Can you take doxylamine and diphenhydramine together?

Hello,

There is a moderate interaction between both medications, moderate meaning:

Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Interactions between your drugs
Moderate
diphenhydrAMINE doxylamine
Applies to: diphenhydramine, doxylamine

Using diphenhydrAMINE together with doxylamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Source and more information:
https://www.drugs.com/interactions-check.php?drug_list=896-0,942-0

I recommend you talk to your Dr. if you have any concerns.

Regards, masso