Skip to main content

Sublocade and Tiredness: What Users Say

Tiredness: mentioned by 21 users (6.9%)

Based on user experiences from 305 Sublocade reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

withdrawal 16.7%
pain 11.1%
burning 7.5%
tiredness 6.9%
depression 5.9%
nausea 4.3%
headaches 3.9%
anxiety 3.3%
constipation 3.3%
cravings 3.3%

Reviews for Sublocade

Commonly mentioned side effects
  • Doo...
  • Taken for 1 to 6 months
  • December 11, 2019

For Opiate Dependence - Maintenance "I’m about like most of you, wanted to feel good. Pain pills, methadone (mistake) methadone is too good and harder to get off of. Then Suboxone, which was fine, but I would be feeling tired or whatever, so I would take another piece. So I was pretty much controlling how much I took. Anyways, Sublocade was offered to me. I was scared, but I decided to do it. I took a 300 mg the first two months and no withdrawals at all. Didn’t feel funny or anything. Now I’ve taken maybe four 100 mg, and I’m scared to stop because of years of depending on something. But I’m pretty sure I’ve had my last shot."

10 / 10
Was this helpful?YesNo
59 Report
  • Jus...
  • September 1, 2020

For Opiate Dependence - Maintenance "I attempted to get off Suboxone two or three times but never past 2 milligrams. I decided to try Sublocade as a way of getting off Suboxone, I would get one shot and then it would slowly leave my system. I went to the clinic for the shot of Sublocade, the injection was super painful as I have very little body fat, it hurt like anything. The injection site was sore for approximately 4 days. The first 2 days I felt 'sub high,' and on the 3rd, I had a super headache and did not feel well. Over the next three or four days, I was super tired and falling asleep in the afternoon. Approximately 7 days in, I began to feel better and I seemed to normalize. I noticed that I no longer feel sick in the morning, so I am no longer reminded of my problem. I began to get up normally and get rolling without issue. I am getting tired earlier in the evening, which is not a bad thing because I was going to bed at approximately 12 every night, now I'm going to bed at 11 and I suspect it will be 10 soon."

8 / 10
Was this helpful?YesNo
36 Report
  • Att...
  • Taken for 1 to 6 months
  • February 24, 2020

For Opiate Dependence - Maintenance "I have been on some form of buprenorphine for over 10 years. When I first started, I was taking 24 mg daily. I was able to wean down to 16 mg daily, which is still an extremely high dose. I have had absolutely no luck lowering it anymore. I also had an issue taking an extra 1 every few days, which would leave me in withdrawal for the last few days. Knowing those strips were there always screwed me up, but I desperately wanted to get off the meds. I explained the issue I was having with my doctor. He suggested switching to Sublocade. I just received my 5th injection and couldn't be happier! Definitely a good choice for patients who are having trouble weaning yourself off. The first month, I was a little tired, but I can tell you now I feel normal. I love that I no longer have the option to take another strip because of 'stress.' Also, the injection does not hurt. It burns for 20 seconds, then nothing. I'm very excited that I finally can see an end in sight."

9 / 10
Was this helpful?YesNo
30 Report

Frequently asked questions

  • Mar...
  • January 31, 2019

For Opioid Use Disorder "I am unsure about this shot. I have gotten it twice now and had to fight for the second injection. The first time I got it, I was only two in 5,000 people where the shot didn’t properly dissolve into my body, and I had extreme withdrawals after two days. They even did a urine and blood test, and my bup scores were 500 on the strips and down to 70 by the time they believed I was in withdrawal and put me back on to strips. I just got my second one by a different doctor after the doctors spoke to pharma and any other doctors about their opinions on me getting a second dose because I want off Suboxone. I’ve been stuck on it for 5 years and had two children during this time. I want to be free, and I experience insane withdrawal when I wean off of strips. So it’s day two, and I am getting some hot and cold sweats but feel a little more tired than last time, and I am not feeling as “sick” as last time. I am so hopeful! I will update this in 10 days! :)"

5 / 10
Was this helpful?YesNo
23 Report
  • Dre...
  • April 9, 2019

For Opiate Dependence - Maintenance "So, I have been on Suboxone for 4 years now in maintenance. I take two 8 mg strips a day and heard about this Suboxone shot because taking strips twice a day becomes an inconvenience. I took the shot Friday at 1:30 PM. It didn’t burn as bad as some people say. I started to feel the injection within a couple of hours. That night, I felt I had a pretty high dose of it in my body. The next day, Saturday, I felt great, plenty of energy, and no negative symptoms at all. I felt amazing. Sunday night, I started to slightly get tired and out of it. It’s now Monday night, and I feel horrible, like I’m withdrawing, like a really bad flu. So now I have to make a decision on what to do. If anyone on here has advice on what I should do, please answer my message. I would greatly appreciate it. I’m not sure if I should wait it out and see what happens. Will it get better or worse? I’m crossing my fingers, and I hope this advice helps someone out there."

5 / 10
Was this helpful?YesNo
21 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Pre...
  • Taken for 2 to 5 years
  • February 15, 2022

For Opiate Dependence - Maintenance "I started on Suboxone 2 years ago. It was fine. No side effects, really, except constipation. I didn't like taking it daily, the whole routine of it, and absolutely didn't like the taste. So I switched to Sublocade. I didn't notice the transition, except being really tired for about two months. I have nothing but good things to say about it, and it's kept me opiate/heroin-free for two years. I have absolutely no desire to use, so I've decided to go off Sublocade cold turkey. After reading the reviews, I'm quite confident."

8 / 10
Was this helpful?YesNo
12 Report
  • Dav...
  • December 26, 2018

For Opiate Dependence - Maintenance "I have been taking 8 mg of Suboxone for 2.5 years now, and decided to make the switch to the shot to break the habit of waking up and expecting to take something every morning. 2 hours in and I am a little tired, but other than that, all is well. Have not taken any Suboxone since yesterday morning, and so far no withdrawal symptoms. So that’s 32 hours without Suboxone and getting the shot 2 hours ago with no withdrawal so far, I think I’m good to go. I was told some people experience withdrawal at the beginning of getting this shot, but I think that only happens to those that switch from a very high dose of Suboxone (above 12 mg) without tapering down some first. I’m no doctor, but have plenty of experience with addiction. My suggestion would be to make sure you’re on a regular dose of 8 mg per day of Suboxone before getting the shot. If you do and attend NA meetings regularly, this medicine is really a lifesaver. Don’t depend on the medicine alone, get involved in your local NA!!"

10 / 10
Was this helpful?YesNo
19 Report

More FAQ

  • Lys...
  • April 13, 2021

For Opioid Use Disorder "Got my first 300 mg injection on 4/6/21. I've been on buprenorphine since October 11, 2010. So this October will be 11 years. 11 years of twice a month, or monthly appointments, visits to the pharmacy, random counts, and UAs. This medication I hope is what every addiction on maintenance needs to get off. 24 hours after injection is the peak levels. I can attest that the first 2 days I felt amazing. Today is 1 week of not taking anything. Knowing I have a backup plan in case something comes up and I feel sick is keeping me calm. Today I feel a little more tired than usual. But nothing I can't push through! I will update again in a few weeks! But as of right now, I am so glad I bucked up and did it. It certainly burns like anything going in, although it wasn't unbearable. The 'depot' of the drug in my abdomen takes some getting used to. Every time I bump it, it swells and hurts. Swelling and bruising have gone away as well."

9 / 10
Was this helpful?YesNo
12 Report
  • Kat...
  • Taken for 1 to 6 months
  • March 26, 2022

For Opiate Dependence - Maintenance "I've been an opiate addict for 20 years now. After 5 years on Suboxone, I was looking for a new solution. I ended up going with Sublocade. I had two 300 mg injections and one 100 mg. It's been 2 months now since my last injection, and I'm still feeling great. The only side effects I had while on the injection were tiredness and constipation. I would absolutely recommend this to anyone who is ready to be sober."

10 / 10
Was this helpful?YesNo
9 Report
  • Kas...
  • Taken for less than 1 month
  • May 24, 2018

For Opiate Dependence - Maintenance "I just received my first Sublocade shot on Tuesday at 12:40. I had been on Suboxone for 4 years and would a lot of times run out of my prescription early because I would always think one more to feel better, just one more. Of course, the only thing it might have done is give me energy for a little while, but since receiving the shot, I have to admit I'm not too impressed. Of course, at this time my head could still be messing with me because I am having issues with the part of taking something every day, but I'm very, very tired with no energy, so I feel like rubbish and I'm still having some hot flashes. I'm hoping it will get better and it will work because I want this to work, but as of now, I'd say the Suboxone strips are a lot better. But I will keep posting updates because I looked and looked for reviews before switching and couldn't find any, so I'd like to help people with my story."

5 / 10
Was this helpful?YesNo
18 Report
  • Tre...
  • Taken for less than 1 month
  • September 14, 2018

For Opiate Dependence - Maintenance "Just awful. I was taking 16 mg of generic buprenorphine a day and decided to try this out because I was sick of having to take my meds twice a day. Days 1-3 were okay, but starting day 4, I noticed that the cravings were back and I felt way more tired. Day 5, I was in full withdrawal. I ended up going back to the doctor and he put me back on my original dose. Be advised that this works very well for some and is a complete disaster for others."

1 / 10
Was this helpful?YesNo
17 Report
  • Jak...
  • Taken for less than 1 month
  • February 14, 2021

For Opiate Dependence - Maintenance "I just got my first injection last week. We started off at 100 mg with intentions of weaning myself off within a few months. I have been on oral Subutex for almost 3 years. I have been EXTREMELY tired, to the point that every time I lay down with my daughter, I am fighting sleep or passing out. This includes nap time before 1 PM and bedtime at 8 PM. Did anyone else experience this? If so, does it go away? What shall I do?"

3 / 10
Was this helpful?YesNo
12 Report
  • Anonymous
  • Taken for less than 1 month
  • February 26, 2023

For Opioid Use Disorder "I have been on Suboxone for 17 years next month. I have changed to Sublocade, and it is my 11th day of getting the injection, and I don’t feel good. It started my third day with symptoms of withdrawal: irritated, chills, hot flashes, yawning, runny nose, and watery eyes. I feel tired a lot more than usual, and I definitely know when my body is withdrawing. I don’t know if I can do this every month."

5 / 10
Was this helpful?YesNo
7 Report
  • Anonymous
  • Taken for less than 1 month
  • February 26, 2023

For Opioid Use Disorder "I have been on Suboxone for 17 years next month. I have changed to Sublocade, and it is my 11th day of getting the injection, and I don’t feel good. It started my third day with symptoms of withdrawal: irritated, chills, hot flashes, yawning, runny nose, and watery eyes. I feel tired a lot more than usual, and I definitely know when my body is withdrawing. I don’t know if I can do this every month."

5 / 10
Was this helpful?YesNo
7 Report
  • Sli...
  • Taken for less than 1 month
  • March 5, 2019

For Opiate Dependence - Maintenance "So today is my first day on Sublocade. I've been on Subutex 2 years this time. But I've been on them all: methadone, dope, Suboxone a few times for each. I was on heroin and Xanax since 2002. It was a real struggle for me to get clean, but I kept trying. Anyway, I got tired of the up and down on Subutex. I feel great in the morning and tired around 6 PM. Plus, my sleep was screwed. So I read that this stuff is supposed to be much smoother. I took the shot about 5 hours ago, and I feel it already. It's not bad at all. I like it, actually. I forgot to say I was on 16 mg of Sub. Anyway, I'll keep updating."

10 / 10
Was this helpful?YesNo
15 Report
  • Meh...
  • Taken for less than 1 month
  • August 6, 2018

For Opiate Dependence - Maintenance "I had my first Sublocade shot this morning at 9 a.m. I feel nothing. It stung, about like a black fly bite. It went away almost immediately. I feel nothing at all. I worry. The small buzz I got from subs kept me going-not craving and using illicit opioids. My doc put me on the Sublocade due to mismanagement of dose. I wish I could just take the strips as prescribed. I'll keep posting. As of day one, I feel nothing at all. Just tired."

5 / 10
Was this helpful?YesNo
15 Report
  • Jun...
  • May 5, 2021

For Opiate Dependence - Maintenance "I took my first Sublocade injection April 30th, 2021. Today is May 4th, 2021, and so far, so good. I've been on Suboxone for the past 3 years (8 mg daily) and was a bit nervous about feeling any type of withdrawal, but I’m on day 5, and I feel great. Today, I woke up feeling a bit tired and my body a bit achy, but nothing I can’t deal with. Overall, I’m very happy with the way I’m feeling! My first injection was 300 mg, and my next will be another 300 mg, and then my third will be 100 mg, and I’m planning on not taking a 4th! I will keep everybody updated throughout my process, but if there’s anybody thinking about getting the injection, DO IT! I know the feeling of waking up every day and dealing with having to put film under your tongue just to feel normal, it sucks! And it’s the worst... Plus, before I decided to get on the Sublocade, I read hundreds of reviews, and they all say the same thing about how great it’s working for them, so I did it, and it’s the best thing I could have ever done, guys!"

10 / 10
Was this helpful?YesNo
7 Report
  • Hap...
  • Taken for 1 to 6 months
  • February 14, 2022

For Opiate Dependence - Maintenance "After many years on ~10 mg Subutex, I switched to a provider that offered Sublocade injections. I had lost most of my previous prescription during a move and decided I didn't want to live always afraid my pills would be lost/stolen, random U/A tests, random pill counts. I received my first injection and, except for some tiredness (difficulty staying awake on grave shifts), I had no side effects. I was prepared to complete the series. When I arrived at my appointment for my second shot, it was not there. The specialty pharmacy would not release it because my name on my insurance and Social Security card is spelled differently than on my license and birth certificate. I would need a legal name change in order to get the injection released to my provider. So, my doctor put me back on the Subutex to start when withdrawal symptoms began. I took a small piece of a pill here and there, but never experienced any real discomfort. This was in November. I haven't had a shot, any Subutex, or any withdrawal since. I am finally DONE!"

10 / 10
Was this helpful?YesNo
4 Report
  • Nic...
  • Taken for 1 to 6 months
  • August 22, 2021

For Opiate Dependence - Maintenance "This stuff's made me so weak and barely sleep! OK, it was alright for a couple of days, however, I can barely do 'daily chores,' let alone concentrate at work now. Been on Buph for nigh on a decade, so I feel this is just prolonging withdrawals. Going back to a weekly script ASAP (hopefully), as I was put back to 'Daily Supervised,' which is the reason I chose this in the first place. Was recommended it, though, but everyone I know on this are (more or less) still using anyway! Not enough info on this lethargic stuff, but if it 'works for you,' then all the BEST.."

1 / 10
Was this helpful?YesNo
4 Report
  • DAN...
  • Taken for less than 1 month
  • June 24, 2022

For Opiate Dependence - Maintenance "I started Sublocade approximately 3 weeks ago this Tuesday. At first, I felt great. I had been on 16 mg for years and was tired of taking meds every single day. Now, two weeks in, and I don't know if it's me in my head or what, but I'm tired all the time and have literally no energy. I want so badly to call my doctor and switch back, but I'm trying to make it through. I'm also having cravings, which I don't understand at all. I haven't had cravings in years."

8 / 10
Was this helpful?YesNo
0 Report
  • DAN...
  • Taken for less than 1 month
  • June 24, 2022

For Opiate Dependence - Maintenance "I started Sublocade approximately 3 weeks ago this Tuesday. At first, I felt great. I had been on 16 mg for years and was tired of taking meds every single day. Now, two weeks in, and I don't know if it's me in my head or what, but I'm tired all the time and have literally no energy. I want so badly to call my doctor and switch back, but I'm trying to make it through. I'm also having cravings, which I don't understand at all. I haven't had cravings in years."

8 / 10
Was this helpful?YesNo
0 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.