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Acetaminophen / hydrocodone User Reviews & Ratings (Page 5)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.0 out of 10 from a total of 1,285 reviews on Drugs.com. 51% of reviewers reported a positive experience, while 35% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

  • Curley
  • June 10, 2020

For Pain "This acetaminophen/hydrocodone Camber brand yellow pill with the number T259 (325 mg/10 mg). This must have come from the black market because it is worthless. I have to stay in pain all month long. It is wrong to have your insurance pay for this pill. No more for me. I have to find out what is in this pill. My pain is too great. Camber, fix this medication."

1 / 10
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72 Report
  • Dee
  • Taken for 10 years or more
  • January 6, 2022

Lortab (acetaminophen / hydrocodone) for Pain "I have taken this medication for 30 years this is by far the worst ! One month ok, the next month like I'm taking nothing! When Watson brand was available I did not have this problem. It's extremely frustrating and painful!"

2 / 10
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50 Report
  • ezzboat
  • Taken for 10 years or more
  • May 27, 2015

Norco (acetaminophen / hydrocodone) for Back Pain "I'm taking Norco 10/325 for over ten years on and off. I'm over sixty-five. I've recently come to the reality that this wonder drug has lowered my back pain, diabetes sugar, depression, and neuropathy pain. I've been told I have reverse side effects from this medication than the average patients the doctor attends to. Everyone else says, 'Oh, you're hooked on pain meds', so what. If they help all of these problems I have and have no bad side effects I can't live with. The best to this drug."

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129 Report
  • Karrie
  • January 7, 2020

For Back Pain "Do not accept these rubbish brands! You don't have to go to CVS, Walgreens, or Walmart. Just find an independent pharmacy as I have done, and they were kind enough to order me the Cara brand, and I said I would cover out of pocket if my insurance didn't cover it. Do not accept useless pain meds! We are human beings, and it's not our fault about the opioid crisis!"

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76 Report
  • wraym...
  • March 11, 2008

Norco (acetaminophen / hydrocodone) for Pain "I have had a severe back injury and have been off work since Nov '06. I was first on Vicodin, which didn't work anymore, so they put me on Norco to manage the pain. It works wonders, and I take 1-2 every 4 hours. However, it has become very habit-forming, and I don't see an easy end to trying to cut back or get off these pills. They work great for pain, but be careful!"

10 / 10
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198 Report

Are you taking this medicine?

  • Wild...
  • Taken for 5 to 10 years
  • February 28, 2020

For Rheumatoid Arthritis "Ok so I agree with everyone about the changes to the pain pill formula. I have tried RP, and Mallinckrodt brand and they do absolutely nothing as far as giving me the overall pain relief. No real relief as they had before like Watson. Mallinckrodt used to be good but that was a long time ago. It’s almost like - might as well take an Aleve and a Tylenol. Problem with that is I have to take a lot of those often and then my kidneys and liver are hurting. Trashed my body even more. Mallinckrodt is better pain relief but nothing much better than Tylenol. There may be some formula out there to avoid the euphoria effect but without triggering that, it doesn't offer any of the pain benefits. Kind of like - have to have both or you get an alternative that does not actually work. But. Then people don't overdose so I get that also... Might be good for the addicts to stop but when I can't open a jar without excruciating pain or lift my arm, something has to give here. These brands all suck!"

1 / 10
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  • KmRie
  • February 21, 2020

For Back Pain "Over the past six months, I can't find any other brand of acetaminophen and hydrocodone but these new pills by Mallinckrodt, and similar. Definitely, this is the government and big pharma trying to curb the opioid epidemic without telling anyone. Who can afford a lawyer big enough to dig into this? Cardinal Health is now a 50-50 partner with CVS, and Cardinal regulates what drugs get distributed to all pharmacies. I heard this from two pharmacists directly. They took away their right to choose order-specific manufacturers. Imagine the money they're making by not even putting the active ingredient in these pills and selling them for the same price. They know that you're going to be treated as if you're a drug addict if you say anything. The only recourse you do have is to complain through the proper channels. That's about like saying you want your tax rate lowered for your income bracket! Unfortunately, people with true chronic pain issues are suffering because they don't fix the issue of addiction."

3 / 10
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74 Report
  • Angry...
  • Taken for 5 to 10 years
  • September 6, 2020

For Back Pain "I’ve had multiple back surgeries, fusions with hardware a few months back. The past 2 months CVS changed to Lupin acetaminophen/hydrocodone 10mg. I’ve had no relief from this medication and went through withdrawals for a couple days. I actually thought I had COVID but tested negative. I found hydrocodone in my medicine cabinet from my last surgery that I tried and had solid pain relief for almost 6 hours. Whatever these manufacturers are putting on the market is complete garbage. I’m going back to my doctor Tuesday to see if she can switch me to oxycodone or change to a brand name."

1 / 10
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67 Report
  • green...
  • Taken for 10 years or more
  • April 6, 2019

For Back Pain "Acetaminophen with hydrocodone generic quality issues. I had thought having to switch back and forth (thru CVS filling prescription) of Qualitest generic, which is good, and the Mallinckrodt generic, which I had thought was the worst. Now I am in pain and no way to shop around, I have had to accept this. Now I have gotten to experience Aurobindo brand of Acetaminophen with hydrocodone, what a joke, and now 3 weeks in, depression has settled in. What in the world do they put in this stuff? At 72, I still work but if this is the brand I will be getting, then I have to admit I may have to quit work. There is a burning pain in the tissues that settles in by the end of the night, and the depression is getting more overwhelming, it seems. I just can't see why us long-term pain patients have to suffer. I don't care what problem they are having with abusers, it doesn't delete me nor my pain."

1 / 10
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84 Report
  • Jantz...
  • Taken for 1 to 2 years
  • December 18, 2020

For Back Pain "I am so done with this generic hydrocodone. It does absolutely nothing for my pain and I don't understand how this medicine is even allowed on the market. There is no way in Hattiesburg there's more than 1 mg of hydrocodone in the 10 mg tablets. This stuff just makes me sick-ish and sleepy. Years ago it always worked, heck a half of one worked, now 2 won't even work. There is not one generic on the market today that is worth taking. If your doctor prescribes this for your pain you're pretty much going to suffer in pain like me and I know I'm not the only one as I know others who have had this med for pain issues and it didn't work for them either. Absolute garbage, the U.S. FDA is garbage as well to allow this."

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62 Report
  • Greg
  • Taken for 5 to 10 years
  • February 29, 2020

For Pain "I just got a script yesterday for the 1st time for these generic pills acetaminophen & hydrocodone. I've been taking 10/325 Norco's for over 6 years due to all my health issues along with OxyContin. I totally feel the difference with these pills. The yellow ones are actually the best I have ever taken, but these are garbage like everyone is saying. I just don't know how to file a complaint? Good luck everyone!"

2 / 10
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  • J in ...
  • Taken for 2 to 5 years
  • August 26, 2019

For Back Pain "I don’t know exactly what’s being put into the acetaminophen and hydrocodone pills these days, but I can clearly see that I’m not the only one that knows something is just not right! But please, people, listen to me when I tell you this: asking different pharmacies what the manufacturer of the pills they carry and asking if they have a different manufacturer of the medication can only get you barred from that location. Take it from me because I have one option in pharmacies these days that will fill my prescription. It’s crazy to me that you’re looked at as an addict if you want a specific generic that works for you. I mean, when did wanting to be pain-free make you a druggy (or junkie as I was referred to as)? But I feel like asking too many questions puts you on the 'do not fill' list, so tread carefully, people, or you may not be able to get anything. Much love, and I wish you all luck in a search for a life with no pain."

2 / 10
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77 Report
  • Bob
  • May 15, 2020

Norco (acetaminophen / hydrocodone) for Back Pain "Been on Norco 7.5/325 for 4 years . Had Spinal Fusion L4-S1 will never be the same . Norco has given me my life back . I am taking the Generic Version . For those of you complaining it DOES work . Be thankful you can get any Narcotics in todays world. They could say 800mgs of ibuprofen. Be thankful you are alive and kicking . Im 62 ."

10 / 10
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68 Report
  • Anonymous
  • December 11, 2019

For Pain "I have Fibromyalgia, neck herniated discs, plantar fasciitis. What is going on? They've been changing the generics, so they don't work. Why are they doing this to us? We are not the criminal junkies overdosing on illegal drugs. I have been taking the same Tris Pharmaceutical brand of acetaminophen with hydrocodone for several years at work okay until last year they changed it, so now it does not work. I know they changed it because I had some old pills left and they looked different. I got my new prescription and it's even worse than it was before. I am devastated. I have to support myself and I won't be able to with this pain being untreated. I can no longer clean my home or care for my sick cat. I am scared to death. Why is the government doing this to us? We need to file a complaint with the drug manufacturer and FDA. Maybe enough people are not complaining to the FDA and that is why all these companies have gotten away with it for so many years, as this all started about 6 years ago, when the Watson brand changed from yellow to white. Please file an FDA complaint."

1 / 10
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73 Report
  • Anonymous
  • Taken for 5 to 10 years
  • March 6, 2019

For Pain "Are all of you that are complaining about Mallinckrodt? Have you already filed complaints with the FDA? I sure hope so because that's the only way they will be stopped. So, sure, complain here BUT PLEASE FILE COMPLAINTS TO THE FDA! Also, do complaints on Tris. They changed their formula and it no longer works; this is sickening! I am gonna be homeless as I had to quit my job due to no pain relief! I know they changed it because I had saved a few pills from the prior month and when I took even HALF, I felt a night and day difference. Yet I called Tris, and they lie and say nothing changed. They are doing something probably illegal, and it also makes my heart race. They are playing with people's health and lives, and it's sickening."

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82 Report
  • Dee
  • Taken for 5 to 10 years
  • May 15, 2018

Vicodin (acetaminophen / hydrocodone) for Rheumatoid Arthritis "I was born with a gene called HLAB27+. I have arthritis and connective tissue disorder. As a child, I tried to play but got tired and it was too painful to stay up for long periods of time. I stayed in bed a lot. I tried to ride bikes with my friends as a teen but struggled. It wasn't until a doctor put me on pain meds in my 40s that I felt relief for the first time. Now the medical field is trying to reverse this decision. They need to hear the other side from people who have been helped. It is not our fault if people misuse their medication. I really do not believe this is the cause of the epidemic. Drunk drivers are caused by drinking too much and driving. If you don't drink excessively and don't drive while drinking, then there's no issue. The same applies here. I truly had no life before this pain medicine."

8 / 10
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91 Report
  • Spike
  • April 24, 2019

For Back Pain "I've been on Watson acetaminophen/hydrocodone 10/325 for the last 8 years and it has been the best medication that has worked, then out of the blue this Mallinckrodt acetaminophen/hydrocodone brand came along, along with the medication not working nearly as well and having an upset stomach and Walgreens does not do damn thing about it. I'm stuck taking something that does not work and corporate America does not care about the little people, they just care about making more money."

3 / 10
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80 Report
  • bkano
  • Taken for 1 to 6 months
  • March 25, 2020

For Rheumatoid Arthritis "I could tell a difference the first tablet I took; it gave me a stomach ache and made me feel almost lethargic after an hour or so. I thought my condition was maybe getting worse. I stopped taking the prescribed amount and just use it when needed; I felt awful for weeks. I got my new prescription of a different brand m365 and OMG I feel like me again without the side effects of this drug. I will be sure to let the pharmacy know that I can not take this brand to many different side effects."

1 / 10
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69 Report
  • skeeter
  • Taken for 5 to 10 years
  • February 7, 2019

For Pain "Like everyone else, I was on Watson brand till they sold out. Mallinckrodt is now what every major pharmacy has in our town of 200,000: Walmart, CVS, HEB, to name a few. First of all, if you call trying to find another brand, they treat you like a drug addict. I'm 70 years old, a retired teacher. What is this country coming to when you can't buy a pain reliever that works but you can get all the marijuana you need? The manufacturer of this Mallinckrodt should be investigated. No one in the government seems to care. Big surprise! I have a prescription for brand name only - guess what? The pharmacy won't even order the brand name. I still don't understand that, so you can't order the brand name. Someone answer that one."

1 / 10
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80 Report
  • Scarlet
  • Taken for 10 years or more
  • June 15, 2019

For Pain "I'm part of the acetaminophen with hydrocodone generic saga. I have had the same bad experience with Lupin brand of acetaminophen with hydrocodone. I've been a long-time, non-addict user of Hydrocodone for my Ehlers-Danlos pain. Recently, I got my first bottle of Lupin's acetaminophen/hydrocodone from CVS and went into withdrawal, increased pain, and my Mast Cell Disorder spiked. Two weeks later I was back to my normal manufacturer and went back to my normal. Today I got Lupin meds again and I'm tanking. This manufacturer is not providing the correct dosage and should be removed from the market."

1 / 10
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75 Report
  • Sassa...
  • May 1, 2020

For Rheumatoid Arthritis "I have been on Vicodin, Norco, Hydrocodone-Acetaminophen off and on for about 11 years with RA, PA, AS, fibromyalgia, spinal stenosis, DDD, neuropathy...well let’s just say my spine is a mess and causing the rest of my body problems. I was on Watson brand at first 5/500 and even 7.5/750 and they worked great and I only took one every 8 hours, even though I was prescribed 1 every 6. In the last year or so I was switched to U03 I have noticed that I am taking them every 6 and I’m even taking my Neurontin (gabapentin 300) more often than I was. I really do agree with a lot of the reviews that there is a new formula or something being implemented by the FDA because I can take one and barely feel the relief I always used to. I know its taking the edge off, so I know its got something in it!"

4 / 10
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65 Report
  • Leigh
  • Taken for 6 months to 1 year
  • February 24, 2019

For Back Pain "Just picked up my script for generic Norco. Pharmacy filled it with the M366 (Mallinckrodt Pharmaceuticals brand), I’ve been trying to figure out why these pain meds aren’t controlling my pain. Spinal fusion, degenerative disc disease, spurs on my disc etc. after reading all the reviews, I now know why it’s not working! It’s trash! I took a pill 2 hours ago and still waiting for pain relief! Ugh!"

1 / 10
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78 Report
  • Patsy
  • Taken for 10 years or more
  • March 13, 2020

For Back Pain "Cambra acetaminophen/hydrocodone yellows t257 not effective. Lots of fillers causing side effects. Reported to rite aid, optum Rx, cambra and fda. Also people who comment if possible mention the pill ID number. There are many generics."

8 / 10
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66 Report
  • Jax
  • March 29, 2019

Norco (acetaminophen / hydrocodone) for Pain "Both Norco and it’s Generic Actavis version 5-300 mg (White Scored Tablets) caused such a reaction that I turned in both prescriptions in to local Police Department Med Drop. CVS noted I could not take Norco, yet one month later they filled a prescription with the Generic form by Actavis, once again I was violently ill. For me Mallinckrodt White Oval Scored Tablet 5-300 mg is a marvel. No side effects whatsoever, just absolute pain relief in 30-45 minutes. Effective up to 5 hours, even 1/2 tablet is effective within an hour lasts perhaps 4-4:30 hours. CVS now only carries LUPIN Pharmaceuticals for Generic Hydrocodone/Acetaminophen 5-300 mg. Agh ! Massive headache, waves of nausea and dizzying lightheaded~No Pain Relief ."

1 / 10
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76 Report
  • 2 cents
  • Taken for 10 years or more
  • December 8, 2019

For Pain "Shocked that I have been taking generic Norco (acetaminophen with hydrocodone) and wondering why IT ISN’T HELPING. I used to get enough relief with the Watson brand to function enough, but that changed in [maybe] 2018. I didn’t know why, and I thought I just had to suffer to the point of being bedridden. I wasn’t aware of the change in manufacturer until now. Mallinckrodt brand of acetaminophen and hydrocodone DOESN’T WORK. I cannot believe that doctors are prescribing this new brand of garbage and allowing severely debilitating pain patients to suffer. I am so glad that I looked at the label on my generic Norco today. Thank you to everyone here who took the time to write about this maddening situation. Thank you so much."

10 / 10
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67 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.