Is it safe to take valerian root if I am take Zoloft 25mg?

You can BUT, it may cause you to be more drowsy because of amplifying the Zoloft so be careful.

"Interactions between your drugs
Moderate
sertraline valerian
Applies to: Zoloft (sertraline), Valerian Root (valerian)

Using sertraline together with valerian may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. "