Drinking alcohol on Zoloft?

Hi, Shaunna! This question comes up frequently and, although many people say they drink with antidepressants with no effects, there's no predicting how it will affect you. Of course, as others have said, mixing a depressant with an antidepressant doesn't make a whole lot of sense.
I'd recommend asking your doctor and following her/his recommendations.
If you feel like you can't have a good time without booze then, at least, be sure you're with people who can keep an eye on you, drive you home, etc.
Best regards and Happy (and safe) Holidays.

There is 1 alcohol/food/lifestyle interaction with Zoloft (sertraline):

Moderate
sertraline ↔ food
Moderate Food Interaction

You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can increase the nervous system side effects of sertraline such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns.

https://www.drugs.com/food-interactions/sertraline,zoloft.html

In my experience, alcohol is obviously not good if you’re depressed. BUT, we don’t always care when we’re depressed. Anyways, anytime I take an SSRI, I can get a hangover from one beer let alone getting drunk. So if you give it a shot, be prepared.

Zoloft is an anti-depressant. Alcohol is a depressant. So you can see why these 2 aren’t a good combination. For the Zoloft to work most effectively you should not drink alcohol with it.