Hi, I'm a newbie. I just wanted to share that I've been on Wellbutrin for 1 year. Wellutrin alone does not work well for my depression and it gives me anxiety, plus insomnia. My doctor added Lexapro to take with Wellbutrin and it seemed to even me out but did nothing really for the depression. After trying this combo for about 9 months, I requested a change since it wasn't helping. Now I take Zoloft with Wellbutrin and I feel great!! I think this is my magic bullet!! I am very sensitive to drugs so I only take 50mg of Wellbutrin and 25 mg of Zoloft (both generic). I take them together in the morning and no side effects so far. I have energy, my mood is great, no anxiety, and I can focus at work. So far, so good! It has only been one week with this new combo and it may be too soon to tell how it will help me in the long run, but I wanted to share my experience thus far.
Has anyone else had good success with this combination??
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43 Answers
DI
Diplodicus
30 April 2022
I like a this thread. It good to remind selves medication work good good for one but bad bad for other.
I take 100 mg Zoloft and 300 Willy but trim and have much success. Thanks doctor for make a feel nice.
I ask though if others feel a bum feel what can only be pressure diplates. On the back of my swallow hole and on my bumper gus.
Any help a good get is nice. Thank you for all good reasons.
Votes: +0
DI
Diplodicus
30 April 2022
Update: Michael take Adam and a long time it took for my medical mixture juice to be positive. Deem a bear necessary to move. Thanks again!
MC
Mccordjo
7 Nov 2021
I use the same combination and am also very sensitive to medication. How do you take 50 mg of Wellbutrin. I can’t find it in lower doses than 150 and that’s too much for me.
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TA
TalmadgeGrayNP
24 July 2020
Yes, Wellbutrin augments Zoloft well as it targets different receptor sites in the brain than Zoloft. It can help with emotional flattening, sexual side effects from the SSRI Zoloft, and with motivation and focus. I have had good success treating patients with this combination. Be cautions in those with a seizure disorder however, as the combo can lower the seizure threshold. I am a board certified psychiatric nurse practitioner two years into practice, and I have almost 17 years of experience in the mental health field. Best of luck to you going forward!
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WI
WildcatVet
4 May 2020
"Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve. Sertraline (Zoloft) | NAMI: National Alliance on Mental Illness"
"How Long Does It Take For Bupropion To Work? While depressed mood, anxiety, and lack of interest in activities may need up to 4-6 weeks to improve, disturbances in sleep, energy, or appetite may show some improvement within the first 1-2 weeks."
Bupropion (Wellbutrin) | NAMI: National Alliance on Mental Illness
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CM
cme3612
4 May 2020
So happy to see your comments it offers encouragement. I’ve been on Zoloft 150mg since March and I was still struggling with anxiety and depression and zero libido. I asked my dr about combination therapy and a week ago he added Wellbutrin XL 150mg. I’m super drug sensitive and usually react opposite with everything. Praying this combination will work and fast. Its only been a week, how long did it take for you to get the benefit of both meds? Realizing everyone is different.
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MA
masso
26 March 2020
Yes, a close friend of mine has had great success.
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LJ
ljbarrett12
26 March 2020
How is it going now that it's been a bit longer? I'm considering this combo myself, w/ those exact dose amounts b/c I too am sensitive.
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CO
Corey-am
24 Jan 2020
Another new, newbie here!
I suffer from Borderline Personality Disorder with Major Depression, Generalized Anxiety Disorder, and Panic Disorder.
In August, 2019, I was taken off of Cymbalta and switched over to 150mg of Wellbutrin (generic) and I was okay for a month or so but all of a sudden I felt very depressed. Around November my anxiety and irritability were becoming very noticeable. By the end of December I started suffering from severe panic attacks here and there. Three weeks ago it was the worst it has been in almost 10 years. I am constantly anxious, having several panic attacks a day, and can't sleep.
I have been on so many medications in my lifetime. They started prescribing me at 14 years old and I am now 32. Nothing has seemed to work (Buspirone, Effexor, Citalopram, Valium, trazodone, Cymbalta, Seroquel, Olanzapine, and even Wellbutrin alone when I was 16... I'm missing some but we get the point). It is now at a point where I am a single parent unable to work and my illnesses have taken over my life.
Last week my doctor prescribed 25mg of Zoloft (generic brand) and after taking it for a week he wants me to increase it to 50mg. I was told o take my Wellbutrin in the morning and Zoloft before bed. I take .05mg of Clonazepam twice daily and while I get used to these medications he has prescribed me 15 0.05mg of Ativan to use as PRN's. I'm hoping this combo helps in some way because I am so desperate. I just want my life back.
I guess I'll keep you updated ad the combo does it's thing and let you know how it worked for me personally.
Votes: +1
TE
terim1
17 May 2019
Was given a prescription today for this combo. Took Lexapro for about a year. Stopped working. Started on Zoloft 50 a few months ago. Raised to 100 within the last month. Doctor started me today on adding 150 Wellbutrin to the existing Zoloft. Curious to see how this works and a tad nervous. Also in menopause and in need of total hysterectomy. Being a girl isn’t for the weak
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OP
Opa805
6 Nov 2019
I wish you the best and thank you for sharing your journey. I've been on Wellbutrin 300XL for almost a year now. Went to Wellbutrin SR 150 twice a day for a month and experienced severe adverse effects. Paranoia, elevated irritability and very quick to anger. Stopped that as soon as I could get back into the doctors. I'm looking forward to the combination of Zoloft and Wellbutrin I get to start hopefully next week.
Good luck to you in your search for what works.
EL
Elanas888
10 Feb 2019
I was taking 300 mg Wellbutrin but think it makes me little shaky so we went down to 150 Wellbutrin and went up on Zoloft to 100 mg. So far I think this is a good combo for me. Glad to hear other people out there are having positive results on this cocktail. I also take Ambien 10mg for sleep. It's my magic sleeping pill. I love it. I have been on Ambien for over 15 years. I'm was starting to worry about long term side effects of taking it so long. Does anyone know about long term use of Ambien??
Votes: +1
CA
Carol 7
9 Feb 2019
Hello - I’m a newbie too... YES! It’s the magic bullet for me as well!
I had taken sertraline at 200mg for severe anxiety for several years, which worked well. But my “brain fog” - which I did not recognise as residual depression at the time - persisted. Adding bupropion has worked like magic - the brain fog disappeared in 3 days. The only thing is that I am now sleeping for 12+ hours, I’ve read that bupropion can enhance the effect of “SSRI fatigue” so I’m thinking of asking my doctor to reduce the sertraline part of the combo. Has anyone else felt sleepy on this combo?
Votes: +1
TR
trudy19505
10 Feb 2019
I know meds effect everyone differently. I just wanted to share what happened to me with zoloft. I am taking 150mg of bupropion. I started having anxiety attacks. My Dr added 50mg of sertraline. No more anxiety. Trouble is after taking the Zoloft for about 3 months I started losing my hair. I have always had a thick head of hair but it started thinning very badly. My Dr took me off the Zoloft. It has been about 4 months now and I think my hair is getting it's thickness back. (thank goodness). The weird thing is I am still on bupropion and I stopped having anxiety attacks. I think my anxiety must of been situational.
PL
plc58
6 Aug 2018
Hi, I just started on the generic version of Wellbutrin, Bupropion HCL XL. I have been on Zoloft for a few years with no great response so my Dr. added this. I'm taking 150mg daily of the Bupropion and 100mg Zoloft. Even though the effects usually doesn't show for about 4 weeks, I don't feel that cloud over my head. I'm hoping this works. I can't stand not being able to concentrate at work, sluggish at home, and just plain unfocused.
Votes: +1
ST
Steve1157
6 Aug 2018
Hi, I am glad you are feeling better, The Wellbutrin XL works well with Zoloft. It will help to increase your energy levels and help with the fog.
HA
Hayleym4
29 Sep 2018
Do you take them ar the same time?
UN
unfocuseddeveloper
11 Jan 2019
Hi plc58, Your comment is extremely familiar to me. I've been on Zoloft (Sertraline) (but only 50mg) for a few years and was just prescribed Bupropion (150mg). While the Sertraline has really helped me with depression and anxiety, lately I am also not able to concentrate at work, feeling sluggish and just plain unfocused! Really sums up my issue recently. So now I am hopeful this will work for me like it worked for you! Hopefully it is still working great that is, I know it has been a long time since you posted this.
OP
Opa805
6 Nov 2019
Hello all, I've been seeing a lot of the "sluggish and cloudy," comments and thought I'd share my experience. I've been taking generic Wellbutrin HCL 300mg once a day for almost a year now. My energy picked up within the first month and my ability to focus being a returning student gave me the confidence I needed to succeed. The energy and focus is exactly what Wellbutrin gave me, also reducing my severe depression symptoms to almost nonexistence. Now I need to tackle the anxiety and social phobias with Zoloft.
My Dr started me out on 300 mg of Wellbutrin and buspar (which was supposed to help with my anxiety). I ended up in the ER with a severe panic attack. My Dr. adjusted my meds to 150mg of Wellbutrin and 50 mg of Zoloft. I haven't had anxiety since! So far this combo has worked for me.
Votes: +1
AU
AutumnLove
28 March 2018
I have been taking this combo now for 7mos and I take 100mg of Zoloft and 200mg Wellbutrin.. generic.. originally for postpartum depression.. but it seems to work rather well for me.. I am able to function and enjoy life.. my children.. family.. and the world around me.. so far this has been my perfect combo.. and I have tried many.. I am functional again..
Votes: +1
EL
Elanas
27 March 2018
I take 150 Wellbutrin with 100 Zoloft and the combo is working well for me too
