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Clomipramine for Depression User Reviews (Page 2)

Brand names: Anafranil

Clomipramine has an average rating of 6.9 out of 10 from a total of 38 reviews for the off-label treatment of Depression. 66% of reviewers reported a positive experience, while 26% reported a negative experience.

Reviews for Clomipramine

  • ImADuck
  • Taken for less than 1 month
  • May 20, 2020

"Strong, nasty drug! Given clomipramine for anxiety, obsessive thoughts/ruminations and depression. SSRIs are not much help, and Effexor helped for a while and then stopped. Pristiq didn’t help. So we tried clomipramine, an older drug. I only took 25mg for 4 days before calling it quits! Very strong sedating effects but didn't really put me to sleep the first 2 days. Then the next three days, wow! This put me on my back the entire day! I couldn’t function and do anything. I just wanted to lay down because I was so exhausted but couldn’t sleep!!! That’s disasterous! I hated that feeling! It also gave me restless legs which further worsened my ability to stay asleep! Now I’m gonna try buspar since I’m so sensitive to medication."

1 / 10
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  • Cera
  • Taken for 6 months to 1 year
  • September 17, 2018

"This did seem to give me a bit of energy but the side effects were not good. At the highest dose I was shaking so bad I couldn't write, I got dizzy every time I stood up, had electric shock feelings in my head and terrible twitching all evening and night. Luckily all the side effects stopped when I came off of it, but this was definitely not the right drug for me."

5 / 10
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13 Report
  • Ufa
  • Taken for 6 months to 1 year
  • May 4, 2020

"I've been about 8 months on clomipramine. It give me obsessive thoughts that weren't there before I started this drug (I was on on it for depression. I shouldn't have taken it. But it was a must since my psychiatrist prescribed it"

1 / 10
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9 Report

Frequently asked questions

  • Anonymous
  • Taken for 1 to 6 months
  • March 27, 2018

Anafranil (clomipramine) "I was prescribed Anafranil for depression after having a stillborn baby. It was given to me intravenously and during one treatment I had a fit which caused my shoulder to dislocate. Following this I was prescribed a smaller dose in tablet form which made no difference to my depression. Not long after I had another fit which again resulted in a dislocated shoulder! Following this second incident I stopped taking the drug. All in all my shoulder dislocated 14 times due to damage caused by this drug until it was finally operated on but I never gained full use of the arm and still experience pain at times. I felt my personality had changed and I was unable to function and finally got better by talking to a very understanding psychologist . I still have episodes of depression but have learned to cope with them with determination and the help of relatives and friend. Needless to say I was not impressed with Anafranil in my case."

1 / 10
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12 Report
  • Kenobi
  • Taken for less than 1 month
  • December 17, 2020

"Only took 25mgs of clomipramine and the effects were horrendous shaking, restlessness, all over body burning ,pins and needles ,anxiety, nausea, insomnia it was so bad I ended up in A&E I'm glad I only took 3 doses"

1 / 10
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8 Report

Are you taking this medicine?

  • GSano
  • Taken for 2 to 5 years
  • July 7, 2021

"This drug was a breakthrough drug for me. I’d tried everything from prozac to ketamine with partial success. Clomipramine levelled out my problems getting to sleep and staying asleep. Ideation was just a fact of life for me until I started this drug. Of course counseling, exercise, diet, and stress management are part of any worthwhile treatment plan for depression, and those haven’t changed. It’s become easier to make and keep good habits. Orgasms take a bit longer, but what antidepressant doesn’t have that effect in men?"

10 / 10
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  • Bird
  • Taken for less than 1 month
  • December 4, 2018

"I have been taking this medication for. as little over two weeks. I started off at 50 mg and then after 14 days, I increased to 100 mg. I thought I would start to feel better, hut I have been so depressed. I have still been struggling with the OCD. I also have bipolar 2. I am also wondering if I am feeling like this from coming off of Lexapro. I am just overwhelmed. I really want this medicine to work. Maybe it will just take more time..."

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  • moadej
  • Taken for 1 to 2 years
  • February 7, 2018

"It's the best medication I've ever had for MDD and GAD. It initially came with sedation, tremor, constipation, urinary retention, body pain and so on, but after being on it for a year (and thanks to some acupuncture) all the side effects are gone. If not for the side effects I'd recommend it to everyone! Only current downside is it only comes in 25mg tablets apparently and I take 150mg so that's 6 tablets and that runs out quickly."

9 / 10
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  • basia
  • Taken for less than 1 month
  • December 7, 2018

"Just started on it few days ago but I have noticed that my racing thoughts have stopped, so far I don't have any side effects, but to keep calm I have been using natural supplements and it seems to be working for me. Good luck to all"

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  • Micky
  • Taken for less than 1 month
  • August 23, 2020

"I'm just starting this medication I've been off meds for the past 6 years because I kept reading horror stories about what antidepressants do to you so I went down the natural root which unfortunately didn't work my anxiety and depression has gradually got worse so I'm going to give this a try but I'm so worried that it might make me worse as I've read a few negative reviews"

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  • Precl...
  • Taken for 6 months to 1 year
  • July 19, 2024

"I've been taking SSRIs since I was 18 for MDD. All of them: Paroxetine, fluoxetine, sertraline, duloxetine, citalopram, escitalopram, and Wellbutrin and so on. Nothing worked. I'm under therapy for 5 years, nothing happened. I told my psychiatrist I'm willing to go under ECT, because I have had enough, I don't want to die, and she brought up clomipramine. In my country, it is extremely rarely prescribed, only for absolutely treatment-resistant major depression. She prescribed it to me. We started with 25mg, now we are at 150mg, and man... It changed my life. I could leave alprazolam, I sleep like a baby, and I feel like a normal human being. Taking a shower is no longer a task, it's a joy. It's making wonders. She saved me from ECT, and it works. I wish I knew about this medicine before I begged for ECT. Give it a try, give it 6 months, you will feel amazing. The only side effect is no libido, but I could not care less, I just want to live. Props to my doc."

10 / 10
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  • JW 84...
  • September 3, 2014

Anafranil (clomipramine) "This medicine has minimal side effects. It makes me less sad or reduces obsessive worry. It lowers my anxiety. It also helps with digestion regularity."

9 / 10
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111 Report
  • RobIn...
  • Taken for 10 years or more
  • September 11, 2016

"Tried every AD pill, and this is the only one that's worked for me."

10 / 10
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31 Report
  • Alexa...
  • Taken for 6 months to 1 year
  • March 25, 2019

"Clomipramine causes mania, psychedelic effects, hallucinations that won't go away. I think this is too strong for bipolar people. Dangerous"

1 / 10
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  • Anonymous
  • Taken for 10 years or more
  • March 15, 2022

"I’ve been on this drug for 30 years, it was like coming out of a dark tunnel. I’ve tried to change them but others don’t work as well for me."

9 / 10
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6 Report
  • Newtome
  • July 17, 2017

"I would like to know everyone's experiences on this drug please. Does it cause insomnia?"

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10 Report
  • Ugh
  • Taken for 1 to 6 months
  • March 28, 2022

"It worked great for me until I got up to 100mgs and got urinary retention and had to get a catheter put in."

4 / 10
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  • Eul
  • Taken for 1 to 6 months
  • December 26, 2019

"This medication doesn't work for me I've been on it for two month on 75mg clomipramine. Now my psychiatrist has made it 100mg. He said to give it a try for two month"

1 / 10
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2 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.