I don’t want to tak anything that makes ckd worse I’m stage 4
Bupropion - Is it safe to take when you have CKD?
Question posted by Fostersinc on 3 May 2022
Last updated on 5 May 2022
Answers
masso
4 May 2022
Moderate
Bupropion (applies to bupropion) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Bupropion metabolites, some of which are pharmacologically active with one-fifth to one-half the potency of the parent drug, are excreted by the kidney. Although pharmacokinetic studies have not been conducted in patients with renal impairment, it is conceivable that bupropion and its metabolites may accumulate in such patients to a greater extent than usual. Therefore, therapy with bupropion should be administered cautiously in the presence of significant renal impairment. A reduced dose and/or dosing frequency should be considered, and patients should be closely monitored for possible adverse effects that could indicate high drug or metabolite levels.
Source: https://www.drugs.com/disease-interactions/bupropion.html#renal_dysfunction
Best regards, masso
masso
4 May 2022
Moderate
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
masso
5 May 2022
To make sure this medicine is safe for you, tell your doctor if you have ever had:
a head injury, seizures, or brain or spinal cord tumor;
narrow-angle glaucoma;
heart disease, high blood pressure, or a heart attack;
diabetes;
kidney or liver disease (especially cirrhosis);
depression, bipolar disorder or other mental illness; or
if you drink alcohol.
Related topics
depression, anxiety, bupropion, chronic kidney disease
Further information
- Bupropion uses and safety info
- Bupropion prescribing info & package insert (for Health Professionals)
- Side effects of Bupropion (detailed)
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