Has anyone tried Zoloft and Wellbutrin together for depression?

I have been on Wellbutrin for several years. It recently has started to not be enough so my Dr prescribed Zoloft. I’m literally going to start Zoloft today. I’m hopeful after reading others’ experiences.

Im on 250 mg Zoloft,with 300 mg Wellbutrin Xl and,dont see a problem taking them same,time I take them every morning

Ive taken generic Wellbutrin xl 300mg for 9 yrs, i felt better within days, increased energy, my mood was more upbeat. Unlike every other antidepressants I'd tried, paxil, prozac, Celexa on Wellbutrin my desire for sex was above average. I easily achieved orgasm. I'm 52 my husband 58, he mentioned one day he'd bet we were having more sex than anyone he knew.
After yrs on Wellbutrin i feel its not working as well on my depression my dr suggested zoloft last week in addition to Wellbutrin. Fingers crossed. If i gain weight or lose desire for sex I'll stop taking it. If either of those happened I'd be depressed anyway.

I have taken 200mg Wellbutrin, 25mg Zoloft twice a day, and in prescribed Ativan for anxiety. I use it to sleep. The first 3 days of taking both antidepressants I felt weird. I had more energy but would get these weird comedown spells of depression through out the day . I'm going to wait another week and if it keeps doing that in going to ses about increasing the Wellbutrin to 300 mg a day in
3 doses. I take pain meds for my back as well but he said they should not I interfere

I have never heard of being on 2 anti-depressants at once, but I have heard of being on one and taking Abilify with it. For me, Abilify kept me WIDE awake. I could not sleep at all! CHECK WITH YOUR DOCTORfor any side effects or questions you may have! Ask as MANY as you have to! Do NOT be scared or embarrassed. I went thru this with my regular doctor for female issues and she was not too happy about it. TOO BAD! Let me know! :) {{{{{{{{{{HUGS}}}}}}}}}}}}}}}}}}}}

I use this combination:

Zoloft: 200mg
Welbutrin XL: 300mg
Ativan: 2 x 1mg

other:
Codeine Phosphate: 60mg as needed/4 hours
Buscapan: Supposed to be 2 pills every 4 hours, but I only use it when
needed
Zofran: 4mg once every 8 hours
Flomax: 4mg once per day when needed

And one other perscription drug that slips my mind at the moment.

Anyway, I've had absolutely no problems with chemical toxicity. (knock on wood)

My husband is on 100mg of Zoloft & 100mg of Wellbutrin. Every med works differently for different people, but yes they can be taken together...

Just started this combo four days ago... will let you know how it works! Also an adderal and colotopin... Everyones input has been helpfull... thought it was crazy for the Dr to put me on two anti depressants; now I understand it could help:)

Unlike most of the people who posted a response to your question, I have in fact taken Zoloft in conjunction with Welbutrin. I have taken the latter for about 20 years to good effect, but added Zoloft because Welbutrin sometimes makes me "jumpy." My experience is they work quite well together because they tend to eliminate each other's shortcomings and each does something that the other lacks. Welbutrin is a congener of amphetamine, so its effects are stimulative, whereas Zoloft is an SSRI, and therefore tends to act more like a sedative. The doses I use are Welbutrin: 300mg SR in morning; Zoloft: 25mg morning and 25mg evening. I highly recommend you try it.

i take 200mg of wellbutrin twice a day and was started on 25mg of sertraline for about a month. Iam still having trouble sleeping i can stay up along time and then when i sleep it can be 10hrs or more. Compared to my past state i am doing way better in terms of my depression. However it feels like i have highs and lows one minute im in a really good mood then out of mowhere for no apparent reason i start feeling sad again. Currently i am trying to prevent a setback. furthermore, i am a female in the 20s and my sex drive is virtually nonexistent and i also have problems in terms of dryness. so the jury is still out on how well Wellbutrin and zoloft work together

yes that is what I am on now and I like it . I am still not 100 % I think I need therapy, but I have very little sexual side effects and the sex is better because I am not rushing and I can have an orgasm. when I was taking celexa and wellbutrin I could nt have an orgasm WHILE haveing sex.And I feel good.Am not nearly as nervous as I was . I am on 200 mg of sertraline and 200 mg of wellbutrin. I think if I went up on the wellbutrin the sex would be even better but m am as of now already paying 40 a month for it but it is worth it.

Merc I am currently taking 200mg per day of Zoloft, along with 150mg wellbutrin (both generics) as prescribed by a psychiatrist. Initially (spring 2010) I was taking Zoloft with a low dose of Klonopin (off of that now) for anxiety & depression. After a few weeks on Zoloft, my Doctor prescribed Wellbutrin to help with low energy, low libido, and depression as well. At first I did not like the idea of taking two Meds that are antidepressants, but had decided to follow my doctors advice after asking questions, etc. So far it does some to help. Hope that helps a little. Definitely talk to your doctor about adding the Wellbutrin.

I have never taken Zoloft but have been on Wellbutrin & Topiramate for over 10 years. Until about 8 years ago I had orgasms that blew me away. Now they just fizzle out just before they should. It's very frustrating & leaves me & my partner up in the air although I try hard not to show it to him. OK, I'm post-menopausal - the doctors' excuse but I have no other problems, i.e. dryness etc. just the orgasm. It has to be the meds. Most people are hoping that Wellbutrin will be the answer to their problems. It has caused mine. I hope you aren't all disappointed.

Hi! I've been on zoloft 250mg for about 10
years with wellbutrin 75mg being added about
7 years ago. (then came topamax too).
This seems to be the right (all three) combo
for me. There have been really bad times, huge
crises and setbacks. But with the meds things
have just not been as devasting as they
could have been to me (breast cancer twice
infidelity, death, etc. ) the depression, anxiety
and Ocd still flares , but goes away quicker
and not quite as detrimental to everyone around me.
The lack of libido is bad - but...