... makes me antsy, so I definitely can't take it at night. The directions say to take it with food. However, at the time of day I take it, I can't have food containing calcium or iron because of the thyroid medication I also take. So very often I do not eat when I take my Effexor or I eat a snack an hour later. I think I can tell a difference in my restlessness (foot tapping and so on) and in my level of emotional tranquility but I have not paid enough attention to be able to connect those things to whether or not I ate with the Effexor