Hi all. My husband has been taking Seroquel for 4 months now and his sex drive has disappeared. All?

At doses higher than 300 mg, and take more than once a day, then it becomes an anti-psychotic. This dose range also possesses mood and emotional stabilizing properties.

Seroquel is A VERY UNIQUE drug. It's meant to block receptors and decrease activity in the brain, but the irony is that alot of the serotonin and norepinephrine receptors it blocks, are actually auto-receptors which increases the release of neurotransmitters in certain parts of the brain

Another thing that makes it unique is that, it also potently increases Norepinephrine (AKA: Nor-Adrenaline), which is a neurotransmitter, that when increased, has an excititory effect, and increases arousal and mood.

Norepinephrine for everyone, it's functions are to regulate arousal, having the ability to concentrate, be alert, have energy, and our short-term and working memory.

What's ironic, is that Seroquel is also a VERRRRY POTENT Anti-histamine (H1 Receptor Antagonist - this is also what allergy meds do, but much, much weaker then Seroquel). Unlike Norepinephrine, drugs that are anti-histamines have a depressant/tranquilzing effect.

When your brain, naturally activates H1(histamine1) receptors it creates neuronal excitation and firing. So when you take Seroquel, which antagonises the H1(histamine1) receptors, an anti-histamine, is reduces the neuronal excitation and firing in the brain.

So, in simpler terms, Seroquel both potently increase brain chemicals that have an activating effect, and at the same time it potently blocks receptors in your brain as well, all at the same time.

My #1 educated guess: If it's the Seroquel causing sexual side effects, it's the potent anti-histamine, which can be counteracted with caffeine, or medications like Provigil/Nuvigil, a stimluant used as a wakefulness-promoting agent.

I believe it's the anti-histamine, because that's the component of it that knocks people out and sleep... which would also decrease the stimulating feelings in sexual encounters because, anti-histamines decrease neuronal firing and arousal.