Prescribed Cymbalta + oxycodone for intense pain. Will this cause confusion, trouble speaking, othe?

Cymbalta (duloxitine) is basically a SNRI drug used to treat depression. However using it off-label is can be effective for pain when used in some people as a pain-relief med for treating fibromyalgia. It is not a pain med though. Oxycodone (an opioid pain med) is the right med to use for hip and lower back pain. Also people who are depressed will sometimes respond well to Cymbalta because depression can cause a person to be more sensitive to nerve pain. Taking Cymbalta with Oxycodone should not be a problem. However taking Cymbalta with Tramadol could cause Serotonin Syndrome since both drugs are used for dealing with serotonin. With the hip and lower back pain that is the type of pain known as Nociceptive pain which oxycodone is the correct drug to treat this type of pain. Cymbalta will not have any effect on nociceptive pain.

Great question! I have been on this combination for about a year and one-half, and "Yes," I have experienced (i.e., although only sporadically) trouble with speaking, with some degree of confusion - often having to stop mid-sentence, and rather than explaining the issue, just stating, "Oh, I'm sorry - I forgot what I was going to say!" Obviously, this has troubled me, but I had no idea that it might be medication related. Sorry for not being able to give you an answer, but thank you for bringing up the issues - I will definitely start doing some research! Please reconnect with me should you find any conclusive evidence!

First oxycodone lowest strength is 5mg that would mean you would have to split the tablet in half which should not be done you could get an uncontrolled dose this medication should not be split chewed or crushed you can read this by going to drugs.com a great resource to review the medication you are on while I did not get any pain relief from C1ymbalta and it was a nightmare coming off of it and not worth taking. Good luck hope this helps

Hi, Birds!
Serotonin syndrome is rare and easily treatable in the early stage. It's good to get acquainted with the symptoms so you know what to watch for::
https://www.drugs.com/interactions-check.php?drug_list=949-2273,1770-0
This is more information for serotonin syndrome:
https://www.drugs.com/cg/serotonin-syndrome.html
Regards and feel better soon!