The `Conflict Checker' didn't list any known conflicts / negative interactions between Zoloft and SAMe (an OTC reputed to have anti-depressant properties); the checker does list MAJOR warning against taking Zoloft with the other / better-known OTC St Johns Wort. Any research- or experience would be appreciated.
Interactions between Zoloft & SAMe?
Question posted by nedclark on 29 June 2013
Last updated on 29 June 2013
Answers
Inactive
29 June 2013
From webmd:
Major Interaction. Do not take this combination.
Medications for depression (Antidepressant drugs) interacts with SAMe
SAMe increases a brain chemical called serotonin. Some medications for depression also increase the brain chemical serotonin. Taking SAMe along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take SAMe if you are taking medications for depression.
Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.
Medications for depression (MAOIs) interacts with SAMe
SAMe increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking SAMe along with these medications used for depression might cause too much serotonin in the body, and serious side effects including heart problems, shivering, and anxiety. Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Delila
29 June 2013
Good find! Great information
nedclark
29 June 2013
Thank you for this info - I was aware of the well-publicized `serotonin syndrome' risks of combining ADs + St John's Wort (practically `skull-&-crossbones' dire on this site), so I was puzzled that I couldn't find any equivalent remarks on SAMe... since I presumed some similarity in its action to SJW... I congratulate you being able to tease this info from WebMD - I couldn't get its `interaction checker' to work! Thanks again,
Related topics
zoloft, depression, interaction, otc
Further information
- Zoloft uses and safety info
- Zoloft prescribing info & package insert (for Health Professionals)
- Side effects of Zoloft (detailed)
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