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Acetaminophen / hydrocodone for Pain User Reviews (Page 5)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.2 out of 10 from a total of 708 reviews for the treatment of Pain. 52% of reviewers reported a positive experience, while 31% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

  • Sannda
  • Taken for 10 years or more
  • September 28, 2022

"I have tried every generic pill of this medication. Can't take any of them. I used to always use Watson, which was excellent. But Watson went out of business. The generics now available make me extremely sick. The sickness lasts into the next day after taking just one generic pill. Found no relief from the pain. But...I just came across one Hydrocodone/Acetaminophen that I can handle. It is made by Rhodes. Well worth your time to look into this heaven-sent medication."

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  • shamy...
  • Taken for 1 to 2 years
  • March 13, 2014

Norco (acetaminophen / hydrocodone) "Been taking Norco for 19 months as I have neuropathic foot, leg, hip, low back pain. Trying not to have back fusion. Norco 5mg/325mg does great for pain control. Without this, I would be flat on my back in bed. Thank goodness for Norco."

10 / 10
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  • Amy
  • Taken for 10 years or more
  • July 27, 2019

"I have been taking various opioids for over 10 different painful health issues, which I will not go into here because I would be here all day. A few, however, are ankylosing spondylitis and scoliosis. I have been taking pain meds for over 10 years now. I was prescribed 2 different pain meds, but have been reduced to only one now. I chose lower back pain all the time. Feeling like I have the flu all the time tried not only my physical pain but also my emotional when feeling this way. They carried the 10 mg pills from a certain manufacturer that were rectangular-shaped. COMPLAIN TO THE FDA... they KNOW WE ARE ON TO THEM!! FILE COMPLAINTS, START PETITIONS!!! NONE of the people who control opioid pain meds actually have ANY TYPE OF SEVERE pain! They are INSULTING OUR INTELLIGENCE!!!"

1 / 10
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  • ghani
  • Taken for less than 1 month
  • January 26, 2014

Norco (acetaminophen / hydrocodone) "Taking this for a very painful dental abscess. It's been a Godsend. Got my first significant bit of sleep in days. It does give me dry mouth, so if you take it for dental reasons, Biotene mouthwash is helpful."

9 / 10
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  • Chron...
  • Taken for 5 to 10 years
  • July 13, 2021

"Report all issues to the FDA. They have a form you can submit to have the issue investigated. I just got switched to Mallinckrodt acetaminophen with hydrocodone and immediately noticed they didn’t work. The only brand of acetaminophen and hydrocodone that worked the best was Watson, since they started using all the other manufacturers, I haven’t found one that works as well. When I was switched to Mallinckrodt, I looked online to find the manufacturer and found a ton of others making the same claims as I was experiencing. I hope everyone is making the reports to get this stuff off the market. There is absolutely something different about these meds, the active ingredient or percent of opioid must be off or something. Google FDA consumer reporting."

1 / 10
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  • Dog...
  • October 24, 2019

"I have taken Watson brand hydrocodone and acetaminophen off and on for many years. Watson brand works great, but they are no longer making the drug. CVS is buying the worst generics available outside the country. Now they only have Aurobindo brand, and it does not work at all! There are many articles online about constant quality problems with Aurobindo. Why doesn't the FDA do something? Why does CVS buy drugs from Aurobindo, knowing there are constant quality control problems? EVERYONE MUST REPORT THESE BAD DRUGS OR THE FDA CAN'T DO ANYTHING! WWW.FDA.GOV/MEDWATCH CLICK ON RED BUTTON FOR REPORT A PROBLEM."

1 / 10
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  • mikel
  • Taken for less than 1 month
  • November 4, 2020

Norco (acetaminophen / hydrocodone) "I have extreme pain from a tooth, and my dentist prescribed me Norco, and I thought the excruciating pain would finally end. This stuff is complete garbage. I usually have to take lower doses due to sensitivity, and this was a full dose. It did absolutely nothing for pain. The only thing it did was make me a tiny bit tired, but Tris needs to figure out what they are doing. DO NOT use this for pain relief, ibuprofen does a lot better."

1 / 10
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  • Hello
  • Taken for 1 to 2 years
  • September 20, 2022

"You can file a complaint online with FDA no longer have to print out and fax. These drug manufacturers need to be fined hugely for making worthless cheap medications that do not work as do the brand name, but also can be dangerous and cause many side effects otherwise not found in properly made brand name medication. Here is link. Takes about 10 minutes all online , submit complaint just google" MedWatch: The FDA Safety Information and Adverse Event Reporting Program"

4 / 10
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  • AJano
  • Taken for less than 1 month
  • January 23, 2020

Norco (acetaminophen / hydrocodone) "Was prescribed this to help manage the insane pain of a kidney stone, and it seems to do pretty much nothing. I don’t take any other opiates, but I have to imagine that they work better than this. I get virtually no relief at all."

2 / 10
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  • OC Guy
  • May 23, 2016

Norco (acetaminophen / hydrocodone) "I tore my adductor muscles from slipping on some mats in a martial arts class 6 years ago. I've had two sports hernia operations, which helped, but I have some permanent nerve damage in my thighs. I get burning and shocks in my thighs. I have been taking 1-2 Norco as needed for several years, and they work great. I know they are highly addictive, but no other pain killer allows me to work, have fun with family and friends, and continue to train in my martial arts. I sometimes go 3-5 days without any and rarely take more than 2 a day. If you have chronic pain or permanent nerve damage, these can give you your life back."

8 / 10
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  • HELP...
  • Taken for 10 years or more
  • September 24, 2021

"I knew I wasn't imagining things. Like so many others, a half to 2 a day used to give me some quality of life. One can take 3 of these within 2 hours and just end up going to bed. Our pain is real, and no one either cares or listens! The government tries to punish the doctors, which in turn punishes those of us in severe pain 24/7. This may seem heartless, but I don't care anymore, we use our medicine legitimately and have been thrown aside to save the addicts! That's wrong! All this did was turn them onto heroin and fentanyl. So, you've created a new problem of needle users and are still dealing with ODs. You have responsible adults suffering and taking more meds than one should, just trying to keep from committing suicide from the horrible pain! I doubt any lawyer is going to risk having the watchdogs following them just to help us. All I do is cry and pray for a solution, either by someone finally hearing us or God taking me away from this. Prayers, blessings, whatever your belief is!"

2 / 10
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  • Paul
  • Taken for 6 months to 1 year
  • February 16, 2020

"Yes, I have felt that there is a difference now in the effectiveness of Watson brand of acetaminophen with hydrocodone 10/325. Now I know I am not crazy. The 5/500 Vicodin back in the '90s worked better than today's 10/325 Watson. Even when I took 10/325 Watson's in 2008, they worked better. I personally thought something was up three years ago, and it started then. The problem is I don't have any pills from that era, '90s or mid-2000s, to test and compare the difference with a lab breaking down the chemicals."

4 / 10
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  • Retired...
  • October 15, 2016

Norco (acetaminophen / hydrocodone) "When they switched me to Norco, I had to deal with more pain. The medication is half as effective and makes me sick to my stomach many times. The government doesn't care about the people with real pain, more concerned with the drug addicts (which more people are becoming because they can't get the pain relief they need.)"

1 / 10
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  • Abriton
  • Taken for 2 to 5 years
  • September 6, 2019

"PS to my previous comments, 2019-08-28, 2019-08-26. It seems from reading the 2019 reviews here that this started this year. I agree. You will see from my previous comments on this page that Mallinckrodt told my pharmacy that they had outsourced their hydrocodone. This may be the reason. The other thing that happened was I used to pay $20 for 30. Last month they charged me $8! I assume Mallinckrodt offered financial incentives! Please, everyone complain to the FDA, to Mallinckrodt headquarters, and your pharmacy if you are having issues with your acetaminophen/hydrocodone. Call around to other pharmacies and ask what brand they use. I did, and found a small, local pharmacy that had Par. I will go there. You can ask your doctor for a paper prescription so you can take it where you like. That is what I do."

1 / 10
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  • Pyt
  • Taken for 2 to 5 years
  • November 15, 2019

"I have taken the acetaminophen with hydrocodone Watson brand 10/325 and now take M367, which is another manufacturing company. I haven’t noticed too much of a difference. My friend, who also suffers with pain, takes acetaminophen with hydrocodone imprinted 358 made by Lupin. She hates them. I never realized that manufacturing companies did this sort of thing. It’s sad for the people who suffer so greatly."

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  • Deedy
  • February 7, 2020

"I've been on Norco, generic (acetaminophen with hydrocodone) 7.5, manufacturer Lupin, but now they have changed manufacturers, and it is not helping me. Mallinckrodt. I take these, and I go to sleep with a little relief, but then wake up with pain. The manufacturer LUPIN worked for me, but now I can't find a pharmacy that carries them. What has happened?"

10 / 10
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  • Missy
  • Taken for 1 to 6 months
  • September 8, 2018

"Since the 'druggies' decided to ruin it for all who actually need an opiate, we're pretty have a problem (Sudafed as well)! I used to take Lortab 10 (Pink). My doctor switched me to Norco 7.5/325, and man 'ole man - junk! I think the Watsons are the best and will only fill if I see an imprint of N357 or 3203-Watson! The M366 (Mallinckrodt Pharmaceuticals) are worthless, and I will NOT fill if that's all they have! My script is now 6 days past due because I'm looking for a pharmacy that doesn't carry that rubbish brand! I take 3, and I still can't move! An Advil works better than those! We shouldn't have to live in pain because SOME people WANT to abuse their meds! I do not, and I'm randomly tested! NEVER failed, so why are we being punished?! We shouldn't be punished, THEY should! This is getting ridiculous!"

1 / 10
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  • Anonymous
  • May 20, 2009

Lortab (acetaminophen / hydrocodone) "I take Lortab because I have osteoarthritis of the spine, and I would not be able to conduct my life on a daily basis if not for this medication. Some doctors don't like giving this medicine out to patients because it is habit-forming. But, like I told my doctor, pain 24/7 or a slight addiction. I will take the addiction. I can get over an addiction, but this pain is here to stay and is not going to get any better."

10 / 10
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  • DeAnna...
  • Taken for 2 to 5 years
  • April 11, 2013

Norco (acetaminophen / hydrocodone) "This medication is prescribed 10/350 mg up to 4 times per day - or as needed. I normally take it 3 times per day. It is the only medication that has not caused stomach bleeding problems as aspirin did, has not caused liver damage as Tylenol did, and has not caused kidney necrosis/nephritis as Advil did."

10 / 10
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  • Always...
  • Taken for 5 to 10 years
  • May 9, 2023

Norco (acetaminophen / hydrocodone) "I am a 53-year-old female who has undergone multiple surgeries on both knees and back twice a year, including knee replacements, steroid injections, cortisone injections, and nerve cauterization. I have been taking 10/325 for 7 years and only receive my prescriptions through a hospital or one Walgreens location because other Walgreens carry hydrocodone with a different formulation. Initially, I only had to take half or 1 pill a day at night, but now I have to take it every 6 or 7 hours due to severe sciatica, RLS, and nerve damage from all the surgeries. It's strange that some of my pills work fine and help relieve my pain, but others in the same bottle make me feel like I took three pills and leave me feeling sick and scared like I am overdosing. I have tried taking OTC naproxen for my back and muscle pain, and it helps to some extent. However, I would appreciate it if Norco was consistent across all Walgreens because they look and make me feel different, even having different numbers on them. I did some research and found out that they don't make them anymore, so the pharmacy might be giving out old meds."

7 / 10
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  • GRGuy
  • Taken for 10 years or more
  • October 13, 2019

"Unfortunately, I’ve been on various hydrocodone/APAP (acetaminophen) combinations since 2001 for chronic pain caused by a gunshot that caused irreparable damage. For about the last 4 years, I’ve been prescribed Norco 10/325. All was well until around the end of 2017. My regular pharmacy began carrying a different generic than the previous Watson brand I was receiving. Prior to this, I did have a few occasions where I did receive a different brand than Watson but never noticed any difference in quality (prior to 2014). Since Watson is long gone, I’ve tried probably 4 different generics, and they are total garbage. They either had no effect or too many negative side effects (heavy sedation, nausea, overall lousy feeling, etc.). Luckily, my doctor and pharmacist are knowledgeable and do not believe in the “generics are the exact same” philosophy. My doctor recently put me on Nalocet (name brand, made in the USA & held to higher standards), and my pain has been properly brought back under control."

4 / 10
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  • Daxton
  • March 30, 2013

Vicodin (acetaminophen / hydrocodone) "Over the years (I'm 75 now), I have used Vicodin 5/325mg for a range of things: had stable fracture of spine after a fall, broke one shoulder in 3 places, and the other a couple years ago. Have chronic back pain and if it gets bad, I get a prescription for it. A few surgeries: prostate, hernia, gall bladder, several dental procedures/surgeries. In each and every one of the mentioned cases, the Vicodin has been the pain management of choice. It frustrates me that after a doctor prescribed a couple of times, they are reluctant to further prescribe, citing the addiction factor. I've heard that doctors tend to UNDER PRESCRIBE because of this."

9 / 10
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  • Jacquie
  • Taken for 2 to 5 years
  • June 10, 2019

"The prescription for hydrocodone 10/325 I got this month from my usual pharmacist was manufactured by Aurobindo, an Indian company. Recently, I saw a documentary on ineffective pharmaceuticals that come from foreign countries, and it concerns me considering how expensive they are. I use CVS for my monthly prescriptions. Norco is getting hard to get for chronic pain patients like myself because the DEA is watching it carefully to make sure it isn't causing addiction. It is pretty much all I get anymore after two decades of chronic pain. I am going to complain to my pharmacist that this Aurobindo drug is ineffective and very expensive. I am prescribed 3 a day, and if I take 3 a day, I am still in pain and end up taking more with little relief. I am not a drug addict. I have serious bone issues that require more than ibuprofen and gabapentin. I am very concerned about the generic drugs we are given through legal processes."

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  • Momof
  • Taken for less than 1 month
  • October 14, 2018

"I have been using hydrocodone for 10 years for multiple problems I have, hormone imbalance that causes migraines, back pain, ulcerative colitis, etc. I do not take them regularly, but as needed, and only get my prescription filled for them twice a year. The couple of times a month I need them, I REALLY need them to function through the pain. This new brand Walgreens has switched to is terrible! I took one for back pain, and the following day I had a migraine that grew worse as the day went on. I can only guess the fillers in this brand are something my body is rejecting. On top of that, it did not remove the pain in my back. Not only did it not take the back pain away, it caused me days' worth of pain to follow in a multi-day migraine. This whole bottle is a waste, I will never put another one of these in my mouth again. The pills are marked G 037, which came up as Tris Pharma Inc. Shame on Walgreens for saving a few dollars at the expense of their patients!"

1 / 10
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  • SGano
  • Taken for 10 years or more
  • September 3, 2019

"I've been on generic Norco acetaminophen/hydrocodone 10/325 Watson for many years, same dose and amount a day. Anyone gone to a compound pharmacy to recreate the meds that work? Since Teva bought Actavis and discontinued this med, I've been on Mallinckrodt and Ameal. Mallinckrodt is awful, but Ameal (sp?) didn't work as well as Watson, but side effects were far less than Mallinckrodt. Now I'm having nausea, pain, sleeping, and normally I didn't have any side effects from Watson. How, since these meds are supposedly dangerous, are the government driving out safe American-made meds overseas, meds that are subpar and no quality? We have to suffer and can't ask for the right quality safe meds."

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.