Oxycodone - Is there a difference in manufacturers of generic drugs?

I have experienced that you are correct with several different types of drugs. Different manufacturers' products are slightly different in the way they are produced which makes the end product also slightly different.

Theoretically one 7.5/325mg if Oxycodone/APAP should be the same as one and a half pills of 5-325mg of Oxycodone/APAP but in the case I'm quoting that's not true; the one and a half dose of 5-325mg acted better in the system than the 7.5mg dose.

I recently was given a different manufacturer and noticed an immediate difference. I have only been taking 10/325 for a year so I cut mine in half. I took them for a week and was having to take a full pill to even take the edge off of my pain. I still had some of the old pills so I took a half of that and I was back on business... it's not in your head. It's absolutely a difference by manufacturer. The ones that didn't work looked like a big Roland tablet and were manufactured by the "Midlothian" pharmaceutical company... I do not recommend them. I don't like taking pills and was even more concerning with having to take a full pill instead of a half. I told my doctor about this and he was the one that mentioned that other patients had complained about the same thing. That is how I ended up here. I googled it and saw that others have experienced the same problem. Next month when I turn my script in, I will ask the pharmacist at PUBLIX which ones they have and will take it somewhere else if that one is still being given out.

Personally, mallinkrodt is the best for me... can't remember what I took before... but I was on it for 3 years and it stopped helping. I find it more.absorbable and softer to break apart for half doses. I take Topamax for bipolar and the generic for them varies wildly. One version from Cipla in the their own factory packaging, makes me vomit and get horrible heartburn ,however, the kind packaged from the pharmacy is fine. ... Amneal. is fine ... both in and out packaging

YES! The different generic companies have a range in which they can make the drug. It is made following a plus or minus .05 of the brand's narcotic composition.

I have had rhoads ocycodone 10mg/325 and both times I suffered in pain. I really think there's no oxycodone in them seriously they are the worst by far I've ever had. Please make sure before you get script filled to ask if they are rhoads or marked rp and if so I'd suggest just refusing and ask for different manufacturer. Terrible ineffective pills !!! I also end up with bad Chest pain in my sernum 20 min after taking them.

I suffer from chronic pain and have been taking 10/325 percocet for 10 years. I've noticed a quality difference between suppliers. CVS was my pharmacy for 7 years and for an example they had 8 suppliers they purchased meds from and they eventually stopped using that one because of complaints. My best recommendation is to use a big name pharmacy such as Sam's Club and CVS. I've had no luck at places like Drug Mart, Rite Aid , Marc's. Find a pharmacy and stick with them.

Yes! I've always felt that way but this last two months it was proven! My pharmacy gave me one brand of oxycodone to only switch it the next month! I immediately thought that my body had gotten use to that dosage in just one month and the side effects had eased up! However, the following month they switched back to the original brand and all those old side effects came right with It!
Now I'm convinced that some generic manufacturers prescription are more potent than others! Leaving the medication to work differently as well as the way you respond to It!

My question to doctors now is, how can you know what is or isn't a true dosage for the condition if all manufacturers medications aren't created equally?

M brand are the best oxycodone 30s.

Yes. I found huge diff from walmart script to new guardian who uses rhodes pharmacy

This has always seemed to be a problem for many drugs that are generic. When I notice that my pills are not the same as the month before, I look on the bottle and it will say, "this is the same medication". I am not sure why they change manufacturers. I do know that a new drug cannot be sold in generic form until it's been on the market for 7 years, which is why they can sell non generic for so much money. Your Pharmacist will have the best answer for you. I hope this helps though. Hugs

Yes! When I went to pick up my Oxycodone the pharmacist told me it was a different manufacturer, and asked me if this was okay. I didn't think much of it, so I said yes. What a mistake!
First off, it doesn't seem to work as well or as long and in addition to that, when it wears off it is like hitting a brick wall.
I get sweaty shaky and wobbly. This happens several times a day so I am miserable. I have until 2/10 before my next fill and I don't know if I can take going through this until then.

In my experience there a huge difference in different brands and i take 20-30 mg oxycodone and feel some 30s are 30 while others are claiming to be 30 feel more like 5-20mg and do not last nearly as long..