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Carbidopa / levodopa and Depression: What Users Say

Brand names: Sinemet, Rytary, Crexont, Duopa, Parcopa, Dhivy Atamet

Depression: mentioned by 5 users (5.3%)

Based on user experiences from 94 Carbidopa / levodopa reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

muscle spasms 12.8%
hallucinations 6.4%
nausea 6.4%
anxiety 5.3%
depression 5.3%
tremors 5.3%
anger 4.3%
drowsiness 4.3%
stiffness 4.3%
confusion 3.2%

Reviews for Carbidopa / levodopa

Showing 5 reviews tagged with "depression". Clear filters to view all 94 reviews.
Commonly mentioned side effects
  • Gig...
  • Taken for less than 1 month
  • January 2, 2020

Carbidopa / levodopa for Parkinson's Disease "I never took illegal drugs, but my experience was like I heard when people took LSD. I had horrid hallucinatory dreams, sweating, depression, increased anger, lack of impulsive control, weight gain, all within two weeks. Having Parkinson's is better than the side effects I had with this drug."

1 / 10
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27 Report
  • You...
  • Taken for 2 to 5 years
  • November 13, 2017

Carbidopa / levodopa for Parkinson's Disease "I've been on Rytary since 2015 and at times was on 5 pills 4 times a day of the 48.75-195 dosage. Partial neuroleptic seizures were a result, mild psychosis, paranoia, anxiety, mood swings, depression, dyskinesia, dystonia, impulse control, sleeplessness, among others, all things I've dealt with at some point along the way. I'm now on 3 pills 5 times a day, with a small dose of 2 mg Artane in between 4 times a day. I have not been able to really lock down whatever makes it work. It is wildly inconsistent, but when it's on, it's on, and I get some normal time. Certain strains of medical marijuana help increase the efficacy of this drug, kicking in sooner and can give me up to 6-7 hours of normal time instead of 1 hour to kick in and 1-2 hours normal time."

3 / 10
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32 Report
  • Hor...
  • Taken for 1 to 6 months
  • March 1, 2023

For Parkinson's Disease "My husband was on carbidopa/levodopa for about 3 months. Last month, he experienced anger, depression, and much confusion. This has set him back. He was taken off this medication, and I am unsure if he will get back to where he was before starting this medication—terrible experience."

1 / 10
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4 Report

Frequently asked questions

  • Ano...
  • Taken for 1 to 6 months
  • April 29, 2018

Carbidopa / levodopa for Parkinson's Disease "I took Sinemet for about a month, and while it lessened my uncoordinated hand movement, I fell into a very deep depression and was having panic attacks. As soon as I stopped taking it, I was better."

2 / 10
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38 Report
  • Anonymous
  • February 15, 2018

For Parkinson's Disease "Do not take this if you have a history of depression. My brother was on for 4 days and became more depressed and suicidal. He is only 55 and never has been suicidal in the past."

1 / 10
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13 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.