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Keflex and Nausea: What Users Say

Nausea: mentioned by 13 users (14.3%)

Based on user experiences from 91 Keflex reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 14.3%
diarrhea 9.9%
headaches 8.8%
upset stomach 7.7%
dizziness 6.6%
tiredness 5.5%
depression 4.4%
fatigue 4.4%
gas 4.4%
itching 4.4%

Reviews for Keflex

Commonly mentioned side effects
  • Her...
  • Taken for less than 1 month
  • September 2, 2019

For Bladder Infection "I started with a bladder infection on Sunday. I was urinating every 10-15 minutes, and it was so painful and I felt a lot of pressure. I called the doctor, and I was put on Bactrim on Monday night. The Bactrim gave me the spins, constipation, and anxiety. It was a nightmare! After 5 doses of Bactrim, my infection kept getting worse. I called the doctor, and they switched me to Keflex. I started the Keflex at 9 pm, and in less than 24 hours, I felt much better. No side effects except a little bit of nausea and dizziness, so remember to eat when you take it. It is a miracle drug for urinary infections and bladder infections."

10 / 10
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  • Fat...
  • Taken for less than 1 month
  • June 6, 2020

For Bladder Infection "So I ended a Saturday at the ER. I ended up having a urinary infection, a severe one. The PA prescribed Keflex 500 mg for 7 days - it really helped after 2 days, but I noticed that it does bring out side effects on myself. I feel nauseous, tired, agitated, eyes feel hot, headaches. Even though I took 2 Advil, it was still there. I also feel super anxious, I've been having mood swings, I feel more sad, and somehow more depressed than I have been in the past. And I still have one more day to go."

8 / 10
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  • eis...
  • Taken for less than 1 month
  • March 27, 2020

For Bladder Infection "I was prescribed Keflex twice a day for 7 days for UTI but I only lasted 4 days. Before I took this medication I had some anxiety, but no other mental health issues besides my ADHD. The 2nd day I took it I became psychotic. I was severely depressed, paranoid, convinced everyone was talking about me or working against me. I cried all day. My mind was racing & convincing me of all kinds of delusions about myself & those around me. I was having vivid disturbing nightmares. I couldn’t eat anything. Constantly felt like I was going to vomit & slept from the time I got home from work until the next morning when I got up for work. I have been on antibiotics before, but this was my first AND LAST time I will ever take this."

1 / 10
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Frequently asked questions

  • rin...
  • February 17, 2009

For Bladder Infection "I usually never have side effects from antibiotics, but I had moderate dizziness and nausea. The nausea is not bad enough to send me to bed all day, but it does interfere with my daily schedule and leaves me extremely worn out and fatigued. It is frustrating. I have to take it four times a day for ten days."

3 / 10
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154 Report
  • dav...
  • Taken for less than 1 month
  • March 16, 2016

For Skin or Soft Tissue Infection "Had an ingrown toenail infection. Was given 500mg Keflex taken 4 times a day for 7 days. It is working and I have no pain in my toe. However, so far I've had diarrhea, stomach pain, tiredness and weakness, dizzy spells, yellow skin, loss of appetite, nausea, red scratchy eyes. So most of the usual stuff. The long and short of it is my toe will be healed as long as I can deal with the side effects for a few more days."

6 / 10
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  • Jea...
  • Taken for less than 1 month
  • May 28, 2019

For Bladder Infection "Took a 500 mg dose of Keflex twice a day for one week - I had a UTI. Side effects were diarrhea, headaches, felt depressed, upset stomach, and nausea. Now I’m having stomach cramping. Just hope the urinary tract infection I had is gone after taking this strong antibiotic."

10 / 10
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  • Anonymous
  • July 22, 2011

For Skin or Soft Tissue Infection "Works very well for treating the cellulitis I got from an insect bite. But don't drink alcohol while you are on this medication. I had half a beer and started feeling really nauseous, had a migraine and my stomach hurt."

10 / 10
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87 Report

More FAQ

  • Jes...
  • Taken for less than 1 month
  • March 2, 2018

For Bladder Infection "I have been going back and forth battling a UTI for about a year. I take D-Mannose, which usually knocks it out in a day or so, but the D-Mannose has been giving me weird pains in my carotids. Anyway, I decided to go get a script after waking up with severe bladder pain a few days ago. About six hours after the first dose, the pain subsided. This medication will make you nauseated if you don't take it with at least 6 oz of water and a snack. No negative side effects yet! Love Keflex!"

9 / 10
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  • fat...
  • Taken for less than 1 month
  • July 23, 2013

For Skin or Soft Tissue Infection "This medication gave me really bad traveling gas with cold sweats and made me very nauseous on the very first pill! I might ask my doctor to replace this medication with something else. I find it very strong, especially for a mild skin infection due to a spider bite!"

2 / 10
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48 Report
  • jes...
  • November 23, 2020

For Upper Respiratory Tract Infection "I went to the ER, they said I had a UTI, so they gave me Keflex 500 mg 4 times a day for a week. I despise ANY medication because of the side effects, but I didn’t want a kidney infection as that’s way worse, so I took it. I had nausea and some mild diarrhea about an hour in, normal, right? So, a few days in, I felt like I was hit by a truck. I woke up fatigued, my anxiety was so bad, and I developed an achy back that lasted a week even after I was done taking it! I still have some mild diarrhea every day, and it’s been a week since I’ve finished the medicine. I have no clue how I pulled through and took all of it. It did indeed clear up my infection, but I still feel sick. I know it’s a turn-off reading this, and it makes you not want to take the medicine, but you HAVE TO unless you want a kidney infection, which is way worse, and you’ll be put on even more antibiotics if that happens. Just pull on through, but if you genuinely don’t feel good when taking it, talk to your doctor."

5 / 10
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  • Hub...
  • Taken for less than 1 month
  • April 24, 2018

For Bacterial Infection "Hubby has a bad tooth, recently started hurting him extremely bad. Got hold of a dentist to get the tooth out. He prescribed Keflex 250 mg, for the first 3-4 doses he was to take 2 x 3 doses then 1 cap x 3/day until finished. Within 1 dose, his tooth pain went away, however, on the 2nd to 3rd dose, the nausea, vomiting, horrible stomach pain that he describes as a nasty pain which he has to make himself puke gives him short-term relief. So if he is able to tolerate the rest of the duration of the script, this will be added to his list of meds he can't take."

5 / 10
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22 Report
  • Ros...
  • Taken for less than 1 month
  • August 7, 2020

For Bladder Infection "I had cystitis and was put on Macrobid for 5 days, only to find out it didn’t do a thing for the infection. My Dr. gave me an injection of Rocephin in the office and suggested Keflex for 7 days, three times a day (500 mg). The Rocephin gave me a stomach ache and diarrhea, then I took Keflex, and it made me queasy the rest of the day. The second pill I was fine and have remained side effect-free since then. I finish my course tomorrow but still feel the cramping and mild pain from a UTI, so I’m not sure this antibiotic worked either. We’ll see!"

9 / 10
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  • owi...
  • Taken for less than 1 month
  • January 5, 2021

For Skin or Soft Tissue Infection "I was taking Bactrim for 2 days with no improvement before being prescribed Keflex QID for 7 days to take with Bactrim for an infected cut on my wrist from punching glass. As soon as I began Keflex, I started noticing improvement. It's hard to say whether the improvement or my side effects were from Keflex or Bactrim, so take this with a grain of salt. I had tachycardia, chills, nausea, indigestion, gas pain that felt like chest pain, itching on arms/legs, petechiae on my upper arms, frequent urination, and eventual yeast infection for which I had to take Diflucan. I had some symptoms together, and some separate. Most of my side effects came at night, though, so it could've been some kind of reaction between the two? The side effects definitely hit me harder in the beginning, but by my 5th day of Keflex, almost all side effects had subsided. I suggest taking with probiotics that can survive stomach acid and easily digestible food and drinking a lot of water."

6 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.