Xiaflex and Discomfort: What Users Say

• Mon...
• Taken for 6 months to 1 year
• June 19, 2019

For Peyronie Disease "Three series of 2 injections (2 injections - 1 injection, then the other in 2 days, 3 months between series, had 6 shots in 9 months). Horribly expensive and very uncomfortable during and after injections. No improvement - worthless - a medical businessman's scam. At least an auto mechanic guarantees his work."

• JBa...
• January 30, 2021

For Dupuytren's contracture "After considering surgery, I decided instead to have a Xiaflex injection to treat Dupuytren's contracture of the pinky finger of my left (non-dominant) hand. At this time (approximately two months post-injection), I am extremely pleased with the result. I did not have to risk the complications and long healing time of surgery, and the contracture has almost completely disappeared, along with the cords that caused it. Yes, there was some pain and discomfort during the administration of the Xiaflex and again the next day, when a local anesthesia was injected prior to the finger manipulation. These were expected and well tolerated. I recovered full use of my hand within a few days after the procedure. It is important to find an experienced hand surgeon who has had a lot of success doing these injections."

• Dud...
• Taken for less than 1 month
• January 10, 2019

For Dupuytren's contracture "Before 1-07-19, I thought the benchmark for pain was the night I had to undergo an emergency bladder catheterization for another issue. The Xiaflex injection that I just experienced completely erased that unpleasant memory with a brand new horrifying one. The next day, when my hand was injected with novocaine before the manipulation, was almost as bad as the Xiaflex. I briefly glanced at my hand when the procedure was complete and saw that my fingers were back to their normal position. My point is simple. As medicine advances, isn't the comfort of the patient supposed to be a main part of the equation? I had Needle Aponuerotomy on two previous occasions, and the discomfort was minor compared to this, not to mention less expensive to all concerned. My other hand is also due, and I would rather live under a freeway bridge than go through Xiaflex again. I'm definitely going back to N.A. even if I have to go out of network and pay out of my pocket."

• Anonymous
• Taken for 6 months to 1 year
• September 3, 2020

For Peyronie Disease "Don't waste your time or money. I went to my urologist for the treatment, who was excellent. Little bruising or discomfort with the injections. After 4 courses of injections over several months, NOTHING. I even purchased an expensive traction device and followed the instructions perfectly.... The only option for this disease, unfortunately, is surgery if you want any results at all. So glad my health insurance paid for this as it's VERY expensive and ineffective."

• MFK...
• October 9, 2022

For Dupuytren's contracture "I was treated for Dupuytren contraction for the ring and pinky finger on my left hand. I had significant discomfort with the Xiaflex injection on fingers, subsequent swelling of the left hand, and minor discomfort in the left armpit, which also turned red. However, after two weeks, the improvement to the fingers has been almost 100%, and it appears to be continuing to improve. Hopefully, I never have to have it again. However, if necessary, I would. Be advised, I’m a 69-year-old male in good health."