I just recently went up on my zoloft to 100mg 6 days ago from 75mg. 7 days before that I was on 50mg for about 6 weeks. I still don't feel better at all and I'm getting very impatient. How long is a dose increase suppose to take to come in effect. I don't know wether to wait it out or just have my doctor change the medication. Also, how do you feel when it does start working.It just feels like I'll never be happy again, it's terrible
Zoloft not working?
Question posted by Omarbadawi on 21 Sep 2014
Last updated on 11 April 2015 by Robeva
5 Answers
I'm in the same situation, took 50 mg for three weeks, when up to 100 and it's been five weeks and still no change, I'm anxious all the time and I don't know if a should persevere or change , again, to another mes.
many people get some relief in 2 weeks or at least by four weeks. if it were me i would not spend alot more time on this drug if it has done nothing for you and try something new. maybe a week or more.
maybe more than just one week but not months.
In the Lippincott's drug guide, you may not know the full effect of the medication Zoloft for up to 16 weeks. But dose increases can be prescribed at no less than 1 week intervals and can be increased to a maximum of 200mg daily. If you are able, consider walking for 20 minutes a day to increase your endorphin's to lift mood. If you can only walk 10 minutes a day, that is the minimum time to get the endorphin's flowing. If you read, I suggest the book Simple Abundance.It has been a great practical guide and inspiration to me and many others. Good Luck in your recovery!
Too much too soon, that's my take on your dilemma. I believe in a 2-3 week minimum before dosage changes are made. You had 2 in a very short time. Be patients realizing your system needs time to adjust, especially with 2 increases in such a short time. 21 days from today, if there's no change, I'd then say this maybe isn't the med for you, and you will need ample time in between if you do switch, again a 2-3 week period minimum otherwise you'll get overlap and won't know up from down. Make sense?
I think the problem lies in the fact that you're first dose wasn't increased for a month and it wasn't enough. I doubt that the 50 was enough and its going to take you time for it to work now at 75. Normally it takes 4-6 weeks for it to work.
Related topics
zoloft, depression, major depressive disorder
Further information
- Zoloft uses and safety info
- Zoloft prescribing info & package insert (for Health Professionals)
- Side effects of Zoloft (detailed)
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