Hi all, have been on Zoloft 50mg for about 4 months for depression and anxiety - was doing ok (I know, it's a small dose) yet three weeks ago I had a major relapse, including goodbye libido. Pdoc has now added 150mg of Wellbutrin to the mix; he feels this is better than upping the Zoloft and should return the libido. My question is - will I have any ramp-up side effects with Wellbutrin, similar to those of first starting out on a med, and, has this mix of Zoloft and Wellbutrin worked for others out there ... I appreciate your opinion as I continue my journey to just experience a genuine smile from within, after numerous years of suffering. Many thanks in advance for your responses.
Wellbutrin with Zoloft?
Question posted by khunlob on 30 Oct 2013
Last updated on 18 January 2019
5 Answers
Rx7girl
7 Sep 2016
I have been on 75mg of zoloft for 15+ years now & recently I felt like it wasn't enough, My doc added wellbutrin 150 xL in the AM. I see people post on here that take both in the morning, but I have been told by my pcp that taking both at the same time can cause serotonin syndrome and make you experience extreme dizziness, libido loss, night sweats,and headaches. I did take both at night for a while and was very sick, so I was told I could take the wellbutrin in the AM and the serotonin at night cause the zoloft at night it makes me so sleepy. Anyone else experience this?
Tnteach
29 Dec 2016
I need the same answer. If the two are prescribed together , do you have to take them at the same time of day ?
Kyle99
9 Feb 2017
I actually just contacted my doctor and he said that zoloft can be taken at night and wellbutrin in the morning. So no, they don't necessarily need to be taken at the same time.
PAULA310
18 Jan 2019
Zoloft is my " Anti D drug of choice ". I've been on SEVERAL dosages. I'm currently on 100mg at breakfast. Night time Never worked for me..Anyhow... Wellbutrin, I'm on 300mg. 100mg tablets ( 2 tablets at breakfast WITH THE ZOLOFT & my Topamax) and 1 tablet at NOON with my other tablet of Topamax. I take no meds at bedtime. I have to take
" immediate release " tablets because I had bypass surgery and I cannot process sustained release medication. I've been on this combination for at least 10+ years w/o any problems.
npariseau
8 Aug 2015
I have taken Wellbutrin for years this March I added Zoloft and it really helps. I did not notice symptoms from eithe. Sexually it works great no problems there with other meds it did not exist, good luck with your journey
marcar
1 Feb 2014
Hi there. Yes, I do have experience with Zoloft and Wellbutrin. I only take 25mg of Zoloft and 50 mg of Wellbutrin. If I take any more Wellbutrin I feel irritable and edgy and I can't sleep well. If I took 150 mg of WB, I would be bouncing off the walls! However, everyone reacts differently to different doses. Starting at a lower dose is always wise, then gradually increase as needed. Good luck!!
rorschach777
9 June 2014
Do you take both meds at the same time? Are you taking them mornings or nights?
Ellah
28 Oct 2014
I take them at the same time and still feel low. Been 7 months now. Maybe I should try different times of day.
marcar
30 Oct 2014
So it's been 1 year ago that I wrote my last post about taking wellbutrin with zoloft. The truth is that as of 1 month now, I am drug free. If it wasn't one thing, it was another with side effects. I got laid off of my job and my benefits stopped so I decided to wean off of everything little by little. I like that I am drug-free, but yes, I do have my down times. I am keeping up with my vitamins and now I just need to exercise. So far, so good. My down times, I noticed, is usually when I'm bored. Not working and being financially strapped is a downer in itself. Good luck everyone... Side note: I do take care of myself spiritually as well. Prayer, worship, and being around my church family helps tremendously :) Just feeling close to God brings me comfort. I constantly ask Him to heal me of any depression & to show me how I can deal with this naturally. My depression is very mild, it is not debilitating.
rorschach777
30 Oct 2014
Great news marcar!!
Please give us updates every now and then. Let us know how you managed to get off ADs.
kaw06
30 Oct 2013
I take welbutrin with an antidepressant and it really helps. You may have a few side affects(or not) for the first week, but it helps energy level and helped my libido as well. Good luck keep us updated!
LaurieShay
30 Oct 2013
Adding Wellbutrin is a viable option. It is known to enhance the libido for some people and will hopefully counteract the anorgasmic effect of the Zoloft. Give it a try and hang in there; it is a journey well worth the effort.
Related topics
wellbutrin, zoloft, depression, anxiety, generalized anxiety disorder, dosage, relapse, libido
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