How does single does Synvisc-One compare to the multidose protocols?

The one dose treatment is usually 6ml of the medication given at one time. Although this may be convenient, the amount of fluid being injected into that space in your knee is EXTREMELY PAINFUL!! Imagine, the three dose treatment... each vial has 2ml in the syringe. Combine all three into one syringe. It may not look like a lot but in the small space, it’s a huge amount!!

I had 3 shots in each knee 3 years ago this August. Before the shots I was dependent on a cane to go anywhere I wanted to go including the bathroom. Since I have had the shots I have only had to use my cane twice. I do have pain sometimes but it is nothing compared to what it was before I had the shots.

I tried this recently and, for me, it worked great. Much better than the three dose injections.

I found that it's about the make up, it took some searching

Orthovisc (high-molecular-weight hyaluronan). Unlike all other viscosupplements, Orthovisc is derived from bacterial cells, not rooster combs. This makes it an ideal option for OA patients with sensitivities or allergies to birds or chickens, eggs, and feathers. Orthovisc is available as a three- or four-dose injection. The most common side effects of an injection of Orthovisc include swelling around the joint and a rash or bruise at the injection site.

Synvisc-One (hylan G-F 20). Synvisc-One is the only viscosupplement approved as a one-dose injection. Studies show this viscosupplement can provide up to six months of OA relief after just one injection. The most common side effects of a Synvisc-One injection include swelling around the affected joint and pain and stiffness in the joint.

Hope that helps

I'm interested in knowing this as well - I get 5 weekly shots of Hyalgan every six months and would love to get 1 shot! Hopefully someone here knows and will enlighten both of us!

Does your doctor charge you anything for the actual cost of the medication (above your copay) or does insurance cover it? My doctor accepts what insurance pays, but most doctors in my area charge $100 per injection for the cost of the medication. So mine would cost me $500 more if I were seen by another doctor. I am very thankful for my doctor! Regards - EJ23