Bipolar
- April 2, 2016
For Bipolar Disorder "I took Depakote 500mg for a week then increased my dose to 1000mg after the next week. The next day I began having terrible stomach pains and pains in my kidneys, especially after eating. I emailed my doctor and he told me the side effects would subside but they didn't. They actually got worse and the abdominal pain would linger all day and night. I also had a hard time sleeping, I would wake up every 1-2 hours and sleep less than 6 hours a night, along with having very vivid dreams. The dreams later got more and more violent/terrifying and I began to fall into a very deep depression, one I had never felt in my entire life. I stopped taking this medication after three weeks. I will never take this medication even if it saved my life."
- akc
- September 27, 2014
For Bipolar Disorder "I started on Depakote by my new neurologist. I've had bad depressions and bipolar attacks, but about 2 yrs ago I started having seizures. This new neurologist took me off of all my medicines and just put me on a low dose of Depakote. I've been seizure free and much happier in general. The only things are the constant snacking and I seem to catch colds and flus easier. Any advice about that?"
- clems...
- Taken for less than 1 month
- December 8, 2015
For Bipolar Disorder "I was recently diagnosed with Bipolar II. This medication has been a life saver (literally) for me. It has helped keep my emotions in check. I took another medication lamicital that caused one continuous headache that never went away. My psychiatrist started me on a low dose of that medication so I wouldn't get a deadly rash. My emotions were all over the place and I was miserable. My psychiatrist put me on Depakote. At first this medication made me sluggish and hungry. I gained 5 lbs in the first 2 weeks. Since then I have laid off the snacks and beverages and have since gotten adjusted to the meds (also taking Zoloft). Three pounds have come off without trying. Each person is different, but this has really worked for me."
- jdk
- March 1, 2013
For Bipolar Disorder "I am on the 500 x 2 ER, and people tell me I'm a lot calmer and they see the change. I guess I was on the depressed side of the spectrum. It may also be that I am on Celexa as well. At first, I was severely drowsy, but after about seven months, it kicks in. As far as weight gain goes, no changes there. Hair loss? I was already losing it. I have been on lithium, and that didn't work. Tried Tegretol as well; come to find out I am allergic. So, if I can feel normal and blood tests on liver and kidneys come back fine, hey, I will give Depakote 2 big thumbs up for a normal life."
Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.
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For Bipolar Disorder "I recently found out I was bipolar 2 at the age of 24. I was 16 getting panic attacks, didn't think anything of it. Finally, I started getting more stress as I got older. I was on an antidepressant for 4 years not knowing I was bipolar. Someone who is bipolar should not just take an antidepressant because it will just put them into mania. That is what was happening to me. I checked myself into the hospital for intrusive thoughts. I'm not depressed; I don't want to hurt anyone or myself, but didn't know why these thoughts were coming so often. I also suffer from severe anxiety. I now take 40mg of Prozac, 500mg of Depakote, and 0.5mg of Ativan twice a day. My medicines are starting to work wonders for me. I'm me again!"