Was wondering if anyone could share with me what they noticed when zoloft started working for them? Was it small tiny improvements at first or was it a significant difference one day?
How do you know Zoloft is starting to work?
Question posted by jerkybubbles on 25 Aug 2015
Last updated on 29 December 2021 by jj1790
7 Answers
It takes about 6 to 8 weeks to work properly im on 5 and half werks and 200mg a day and still getting anxiety but yestsrday afternoon felt better and this morning was better tonight got anxiety so its starting to work just takes time if you can hang in there remember nothing happens over night
I've taken it twice and in both cases, it got worse before it gets better:
1. The first time, it increased anxiety and intrusive thoughts for about a week, peaking on day 7 when I increased from 25 to 50 mg. Over the week that followed, it was a very noticeable improvement for me. Insomnia, no appetite, and anxiety were the side effects for me.
2. The second time, it increased anxiety in the mornings until the early afternoon. Days 2-6 were rough but I felt like it was a more gradual improvement this time around. I'm only on day 13 so I'm still holding out for improvements to come.
For reference, I was in a much lower mental state the first time - a tiny improvement then probably had a much bigger impact on my outlook at the time. What I'm going through now is more like a series of stresses around the holidays that just wore me down. I've missed a few days of work and I'm having some difficulty with anxiety in the mornings and getting out of bed.
How are you doing now ?
I need advice as I’m on 150 for week 3 now and I’m not happy or excited at all .
I took it for anxiety (GAD) also this is my second time on it .
I've been taking 50mg for almost 4 weeks and have began to feel like doing more than sit around all day. I seem to enjoy things more and not sweat the small stuff. It has been gradual so far for me.
I’m back down to 25mg as the 37.5 mg I was a zombie. I’ve been down to the 25mg for 2 weeks now & still tired. Am I the only person to have this ? It is helping my depression, I’ve tried too many that haven’t helped at all... I also take 10 mg Adderall xr for adhd which slightly helps the fatigue. I’m too sensitive to all of these meds!
How do you know it's working
I started on 25mg and noticed my depression was less after 2–3 weeks. I’m now taking 37.5mg. The only problem is I’m completely exhausted. I may try taking at night. (I’m very sensitive to meds) I’ve tried quite a few antidepressants & so far this is the only one that may help me. But everyone is different.
Simple answer: You start feeling better.
"Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve.
Sertraline (Zoloft) | NAMI: National Alliance on Mental Illness"
Personally I always notice the side effects first. With sertraline it was insomnia and inability to reach a sexual climax. And I was aroused as hell so it was very frustrating. Side effects used to scare me. Now I see them as a sign that the meds are kicking in. BTW, rhe side effects I mentioned were gone within a week.
With me it was big things like wanting to get out of bed. Then little stuff like actually wanting to clean house. My mind set was better. I wanted to call family and just talk. Even taking a walk. I no longer wanted to stay in bed. I wanted to start living again. I have my ups and downs as we all do. It took the zoloft about a good month to fully set in for me. Within that first month I felt more anxiety and depression but that's part of the side effects. I hope this info helps you some and hope you feel better.
Related topics
zoloft, depression, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, premenstrual dysphoric disorder, social anxiety disorder, postpartum depression, major depressive disorder
Further information
- Zoloft uses and safety info
- Zoloft prescribing info & package insert (for Health Professionals)
- Side effects of Zoloft (detailed)
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