Is it safe to take a daily dose of 5mg tadalafil with 25mg losartan?

Hi, Blake!
There is a possibility of a very minor interaction but it's too technical for anyone but a physician or pharmacist to understand.
If your doctor prescribed both medications it may be that they feel the benefit is much greater than the risk.
I'd recommend talking with your doctor or pharmacist if you have concerns.
Sorry I couldn't be of more help.
Best regards,